JP2002504550A - 抗微生物剤として有用な置換アミノメチルイソオキサゾリン誘導体 - Google Patents

抗微生物剤として有用な置換アミノメチルイソオキサゾリン誘導体

Info

Publication number
JP2002504550A
JP2002504550A JP2000533427A JP2000533427A JP2002504550A JP 2002504550 A JP2002504550 A JP 2002504550A JP 2000533427 A JP2000533427 A JP 2000533427A JP 2000533427 A JP2000533427 A JP 2000533427A JP 2002504550 A JP2002504550 A JP 2002504550A
Authority
JP
Japan
Prior art keywords
alkyl
alkoxy
optionally substituted
phenyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000533427A
Other languages
English (en)
Japanese (ja)
Inventor
マイケル・アール・バーバチン
ジョエル・モリス
ドン・ジー・ウィシュカ
リチャード・シー・トーマス
デイビッド・アール・グラバー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co filed Critical Pharmacia and Upjohn Co
Publication of JP2002504550A publication Critical patent/JP2002504550A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2000533427A 1998-02-25 1999-02-10 抗微生物剤として有用な置換アミノメチルイソオキサゾリン誘導体 Pending JP2002504550A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7591498P 1998-02-25 1998-02-25
US60/075,914 1998-02-25
PCT/US1999/004262 WO1999043671A1 (fr) 1998-02-25 1999-02-10 Derives d'isoxazoline aminomethyle substitues utiles en tant qu'agents antimicrobiens

Publications (1)

Publication Number Publication Date
JP2002504550A true JP2002504550A (ja) 2002-02-12

Family

ID=22128730

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000533427A Pending JP2002504550A (ja) 1998-02-25 1999-02-10 抗微生物剤として有用な置換アミノメチルイソオキサゾリン誘導体

Country Status (5)

Country Link
EP (1) EP1060179A1 (fr)
JP (1) JP2002504550A (fr)
AU (1) AU3180999A (fr)
CA (1) CA2318762A1 (fr)
WO (1) WO1999043671A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0103082A3 (en) 1998-06-05 2002-12-28 Astrazeneca Ab Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them
EP1443930A1 (fr) 2001-10-25 2004-08-11 AstraZeneca AB Derives d'isoxazoline utilises en tant qu'agents antimicrobiens
TW200626138A (en) 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
AR051091A1 (es) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
CN101083982A (zh) 2004-09-20 2007-12-05 泽农医药公司 用于治疗硬脂酰CoA去饱和酶介导的疾病的杂环衍生物
JP4958786B2 (ja) 2004-09-20 2012-06-20 ゼノン・ファーマシューティカルズ・インコーポレイテッド 複素環誘導体および治療薬としてのそれらの使用
AU2005329423A1 (en) 2004-09-20 2006-09-28 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
CN101083992A (zh) 2004-09-20 2007-12-05 泽农医药公司 抑制人硬脂酰CoA去饱和酶的哒嗪衍生物
WO2006034441A1 (fr) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Derives heterocycliques et leur utilisation en tant qu'inhibiteurs de la stearoyl-coa desaturase
MX2007015216A (es) 2005-06-03 2008-02-22 Xenon Pharmaceuticals Inc Derivados de aminotiazol y sus usos como agentes terapeuticos.
MX361458B (es) 2011-08-23 2018-12-06 Asana Biosciences Llc Compuestos de pirimido-piridazinona y uso de los mismos.
CN108137545B (zh) 2015-05-20 2020-09-22 美国安进公司 Apj受体的***激动剂
EP3452466B1 (fr) 2016-05-03 2020-08-12 Amgen Inc. Composés triazole hétérocycliques utilisés en tant qu'agonistes du récepteur apj
EP3541792B1 (fr) 2016-11-16 2020-12-23 Amgen Inc. Composés de triazole furane utilisés en tant qu'agonistes du récepteur apj
WO2018097945A1 (fr) 2016-11-16 2018-05-31 Amgen Inc. Triazoles substitués par hétéroaryle utilisés en tant qu'agonistes du récepteur apj
US11020395B2 (en) 2016-11-16 2021-06-01 Amgen Inc. Cycloalkyl substituted triazole compounds as agonists of the APJ receptor
WO2018093579A1 (fr) 2016-11-16 2018-05-24 Amgen Inc. Composés phényle triazole en tant qu'agonistes du récepteur apj
US11191762B2 (en) 2016-11-16 2021-12-07 Amgen Inc. Alkyl substituted triazole compounds as agonists of the APJ Receptor
CN117503775A (zh) 2017-04-28 2024-02-06 自由生物有限公司 治疗特应性皮炎以及提高活性药物成分稳定性的制剂、方法、试剂盒和剂型
US11807624B2 (en) 2018-05-01 2023-11-07 Amgen Inc. Substituted pyrimidinones as agonists of the APJ receptor

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL137326C (fr) * 1967-08-26
US3711495A (en) * 1970-01-07 1973-01-16 Merck & Co Inc Isoxazalin-3-yl-substituted-5-nitroimidazoles
US4283403A (en) * 1976-06-14 1981-08-11 Eli Lilly And Company Substituted isoxazolines for control of plant phytopathogens
PL185872B1 (pl) * 1995-02-03 2003-08-29 Upjohn Co Nowe podstawione fenylooksazolidynonyNowe podstawione fenylooksazolidynony
DE19601264A1 (de) * 1996-01-16 1997-07-17 Bayer Ag Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone
EP0920421B1 (fr) * 1996-08-21 2002-11-06 PHARMACIA & UPJOHN COMPANY Derives d'isoxazoline utiles comme agents antimicrobiens
CN1138765C (zh) * 1997-05-30 2004-02-18 法玛西雅厄普约翰美国公司 带有硫代羰基功能基的噁唑烷酮抗菌剂

Also Published As

Publication number Publication date
EP1060179A1 (fr) 2000-12-20
CA2318762A1 (fr) 1999-09-02
AU3180999A (en) 1999-09-15
WO1999043671A1 (fr) 1999-09-02

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