JP2002504833A - 総吸入容積を制御することによる制御された用量でインスリンを投与するための装置 - Google Patents
総吸入容積を制御することによる制御された用量でインスリンを投与するための装置Info
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- A61K9/007—Pulmonary tract; Aromatherapy
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
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- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
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- Proteomics, Peptides & Aminoacids (AREA)
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.以下の手段を含む、ヒト患者へ吸入によってインスリンまたはインスリン類 似体を投与するための装置: (a)呼気した空気の容積を決定する手段; (b)インスリンまたはインスリン類似体製剤をエアロゾル化する手段; (c)吸入したエアロゾル化製剤の容積を測定する手段; (d)(a)において吸入された空気の決定された容積が各段階(a)に関して実 質的に同じで、(c)における空気の決定された容積が各段階(c)に関して実質 的に同じであるように、(a)、(b)および(c)を複数回繰り返す手段。 2.呼気容積を決定する手段および吸入された製剤の容積を決定する手段が電子 的測定手段である、請求項1記載の装置。 3.以下の手段をさらに含む、請求項1記載の装置: (e)患者の吸気流速を測定する手段;および (f)患者の吸気容積を測定する手段。 4.エアロゾル化する手段が、直径約0.5〜3.0ミクロンの範囲の孔を有する多孔 性の膜を含み;およびインスリン製剤が液体の流動可能な製剤であって、インス リン製剤がヒト組換え型インスリンおよび組換え型インスリン類似体からなる群 より選択される活性成分を含む、請求項1記載の装置。 5.製剤がインスリンリスプロを含む、請求項1記載の装置。 6.以下を含む、薬物輸送装置: その中に空気を吸入することができる第一の開口部と、そこから空気を吸引す ることができる第二の開口部と、それを通じてエアロゾル化粒子がチャンネルの 中に入る第3の開口部とを含むチャンネル; その中に薬物製剤を含む容器; 程度の異なる力を加えることによって異なる量の製剤のエアロゾル化が起こる 、製剤に対して程度の異なる物理的な力を加える調整可能な手段。 7.程度の異なる力を加える手段が、容器から力によって放出される製剤量を設 定するために対応する程度の力を提供するよう調整可能である、 以下をさらに含む、請求項6記載の装置: 直径約0.5〜3ミクロンの孔を有する、それを通じて製剤が押し出される使い捨 ての多孔性の膜;および 使い捨ての膜をエアロゾル化に用いるために薬物放出位置に移動させ、使用後 薬物放出位置から移動させる手段。 8. 薬物が、ヒト組換え型インスリンおよび組換え型インスリン類似体からな る群より選択される活性成分を含む、インスリンまたはインスリン類似体製剤で あり; 装置が総重量1キログラム未満の手持ち式で自給式の装置であり;且つ 力を加えるための調整可能手段がピストン、カム、および振動装置からなる群 より選択される、以下をさらに含む請求項6記載の装置: 第二の開口部への空気の流れをブロックする手段; 測定された空気の既定の容積に反応して空気をブロックする手段を作動させる 手段; チャンネル内へ吸入された空気にエネルギーを加える空気加熱装置;および チャンネル内の第一の開口部の後で、且つ第二の開口部および第三の開口部の 前のある点において、第一の開口部から第二の開口部へ、そして次に第三の開口 部への流れの方向に位置するデシケータ。 9.薬物がヒトインスリンまたはヒトインスリン類似体である、請求項6記載の 装置。 10.薬物がインスリンリスプロである、請求項6記載の装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/846,243 | 1997-04-25 | ||
US08/846,243 US5884620A (en) | 1993-01-29 | 1997-04-25 | Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume |
PCT/US1998/008238 WO1998048873A1 (en) | 1997-04-25 | 1998-04-23 | Device for administering insulin in controlled dosages by controlling total inhaled volume |
Publications (2)
Publication Number | Publication Date |
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JP2002504833A true JP2002504833A (ja) | 2002-02-12 |
JP2002504833A5 JP2002504833A5 (ja) | 2005-12-02 |
Family
ID=25297344
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP54714398A Pending JP2002504833A (ja) | 1997-04-25 | 1998-04-23 | 総吸入容積を制御することによる制御された用量でインスリンを投与するための装置 |
Country Status (9)
Country | Link |
---|---|
US (8) | US5888477A (ja) |
EP (2) | EP1576978B1 (ja) |
JP (1) | JP2002504833A (ja) |
AR (1) | AR007491A1 (ja) |
AT (1) | ATE308356T1 (ja) |
AU (1) | AU741913B2 (ja) |
DE (2) | DE69832183T2 (ja) |
ES (1) | ES2321951T3 (ja) |
WO (1) | WO1998048873A1 (ja) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007116953A1 (en) * | 2006-04-10 | 2007-10-18 | Canon Kabushiki Kaisha | Ingesta administration device |
JP2009045446A (ja) * | 2007-07-20 | 2009-03-05 | Canon Inc | 吸入装置 |
JP2009268665A (ja) * | 2008-05-07 | 2009-11-19 | Canon Inc | 吸入装置 |
JP2019022673A (ja) * | 2013-03-15 | 2019-02-14 | マイクロドース セラピューテクス,インコーポレイテッド | 吸入装置、制御方法およびコンピュータプログラム |
Families Citing this family (220)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6024090A (en) * | 1993-01-29 | 2000-02-15 | Aradigm Corporation | Method of treating a diabetic patient by aerosolized administration of insulin lispro |
US5888477A (en) * | 1993-01-29 | 1999-03-30 | Aradigm Corporation | Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin |
US7448375B2 (en) * | 1993-01-29 | 2008-11-11 | Aradigm Corporation | Method of treating diabetes mellitus in a patient |
US6632456B1 (en) * | 1993-06-24 | 2003-10-14 | Astrazeneca Ab | Compositions for inhalation |
US6428771B1 (en) * | 1995-05-15 | 2002-08-06 | Pharmaceutical Discovery Corporation | Method for drug delivery to the pulmonary system |
SE9700423D0 (sv) * | 1997-02-07 | 1997-02-07 | Astra Ab | Disposable inhaler |
US6349719B2 (en) | 1997-02-24 | 2002-02-26 | Aradigm Corporation | Formulation and devices for monitoring the efficacy of the delivery of aerosols |
US6192882B1 (en) * | 1997-02-24 | 2001-02-27 | Aradigm Corporation | Formulation and devices for monitoring the efficacy of the delivery of aerosols |
DE19733651A1 (de) * | 1997-08-04 | 1999-02-18 | Boehringer Ingelheim Pharma | Wässrige Aerosolzubereitungen enthaltend biologisch aktive Markomoleküle und Verfahren zur Erzeugung entsprechender Aerosole |
US20060239930A1 (en) * | 1997-08-04 | 2006-10-26 | Herbert Lamche | Process for nebulizing aqueous compositions containing highly concentrated insulin |
ZA989744B (en) * | 1997-10-31 | 2000-04-26 | Lilly Co Eli | Method for administering acylated insulin. |
BR9908771A (pt) | 1998-03-16 | 2000-12-12 | Inhale Therapeutic Syst | Processos para a liberação de um agente ativo e de insulina para os pulmões de um paciente humano, dispositivo para aumentar a biodisponibilidade de um agente ativo, e, dispositivos para a liberação de um agente ativo e de insulina para os pulmões de um paciente humano |
WO1999064094A1 (en) * | 1998-06-12 | 1999-12-16 | Aradigm Corporation | Methods of delivering aerosolized polynucleotides to the respiratory tract |
US6956021B1 (en) * | 1998-08-25 | 2005-10-18 | Advanced Inhalation Research, Inc. | Stable spray-dried protein formulations |
UA73924C2 (en) * | 1998-10-09 | 2005-10-17 | Nektar Therapeutics | Device for delivering active agent formulation to lungs of human patient |
US6234167B1 (en) | 1998-10-14 | 2001-05-22 | Chrysalis Technologies, Incorporated | Aerosol generator and methods of making and using an aerosol generator |
US20060171899A1 (en) * | 1998-12-10 | 2006-08-03 | Akwete Adjei | Water-stabilized aerosol formulation system and method of making |
US20040214747A1 (en) * | 1999-01-06 | 2004-10-28 | Dimarchi Richard Dennis | Method for administering monomeric insulin |
US9006175B2 (en) * | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
ATE545652T1 (de) | 1999-06-29 | 2012-03-15 | Mannkind Corp | Reinigung und stabilisierung von proteinen und peptiden in pharmaceutischen agentien |
US6606992B1 (en) * | 1999-06-30 | 2003-08-19 | Nektar Therapeutics | Systems and methods for aerosolizing pharmaceutical formulations |
US7305986B1 (en) | 1999-07-23 | 2007-12-11 | Mannkind Corporation | Unit dose capsules for use in a dry powder inhaler |
US7464706B2 (en) * | 1999-07-23 | 2008-12-16 | Mannkind Corporation | Unit dose cartridge and dry powder inhaler |
US7678364B2 (en) | 1999-08-25 | 2010-03-16 | Alkermes, Inc. | Particles for inhalation having sustained release properties |
WO2001051030A1 (en) * | 2000-01-10 | 2001-07-19 | Dura Pharmaceuticals, Inc. | Pharmaceutical formulation and method for pulmonary and oral delivery |
GB0003839D0 (en) * | 2000-02-19 | 2000-04-05 | Glaxo Group Ltd | Housing for an inhaler |
MY136453A (en) * | 2000-04-27 | 2008-10-31 | Philip Morris Usa Inc | "improved method and apparatus for generating an aerosol" |
US6629524B1 (en) | 2000-07-12 | 2003-10-07 | Ponwell Enterprises Limited | Inhaler |
DE10040528A1 (de) * | 2000-08-18 | 2002-02-28 | Pari Gmbh | Inhalationsvorrichtung und Verfahren zur Erzeugung eines Partikelnebels für Inhalationszwecke |
GB0025749D0 (en) * | 2000-10-20 | 2000-12-06 | Glaxo Group Ltd | Inhaler |
US6539939B2 (en) * | 2000-12-18 | 2003-04-01 | Darren Rubin | Multi-function oral breathing support system |
US6491233B2 (en) | 2000-12-22 | 2002-12-10 | Chrysalis Technologies Incorporated | Vapor driven aerosol generator and method of use thereof |
US6501052B2 (en) | 2000-12-22 | 2002-12-31 | Chrysalis Technologies Incorporated | Aerosol generator having multiple heating zones and methods of use thereof |
US6681998B2 (en) | 2000-12-22 | 2004-01-27 | Chrysalis Technologies Incorporated | Aerosol generator having inductive heater and method of use thereof |
US6701921B2 (en) | 2000-12-22 | 2004-03-09 | Chrysalis Technologies Incorporated | Aerosol generator having heater in multilayered composite and method of use thereof |
US7077130B2 (en) * | 2000-12-22 | 2006-07-18 | Chrysalis Technologies Incorporated | Disposable inhaler system |
US6799572B2 (en) | 2000-12-22 | 2004-10-05 | Chrysalis Technologies Incorporated | Disposable aerosol generator system and methods for administering the aerosol |
GB0100756D0 (en) | 2001-01-11 | 2001-02-21 | Powderject Res Ltd | Needleless syringe |
US7073499B1 (en) | 2001-02-06 | 2006-07-11 | Injet Digital Aerosols Limited | Inhaler with airflow regulation |
US6652838B2 (en) * | 2001-04-05 | 2003-11-25 | Robert E. Weinstein | Method for treating diabetes mellitus |
JP3484435B2 (ja) | 2001-04-25 | 2004-01-06 | 松下電器産業株式会社 | 投写型表示装置 |
DE10123749A1 (de) * | 2001-05-16 | 2002-12-12 | Inamed Gmbh | Vorrichtung zum Verabreichen von Aerosolen |
US7645442B2 (en) | 2001-05-24 | 2010-01-12 | Alexza Pharmaceuticals, Inc. | Rapid-heating drug delivery article and method of use |
US7458374B2 (en) | 2002-05-13 | 2008-12-02 | Alexza Pharmaceuticals, Inc. | Method and apparatus for vaporizing a compound |
US7090830B2 (en) * | 2001-05-24 | 2006-08-15 | Alexza Pharmaceuticals, Inc. | Drug condensation aerosols and kits |
US7766013B2 (en) | 2001-06-05 | 2010-08-03 | Alexza Pharmaceuticals, Inc. | Aerosol generating method and device |
US20070122353A1 (en) | 2001-05-24 | 2007-05-31 | Hale Ron L | Drug condensation aerosols and kits |
US7244703B2 (en) * | 2001-06-22 | 2007-07-17 | Bentley Pharmaceuticals, Inc. | Pharmaceutical compositions and methods for peptide treatment |
DE10131516B4 (de) * | 2001-07-02 | 2004-05-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Steuereinheit zur Flussregulierung |
US6640050B2 (en) | 2001-09-21 | 2003-10-28 | Chrysalis Technologies Incorporated | Fluid vaporizing device having controlled temperature profile heater/capillary tube |
US6568390B2 (en) | 2001-09-21 | 2003-05-27 | Chrysalis Technologies Incorporated | Dual capillary fluid vaporizing device |
US20030068361A1 (en) * | 2001-10-09 | 2003-04-10 | Rimona Margalit | Liposome-encapsulated insulin formulations |
US6804458B2 (en) * | 2001-12-06 | 2004-10-12 | Chrysalis Technologies Incorporated | Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate |
US6681769B2 (en) | 2001-12-06 | 2004-01-27 | Crysalis Technologies Incorporated | Aerosol generator having a multiple path heater arrangement and method of use thereof |
US20030168057A1 (en) * | 2001-12-14 | 2003-09-11 | Inhale Therapeutic Systems, Inc. | Electronically controllable aerosol delivery |
US6701922B2 (en) | 2001-12-20 | 2004-03-09 | Chrysalis Technologies Incorporated | Mouthpiece entrainment airflow control for aerosol generators |
US6705316B2 (en) | 2002-03-11 | 2004-03-16 | Battelle Pulmonary Therapeutics, Inc. | Pulmonary dosing system and method |
US7008644B2 (en) * | 2002-03-20 | 2006-03-07 | Advanced Inhalation Research, Inc. | Method and apparatus for producing dry particles |
US20050163725A1 (en) * | 2002-03-20 | 2005-07-28 | Blizzard Charles D. | Method for administration of growth hormone via pulmonary delivery |
ES2300568T3 (es) | 2002-03-20 | 2008-06-16 | Mannkind Corporation | Aparato de inhalacion. |
CA2478327A1 (en) * | 2002-03-20 | 2003-10-02 | Advanced Inhalation Research, Inc. | Hgh (human growth hormone) formulations for pulmonary administration |
US6830046B2 (en) * | 2002-04-29 | 2004-12-14 | Hewlett-Packard Development Company, L.P. | Metered dose inhaler |
US20040151059A1 (en) * | 2002-05-01 | 2004-08-05 | Roberts Ii William Leroy | Deagglomerator apparatus and method |
US6985798B2 (en) | 2002-05-10 | 2006-01-10 | Oriel Therapeutics, Inc. | Dry powder dose filling systems and related methods |
US7118010B2 (en) | 2002-05-10 | 2006-10-10 | Oriel Therapeutics, Inc. | Apparatus, systems and related methods for dispensing and /or evaluating dry powders |
US6889690B2 (en) * | 2002-05-10 | 2005-05-10 | Oriel Therapeutics, Inc. | Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages |
US7677411B2 (en) * | 2002-05-10 | 2010-03-16 | Oriel Therapeutics, Inc. | Apparatus, systems and related methods for processing, dispensing and/or evaluatingl dry powders |
US20060193788A1 (en) * | 2002-11-26 | 2006-08-31 | Hale Ron L | Acute treatment of headache with phenothiazine antipsychotics |
US7185651B2 (en) * | 2002-06-18 | 2007-03-06 | Nektar Therapeutics | Flow regulator for aerosol drug delivery and methods |
AU2003253792A1 (en) * | 2002-06-27 | 2004-01-19 | Oriel Therapeutics, Inc. | Apparatus, systems and related methods for processing, dispensing and/or evaluating non-pharmaceutical dry powders |
GB0215270D0 (en) * | 2002-07-02 | 2002-08-14 | Optinose As | Nasal devices |
US20040105818A1 (en) * | 2002-11-26 | 2004-06-03 | Alexza Molecular Delivery Corporation | Diuretic aerosols and methods of making and using them |
AU2003295823B2 (en) * | 2002-11-26 | 2009-11-05 | Alexza Pharmaceuticals, Inc. | Treatment of headache with antipsychotics delivered by inhalation |
WO2004047844A1 (en) * | 2002-11-26 | 2004-06-10 | Alexza Pharmaceuticals, Inc. | Use of loxapine and amoxapine for the manufacture of a medicament for the treatment of pain |
US7913688B2 (en) | 2002-11-27 | 2011-03-29 | Alexza Pharmaceuticals, Inc. | Inhalation device for producing a drug aerosol |
US20050236296A1 (en) * | 2002-12-30 | 2005-10-27 | Nektar Therapeutics (Formerly Inhale Therapeutic Systems, Inc.) | Carry case for aerosolization apparatus |
US7683029B2 (en) * | 2003-05-07 | 2010-03-23 | Philip Morris Usa Inc. | Liquid aerosol formulations containing insulin and aerosol generating devices and methods for generating aerosolized insulin |
EP1625334B9 (en) | 2003-05-21 | 2012-07-25 | Alexza Pharmaceuticals, Inc. | Percussively ignited self-contained heating unit |
US7591801B2 (en) | 2004-02-26 | 2009-09-22 | Dexcom, Inc. | Integrated delivery device for continuous glucose sensor |
US7146977B2 (en) | 2003-09-25 | 2006-12-12 | Deka Products Limited Partnership | Valve system and method for aerosol delivery |
US7342660B2 (en) * | 2003-09-25 | 2008-03-11 | Deka Products Limited Partnership | Detection system and method for aerosol delivery |
US7377277B2 (en) * | 2003-10-27 | 2008-05-27 | Oriel Therapeutics, Inc. | Blister packages with frames and associated methods of fabricating dry powder drug containment systems |
US7451761B2 (en) * | 2003-10-27 | 2008-11-18 | Oriel Therapeutics, Inc. | Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances |
US7338171B2 (en) * | 2003-10-27 | 2008-03-04 | Jen-Chuen Hsieh | Method and apparatus for visual drive control |
SE0303570L (sv) * | 2003-12-03 | 2005-06-04 | Microdrug Ag | Fukt-känslig medicinsk produkt |
DK1706128T3 (da) | 2003-12-08 | 2010-10-04 | Cpex Pharmaceuticals Inc | Farmaceutiske sammensætninger og fremgangsmåder til insulin-behandling |
CN101027082A (zh) * | 2004-01-12 | 2007-08-29 | 曼恩坎德公司 | 降低2型糖尿病患者血清胰岛素原水平的方法 |
JP4601627B2 (ja) * | 2004-01-16 | 2010-12-22 | バイオデル, インコーポレイテッド | 舌下薬物送達デバイス |
US7380550B2 (en) * | 2004-01-30 | 2008-06-03 | Hewlett-Packard Development Company, L.P. | Systems and methods for particle detection |
US7819115B2 (en) * | 2004-01-30 | 2010-10-26 | Hewlett-Packard Development Company, L.P. | Inhalers and methods of controlling airflow in inhalers |
WO2009048462A1 (en) | 2007-10-09 | 2009-04-16 | Dexcom, Inc. | Integrated insulin delivery system with continuous glucose sensor |
EP1721421A1 (en) * | 2004-02-26 | 2006-11-15 | Novo Nordisk A/S | A method and a system for safe pairing of wireless communication devices |
US20080090753A1 (en) | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
US20080248999A1 (en) * | 2007-04-04 | 2008-10-09 | Biodel Inc. | Amylin formulations |
ES2398318T3 (es) * | 2004-03-12 | 2013-03-15 | Biodel, Inc. | Composiciones de suministro de fármacos de acción rápida |
JP2007529928A (ja) * | 2004-03-19 | 2007-10-25 | ノボ・ノルデイスク・エー/エス | 医療用デバイスのデータ伝送に使用されるパケットヘッダのフォーマットサイズの削減 |
EP1735729A2 (en) * | 2004-03-26 | 2006-12-27 | Novo Nordisk A/S | Device for displaying data relevant for a diabetic patient |
EP1740242A4 (en) * | 2004-04-20 | 2009-12-23 | Aerogen Inc | AEROSOL LABELING DEVICE, METHOD AND COMPOSITIONS FOR PRESSURE SUPPORTED AIR SYSTEMS |
US7946291B2 (en) | 2004-04-20 | 2011-05-24 | Novartis Ag | Ventilation systems and methods employing aerosol generators |
EP1745247B1 (en) * | 2004-04-23 | 2015-11-11 | Philip Morris Products S.a.s. | Aerosol generators and methods for producing aerosols |
US7540286B2 (en) | 2004-06-03 | 2009-06-02 | Alexza Pharmaceuticals, Inc. | Multiple dose condensation aerosol devices and methods of forming condensation aerosols |
WO2005123165A1 (en) * | 2004-06-15 | 2005-12-29 | Novo Nordisk A/S | Inhalation breath assistant apparatus and method for assisting in inhalation therapies |
FR2872798B1 (fr) * | 2004-07-09 | 2007-10-05 | Valois Sas | Ensemble de blisters pour dispositif d'inhalation |
CA2575692C (en) | 2004-08-20 | 2014-10-14 | Mannkind Corporation | Catalysis of diketopiperazine synthesis |
KR20130066695A (ko) | 2004-08-23 | 2013-06-20 | 맨카인드 코포레이션 | 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염 |
WO2006021566A2 (en) * | 2004-08-24 | 2006-03-02 | Novo Nordisk A/S | Giving a service to a patient |
WO2006048417A1 (en) | 2004-11-02 | 2006-05-11 | Novo Nordisk A/S | Inhalation therapy compliance tracking system and apparatus |
EP1858486A2 (en) * | 2005-01-10 | 2007-11-28 | MannKind Corporation | Methods and compositions for minimizing accrual of inhalable insulin in the lungs |
GB0507100D0 (en) * | 2005-04-08 | 2005-05-11 | Team Holdings Uk Ltd | Improvements in or relating to inhalers |
MX2007014867A (es) * | 2005-05-25 | 2008-02-21 | Aerogen Inc | Sistema y metodos de vibracion. |
US20070157931A1 (en) * | 2005-07-11 | 2007-07-12 | Richard Parker | System and method for optimized delivery of an aerosol to the respiratory tract |
US7900625B2 (en) * | 2005-08-26 | 2011-03-08 | North Carolina State University | Inhaler system for targeted maximum drug-aerosol delivery |
JP4789555B2 (ja) * | 2005-09-13 | 2011-10-12 | キヤノン株式会社 | 液剤吐出装置 |
CN104324362B (zh) | 2005-09-14 | 2018-04-24 | 曼金德公司 | 以提高活性试剂对结晶微粒表面的亲和力为基础的药物配制方法 |
US20070086952A1 (en) * | 2005-09-29 | 2007-04-19 | Biodel, Inc. | Rapid Acting and Prolonged Acting Inhalable Insulin Preparations |
US8084420B2 (en) * | 2005-09-29 | 2011-12-27 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
US7713929B2 (en) | 2006-04-12 | 2010-05-11 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
US9656903B2 (en) * | 2005-11-04 | 2017-05-23 | Ocv Intellectual Capital, Llc | Method of manufacturing high strength glass fibers in a direct melt operation and products formed there from |
CN104162200B (zh) | 2006-02-09 | 2018-03-27 | 德卡产品有限公司 | ****** |
MX2008010721A (es) | 2006-02-22 | 2008-09-01 | Mannkind Corp | Un metodo para mejorar las propiedades farmaceuticas de microparticulas que contienen dicetopiperazina y un agente activo. |
WO2007106686A2 (en) * | 2006-03-10 | 2007-09-20 | Novo Nordisk A/S | Medical apparatus and method for homogenous aerosol creation |
AU2007238114B2 (en) * | 2006-04-12 | 2010-10-14 | Biodel, Inc. | Rapid acting and long acting insulin combination formulations |
US8927015B2 (en) * | 2006-04-12 | 2015-01-06 | Emisphere Technologies, Inc. | Formulations for delivering insulin |
JP4895388B2 (ja) | 2006-07-25 | 2012-03-14 | キヤノン株式会社 | 薬剤吐出装置 |
US20090325860A1 (en) * | 2006-08-04 | 2009-12-31 | Nastech Pharmaceutical Company Inc. | Compositions for intranasal delivery of human insulin and uses thereof |
ES2594867T3 (es) | 2007-03-09 | 2016-12-23 | Alexza Pharmaceuticals, Inc. | Unidad de calentamiento para usar en un dispositivo de administración de fármaco |
US8616199B2 (en) * | 2007-03-16 | 2013-12-31 | Canon Kabushiki Kaisha | Inhaler and ejection head unit attachable to the inhaler |
WO2008118387A2 (en) * | 2007-03-23 | 2008-10-02 | Wayne State University | Erythrocyte atp-release modulators |
GB0708758D0 (en) | 2007-05-04 | 2007-06-13 | Powderject Res Ltd | Particle cassettes and process thereof |
US8261738B2 (en) * | 2007-07-24 | 2012-09-11 | Respironics Respiratory Drug Delivery (Uk) Ltd. | Apparatus and method for maintaining consistency for aerosol drug delivery treatments |
US20090042065A1 (en) * | 2007-08-10 | 2009-02-12 | Mphase Technologies, Inc. | Event Activated Micro Control Devices |
US20090151716A1 (en) * | 2007-09-18 | 2009-06-18 | Robert Abrams | Semi-automatic emergency medication dose nebulizer |
US8015969B2 (en) * | 2007-09-18 | 2011-09-13 | Robert Abrams | Semi-automatic emergency medication dose nebulizer |
US7814902B2 (en) * | 2007-09-18 | 2010-10-19 | Robert Abrams | Semi-automatic emergency medication dose nebulizer |
US20090071470A1 (en) * | 2007-09-18 | 2009-03-19 | Robert Abrams | Emergency medication dose nebulizer |
US8291902B2 (en) | 2007-09-18 | 2012-10-23 | Robert Abrams | Enhanced semi-automatic emergency medication dose nebulizer |
US7836885B2 (en) * | 2007-09-18 | 2010-11-23 | Robert Abrams | Semi-automatic emergency medication dose nebulizer |
US8785396B2 (en) | 2007-10-24 | 2014-07-22 | Mannkind Corporation | Method and composition for treating migraines |
KR20190045414A (ko) | 2007-11-30 | 2019-05-02 | 애브비 바이오테크놀로지 리미티드 | 단백질 제형 및 이의 제조방법 |
EP2230934B8 (en) | 2007-12-14 | 2012-10-24 | AeroDesigns, Inc | Delivering aerosolizable food products |
EP2077132A1 (en) | 2008-01-02 | 2009-07-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispensing device, storage device and method for dispensing a formulation |
US20090175840A1 (en) * | 2008-01-04 | 2009-07-09 | Biodel, Inc. | Insulin formulations for insulin release as a function of tissue glucose levels |
SG10201610381XA (en) * | 2008-03-27 | 2017-01-27 | Mannkind Corp | A dry powder inhalation system |
US8424518B2 (en) | 2008-06-13 | 2013-04-23 | Mannkind Corporation | Dry powder inhaler and system for drug delivery |
US8485180B2 (en) * | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
EP2609954B1 (en) | 2008-06-20 | 2021-12-29 | MannKind Corporation | An interactive apparatus for real-time profiling of inhalation efforts |
WO2010011329A2 (en) * | 2008-07-23 | 2010-01-28 | Map Pharmaceuticals, Inc. | The delivery of powdered drug via inhalation |
TWI494123B (zh) | 2008-08-11 | 2015-08-01 | Mannkind Corp | 超快起作用胰島素之用途 |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
US9060927B2 (en) * | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
JP5667095B2 (ja) | 2009-03-11 | 2015-02-12 | マンカインド コーポレイション | 吸入器の抵抗を測定するための装置、システムおよび方法 |
US20100242955A1 (en) * | 2009-03-19 | 2010-09-30 | Hansen Leland G | Aerosolized Drug Delivery System |
EP2662472B1 (de) | 2009-03-31 | 2019-02-27 | Boehringer Ingelheim International Gmbh | Verfahren zur Beschichtung einer Oberfläche eines Bauteils |
US9265910B2 (en) | 2009-05-18 | 2016-02-23 | Boehringer Ingelheim International Gmbh | Adapter, inhalation device, and nebulizer |
KR20180036807A (ko) | 2009-06-12 | 2018-04-09 | 맨카인드 코포레이션 | 한정된 비표면적을 갖는 디케토피페라진 마이크로입자 |
EP3556356B1 (en) * | 2009-06-12 | 2021-05-05 | MannKind Corporation | Diketopiperazine microparticles with defined isomer content |
US9149605B2 (en) | 2009-07-28 | 2015-10-06 | Clement Kleinstreuer | Methods and devices for targeted injection of microspheres |
WO2011056889A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
WO2011064163A1 (en) | 2009-11-25 | 2011-06-03 | Boehringer Ingelheim International Gmbh | Nebulizer |
UA107097C2 (en) | 2009-11-25 | 2014-11-25 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Dispenser |
US9180261B2 (en) | 2010-01-12 | 2015-11-10 | Dance Biopharm Inc. | Preservative free insulin formulations and systems and methods for aerosolizing |
US9545488B2 (en) | 2010-01-12 | 2017-01-17 | Dance Biopharm Inc. | Preservative-free single dose inhaler systems |
US20130269684A1 (en) | 2012-04-16 | 2013-10-17 | Dance Pharmaceuticals, Inc. | Methods and systems for supplying aerosolization devices with liquid medicaments |
US9095175B2 (en) * | 2010-05-15 | 2015-08-04 | R. J. Reynolds Tobacco Company | Data logging personal vaporizing inhaler |
US8757147B2 (en) | 2010-05-15 | 2014-06-24 | Minusa Holdings Llc | Personal vaporizing inhaler with internal light source |
US9999250B2 (en) | 2010-05-15 | 2018-06-19 | Rai Strategic Holdings, Inc. | Vaporizer related systems, methods, and apparatus |
US10159278B2 (en) | 2010-05-15 | 2018-12-25 | Rai Strategic Holdings, Inc. | Assembly directed airflow |
US10136672B2 (en) | 2010-05-15 | 2018-11-27 | Rai Strategic Holdings, Inc. | Solderless directly written heating elements |
US9861772B2 (en) | 2010-05-15 | 2018-01-09 | Rai Strategic Holdings, Inc. | Personal vaporizing inhaler cartridge |
US9743691B2 (en) | 2010-05-15 | 2017-08-29 | Rai Strategic Holdings, Inc. | Vaporizer configuration, control, and reporting |
US9259035B2 (en) | 2010-05-15 | 2016-02-16 | R. J. Reynolds Tobacco Company | Solderless personal vaporizing inhaler |
CA2801936C (en) | 2010-06-21 | 2021-06-01 | Mannkind Corporation | Dry powder drug delivery system and methods |
JP5874724B2 (ja) | 2010-06-24 | 2016-03-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ネブライザ |
EP2694220B1 (de) | 2011-04-01 | 2020-05-06 | Boehringer Ingelheim International GmbH | Medizinisches gerät mit behälter |
CN103826988B (zh) | 2011-04-01 | 2016-03-09 | 曼金德公司 | 用于药物药盒的泡罩包装 |
RU2014110005A (ru) | 2011-04-12 | 2015-09-20 | СИС Ресорсиз, Лтд. | Батарейный коннектор для электронной сигареты с боковым забором воздуха |
US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
EP2995986B1 (en) | 2011-08-24 | 2017-04-12 | Rockwell Collins, Inc. | Data display |
AU2012328885B2 (en) | 2011-10-24 | 2017-08-31 | Mannkind Corporation | Methods and compositions for treating pain |
EP2809780B1 (en) | 2012-02-01 | 2018-05-02 | Protalix Ltd. | Dnase i polypeptides, polynucleotides encoding same, methods of producing dnase i and uses thereof in therapy |
WO2013152894A1 (de) | 2012-04-13 | 2013-10-17 | Boehringer Ingelheim International Gmbh | Zerstäuber mit kodiermitteln |
AU2013289957B2 (en) | 2012-07-12 | 2017-02-23 | Mannkind Corporation | Dry powder drug delivery systems and methods |
WO2014066856A1 (en) | 2012-10-26 | 2014-05-01 | Mannkind Corporation | Inhalable influenza vaccine compositions and methods |
US10034988B2 (en) | 2012-11-28 | 2018-07-31 | Fontem Holdings I B.V. | Methods and devices for compound delivery |
CA2906817C (en) | 2013-03-15 | 2022-01-18 | Mannkind Corporation | Microcrystalline diketopiperazine compositions and methods |
US10596334B2 (en) * | 2013-04-04 | 2020-03-24 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Nasal aerosol delivery system |
CN105530916B (zh) * | 2013-07-11 | 2020-04-07 | 艾利斯达医药品公司 | 与间水杨酸形成的烟碱盐 |
MX2016000739A (es) | 2013-07-18 | 2017-04-06 | Mannkind Corp | Composiciones farmacéuticas en polvo seco estables al calor y métodos. |
CA2920488C (en) | 2013-08-05 | 2022-04-26 | Mannkind Corporation | Insufflation apparatus and methods |
JP6643231B2 (ja) | 2013-08-09 | 2020-02-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ネブライザ |
EP2835146B1 (en) | 2013-08-09 | 2020-09-30 | Boehringer Ingelheim International GmbH | Nebulizer |
WO2015042412A1 (en) | 2013-09-20 | 2015-03-26 | E-Nicotine Technology. Inc. | Devices and methods for modifying delivery devices |
WO2015148905A1 (en) | 2014-03-28 | 2015-10-01 | Mannkind Corporation | Use of ultrarapid acting insulin |
JP6580070B2 (ja) | 2014-05-07 | 2019-09-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 容器、ネブライザ、及び使用 |
HUE055604T2 (hu) | 2014-05-07 | 2021-12-28 | Boehringer Ingelheim Int | Porlasztó |
DK3139983T3 (da) | 2014-05-07 | 2023-09-11 | Boehringer Ingelheim Int | Beholder og indikatoranordning, samt forstøver |
US10307550B2 (en) | 2014-06-09 | 2019-06-04 | Dance Biopharm Inc. | Liquid drug cartridges and associated dispenser |
US10471222B2 (en) | 2014-07-01 | 2019-11-12 | Dance Biopharm Inc. | Aerosolization system with flow restrictor and feedback device |
US11273271B2 (en) | 2014-07-01 | 2022-03-15 | Aerami Therapeutics, Inc. | Aerosolization system with flow restrictor and feedback device |
US10857313B2 (en) | 2014-07-01 | 2020-12-08 | Aerami Therapeutics, Inc. | Liquid nebulization systems and methods |
US10933207B2 (en) | 2014-08-26 | 2021-03-02 | Asmedic Ltd. | Drug delivery apparatus |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
CN107406837A (zh) | 2015-01-04 | 2017-11-28 | 波塔力克斯有限公司 | 修饰的dna酶及其用途 |
JP2019503829A (ja) | 2015-12-21 | 2019-02-14 | スリーエム イノベイティブ プロパティズ カンパニー | 医療用吸入器で使用するための流れ調整器アセンブリ |
WO2017112748A1 (en) | 2015-12-21 | 2017-06-29 | 3M Innovative Properties Company | Flow govenors for use in medicinal inhalers |
KR102295739B1 (ko) | 2016-05-03 | 2021-08-30 | 뉴마 레스퍼러토리 인코포레이티드 | 유체들의 폐기관계로의 전달을 위한 액적 전달 디바이스 및 사용 방법 |
CA3024721A1 (en) | 2016-05-19 | 2017-11-23 | Mannkind Corporation | Apparatus, system and method for detecting and monitoring inhalations |
US11019847B2 (en) * | 2016-07-28 | 2021-06-01 | Rai Strategic Holdings, Inc. | Aerosol delivery devices including a selector and related methods |
CA3064005C (en) | 2017-05-19 | 2023-03-07 | Pneuma Respiratory, Inc. | Dry powder delivery device and methods of use |
AU2018272759B2 (en) * | 2017-05-26 | 2020-08-06 | Microdose Therapeutx, Inc. | Inhaler with synthetic jetting |
US11738158B2 (en) | 2017-10-04 | 2023-08-29 | Pneuma Respiratory, Inc. | Electronic breath actuated in-line droplet delivery device and methods of use |
US11458267B2 (en) | 2017-10-17 | 2022-10-04 | Pneuma Respiratory, Inc. | Nasal drug delivery apparatus and methods of use |
US11771852B2 (en) | 2017-11-08 | 2023-10-03 | Pneuma Respiratory, Inc. | Electronic breath actuated in-line droplet delivery device with small volume ampoule and methods of use |
WO2019195239A1 (en) * | 2018-04-02 | 2019-10-10 | Pneuma Respiratory, Inc. | Handheld digital nebulizer device and methods of use |
US11071842B2 (en) | 2018-07-09 | 2021-07-27 | Perma Pure Llc | Low-flow oxygen therapy humidifier and method |
WO2022160197A1 (zh) * | 2021-01-28 | 2022-08-04 | 深圳麦科田生物医疗技术股份有限公司 | 自动换药雾化装置 |
KR20240037245A (ko) | 2021-06-22 | 2024-03-21 | 뉴마 레스퍼러토리 인코포레이티드 | 푸시 이젝션에 의한 액적 전달 장치 |
CN113577466B (zh) * | 2021-09-02 | 2022-03-01 | 平远县中医医院(平远县中医医院医共体总院) | 雾化吸入装置 |
Family Cites Families (89)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3812854A (en) * | 1972-10-20 | 1974-05-28 | A Michaels | Ultrasonic nebulizer |
US3923043A (en) * | 1973-09-28 | 1975-12-02 | Roman L Yanda | Method for acquisition of exhalation tidal volume and minute ventilation data |
US4468464A (en) * | 1974-11-04 | 1984-08-28 | The Board Of Trustees Of The Leland Stanford Junior University | Biologically functional molecular chimeras |
US3977394A (en) * | 1975-02-07 | 1976-08-31 | Jones Medical Instrument Company | Computerized pulmonary analyzer |
US3991304A (en) * | 1975-05-19 | 1976-11-09 | Hillsman Dean | Respiratory biofeedback and performance evaluation system |
US4153689A (en) * | 1975-06-13 | 1979-05-08 | Takeda Chemical Industries, Ltd. | Stable insulin preparation for nasal administration |
US4106503A (en) * | 1977-03-11 | 1978-08-15 | Richard R. Rosenthal | Metering system for stimulating bronchial spasm |
US4361401A (en) * | 1978-05-22 | 1982-11-30 | Instrumentation Laboratory Inc. | Automatic sample deposition in flameless analysis |
US4727028A (en) * | 1981-06-22 | 1988-02-23 | Eli Lilly And Company | Recombinant DNA cloning vectors and the eukaryotic and prokaryotic transformants thereof |
US4343798A (en) * | 1981-06-23 | 1982-08-10 | The Procter & Gamble Company | Topical antimicrobial anti-inflammatory compositions |
GB2104393B (en) * | 1981-08-13 | 1984-11-07 | Glaxo Group Ltd | Medical inhalation devices |
FI79651C (fi) * | 1982-10-08 | 1990-02-12 | Glaxo Group Ltd | Doseringsanordning foer medicin. |
JPS608225A (ja) * | 1983-06-29 | 1985-01-17 | Kowa Co | 腸管吸収医薬組成物 |
US4604847A (en) * | 1983-09-14 | 1986-08-12 | Moulding Jr Thomas S | Medicine package, method of opening the package, and machine for performing the method |
DD230730A3 (de) * | 1984-01-02 | 1985-12-11 | Zentralinstitut Fuer Diabetes | Einrichtung zur prospektiven automatischen bestimmung individualspezifischer glukoseregulationsparameter |
US4624251A (en) * | 1984-09-13 | 1986-11-25 | Riker Laboratories, Inc. | Apparatus for administering a nebulized substance |
FI76929C (fi) | 1984-09-25 | 1989-01-10 | Etelae Haemeen Keuhkovammayhdi | Inhalationsdoseringsanordning, som aer avsedd foer nogrann dosering av disponerande laekemedel som ges aot andningssjuka i undersoekningsskedet och/eller laekemedel som ges som spray under behandlingen. |
NZ209900A (en) * | 1984-10-16 | 1989-08-29 | Univ Auckland | Automatic inhaler |
US4648393A (en) * | 1984-11-02 | 1987-03-10 | Ackrad Laboratories, Inc. | Breath activated medication spray |
CA1274774A (en) * | 1985-04-15 | 1990-10-02 | Kenneth S. Su | Method for administering insulin |
US4686231A (en) * | 1985-12-12 | 1987-08-11 | Smithkline Beckman Corporation | Inhibition of 5-lipoxygenase products |
NZ219021A (en) * | 1986-01-27 | 1989-06-28 | Gea Farmaceutisk Fabrik As | Inhaler: medicine discharged intermittently during each inhalation |
US4926852B1 (en) * | 1986-06-23 | 1995-05-23 | Univ Johns Hopkins | Medication delivery system phase one |
US4790305A (en) * | 1986-06-23 | 1988-12-13 | The Johns Hopkins University | Medication delivery system |
DE3627222A1 (de) * | 1986-08-11 | 1988-02-18 | Siemens Ag | Ultraschall-taschenzerstaeubergeraet |
AU8023787A (en) * | 1986-10-07 | 1988-05-06 | Mainframe Data Ltd. | Apparatus and method for controlling transmission of defects |
DE3636669C2 (de) * | 1986-10-28 | 2001-08-16 | Siemens Ag | Anordnung zur Zufuhr von Aerosol zu den Luftwegen und/oder Lungen eines Patienten |
US5126257A (en) * | 1986-11-26 | 1992-06-30 | Cornell Research Foundation | Antimicrobial proteins, compositions containing same and uses thereof |
US4796614A (en) * | 1987-02-26 | 1989-01-10 | Trutek Research, Inc. | Collapsible inhalation valve |
US5198541A (en) * | 1987-08-11 | 1993-03-30 | New York University | Dna encoding bactericidal/permeability-increasing proteins |
DE3856588T2 (de) * | 1987-08-11 | 2006-09-07 | New York University | Biologisch-aktive Bakterizide/permeabilitätserhöhende Proteinbruchstücke |
US4852582A (en) * | 1987-09-11 | 1989-08-01 | Pell Donald M | Method and kit for measuring the effectiveness of bronchodilators |
US4907581A (en) * | 1988-06-30 | 1990-03-13 | Medi-Nuclear Corporation, Inc. | Radioactive aerosol inhalation apparatus |
GB8815978D0 (en) * | 1988-07-05 | 1988-08-10 | British Telecomm | Method & apparatus for encoding decoding & transmitting data in compressed form |
US4984158A (en) * | 1988-10-14 | 1991-01-08 | Hillsman Dean | Metered dose inhaler biofeedback training and evaluation system |
US5006343A (en) * | 1988-12-29 | 1991-04-09 | Benson Bradley J | Pulmonary administration of pharmaceutically active substances |
US5011678A (en) * | 1989-02-01 | 1991-04-30 | California Biotechnology Inc. | Composition and method for administration of pharmaceutically active substances |
US5514646A (en) * | 1989-02-09 | 1996-05-07 | Chance; Ronald E. | Insulin analogs modified at position 29 of the B chain |
US5171739A (en) * | 1989-02-14 | 1992-12-15 | Incyte Pharmaceuticals, Inc. | Treatment of endotoxin-associated shock and preventation thereof using a BPI protein |
ATE120762T1 (de) * | 1989-04-20 | 1995-04-15 | Sinai School Medicine | Hepatospezifische insulin-analoga. |
FR2654755B2 (fr) * | 1989-05-22 | 1993-04-30 | Baumann Felix | Perfectionnement aux cylindres secheurs dans les installations de fabrication de papier. |
JPH0371816A (ja) * | 1989-08-11 | 1991-03-27 | Komatsu Ltd | 射出プレス複合成形機のノズルタッチ機構 |
JPH0399667A (ja) | 1989-09-14 | 1991-04-24 | Terumo Corp | 医療用容器 |
US5152456A (en) | 1989-12-12 | 1992-10-06 | Bespak, Plc | Dispensing apparatus having a perforate outlet member and a vibrating device |
SG45171A1 (en) * | 1990-03-21 | 1998-01-16 | Boehringer Ingelheim Int | Atomising devices and methods |
US5192548A (en) * | 1990-04-30 | 1993-03-09 | Riker Laboratoires, Inc. | Device |
JP3219096B2 (ja) * | 1990-05-10 | 2001-10-15 | ニコメド ファーマ エイエス | n―グリコフロール類及びn―エチレングリコール類を含有する医薬製剤 |
GB9015845D0 (en) * | 1990-07-19 | 1990-09-05 | Emery Vincent C | Diagnostic method |
GB9016789D0 (en) | 1990-07-31 | 1990-09-12 | Lilly Industries Ltd | Medicament administering devices |
US5230884A (en) * | 1990-09-11 | 1993-07-27 | University Of Wales College Of Cardiff | Aerosol formulations including proteins and peptides solubilized in reverse micelles and process for making the aerosol formulations |
GB9023282D0 (en) * | 1990-10-25 | 1990-12-05 | Riker Laboratories Inc | Inhalation device |
GB9026025D0 (en) * | 1990-11-29 | 1991-01-16 | Boehringer Ingelheim Kg | Inhalation device |
FR2673142A1 (fr) * | 1991-02-21 | 1992-08-28 | Ribal Annick | Dispositif de soudure autonome, portatif pour poches plastiques. |
US5404871A (en) * | 1991-03-05 | 1995-04-11 | Aradigm | Delivery of aerosol medications for inspiration |
US5394866A (en) * | 1991-03-05 | 1995-03-07 | Aradigm Corporation | Automatic aerosol medication delivery system and methods |
US5450336A (en) * | 1991-03-05 | 1995-09-12 | Aradigm Corporation | Method for correcting the drift offset of a transducer |
GB9109064D0 (en) * | 1991-04-26 | 1991-06-12 | Dunne Miller Weston Ltd | Dispensing device |
US5327883A (en) * | 1991-05-20 | 1994-07-12 | Dura Pharmaceuticals, Inc. | Apparatus for aerosolizing powdered medicine and process and using |
JP2525299B2 (ja) | 1991-07-26 | 1996-08-14 | ティーディーケイ株式会社 | 超音波霧化器 |
JPH05317041A (ja) * | 1991-06-05 | 1993-12-03 | Nippon Oil Co Ltd | 動物細胞増殖促進剤及び無血清培地 |
EP0592540B1 (en) * | 1991-07-02 | 2000-01-26 | Inhale, Inc. | Method and device for delivering aerosolized medicaments |
US5268453A (en) * | 1991-08-08 | 1993-12-07 | Scios Inc. | Tissue-selective insulin analogs |
US5167506A (en) * | 1991-10-24 | 1992-12-01 | Minnesota Mining And Manufacturing Company | Inhalation device training system |
US5363842A (en) * | 1991-12-20 | 1994-11-15 | Circadian, Inc. | Intelligent inhaler providing feedback to both patient and medical professional |
US5320094A (en) * | 1992-01-10 | 1994-06-14 | The Johns Hopkins University | Method of administering insulin |
EP0558879B1 (en) * | 1992-03-04 | 1997-05-14 | Astra Aktiebolag | Disposable inhaler |
US5284133A (en) * | 1992-07-23 | 1994-02-08 | Armstrong Pharmaceuticals, Inc. | Inhalation device with a dose-timer, an actuator mechanism, and patient compliance monitoring means |
US5333106A (en) * | 1992-10-09 | 1994-07-26 | Circadian, Inc. | Apparatus and visual display method for training in the power use of aerosol pharmaceutical inhalers |
US6024090A (en) * | 1993-01-29 | 2000-02-15 | Aradigm Corporation | Method of treating a diabetic patient by aerosolized administration of insulin lispro |
US5558085A (en) * | 1993-01-29 | 1996-09-24 | Aradigm Corporation | Intrapulmonary delivery of peptide drugs |
US5888477A (en) * | 1993-01-29 | 1999-03-30 | Aradigm Corporation | Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin |
US5743250A (en) * | 1993-01-29 | 1998-04-28 | Aradigm Corporation | Insulin delivery enhanced by coached breathing |
US5672581A (en) * | 1993-01-29 | 1997-09-30 | Aradigm Corporation | Method of administration of insulin |
US5364838A (en) * | 1993-01-29 | 1994-11-15 | Miris Medical Corporation | Method of administration of insulin |
US6131567A (en) * | 1993-01-29 | 2000-10-17 | Aradigm Corporation | Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin |
US5915378A (en) * | 1993-01-29 | 1999-06-29 | Aradigm Corporation | Creating an aerosolized formulation of insulin |
US7448375B2 (en) * | 1993-01-29 | 2008-11-11 | Aradigm Corporation | Method of treating diabetes mellitus in a patient |
US5497763A (en) * | 1993-05-21 | 1996-03-12 | Aradigm Corporation | Disposable package for intrapulmonary delivery of aerosolized formulations |
FR2705911B1 (fr) * | 1993-06-02 | 1995-08-11 | Oreal | Appareil de nébulisation piézoélectrique. |
US5437267A (en) * | 1993-08-03 | 1995-08-01 | Weinstein; Allan | Device for delivering aerosol to the nasal membranes and method of use |
US5461031A (en) * | 1994-06-16 | 1995-10-24 | Eli Lilly And Company | Monomeric insulin analog formulations |
SE9402237D0 (sv) * | 1994-06-23 | 1994-06-23 | Astra Ab | Measurement methods and systems |
US5509404A (en) * | 1994-07-11 | 1996-04-23 | Aradigm Corporation | Intrapulmonary drug delivery within therapeutically relevant inspiratory flow/volume values |
US5547929A (en) * | 1994-09-12 | 1996-08-20 | Eli Lilly And Company | Insulin analog formulations |
US5522385A (en) * | 1994-09-27 | 1996-06-04 | Aradigm Corporation | Dynamic particle size control for aerosolized drug delivery |
US5758637A (en) * | 1995-08-31 | 1998-06-02 | Aerogen, Inc. | Liquid dispensing apparatus and methods |
US5694920A (en) * | 1996-01-25 | 1997-12-09 | Abrams; Andrew L. | Inhalation device |
US6694975B2 (en) * | 1996-11-21 | 2004-02-24 | Aradigm Corporation | Temperature controlling device for aerosol drug delivery |
US6131570A (en) * | 1998-06-30 | 2000-10-17 | Aradigm Corporation | Temperature controlling device for aerosol drug delivery |
-
1997
- 1997-01-31 US US08/792,616 patent/US5888477A/en not_active Expired - Lifetime
- 1997-04-25 US US08/846,243 patent/US5884620A/en not_active Expired - Lifetime
-
1998
- 1998-04-23 AU AU72556/98A patent/AU741913B2/en not_active Ceased
- 1998-04-23 JP JP54714398A patent/JP2002504833A/ja active Pending
- 1998-04-23 WO PCT/US1998/008238 patent/WO1998048873A1/en active IP Right Grant
- 1998-04-23 DE DE69832183T patent/DE69832183T2/de not_active Expired - Lifetime
- 1998-04-23 EP EP20050013890 patent/EP1576978B1/en not_active Expired - Lifetime
- 1998-04-23 EP EP98919861A patent/EP1011767B1/en not_active Expired - Lifetime
- 1998-04-23 AT AT98919861T patent/ATE308356T1/de not_active IP Right Cessation
- 1998-04-23 DE DE69840638T patent/DE69840638D1/de not_active Expired - Lifetime
- 1998-04-23 ES ES05013890T patent/ES2321951T3/es not_active Expired - Lifetime
- 1998-04-24 AR ARP980101907 patent/AR007491A1/es active IP Right Grant
- 1998-09-25 US US09/160,909 patent/US5941240A/en not_active Expired - Fee Related
-
1999
- 1999-08-20 US US09/378,638 patent/US6167880B1/en not_active Expired - Fee Related
-
2001
- 2001-09-10 US US09/950,562 patent/US6688304B2/en not_active Expired - Fee Related
-
2003
- 2003-11-04 US US10/701,967 patent/US7028686B2/en not_active Expired - Fee Related
-
2006
- 2006-01-31 US US11/345,061 patent/US20060124125A1/en not_active Abandoned
-
2007
- 2007-10-26 US US11/925,399 patent/US20080099011A1/en not_active Abandoned
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2009045446A (ja) * | 2007-07-20 | 2009-03-05 | Canon Inc | 吸入装置 |
JP2009268665A (ja) * | 2008-05-07 | 2009-11-19 | Canon Inc | 吸入装置 |
JP2019022673A (ja) * | 2013-03-15 | 2019-02-14 | マイクロドース セラピューテクス,インコーポレイテッド | 吸入装置、制御方法およびコンピュータプログラム |
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US6688304B2 (en) | 2004-02-10 |
US20040089290A1 (en) | 2004-05-13 |
US20060124125A1 (en) | 2006-06-15 |
AR007491A1 (es) | 1999-11-10 |
ATE308356T1 (de) | 2005-11-15 |
EP1011767A1 (en) | 2000-06-28 |
WO1998048873A1 (en) | 1998-11-05 |
AU7255698A (en) | 1998-11-24 |
US20020046750A1 (en) | 2002-04-25 |
US5941240A (en) | 1999-08-24 |
US6167880B1 (en) | 2001-01-02 |
US20080099011A1 (en) | 2008-05-01 |
US5888477A (en) | 1999-03-30 |
ES2321951T3 (es) | 2009-06-15 |
US5884620A (en) | 1999-03-23 |
DE69840638D1 (de) | 2009-04-16 |
DE69832183D1 (de) | 2005-12-08 |
AU741913B2 (en) | 2001-12-13 |
DE69832183T2 (de) | 2006-08-03 |
EP1011767B1 (en) | 2005-11-02 |
US7028686B2 (en) | 2006-04-18 |
EP1011767A4 (en) | 2001-03-14 |
EP1576978A3 (en) | 2005-11-30 |
EP1576978A2 (en) | 2005-09-21 |
EP1576978B1 (en) | 2009-03-04 |
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