JP2003088329A - Analgesic health supplement - Google Patents
Analgesic health supplementInfo
- Publication number
- JP2003088329A JP2003088329A JP2001285178A JP2001285178A JP2003088329A JP 2003088329 A JP2003088329 A JP 2003088329A JP 2001285178 A JP2001285178 A JP 2001285178A JP 2001285178 A JP2001285178 A JP 2001285178A JP 2003088329 A JP2003088329 A JP 2003088329A
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- analgesic
- pain
- antioxidant
- health supplement
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
Description
【０００１】[0001]
【産業上の利用分野】この発明は鎮痛用組成物、特に植
物系生薬に抗酸化剤と複合ビタミンを配合した鎮痛用健
康補助食品に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an analgesic composition, and more particularly to an analgesic health supplement containing a botanical crude drug containing an antioxidant and a complex vitamin.
【０００２】[0002]
【従来の技術】痛みを伴う症状には、生体に対して外
部から組織を傷つけるか、傷つける可能性を持つ侵害刺
激を加えた場合、発痛作用を持つ内因物質を外部から
適用した場合、神経を含む組織に炎症などの病変や異
常がある場合 等のように明らかな原因がある場合だけ
でなく、既にない身体の一部に痛みを覚える幻肢痛、ス
トレスに伴う心因性の痛みなど、十分には解明されてい
ない原因とその結果によるものが極めて多い。特に、近
年の急速な高齢化に伴い、骨粗鬆症、自律神経異常、筋
肉疲労、体液異常などの慢性成人病的な要素を持つもの
も加齢と共に増加しており、単に痛みの改善除去だけで
なく、その予防に対する社会的需要も高まっている。2. Description of the Related Art Painful symptoms include nerve damage to a living body from the outside when a noxious stimulus is applied to the living body or a noxious stimulus that may damage the living body, and an endogenous substance having a pain-producing effect is applied from the outside. Not only when there is an obvious cause such as inflammation or other lesions or abnormalities in tissues that include phantom limb pain that causes pain in a part of the body that does not already exist, psychogenic pain associated with stress, etc. However, there are a large number of causes and results that have not been fully clarified. In particular, with the recent rapid aging of the population, those with chronic adult pathological factors such as osteoporosis, autonomic nervous system abnormality, muscle fatigue, and body fluid abnormality are increasing with age, and not only improving and eliminating pain but also , Social demand for its prevention is also increasing.
【０００３】従来、末期ガン患者に対するモルヒネの投
与に典型例が見られるように、薬物投与による痛みの軽
減が試みられているが、肝臓・腎臓に対する副作用の
他、習慣性の問題もあり、特に慢性関節リウマチ（Ｒ
Ａ）など、免疫異常を背景に持つ慢性炎症性疾患につい
ては使用することは困難である。副作用の少ない鎮痛医
薬として、生薬系の漢方薬が注目されており、特開平６
−１０７５５３号、特開平６−１０７５５６号などにそ
の例が見られる。[0003] Conventionally, as is typical in the administration of morphine to end-stage cancer patients, attempts have been made to reduce pain by drug administration, but there are side effects on the liver and kidneys as well as addictive problems. Rheumatoid arthritis (R
It is difficult to use for chronic inflammatory diseases such as A) which have a background of immune abnormality. As an analgesic drug with few side effects, a herbal medicine of Chinese herbs has been attracting attention.
Examples thereof are found in Japanese Patent Application Laid-Open No. 1075553 and Japanese Patent Application Laid-Open No. 6-107556.
【０００４】特開平６−１０７５５３号は、哺乳動物に
おける免疫系の中枢臓器である胸腺を主成分とするもの
である。人体においては痛みを抑制または除去するため
にモルヒネ様の作用を有するβエンドルフィン等のオピ
オイドペプチドが分泌される機能が備わっているが、そ
の活性化は免疫系が十分に機能しているかどうかによっ
て大きな違いがある。胸腺の摂取は、これによって直接
にオピオイドペプチドの分泌を産生するものではない
が、免疫機能の改善によってオピオイドペプチドの分泌
を促進しようとするものである。この組成物は、従っ
て、免疫異常を背景に持つ慢性炎症性疾患については免
疫機能の改善の結果としての効果が見られるとしても、
心因性の痛み等を除去することは難しい。また、近年の
狂牛病の発生に伴い欧州においては胸腺の取引を禁止す
る措置が取られている等の問題もあり、動物臓器の使用
が需要者に支持され難くなっている。これに対して特開
平６−１０７５５６号は、植物系漢方生薬のみからなる
鎮痛剤を開示しており、鎮痛、沈静、抗炎症作用を有す
る成分と消化吸収促進、滋養強壮、血行改善などの作用
を有する成分とを配合したとしている。これにより根本
原因の改善作用として支持組織・筋肉を滋養し、２次原
因である体内の余分な水分の***、血行不良による手足
の冷えなどを改善することによる鎮痛作用が生じるとし
ている。Japanese Unexamined Patent Publication (Kokai) No. 6-107553 mainly contains the thymus, which is a central organ of the immune system in mammals. The human body has the function of secreting opioid peptides such as β-endorphin, which has a morphine-like action in order to suppress or eliminate pain, but its activation depends on whether the immune system is fully functioning or not. There is a difference. Ingestion of the thymus does not thereby directly produce secretion of opioid peptides, but it does seek to promote secretion of opioid peptides by improving immune function. This composition, therefore, is effective as a result of the improvement of immune function for chronic inflammatory diseases with a background of immune disorders.
It is difficult to remove psychogenic pain. Further, with the recent outbreak of mad cow disease, there are problems such as the prohibition of thymus trading in Europe, which makes it difficult for consumers to support the use of animal organs. On the other hand, Japanese Patent Laid-Open No. 6-107556 discloses an analgesic consisting only of a herbal herb of plants, which has an action of analgesic, sedative, anti-inflammatory component and digestive absorption promotion, nourishing tonic, blood circulation improvement and the like. It is said that it is blended with a component having. As a result, it is said that as an effect of improving the root cause, the supporting tissues and muscles are nourished, and an analgesic effect is produced by improving the secondary causes such as excretion of excess water in the body and coldness of the limbs due to poor circulation.
【０００５】一方、特開平５−１１２４４８号は、活性
酸素に着目し、抗酸化剤としてβカロチンを配合した鎮
痛薬を開示している。近年、活性酸素が人体に及ぼす影
響が明らかになりつつあり、その関与が疑われている疾
患は、ガン、動脈硬化、老人性痴呆、脳梗塞、神経痛、
関節炎、リウマチ性疾患、心筋梗塞、痛風、糖尿病、ア
レルギー性疾患と、２００以上にのぼるとされている。
このような観点から、アスピリン、アセトアミノフェン
などの鎮痛薬と抗酸化剤としてのβカロチンとを配合す
ることが提案されている。しかし、ここで使用されてい
る西洋薬剤仕様の鎮痛薬は、身体機能全般にわたる改善
作用はなく、上記の漢方生薬による鎮痛薬に比べて、心
因性の痛みまでを含めた幅広い痛みに対応することは困
難である。On the other hand, Japanese Unexamined Patent Publication (Kokai) No. 5-112448 discloses an analgesic containing β-carotene as an antioxidant, focusing on active oxygen. In recent years, the influence of active oxygen on the human body has been clarified, and diseases suspected to be involved are cancer, arteriosclerosis, senile dementia, cerebral infarction, neuralgia,
It is said to be over 200 with arthritis, rheumatic diseases, myocardial infarction, gout, diabetes and allergic diseases.
From such a viewpoint, it has been proposed to combine an analgesic such as aspirin and acetaminophen with β-carotene as an antioxidant. However, the Western drug-specific analgesics used here do not have an improving effect on all physical functions, and they can deal with a wide range of pains including psychogenic pains, compared to the above-mentioned Chinese herbal medicine analgesics. Is difficult.
【０００６】[0006]
【発明が解決しようとする問題点】本発明は、植物系生
薬によるβエンドルフィン等のオピオイドペプチドの産
生の活性化と抗酸化剤及び複合ビタミンの相乗効果で痛
みを消すと共に、身体の機能亢進による免疫機能の改
善、活性酸素の除去により、鎮痛作用と共に加齢性疾
患、その他の痛みを伴う疾患の予防効果をも得ることが
できる鎮痛用健康補助食品を得ようとするものである。DISCLOSURE OF THE INVENTION Problems to be Solved by the Invention The present invention is based on activation of the production of opioid peptides such as β-endorphin by a botanical herb and the synergistic effect of antioxidants and complex vitamins to eliminate pain and enhance the function of the body. It is intended to obtain a dietary supplement for analgesia that can improve the immune function and remove active oxygen, and can also have an analgesic effect as well as a preventive effect on age-related diseases and other painful diseases.
【０００７】[0007]
【課題を解決するための手段】上記目的を達成するため
の本発明の鎮痛用健康補助食品は、植物系生薬による鎮
痛薬と抗酸化剤及び複合ビタミンとからなることを特徴
とする。上記植物系生薬による鎮痛薬は、漢方生薬であ
るハトムギ、鶏血藤、松葉、桂皮、甘草、降香、紅花、
五加皮、山椒、真珠貝末、陳皮末、生姜を含み、さらに
これに南アフリカ原産の植物生薬であるデビルズクロー
を配合した組成物であり、上記抗酸化剤は、ビタミン
Ｅ、アスタキサンチン、エンゾジノールの中の少なくと
も１種あるいはそれらの組合せを含む。また、上記複合
ビタミンは、ビタミンＢ１、ビタミンＢ２、ビタミンＢ
６、ビタミンＢ１２、ビタミンＤ３、の中の１種あるい
はそれらの組合せを含む。さらに、身体の機能亢進、免
疫機能の改善、加齢性疾患の予防のためには、コンドロ
イチン、コラーゲン、グルコサミン、イソフラボン、エ
キナセアの中の１種あるいはそれらの組合せを含むこと
が望ましい。Means for Solving the Problems The dietary supplement for analgesia of the present invention for achieving the above object is characterized by comprising an analgesic by a botanical crude drug, an antioxidant and a complex vitamin. The above-mentioned botanical herbal analgesics are herb crude drugs such as pearl barley, chicken blood wilt, pine needles, cinnamon, licorice, aroma, safflower,
It is a composition containing Goka skin, Japanese pepper, pearl shell powder, Chen skin powder, ginger, and further mixed with Devil's claw, which is a herbal drug native to South Africa. The antioxidant is vitamin E, astaxanthin, or enzogenol. At least one of them or a combination thereof is included. The above-mentioned complex vitamins are vitamin B1, vitamin B2, and vitamin B.
6, Vitamin B12, Vitamin D3, or a combination thereof. Further, in order to enhance the function of the body, improve the immune function, and prevent age-related diseases, it is desirable to include one or a combination of chondroitin, collagen, glucosamine, isoflavone, and echinacea.
【０００８】ここで配合される各成分中、植物系鎮痛薬
成分は漢方生薬としてハトムギ 東洋医学においては、
利水、抗ウイルス作用のほか、鎮痛、除麻痺作用がある
とされ、特に神経痛によい。鶏血藤 血流改善により、
循環状態を改善して鎮痛するほか、手足の萎縮、しび
れ、麻痺などに強い効き目が得られる。松葉 東洋医学
において、不眠の改善、関節痛などの鎮痛・沈静作用に
強い効き目が得られるとされる。桂皮 解熱、健胃、抗
菌、抗ウイルス、抗真菌作用のほか、特に頭部血管攣縮
による頭痛に対する強い鎮痛効果が得られる。甘草 補
脾益気、清熱解毒作用のほか、強い鎮痛、沈静作用が得
られる。降香 理気止痛、活血などの作用がある。紅花
血流改善作用があり、月経痛、狭心痛、挫傷、捻挫、
打撲による疼痛、内出血、腫脹に強い効き目が得られ
る。五加皮 肝腎を補い、筋骨の強化、抗炎症作用、浮
腫を除く作用のほか、鎮痛作用があり、慢性関節リウマ
チや関節痛などに利用されている。山椒 健胃整腸、解
毒作用のほか、鎮痛効果があり、特に神経痛に強い効き
目が得られる。真珠貝末 神経系の安定による沈静効
果、ひいては痛み感覚の軽減に強い効き目が得られる。
陳皮末 フラボノイド、リモネンを含み、消化促進、健
胃整腸作用を持ち、胃のもたれ、不快感の予防に強い効
き目が得られる。生姜 血行不良の改善作用を持ち、頭
痛、腹痛、腰痛に強い効き目が得られる。また、漢方以
外の生薬としてデビルズクロー 根の部分に強い消炎、
鎮痛作用があり、ヨーロッパでは関節炎、リウマチの治
療薬として販売の実績を積んでいる。Among the components to be blended here, the plant-based analgesic component is a Chinese herbal medicine in pearl barley Oriental medicine,
It is said to have water repellent and antiviral effects as well as analgesic and deparalytic effects, and is especially good for neuralgia. By improving blood flow,
In addition to improving circulatory status and analgesia, it has a strong effect on atrophy of the limbs, numbness and paralysis. Matsuba In Oriental medicine, it is said to be effective in improving insomnia and analgesic / sedative effects such as joint pain. Cinnamomi In addition to antipyretic, stomachic, antibacterial, antiviral and antifungal actions, a strong analgesic effect is obtained especially for headache caused by head vasospasm. Licorice spleen In addition to spleen gain energy and clear heat detoxification, strong analgesic and sedative effects are obtained. Aroma scent There are effects such as sedation and live blood. Safflower has a blood flow improving effect, and has menstrual pain, angina, contusion, sprain,
It has a strong effect on bruising pain, internal bleeding and swelling. Pentacarpium Supplements hepatorenal, strengthens muscles and bones, has anti-inflammatory action, removes edema, and has an analgesic action, and is used for rheumatoid arthritis and joint pain. Sansho In addition to a healthy stomach intestine and detoxification, it also has an analgesic effect, and is particularly effective against neuralgia. Pearl pearl oyster A sedative effect due to the stabilization of the nervous system, and thus a strong effect in reducing pain sensation, is obtained.
Containing flavonoids and limonene at the end of rind skin, it has a digestive effect and a gastric intestinal function, and is highly effective in preventing stomach upset and discomfort. It has the effect of improving poor circulation of ginger and has a strong effect on headache, abdominal pain and low back pain. In addition, as a herbal medicine other than Kampo, strong inflammatory effects on the roots of Devils claw,
It has an analgesic effect and has been sold in Europe as a therapeutic drug for arthritis and rheumatism.
【０００９】抗酸化剤成分は、活性酸素除去の作用を持
ち、活性酸素が関与する疾患の鎮痛とその予防効果を期
待することができる。ビタミンＥ 血行の促進による鎮
痛作用と、炎症の発生に大きな役割を果たす過酸化脂質
などのフリーラジカルの発生を抑えることによる痛みの
予防に強い効き目が得られるとともに、カルシウムの産
生に役立つ。アスタキサンチン ビタミンＥと比較し
て、濃度によっては１００〜１０００倍にも及ぶ高い活
性酸素除去作用を持ち（特許第２６１９９１号明細書
図４およびその説明）、動脈硬化を防止し、血流を改善
する。また、抗ストレス作用により、人体の機能を支え
る気、血、水の滞りを防止する。エンゾジノール ニュ
ージーランドにおいて開発された抗酸化剤で、バイナス
ラジアタ科の松の樹皮から抽出されたオリゴフェノリッ
ク化合物で、強い抗酸化作用を持つ。The antioxidant component has a function of removing active oxygen, and can be expected to have an analgesic effect on diseases associated with active oxygen and its preventive effect. Vitamin E It has an analgesic effect by promoting blood circulation, and it has a strong effect on the prevention of pain by suppressing the generation of free radicals such as lipid peroxide, which plays a major role in the occurrence of inflammation, and also contributes to the production of calcium. Astaxanthin Compared with Vitamin E, it has a high activity of removing active oxygen up to 100 to 1000 times depending on the concentration (Patent No. 261,991).
4 and its description), prevent arteriosclerosis and improve blood flow. In addition, the anti-stress action prevents the retention of energy, blood, and water that support the functions of the human body. Enzogenol An antioxidant developed in New Zealand. It is an oligophenolic compound extracted from the bark of Pinus radiata, which has a strong antioxidant effect.
【００１０】ビタミン剤は、神経痛、関節痛、神経炎な
どの予防と回復、抗炎症作用を有することが知られてお
り、本組成物に配合されるものは、ビタミンＢ１ 神経
痛や関節痛、末梢神経炎による手足のしびれを抑える。
ビタミンＢ２ 免疫賦活作用、皮膚・粘膜の保護作用の
ほか、痛みの主要な原因の一つである炎症に対する抗炎
作用がある。ビタミンＢ６ 皮膚・粘膜・神経機能の正
常化作用があり、痛覚神経の過剰反応を抑える強い効き
目が得られる。ビタミンＢ１２ 末梢神経の痛みを鎮め
る強い効き目が得られる。ビタミンＤ３ カルシウムの
産生に役立ち、骨粗鬆症を予防する。[0010] Vitamin preparations are known to have a preventive and recovering effect on neuralgia, arthralgia, neuritis and the like, and have an anti-inflammatory effect. The composition contained in this composition is vitamin B1 neuralgia, arthralgia and peripheral pain. Reduces numbness in limbs due to neuritis.
Vitamin B2 In addition to its immunostimulatory action and skin / mucous membrane protective action, it also has an anti-inflammatory action against inflammation, which is one of the major causes of pain. Vitamin B6 Has a normalizing effect on skin, mucous membranes, and nerve functions, and has a strong effect of suppressing excessive reaction of the pain nerve. Vitamin B12 A strong effect for soothing peripheral nerve pain is obtained. Helps produce Vitamin D3 calcium and prevents osteoporosis.
【００１１】痛みの間接原因として、ストレス、自律神
経異常、ホルモン異常、血行不良、関節異常等があり、
上記の配合成分にもこれらの改善効果を有するものが見
られるが、さらに、この間接原因の除去に役立ち、痛み
の予防効果を高めることを目的として、以下の成分を配
合する。コンドロイチン（鮫軟骨） 軟骨中に存在し、
骨と骨の間のクッションの役目をする。コラーゲン 多
細胞動物の結合組織中に見られ、ステロイド皮膚炎の改
善作用がある。グルコサミン 決定的な治療法や有効な
医薬が見当らない変形性関節炎に、安全で優れた機能性
を持つとされる。イソフラボン 女性ホルモン様作用を
有し、エストロゲン分泌低下に原因する不定愁訴による
障害を鎮める。また、骨からのカルシウムの流失を防止
し、骨粗鬆症を予防する。エキナセア 北米インディア
ンの万能薬として知られ、ヨーロッパを中心として広く
利用されているが、頭痛、喉の痛み、鼻炎、気管支炎、
慢性的炎症など、広く効果があり、免疫機能の回復作用
を持つ。これらの成分中、コラーゲンによる皮膚の性状
改善、コンドロイチンによる関節機能の改善などの作用
は、配合された抗酸化剤による老化の進行の抑制、ビタ
ミンなどによる身体機能の亢進作用との相乗効果によっ
て、若さを保ち、美容にも良い効果を生じる。Indirect causes of pain include stress, autonomic nerve abnormality, hormonal abnormality, poor blood circulation, joint abnormality, etc.
Some of the above-mentioned ingredients also have these improving effects, and the following ingredients are added for the purpose of helping eliminate this indirect cause and enhancing the preventive effect on pain. Chondroitin (shark cartilage) is present in cartilage,
It acts as a cushion between the bones. Collagen It is found in the connective tissue of multicellular animals and has the action of improving steroid dermatitis. Glucosamine It is said to have safe and excellent functionality for osteoarthritis for which no definitive treatment or effective drug is found. Isoflavone has a female hormone-like action and suppresses disorders caused by indefinite complaints caused by decreased estrogen secretion. It also prevents the loss of calcium from the bone and prevents osteoporosis. Echinacea Known as a panacea of North American Indians and widely used mainly in Europe, it has headache, sore throat, rhinitis, bronchitis,
It has a wide range of effects such as chronic inflammation, and has an effect of restoring immune function. Among these ingredients, the action of collagen to improve skin properties, the action of chondroitin to improve joint function, etc., is due to the combined effect of suppressing the progress of aging by the combined antioxidants and enhancing the physical function of vitamins, etc. It keeps youthful and has a good effect on beauty.
【００１２】[0012]
【発明の実施の態様】上記漢方生薬はすべて薬種店で粉
末あるいはエキスの状態で販売されており、その他の薬
剤も一般に市販されており、容易に入手可能である。こ
れらは他の成分と共に、長く薬剤あるいは健康食品とし
て販売利用されてきたものであり、副作用も毒性もない
ことが周知されている。粉末状の各成分を賦形剤と共
に、１錠３５０ｍｇとなるように打錠する。これによ
り、保存中の変質を避け、携帯に便利でどこでも摂取出
来る等の利点を生じる。各成分の望ましい配合比は以下
のようである。
ハトムギ １５〜５％
鶏血藤 １０〜３％
松葉 １０〜３％
桂皮 ７〜１％
甘草 ７〜１％
降香 ７〜１％
紅花 ７〜１％
五加皮 １０〜３％
山椒 ３〜０．５％
真珠貝末 ２０〜５％
陳皮末 ５〜１％
生姜 ３〜０．５％
アスタキサンチン １０〜３％
エンゾジノール ６〜１％
ビタミンＢ１ ７〜１％
ビタミンＢ２ ２〜０．１％
ビタミンＢ６ ２〜０．１％
ビタミンＢ１２ ０．１〜０．００５％
ビタミンＤ３ ０．１〜０．００３％
ビタミンＥ １〜０．１％
コンドロイチン ２０〜５％
コラーゲン ２０〜５％
グルコサミン ２０〜５％
イソフラボン ７〜１％
エキナセア ５〜０．５％BEST MODE FOR CARRYING OUT THE INVENTION All the above Chinese herbal medicines are sold in the form of powder or extract at drug stores, and other medicines are generally commercially available and easily available. It has been well known that these, along with other components, have been sold and used as medicines or health foods for a long time and have neither side effects nor toxicity. Each ingredient in powder form is tableted together with an excipient to give 350 mg per tablet. As a result, there are advantages such as avoiding alteration during storage, being convenient to carry, and being able to be taken anywhere. The desirable compounding ratio of each component is as follows. Pearl barley 15-5% chicken blood wilt 10-3% pine needles 10-3% cinnamon bark 7-1% licorice 7-1% aroma fragrance 7-1% safflower 7-1% gokakin 10-3% sansho 3-0. 5% Pearl shell powder 20-5% Chen skin powder 5-1% Ginger 3-0.5% Astaxanthin 10-3% Enzogenol 6-1% Vitamin B1 7-1% Vitamin B2 2-0.1% Vitamin B62 2- 0.1% Vitamin B12 0.1-0.005% Vitamin D3 0.1-0.003% Vitamin E 1-0.1% Chondroitin 20-5% Collagen 20-5% Glucosamine 20-5% Isoflavone 7- 1% Echinacea 5-0.5%
【００１３】[0013]
【実施例】以下、錠剤形態の本発明の鎮痛用医薬組成物
の１例を示す。配合比の１例は、錠剤１粒を３５０ｍｇ
としたとき、以下のようである。
ハトムギ ２３．００（ｍｇ）
鶏血藤 １７．００
松葉 １４．００
桂皮 ８．５０
甘草 ８．５０
降香 ８．５０
紅花 ８．５０
五加皮 １８．００
山椒 ４．００
真珠貝末 ３０．００
陳皮末 ６．００
生姜 ３．００
ビタミンＥ １．００
アスタキサンチン ２０．００
エンゾジノール ５．００
ビタミンＢ１ ８．００
ビタミンＢ２ １．５０
ビタミンＢ６ １．５０
ビタミンＢ１２ ０．０２
ビタミンＤ３ ０．０２
コンドロイチン ３０．００
コラーゲン ３０．００
グルコサミン ３０．００
イソフラボン １０．００
エキナセア ５．００
賦形剤 残部EXAMPLE One example of the analgesic pharmaceutical composition of the present invention in the form of tablets is shown below. One example of the compounding ratio is 350 mg per tablet.
Then, it is as follows. Pearl barley 23.00 (mg) chicken blood marrow 17.00 pine needles 14.00 cinnamon skin 8.50 licorice 8.50 fragrance 8.50 safflower 8.50 gokakin 18.00 sansho 4.00 pearl shell powder 30.00 Cinnamon powder 6.00 Ginger 3.00 Vitamin E 1.00 Astaxanthin 20.00 Enzogenol 5.00 Vitamin B1 8.00 Vitamin B2 1.50 Vitamin B6 1.50 Vitamin B12 0.02 Vitamin D3 0.02 Chondroitin 30. 00 Collagen 30.00 Glucosamine 30.00 Isoflavone 10.00 Echinacea 5.00 Excipient Excipient
【００１４】以下、中国長春中医学院において行った臨
床試験の結果を、配合別、病名別、１日投与量、投与期
間別に表１、表２に示す。表３に示す対照とした鎮痛薬
は植物系漢方生薬とビタミンを配合したもので、その各
成分とその配合量は、１錠を３００ｍｇとして以下のよ
うである。
ハトムギ ３９．００（ｍｇ）
鶏血藤 ２９．００
松葉 ２４．００
桂皮 １４．５０
甘草 １４．５０
降香 １４．５０
紅花 １４．５０
五加皮 ３０．００
山椒 ７．００
真珠貝末 ５０．００
陳皮末 １０．００
生姜 ５．００
ビタミンＢ６ ２．５０
ビタミンＢ１２ ０．０４
賦形剤 残部The results of the clinical tests conducted at the Chinese Changchun Chinese Medical School are shown in Tables 1 and 2 by combination, disease name, daily dose, and administration period. The analgesic used as a control in Table 3 is a mixture of botanical herbal medicine and vitamins, and the components and the amounts thereof are as follows with one tablet being 300 mg. Coix sprouts 39.00 (mg) Chicken blood wilt 29.00 Matsuba 24.00 Keihin 14.50 Licorice 14.50 Perfume 14.50 Safflower 14.50 Gokakin 30.00 Sansho 7.00 Pearl shell powder 50.00 Cinnamon powder 10.00 Ginger 5.00 Vitamin B6 2.50 Vitamin B12 0.04 Excipients balance
【００１５】上記実施例の錠剤を１日３錠、６錠、９
錠、１２錠ずつ、１週間投与した場合の成績を表１に示
す。１００症例中、著効例１４、有効例３９、合計５３
例であり、有効率は５３％であった。さらに続けて、１
か月投与した場合の成績を表２に示す。１００症例中、
著効例３９、有効例４４、合計８３例であり、有効率は
８３％と顕著に高まった。これは、身体機能の亢進、お
よび抗酸化剤による活性酸素の除去による体調の向上効
果は、即効性を持つのではなく、徐々に効果を現してく
るためと考えられ、継続投与が有効であることを示して
いる。上記対照組成物を投与した結果を表３に示すが、
１００症例中、著効例１２、有効例２９、合計４１例で
あり、有効率は４１％であった。この組成物においては
本発明組成物のような継続投与による効果の高まりはほ
とんど見られず、１週間投与における成績の差違（表１
と表３）はそれほど見られないが、１か月間の投与の成
績（表２）と比較すれば大きな差違が見られる。The tablets of the above-mentioned Examples are 3 tablets per day, 6 tablets and 9 tablets.
Table 1 shows the results of administration of 12 tablets each for 1 week. Out of 100 cases, 14 excellent cases, 39 effective cases, 53 in total
This is an example, and the effective rate was 53%. Further on, 1
The results when administered monthly are shown in Table 2. Out of 100 cases,
There were a total of 83 cases, with 39 excellent cases and 44 effective cases, and the effective rate was significantly increased to 83%. It is considered that this is because the enhancement of physical function and the improvement of physical condition by removal of active oxygen by antioxidant do not have immediate effect but gradually show effect, and continuous administration is effective. It is shown that. The results of administration of the above control composition are shown in Table 3.
Out of 100 cases, there were 12 excellent cases and 29 effective cases, for a total of 41 cases, and the effective rate was 41%. In this composition, almost no increase in the effect due to continuous administration like that of the composition of the present invention was observed, and there was a difference in the results after one week of administration (Table 1).
And Table 3) are not so much seen, but there is a big difference compared with the results of administration for one month (Table 2).
【００１６】[0016]
【表１】 [Table 1]
【００１７】[0017]
【表２】 [Table 2]
【００１８】[0018]
【表３】 [Table 3]
【００１９】以下、体験例により服用の結果を示す。
１．Ｔ．Ｓ． ５１歳 女性
主 訴：指の全関節痛と浮腫
平成１０年９月中旬から左手の指のすべての関節の疼痛
と関節の腫脹が認められるようになった。血清検査の結
果、全身性エリテマトーデス（ＳＬＥ）と診断され、平
成１０年１１月から疼痛対策として上記実施例の錠剤を
１日１２錠投与された。併用薬はなかった。投与後２日
目で疼痛の消失を認め、関節の腫脹も消褪したので、上
記実施例の錠剤の投与を６日目から１日６錠に減じた。
平成１２年１０月まで、投与を続けているが、病状の再
発は見られず、副作用も一切生じていない。Hereinafter, the results of taking the medicine will be shown by experience examples. 1. T. S. 51-year-old female Main complaint: Total joint pain and edema of fingers Since mid-September 1998, pain and swelling of all joints of the fingers of the left hand have been observed. As a result of serodiagnosis, systemic lupus erythematosus (SLE) was diagnosed, and 12 tablets of the above-mentioned example were administered daily from November 1998 as a measure against pain. There was no concomitant drug. On the second day after the administration, the pain disappeared and the swelling of the joint disappeared. Therefore, the administration of the tablets of the above Examples was reduced from the sixth day to six tablets per day.
Administration was continued until October 2000, but no recurrence of the medical condition was observed and no side effects occurred.
【００２０】２．Ｈ．Ｔ． ４６歳 男性
主 訴：両側膝関節炎
平成１０年１１月頃から両膝関節通が持続したため、慢
性関節リウマチ（ＲＡ）を疑い、諸検査を行った。その
結果、抗核抗体が３５倍と陽性のため、全身性エリテマ
トーデス（ＳＬＥ）との診断のもとに、上記実施例の錠
剤を平成１１年２月２１日から１日６錠の投与を開始し
た。その後、症状は漸次軽快し、同年４月２日の受診時
には症状は全く消失しており、錠剤の投与を中止した
が、以後、今日まで疼痛を認めていない。2. H. T. A 46-year-old man complained: bilateral knee arthritis Suspected chronic rheumatoid arthritis (RA) because bilateral knee joint continuity had persisted from around November 1998, and various tests were performed. As a result, since the antinuclear antibody was positive by 35 times, administration of 6 tablets per day from February 21, 1999 was started under the diagnosis of systemic lupus erythematosus (SLE). did. Thereafter, the symptom gradually improved, and the symptom had completely disappeared at the time of the examination on April 2, the same year, and the administration of the tablet was discontinued, but thereafter, no pain has been observed.
【００２１】３．Ｎ．Ｋ． ５８歳 男性
主 訴：腰痛、両膝関節痛
平成１０年８月、腰痛のため整形外科を受診し、腰椎椎
間板ヘルニアと診断され、消炎剤、外用薬の処方を受け
たが改善せず、平成１１年９月、両膝関節痛および全身
倦怠感が加わったため、同年１０月、内科を受診し、諸
検査の結果、多発性関節リウマチと診断され、同年１２
月１５日から上記実施例の錠剤のみを１日９錠投与され
た。２週間後の受診時には関節痛は全く消失していた
が、念の為、１日３錠の投与を継続した。平成１２年１
０月まで、関節痛の再発は見られず、副作用もまったく
見られない。3. N. K. A 58-year-old man: Low back pain, bilateral knee pain In August 1998, he underwent orthopedic surgery due to low back pain and was diagnosed with lumbar disc herniation. He was prescribed anti-inflammatory and topical drugs, but did not improve. In September 2011, due to bilateral knee pain and general malaise, he visited the internal medicine department in October of the same year. As a result of various examinations, he was diagnosed with multiple rheumatoid arthritis.
From the 15th of the month, only 9 tablets of the above-mentioned example were administered per day. Although the joint pain had completely disappeared at the time of the examination 2 weeks later, the administration of 3 tablets per day was continued just in case. 2000 1
By October, no recurrence of joint pain was seen and no side effects were seen.
【００２２】４．Ｋ．Ａ． ２５歳 女性
主 訴：両膝関節痛、前胸部痛
現病歴：平成１０年６月頃から両膝関節痛があり、疼痛
は運動時及び正座時に強かった。同年８月から整骨院に
おいて電気療法を受けたが改善せず、平成１１年１月整
形外科を受診し、外用薬の投与を受けて一時軽快した。
平成１１年１０月ごろから、再び両膝関節痛と前胸部痛
があり、内科を受診した。胸骨前縁に圧痛を認め、諸検
査の結果ＳＬＥと診断され、鎮痛剤及びビタミンＢ６と
ビタミンＢ１２からなる上記対照組成物の投与を受けた
が疼痛は改善せず、同年１２月６日から上記実施例の錠
剤を１日１２錠投与され、平成１２年１０月現在、関節
痛はほとんど消失している。4. K. A. 25-year-old female Main complaint: Bilateral knee joint pain, Precordial chest pain Current medical history: Since June 1998, there was bilateral knee joint pain, and the pain was strong during exercise and sitting. He received electrical therapy at the osteopathic clinic from August of the same year, but did not improve. He went to orthopedic surgery in January 1999 and was treated with an external medicine, and was temporarily relieved.
From around October 1999, he had bilateral knee joint pain and precordial chest pain again, and went to see a doctor. Tenderness was observed at the front edge of the sternum, and as a result of various tests, SLE was diagnosed. The analgesic and the above control composition consisting of vitamin B6 and vitamin B12 were administered, but the pain did not improve. Twelve tablets of the example were administered daily, and as of October 2000, joint pain has almost disappeared.
【００２３】５．Ｍ．Ｔ． ６８歳 女性
主 訴：慢性腰痛
５０歳の頃から腰痛がひどく、時々寝込むことがあっ
た。薬局で鎮痛剤や漢方薬を求めていたが、寒いときや
疲労が溜ると痛みがひどくなり、つらい生活を送ってい
た。骨粗鬆症の心配があるとの指摘を受け、平成１１年
１月に整形外科を受診した。レントゲン検査の結果は骨
粗鬆症の心配はないとされ、上記実施例の錠剤を１日９
錠ずつ投与された。投与後７日目に急に痛みが消失し驚
いた。痛みの再発を恐れるのと、成分中のビタミンＤ３
やイソフラボンが骨粗鬆症によいと言われたので、現在
も１日３錠ずつを服用している。5. M. T. A 68-year-old woman complained: Chronic low back pain Back pain was severe from the age of 50, and she sometimes fell asleep. I was looking for painkillers and herbal medicine at the pharmacy, but when I was cold and tired, my pain worsened, and I had a hard life. In January 1999, I visited an orthopedic clinic because I was told that I was concerned about osteoporosis. The result of the X-ray test showed that there was no concern of osteoporosis.
It was administered in tablets. On the 7th day after administration, the pain suddenly disappeared and I was surprised. Fear of pain recurrence and vitamin D3 in the ingredients
I was told that isoflavone and isoflavone are good for osteoporosis, so I still take 3 tablets each day.
【００２４】６．Ｙ．Ｋ． ５０歳 女性
主 訴：肩関節周囲炎
肩がコチコチに凝り、動かすと激しい痛みを感じたの
で、受診したところ、いわゆる五十肩と診断された。痛
みが激しかったので上記実施例の錠剤を平成１１年３月
から１日１２錠ずつ服用した。服用後３日目には痛みが
激減したが、再発防止と完全治癒を目指して服用を続け
た。半年経った頃、友人の一人に最近きれいになったと
言われ、別の友人には若くなったと言われて驚いた。医
師によれば、錠剤成分中、コラーゲン、ビタミン、ハト
ムギ、コンドロイチンが肌の張りを良くし、関節の動き
が滑らかになったので、動作を含め全体が若くなったと
の印象を作ったのではないかとのことであった。6. Y. K. A 50-year-old woman complained: Periarthritis of the shoulder joint The shoulder stiffened, and when I moved it, I felt severe pain. Since the pain was severe, the tablets of the above-mentioned example were taken 12 tablets a day from March 1999. Although the pain decreased sharply on the third day after taking the drug, he continued to take the drug with the aim of preventing recurrence and complete healing. About half a year later, I was surprised when one of my friends told me that I was clean recently and another friend told me that I was younger. According to the doctor, collagen, vitamins, pearl barley, and chondroitin in the tablet ingredients improved skin firmness and smoothed joint movements, so I did not make the impression that the whole body, including movements, became younger. It was a heel.
【００２５】[0025]
【発明の効果】本発明の鎮痛用健康補助食品は、上記の
ように、植物系生薬を中心とし、これに抗酸化剤と複合
ビタミンを配合し、その鎮痛効果と身体の機能亢進効果
との相乗作用を有するものであるので、毒性、副作用の
恐れもなく、各体験症例で見るように、単に高い鎮痛作
用を持つだけでなく、身体の機能亢進による免疫機能の
改善による体調の向上と痛みを伴う疾患の予防にも高い
効果を奏するものである。その上、肌の状態の改善など
の美容上の効果、運動機能の回復等をも有するという従
来に例をみない健康補助食品を得ることが出来たもので
ある。As described above, the analgesic dietary supplement of the present invention mainly comprises a botanical herbal medicine, which is mixed with an antioxidant and a complex vitamin, and has the analgesic effect and the hyperactivity of the body. As it has a synergistic effect, there is no fear of toxicity and side effects, and as seen in each experience case, it not only has a high analgesic effect, but also improves physical condition and pain by improving immune function due to hyperactivity of the body. It also has a high effect on the prevention of diseases associated with. Moreover, it is possible to obtain an unprecedented health supplement that has cosmetic effects such as improvement of skin condition and recovery of motor function.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.7 識別記号 ＦＩ テーマコート゛(参考） Ａ６１Ｋ 31/355 Ａ６１Ｋ 31/355 31/4415 31/4415 31/51 31/51 31/519 31/519 31/593 31/593 31/726 31/726 31/737 31/737 35/78 35/78 Ｗ 38/17 45/06 45/06 Ａ６１Ｐ 25/04 Ａ６１Ｐ 25/04 29/00 29/00 Ａ６１Ｋ 37/12 Ｆターム(参考） 4B018 MD07 MD20 MD23 MD27 MD37 MD48 MD61 ME06 ME14 4C084 AA24 DC50 MA02 MA52 ZA08 4C086 AA01 AA02 BA08 BA09 BC18 BC83 CB04 CB09 DA14 EA20 EA22 EA26 MA03 MA04 MA52 ZA08 4C088 AB03 AB11 AB12 AB26 AB33 AB60 AB62 AB74 AB81 MA03 MA52 ZA08 4C206 AA01 AA02 CB25 KA01 MA03 MA04 MA17 MA28 MA72 ZA08─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. 7 Identification code FI theme code (reference) A61K 31/355 A61K 31/355 31/4415 31/4415 31/51 31/51 31/519 31/519 31 / 593 31/593 31/726 31/726 31/737 31/737 35/78 35/78 W 38/17 45/06 45/06 A61P 25/04 A61P 25/04 29/00 29/00 A61K 37 / 12F term (reference) 4B018 MD07 MD20 MD23 MD27 MD37 MD48 MD61 ME06 ME14 4C084 AA24 DC50 MA02 MA52 ZA08 4C086 AA01 AA02 BA08 BA09 BC18 BC83 CB04 CB09 DA14 EA20 EA22 EA26 MA03 MA04 MA52 ZA08 4C0 AB62 AB33 AB11 AB26 AB33 AB11 AB26 AB33 AB11 AB26 AB11 AB26 MA52 ZA08 4C206 AA01 AA02 CB25 KA01 MA03 MA04 MA17 MA28 MA72 ZA08
Claims (6)
複合ビタミンとからなることを特徴とする鎮痛用健康補
助食品1. A dietary supplement for analgesia, which comprises an analgesic derived from a botanical crude drug, an antioxidant and a complex vitamin.
ギ、鶏血藤、松葉、桂皮、甘草、降香、紅花、五加皮、
山椒、真珠貝末、陳皮末、生姜、デビルズクローからな
る組成物であることを特徴とする請求項１の鎮痛用健康
補助食品2. The above-mentioned plant-based crude drug analgesics include coix, chicken blood wilt, pine needles, cinnamon, licorice, aromatization, safflower, five-kakin,
The analgesic health supplement according to claim 1, which is a composition consisting of Japanese pepper, pearl shell powder, Chen skin powder, ginger and devil's claw.
Ｅ、アスタキサンチン、エンゾジノールの中の１種を含
むことを特徴とする請求項１あるいは請求項２の鎮痛用
健康補助食品3. The dietary supplement for pain relief according to claim 1 or 2, wherein the antioxidant contains at least one of vitamin E, astaxanthin and enzogenol.
タミンＢ２、ビタミンＢ６、ビタミンＢ１２、ビタミン
Ｄ３、の中の１種あるいはそれらの組合せを含むことを
特徴とする請求項１ないし請求項３の何れかの鎮痛用健
康補助食品4. The complex vitamin comprises one of vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin D3, or a combination thereof, in any one of claims 1 to 3. Dietary supplement for pain relief
ミン、イソフラボン、エキナセアの中の１種あるいはそ
れらの組合せを含むことを特徴とする請求項１ないし請
求項４の何れかの鎮痛用健康補助食品5. The analgesic health supplement according to any one of claims 1 to 4, which comprises one or a combination of chondroitin, collagen, glucosamine, isoflavone, and echinacea.
かの鎮痛用健康補助食品6. The compounding ratio of each component is as follows: pearl barley 15-5% chicken blood widow 10-3% pine needles 10-3% cinnamon bark 7-1% licorice 7-1% aroma 7-1% safflower 7-1% Pentacarp 10-3% Sansho 3-0.5% Pearl shell powder 20-5% Chenpi powder 5-1% Ginger 3-0.5% Astaxanthin 10-3% Enzogenol 6-1% Vitamin B1 7-1% Vitamin B2 2 to 0.1% Vitamin B6 2 to 0.1% Vitamin B12 0.1 to 0.005% Vitamin D3 0.1 to 0.003% Vitamin E 1 to 0.1% Chondroitin 20 to 5% Collagen 20-5% Glucosamine 20-5% Isoflavone 7-1% Echinacea 5-0.5% It is characterized in that it is a dietary supplement for analgesia according to any one of claims 1 to 5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| JP2001285178A JP2003088329A (en) | 2001-09-19 | 2001-09-19 | Analgesic health supplement |
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| Application Number | Priority Date | Filing Date | Title |
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| JP2001285178A JP2003088329A (en) | 2001-09-19 | 2001-09-19 | Analgesic health supplement |
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| JP2003088329A true JP2003088329A (en) | 2003-03-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2001285178A Withdrawn JP2003088329A (en) | 2001-09-19 | 2001-09-19 | Analgesic health supplement |
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| JP2004182599A (en) * | 2001-12-18 | 2004-07-02 | Daicho Kikaku:Kk | Muscle-strengthening drug and antiinflammatory drug |
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| JP2006028134A (en) * | 2004-07-21 | 2006-02-02 | Rohto Pharmaceut Co Ltd | Composition for oral administration |
| JP2006298791A (en) * | 2005-04-18 | 2006-11-02 | Kotobuki Seiyaku Kk | Medicine for oral administration, health food or nutrient chemical composition containing glycosaminoglycan or its salt |
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| JP2006327970A (en) * | 2005-05-25 | 2006-12-07 | Daicho Kikaku:Kk | Digestive apparatus agent and anti-stress agent |
| JP2006335640A (en) * | 2005-05-06 | 2006-12-14 | Daicho Kikaku:Kk | Drug for animal |
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| JP2004182599A (en) * | 2001-12-18 | 2004-07-02 | Daicho Kikaku:Kk | Muscle-strengthening drug and antiinflammatory drug |
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| JP2006014730A (en) * | 2004-05-31 | 2006-01-19 | Toyo Shinyaku:Kk | Food product |
| JP2006028134A (en) * | 2004-07-21 | 2006-02-02 | Rohto Pharmaceut Co Ltd | Composition for oral administration |
| JP2006298791A (en) * | 2005-04-18 | 2006-11-02 | Kotobuki Seiyaku Kk | Medicine for oral administration, health food or nutrient chemical composition containing glycosaminoglycan or its salt |
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| JP2007031315A (en) * | 2005-07-25 | 2007-02-08 | Pias Arise Kk | Transcription factor nrf2 activator and skin care preparation, cosmetic, and food and drink formulated with the transcription factor nrf2 activator |
| JP2008156256A (en) * | 2006-12-22 | 2008-07-10 | Pola Chem Ind Inc | Oral administration composition |
| JP2013241418A (en) * | 2007-05-11 | 2013-12-05 | Meiji Co Ltd | New antiphlogistic-analgesic agent |
| JP2011231110A (en) * | 2010-04-23 | 2011-11-17 | Kyoung Sam Byun | Pharmaceutical composition for treatment of prolapse of lumber intervertebral disc and method for producing the same |
| JP2013001688A (en) * | 2011-06-20 | 2013-01-07 | Sankyo:Kk | Arthritis improvement composition |
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| A300 | Withdrawal of application because of no request for examination |
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