JP2002504550A - 抗微生物剤として有用な置換アミノメチルイソオキサゾリン誘導体 - Google Patents
抗微生物剤として有用な置換アミノメチルイソオキサゾリン誘導体Info
- Publication number
- JP2002504550A JP2002504550A JP2000533427A JP2000533427A JP2002504550A JP 2002504550 A JP2002504550 A JP 2002504550A JP 2000533427 A JP2000533427 A JP 2000533427A JP 2000533427 A JP2000533427 A JP 2000533427A JP 2002504550 A JP2002504550 A JP 2002504550A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- optionally substituted
- phenyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7591498P | 1998-02-25 | 1998-02-25 | |
US60/075,914 | 1998-02-25 | ||
PCT/US1999/004262 WO1999043671A1 (fr) | 1998-02-25 | 1999-02-10 | Derives d'isoxazoline aminomethyle substitues utiles en tant qu'agents antimicrobiens |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2002504550A true JP2002504550A (ja) | 2002-02-12 |
Family
ID=22128730
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000533427A Pending JP2002504550A (ja) | 1998-02-25 | 1999-02-10 | 抗微生物剤として有用な置換アミノメチルイソオキサゾリン誘導体 |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1060179A1 (fr) |
JP (1) | JP2002504550A (fr) |
AU (1) | AU3180999A (fr) |
CA (1) | CA2318762A1 (fr) |
WO (1) | WO1999043671A1 (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP0103082A3 (en) | 1998-06-05 | 2002-12-28 | Astrazeneca Ab | Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them |
EP1443930A1 (fr) | 2001-10-25 | 2004-08-11 | AstraZeneca AB | Derives d'isoxazoline utilises en tant qu'agents antimicrobiens |
TW200626138A (en) | 2004-09-20 | 2006-08-01 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as therapeutic agents |
AR051091A1 (es) | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
CN101083982A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 用于治疗硬脂酰CoA去饱和酶介导的疾病的杂环衍生物 |
JP4958786B2 (ja) | 2004-09-20 | 2012-06-20 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 複素環誘導体および治療薬としてのそれらの使用 |
AU2005329423A1 (en) | 2004-09-20 | 2006-09-28 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
CN101083992A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 抑制人硬脂酰CoA去饱和酶的哒嗪衍生物 |
WO2006034441A1 (fr) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Derives heterocycliques et leur utilisation en tant qu'inhibiteurs de la stearoyl-coa desaturase |
MX2007015216A (es) | 2005-06-03 | 2008-02-22 | Xenon Pharmaceuticals Inc | Derivados de aminotiazol y sus usos como agentes terapeuticos. |
MX361458B (es) | 2011-08-23 | 2018-12-06 | Asana Biosciences Llc | Compuestos de pirimido-piridazinona y uso de los mismos. |
CN108137545B (zh) | 2015-05-20 | 2020-09-22 | 美国安进公司 | Apj受体的***激动剂 |
EP3452466B1 (fr) | 2016-05-03 | 2020-08-12 | Amgen Inc. | Composés triazole hétérocycliques utilisés en tant qu'agonistes du récepteur apj |
EP3541792B1 (fr) | 2016-11-16 | 2020-12-23 | Amgen Inc. | Composés de triazole furane utilisés en tant qu'agonistes du récepteur apj |
WO2018097945A1 (fr) | 2016-11-16 | 2018-05-31 | Amgen Inc. | Triazoles substitués par hétéroaryle utilisés en tant qu'agonistes du récepteur apj |
US11020395B2 (en) | 2016-11-16 | 2021-06-01 | Amgen Inc. | Cycloalkyl substituted triazole compounds as agonists of the APJ receptor |
WO2018093579A1 (fr) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Composés phényle triazole en tant qu'agonistes du récepteur apj |
US11191762B2 (en) | 2016-11-16 | 2021-12-07 | Amgen Inc. | Alkyl substituted triazole compounds as agonists of the APJ Receptor |
CN117503775A (zh) | 2017-04-28 | 2024-02-06 | 自由生物有限公司 | 治疗特应性皮炎以及提高活性药物成分稳定性的制剂、方法、试剂盒和剂型 |
US11807624B2 (en) | 2018-05-01 | 2023-11-07 | Amgen Inc. | Substituted pyrimidinones as agonists of the APJ receptor |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL137326C (fr) * | 1967-08-26 | |||
US3711495A (en) * | 1970-01-07 | 1973-01-16 | Merck & Co Inc | Isoxazalin-3-yl-substituted-5-nitroimidazoles |
US4283403A (en) * | 1976-06-14 | 1981-08-11 | Eli Lilly And Company | Substituted isoxazolines for control of plant phytopathogens |
PL185872B1 (pl) * | 1995-02-03 | 2003-08-29 | Upjohn Co | Nowe podstawione fenylooksazolidynonyNowe podstawione fenylooksazolidynony |
DE19601264A1 (de) * | 1996-01-16 | 1997-07-17 | Bayer Ag | Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone |
EP0920421B1 (fr) * | 1996-08-21 | 2002-11-06 | PHARMACIA & UPJOHN COMPANY | Derives d'isoxazoline utiles comme agents antimicrobiens |
CN1138765C (zh) * | 1997-05-30 | 2004-02-18 | 法玛西雅厄普约翰美国公司 | 带有硫代羰基功能基的噁唑烷酮抗菌剂 |
-
1999
- 1999-02-10 EP EP99913819A patent/EP1060179A1/fr not_active Withdrawn
- 1999-02-10 CA CA002318762A patent/CA2318762A1/fr not_active Abandoned
- 1999-02-10 AU AU31809/99A patent/AU3180999A/en not_active Abandoned
- 1999-02-10 JP JP2000533427A patent/JP2002504550A/ja active Pending
- 1999-02-10 WO PCT/US1999/004262 patent/WO1999043671A1/fr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1060179A1 (fr) | 2000-12-20 |
CA2318762A1 (fr) | 1999-09-02 |
AU3180999A (en) | 1999-09-15 |
WO1999043671A1 (fr) | 1999-09-02 |
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