JP2002511861A - 長期の貯蔵寿命を有する、極性薬物又は極性プロドラッグを含有する医薬組成物、及びその製造方法 - Google Patents
長期の貯蔵寿命を有する、極性薬物又は極性プロドラッグを含有する医薬組成物、及びその製造方法Info
- Publication number
- JP2002511861A JP2002511861A JP50289599A JP50289599A JP2002511861A JP 2002511861 A JP2002511861 A JP 2002511861A JP 50289599 A JP50289599 A JP 50289599A JP 50289599 A JP50289599 A JP 50289599A JP 2002511861 A JP2002511861 A JP 2002511861A
- Authority
- JP
- Japan
- Prior art keywords
- drug
- prodrug
- cyclodextrin
- pharmaceutical composition
- phenytoin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.シクロデキストリン、薬学的活性を有する薬品又はプロドラッグ、及び薬学 的に許容される担体を包含し、該シクロデキストリンを、該薬学的活性を有する 薬品又は該プロドラッグのモル量に対して75%未満のモル量含有する医薬組成 物。 2.該担体が水性液体であることを特徴とする請求項1に記載の医薬組成物。 3.該シクロデキストリンを、該薬学的活性を有する薬品又は該プロドラッグの モル量に対して50%未満のモル量含有することを特徴とする請求項1に記載の 医薬組成物。 4.該シクロデキストリンを、該薬学的活性を有する薬品又は該プロドラッグの モル量に対して25%未満のモル量含有することを特徴とする請求項1に記載の 医薬組成物。 5.該シクロデキストリンが、スルホアルキルエーテルシクロデキストリン及び ヒドロキシプロピル−β−シクロデキストリンよりなる群から選ばれることを特 徴とする請求項1に記載の医薬組成物。 6.該薬学的活性を有する薬品又は該プロドラッグが、極性ドラッグ又は極性プ ロドラッグ化合物であることを特徴とする請求項1に記載の医薬組成物。 7.該薬学的活性を有する薬品又は該プロドラッグが、ステロイドリン酸エステ ル、ステロイド又はクロラムフェニコールのヘミコハタ酸エステル、及びエスト ロゲン硫酸エステルよりなる群から選ばれることを特徴とする請求項1に記載の 医薬組成物。 8.該プロドラッグが、ホスフェニトインであることを特徴とする請求項1に記 載の医薬組成物。 9.pH値が7.0〜8.5であることを特徴とする請求項8に記載の医薬組成 物。 10.シクロデキストリン、及び薬学的活性を有する薬品又はプロドラッグを包 含し、該シクロデキストリンを、該薬学的活性を有する薬品又は該プロドラッグ のモル量に対して75モル%未満含有する凍結乾燥医薬組成物。 11.凍結乾燥された薬学的に許容される担体を更に含むことを特徴とする請求 項10に記載の凍結乾燥医薬組成物。 12.該シクロデキストリンを、該薬学的活性を有する薬品又は該プロドラッグ のモル量に対して50%未満のモル量含有することを特徴とする請求項10に記 載の凍結乾燥医薬組成物。 13.少なくとも1種のシクロデキストリンを、薬学的活性を有する薬品又はプ ロドラッグを含有する組成物に、該薬学的活性を有する薬品又は該プロドラッグ のモル量に対して75%未満のモル量添加することを包含する、薬学的活性を有 する薬品又はプロドラッグの貯蔵寿命を延ばす方法。 14.少なくとも1種のシクロデキストリンを、薬学的活性を有する薬品又はプ ロドラッグと、薬学的に許容される担体との混合物に、該薬学的活性を有する薬 品又は該プロドラッグのモル量に対して75%未満のモル量添加し、これにより 溶液を得、 該溶液を凍結乾燥する ことを包含する、薬学的活性を有する薬品又はプロドラッグの貯蔵寿命を延ばす 方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5090997P | 1997-06-13 | 1997-06-13 | |
US60/050,909 | 1997-06-13 | ||
PCT/US1998/011596 WO1998056422A1 (en) | 1997-06-13 | 1998-06-12 | Polar drug or prodrug compositions with extended shelf-life storage and a method of making thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2002511861A true JP2002511861A (ja) | 2002-04-16 |
JP2002511861A5 JP2002511861A5 (ja) | 2005-12-02 |
JP4439596B2 JP4439596B2 (ja) | 2010-03-24 |
Family
ID=21968241
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50289599A Expired - Lifetime JP4439596B2 (ja) | 1997-06-13 | 1998-06-12 | 長期の貯蔵寿命を有する、極性薬物又は極性プロドラッグを含有する医薬組成物、及びその製造方法 |
Country Status (9)
Country | Link |
---|---|
US (1) | US6133248A (ja) |
EP (1) | EP0986403B1 (ja) |
JP (1) | JP4439596B2 (ja) |
AT (1) | ATE253941T1 (ja) |
AU (1) | AU750207B2 (ja) |
DE (1) | DE69819721T2 (ja) |
ES (1) | ES2210769T3 (ja) |
PT (1) | PT986403E (ja) |
WO (1) | WO1998056422A1 (ja) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7198801B2 (en) | 2000-08-03 | 2007-04-03 | Antares Pharma Ipl Ag | Formulations for transdermal or transmucosal application |
DE60143360D1 (de) * | 2000-08-03 | 2010-12-09 | Antares Pharma Ipl Ag | Zusammensetzung zur transdermalen und/oder transmukosalen Verabreichung von Wirkstoffen, die ausreichende therapeutische Spiegel garantiert |
US20040198706A1 (en) * | 2003-03-11 | 2004-10-07 | Carrara Dario Norberto R. | Methods and formulations for transdermal or transmucosal application of active agents |
US8980290B2 (en) | 2000-08-03 | 2015-03-17 | Antares Pharma Ipl Ag | Transdermal compositions for anticholinergic agents |
PE20020300A1 (es) * | 2000-08-22 | 2002-05-10 | Pharmacia Corp | Composicion de solucion de un farmaco antibiotico a base de oxazolidinona con mejoramiento de la carga de farmaco |
PE20020578A1 (es) | 2000-10-10 | 2002-08-14 | Upjohn Co | Una composicion de antibiotico topico para el tratamiento de infecciones oculares |
US6566556B2 (en) * | 2000-12-19 | 2003-05-20 | Nippon Shokubai Co., Ltd. | Method for production of alkanolamine and apparatus therefor |
WO2003002152A2 (en) * | 2001-06-29 | 2003-01-09 | Maxygen Aps | Stabilized formulations of interferons with sulfoalkyl ether cyclodextrins |
US7141540B2 (en) * | 2001-11-30 | 2006-11-28 | Genta Salus Llc | Cyclodextrin grafted biocompatible amphilphilic polymer and methods of preparation and use thereof |
AU2002366809A1 (en) * | 2001-12-20 | 2003-07-09 | Schering-Plough Corporation | Syn3 compositions and methods |
BR0307898A (pt) * | 2002-02-22 | 2004-12-07 | Pharmacia Corp | Formulações de droga antibiótica oftálmica contendo um composto de ciclodextrina e cloreto de cetil piridìnio |
CA2477044A1 (en) * | 2002-02-22 | 2003-09-04 | Pharmacia Corporation | Ophthalmic formulation with gum system |
MXPA06003316A (es) | 2003-10-10 | 2006-06-08 | Antares Pharma Ipl Ag | Formulacion farmaceutica transdermica para minimizar los residuos en la piel. |
CN103554222A (zh) | 2004-04-15 | 2014-02-05 | 欧尼斯治疗公司 | 用于抑制蛋白酶体酶的化合物 |
US8198270B2 (en) * | 2004-04-15 | 2012-06-12 | Onyx Therapeutics, Inc. | Compounds for proteasome enzyme inhibition |
JP5108509B2 (ja) * | 2004-05-10 | 2012-12-26 | プロテオリックス, インコーポレイテッド | 酵素阻害のための化合物 |
EP2260835B1 (en) * | 2004-12-07 | 2013-03-06 | Onyx Therapeutics, Inc. | Composition for proteasome inhibition |
US8067399B2 (en) | 2005-05-27 | 2011-11-29 | Antares Pharma Ipl Ag | Method and apparatus for transdermal or transmucosal application of testosterone |
NZ595196A (en) | 2005-11-09 | 2013-03-28 | Proteolix Inc | Peptide-based compounds for enzyme inhibition |
BRPI0618653A2 (pt) * | 2005-11-15 | 2011-09-06 | Baxter Int | composições compreendendo inibidores da lipoxigenase e ciclodextrina |
US20070135586A1 (en) * | 2005-12-09 | 2007-06-14 | Shreyas Chakravarti | Polyamide blend compositions formed article and process thereof |
CN101426475A (zh) | 2006-04-21 | 2009-05-06 | 安塔雷斯制药Ipl股份公司 | 使用用于经皮或经粘膜应用的制剂治疗热潮红的方法 |
PL2041158T3 (pl) | 2006-06-19 | 2013-08-30 | Onyx Therapeutics Inc | Peptydowe epoksyketony do hamowania proteasomu |
US20090239942A1 (en) * | 2006-09-15 | 2009-09-24 | Cloyd James C | Topiramate Compositions and Methods of Making and Using the Same |
EP2061458B1 (en) * | 2006-09-15 | 2014-12-10 | Regents of the University of Minnesota | Topiramate compositions and methods for their use |
HUE053158T2 (hu) | 2007-04-27 | 2021-06-28 | Cydex Pharmaceuticals Inc | Clopidogrelt és szulfoalkiléter ciklodextrint tartalmazó készítmények és alkalmazási eljárások |
US20090082400A1 (en) * | 2007-07-31 | 2009-03-26 | Ving Lee | Soluble pyrone analogs methods and compositions |
PL2207791T5 (pl) * | 2007-10-04 | 2020-07-27 | Onyx Therapeutics, Inc. | Krystaliczne peptydo- epoksy ketonowe inhibitory proteazy i synteza keto-epoksydów Aminokwasowych |
US7635773B2 (en) | 2008-04-28 | 2009-12-22 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions |
WO2009141116A1 (en) * | 2008-05-19 | 2009-11-26 | Texcontor Etablissement | Fosphenytoin composition |
AP2011005690A0 (en) | 2008-10-21 | 2011-06-30 | Onyx Therapeutics Inc | Combination therapy with peptide epoxyketones. |
WO2010053487A1 (en) | 2008-11-07 | 2010-05-14 | Cydex Pharmaceuticals, Inc. | Composition containing sulfoalkyl ether cyclodextrin and latanoprost |
TWI504598B (zh) | 2009-03-20 | 2015-10-21 | Onyx Therapeutics Inc | 結晶性三肽環氧酮蛋白酶抑制劑 |
PL3100728T3 (pl) * | 2009-05-13 | 2020-05-18 | Cydex Pharmaceuticals, Inc. | Kompozycje farmaceutyczne zawierające prasugrel i pochodne cyklodekstryny oraz sposoby ich wytwarzania i zastosowania |
US11020363B2 (en) | 2009-05-29 | 2021-06-01 | Cydex Pharmaceuticals, Inc. | Injectable nitrogen mustard compositions comprising a cyclodextrin derivative and methods of making and using the same |
ES2767880T3 (es) | 2009-05-29 | 2020-06-18 | Cydex Pharmaceuticals Inc | Composiciones inyectables de melfalán que comprenden un derivado de ciclodextrina y métodos de preparación y uso de las mismas |
HRP20171415T4 (hr) | 2009-06-25 | 2023-03-03 | Alkermes Pharma Ireland Limited | Heterociklični spojevi za liječenje neuroloških i psiholoških poremećaja |
WO2010151711A1 (en) | 2009-06-25 | 2010-12-29 | Alkermes, Inc. | Prodrugs of nh-acidic compounds |
JP5919196B2 (ja) | 2009-11-13 | 2016-05-18 | オニキス セラピューティクス, インク.Onyx Therapeutics, Inc. | 転移抑制のためのペプチドエポキシケトンの使用 |
BR112012022060A2 (pt) | 2010-03-01 | 2018-05-08 | Onyx Therapeutics Inc | composto para a inibição de imunoproteassoma |
NZ602872A (en) | 2010-04-07 | 2014-05-30 | Onyx Therapeutics Inc | Crystalline peptide epoxyketone immunoproteasome inhibitor |
WO2011163594A2 (en) | 2010-06-24 | 2011-12-29 | Alkermes, Inc. | Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives |
DE102011011028A1 (de) * | 2011-02-11 | 2012-08-16 | Ditter Plastic Gmbh + Co. Kg | Frontplatte mit darin eingespritztem Lichtleiter |
CN103561746B (zh) | 2011-03-18 | 2018-05-29 | 奥克梅斯制药爱尔兰有限公司 | 包含脱水山梨糖醇酯的药物组合物 |
DK2758052T3 (en) | 2011-09-18 | 2018-05-28 | Euro Celtique Sa | Pharmaceutical composition comprising an HDAC inhibitor and a cyclopolysaccharide |
NZ722096A (en) | 2011-12-15 | 2016-11-25 | Alkermes Pharma Ireland Ltd | Prodrugs of secondary amine compounds |
TWI573792B (zh) | 2012-02-01 | 2017-03-11 | 歐陸斯迪公司 | 新穎治療劑 |
US9751957B2 (en) | 2012-02-15 | 2017-09-05 | Cydex Pharmaceuticals, Inc. | Manufacturing process for cyclodextrin derivatives |
CN104704007A (zh) | 2012-02-28 | 2015-06-10 | 锡德克斯药物公司 | 烷基化环糊精组合物及其制备和使用方法 |
CA2867137C (en) | 2012-03-19 | 2020-12-08 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising aripiprazole prodrugs and benzyl alcohol |
CA2867123C (en) | 2012-03-19 | 2021-02-16 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising water-insoluble antipsychotic agents and glycerol esters |
EP2827868B8 (en) | 2012-03-19 | 2019-12-18 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising fatty acid esters |
JP2015524394A (ja) | 2012-07-09 | 2015-08-24 | オニキス セラピューティクス, インク.Onyx Therapeutics, Inc. | ペプチドエポキシケトンプロテアーゼ阻害剤のプロドラッグ |
CA2885196C (en) | 2012-09-19 | 2021-06-22 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions having improved storage stability |
KR102112119B1 (ko) | 2012-10-22 | 2020-05-19 | 사이덱스 파마슈티칼스, 인크. | 알킬화된 시클로덱스트린 조성물 및 이의 제조 및 사용 방법 |
CN110368360A (zh) | 2014-03-20 | 2019-10-25 | 奥克梅斯制药爱尔兰有限公司 | 具有增加的注射速度的阿立哌唑制剂 |
GB201409485D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
GB201409471D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
GB201409488D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
WO2016029179A1 (en) | 2014-08-22 | 2016-02-25 | Cydex Pharmaceuticals, Inc. | Fractionated alkylated cyclodextrin compositions and processes for preparing and using the same |
GB201609222D0 (en) | 2016-05-25 | 2016-07-06 | F2G Ltd | Pharmaceutical formulation |
US11266631B2 (en) | 2016-10-11 | 2022-03-08 | Purdue Pharmaceutical Products L.P. | Hodgkin lymphoma therapy |
GB201709405D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating ovarian cancer |
GB201709403D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating sarcoma |
GB201709402D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating t-pll |
GB201709406D0 (en) | 2017-06-13 | 2017-07-26 | Euro-Cletique S A | Compounds for treating TNBC |
CN112423754A (zh) | 2018-03-05 | 2021-02-26 | 奥克梅斯制药爱尔兰有限公司 | 阿立哌唑的给药策略 |
US11819503B2 (en) | 2019-04-23 | 2023-11-21 | F2G Ltd | Method of treating coccidioides infection |
CN110279664B (zh) * | 2019-07-30 | 2021-09-03 | 四川农业大学 | 一种氟苯尼考包合物冻干粉针剂及其制备方法 |
CN114555127A (zh) | 2019-08-06 | 2022-05-27 | L.E.A.F.控股集团公司 | 制备聚谷氨酸化抗叶酸剂的方法以及它们的组合物的用途 |
CN118161457A (zh) * | 2020-12-04 | 2024-06-11 | 四川科瑞德制药股份有限公司 | 磷苯妥英钠固体组合物、冻干方法、及其用途 |
EP4257120A1 (en) | 2020-12-04 | 2023-10-11 | Sichuan Credit Pharmaceutical Co., Ltd | Fosphenytoin sodium solid composition, lyophilization method, and use of fosphenytoin sodium solid composition |
WO2023225113A1 (en) * | 2022-05-18 | 2023-11-23 | Bexson Biomedical, Inc. | Complexing agent salt formulations of pharmaceutical compounds at low stoichiometric ratios |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU191101B (en) * | 1983-02-14 | 1987-01-28 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu | Process for preparing water-soluble cyclodextrin polymers substituted with ionic groups |
US4616008A (en) * | 1984-05-02 | 1986-10-07 | Takeda Chemical Industries, Ltd. | Antibacterial solid composition for oral administration |
JPS61165322A (ja) * | 1985-01-14 | 1986-07-26 | Microbial Chem Res Found | スパガリン類の注射用凍結乾燥製剤 |
US4728509A (en) * | 1985-08-19 | 1988-03-01 | Takeda Chemical Industries, Ltd. | Aqueous liquid preparation |
US4925860A (en) * | 1987-08-05 | 1990-05-15 | E. I. Du Pont De Nemours And Company | Stable pharmaceutical composition of 3-(hydroxymethyl)-5,5-diphenylhydantoin disodium phosphate ester |
DE3938227C1 (en) * | 1989-11-17 | 1991-05-02 | Dolorgiet Gmbh & Co Kg, 5205 St Augustin, De | Oral antiinflammatory and analgetic pharmaceutical compsn. - comprises magnesium ibuprofen dissolved in mixt. of water, propane-1,2-diol and glycerol |
US5376645A (en) * | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
KR0166088B1 (ko) * | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
US5324718A (en) * | 1992-07-14 | 1994-06-28 | Thorsteinn Loftsson | Cyclodextrin/drug complexation |
DE69612097D1 (de) * | 1996-10-29 | 2001-04-19 | Staroil Ltd | Mundlösliche Zusammensetzungen die N-Acetylcystein und Cyclodextrin enthalten |
-
1998
- 1998-06-12 US US09/096,747 patent/US6133248A/en not_active Expired - Lifetime
- 1998-06-12 ES ES98928901T patent/ES2210769T3/es not_active Expired - Lifetime
- 1998-06-12 AU AU80591/98A patent/AU750207B2/en not_active Expired
- 1998-06-12 JP JP50289599A patent/JP4439596B2/ja not_active Expired - Lifetime
- 1998-06-12 WO PCT/US1998/011596 patent/WO1998056422A1/en active IP Right Grant
- 1998-06-12 AT AT98928901T patent/ATE253941T1/de active
- 1998-06-12 PT PT98928901T patent/PT986403E/pt unknown
- 1998-06-12 DE DE69819721T patent/DE69819721T2/de not_active Expired - Lifetime
- 1998-06-12 EP EP98928901A patent/EP0986403B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP4439596B2 (ja) | 2010-03-24 |
ES2210769T3 (es) | 2004-07-01 |
PT986403E (pt) | 2004-04-30 |
US6133248A (en) | 2000-10-17 |
EP0986403A1 (en) | 2000-03-22 |
DE69819721T2 (de) | 2004-09-23 |
EP0986403B1 (en) | 2003-11-12 |
ATE253941T1 (de) | 2003-11-15 |
AU8059198A (en) | 1998-12-30 |
AU750207B2 (en) | 2002-07-11 |
DE69819721D1 (de) | 2003-12-18 |
WO1998056422A1 (en) | 1998-12-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2002511861A (ja) | 長期の貯蔵寿命を有する、極性薬物又は極性プロドラッグを含有する医薬組成物、及びその製造方法 | |
JP3393253B2 (ja) | 水溶性の高いシクロデキストリン誘導体及びその使用 | |
Jansook et al. | Cyclodextrins: structure, physicochemical properties and pharmaceutical applications | |
DE69130165T2 (de) | Cyclodextrinderivate mit erhöhter wasserlöslichkeit sowie deren verwendung | |
Stella et al. | Cyclodextrins: their future in drug formulation and delivery | |
CA2071623C (en) | Cyclodextrin composition | |
KR100349754B1 (ko) | 제약조성물 | |
WO1994002518A9 (en) | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof | |
EP0814844A2 (en) | Thyroxine/cyclodextrin complexes and pharmaceutical compositions containing the same | |
JP2003535893A (ja) | 透明水性麻酔剤組成物 | |
WO2002055076A1 (fr) | Preparation pharmaceutique contenant de la cyclodextrine | |
JP3509866B2 (ja) | 薬物等の疎水性化合物を溶解するために特に使用可能な新規シクロデキストリン誘導体およびその調製方法 | |
EP0756493B1 (en) | High solubility multicomponent inclusion complexes consisting of an acidic drug, a cyclodextrin and a base | |
JP3007312B2 (ja) | 包接複合体を製造するための塩の選別法 | |
EP0399716B1 (en) | Hypoallergenic steroidal anesthetic/hypnotic compositions | |
JP2000507258A (ja) | ジクロフェナック/ガンマ―シクロデキストリン包接化合物 | |
KUM et al. | THE CYCLODEXTRINS: A REVIEW | |
Dumore et al. | Cyclodextrins Inclusion Complexation: A Review | |
JPH04134093A (ja) | ポリ―γ―シクロデキストリン包接化合物 | |
JPH0660101B2 (ja) | クロベタゾン−17−ブチレ−トの水性製剤 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20050404 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20050404 |
|
RD07 | Notification of extinguishment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7427 Effective date: 20070501 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20081125 |
|
A72 | Notification of change in name of applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A721 Effective date: 20090114 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20090224 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20090413 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20090324 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20090511 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20090423 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20090608 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090522 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090707 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20091006 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20091208 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20100106 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130115 Year of fee payment: 3 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130115 Year of fee payment: 3 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
EXPY | Cancellation because of completion of term |