JP2001516262A - 骨の修復のための骨形成デバイスおよびその使用 - Google Patents
骨の修復のための骨形成デバイスおよびその使用Info
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- JP2001516262A JP2001516262A JP54086898A JP54086898A JP2001516262A JP 2001516262 A JP2001516262 A JP 2001516262A JP 54086898 A JP54086898 A JP 54086898A JP 54086898 A JP54086898 A JP 54086898A JP 2001516262 A JP2001516262 A JP 2001516262A
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- bone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/043—Proteins; Polypeptides; Degradation products thereof
- A61L31/047—Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Prostheses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.局所性の骨形成または軟骨形成を誘導するためのデバイスであって、以下: 骨形成タンパク質; 非合成、非ポリマー性物質に由来するマトリクス;および 結合剤、 を含む骨形成デバイス。 2.前記骨形成タンパク質が、OP-1;OP-2;OP-3;BMP2;BMP3;BMP4;BMP5;BM P6;BMP9;BMP-10;BMP-11、BMP-12、BMP-15、BMP-16、DPP;Vgl;Vgr;60Aタン パク質;GDF-1;GDF-3、GDF-5、GDF-6、GDF-7、GDF-8、GDF-9、GDF-10、GDF-11 ;およびそれらの各々のアミノ酸配列改変体からなる群より選択される、請求項 1に記載のデバイス。 3.前記骨形成タンパク質が、OP-1;OP-2、BMP2;BMP4;BMP5;BMP6;およびそ れらの各々のアミノ酸配列改変体からなる群より選択される、請求項1に記載の デバイス。 4.前記骨形成タンパク質が、ヒトOP-1の、保存された7つのシステインドメイ ンを含む、C末端102〜106アミノ酸と少なくとも70%の相同性を有するアミノ酸 配列を含む、請求項1に記載のデバイス。 5.前記骨形成タンパク質がOP-1である、請求項1に記載のデバイス。 6.少なくとも2つの異なる骨形成タンパク質を含む、請求項1に記載のデバイ ス。 7.前記マトリクスが、コラーゲン、鉱質除去骨、アパタイト、ヒドロキシアパ タイト、リン酸三カルシウム、およびそれらの混合物からなる群より選択される 、 請求項1に記載のデバイス。 8.前記マトリクスがコラーゲンである、請求項1に記載のデバイス。 9.前記マトリクスがβ−リン酸三カルシウムである、請求項1に記載のデバイ ス。 10.少なくとも2つの異なるマトリクス物質を含む、請求項1に記載のデバイ ス。 11.前記結合剤が、マンニトール、デキストラン、白色ワセリン、マンニトー ル/デキストランの組合せ、マンニトール/白色ワセリンの組合せ、ゴマ油、ア ルキルセルロース類、フィブリンのり、およびそれらの混合物からなる群から選 択される、請求項1に記載のデバイス。 12.前記結合剤がアルキルセルロース類からなる群より選択される、請求項1 に記載のデバイス。 13.前記結合剤がメチルセルロース、メチルヒドロキシエチルセルロース、ヒ ドロキシエチルセルロース、ヒドロキシプロピルメチルセルロース、カルボキシ メチルセルロース、カルボキシメチルセルロースナトリウム、ヒドロキシアルキ ルセルロース、およびそれらの混合物からなる群より選択される、請求項1に記 載のデバイス。 14.前記結合剤がカルボキシメチルセルロースまたはそのナトリウム塩である 、請求項1に記載のデバイス。 15.前記結合剤がフィブリンのりであり、該フィブリンのりが哺乳動物フィブ リノーゲンおよびトロンビンの混合物である、請求項1に記載のデバイス。 16.前記デバイスが少なくとも2つの異なる結合剤を含む、請求項1に記載の デバイス。 17.湿潤剤をさらに含む、請求項1に記載のデバイス。 18.前記湿潤剤が生理食塩水である、請求項17に記載のデバイス。 19.局所性の骨形成または軟骨形成を誘導するためのデバイスであって、以下 : 約1.25mgの骨形成タンパク質OP-1; 約1000mgのコラーゲンマトリクス;および 少なくとも約180mgのカルボキシメチルセルロース、 を含む、デバイス。 20.少なくとも約2.5mgのOP-1をさらに含む、請求項19に記載のデバイス。 21.少なくとも約200mgのカルボキシメチルセルロースをさらに含む、請求項 19または20に記載のデバイス。 22.局所性の骨形成または軟骨形成を誘導するためのデバイスであって、以下 : 約0.4mgの骨形成タンパク質; 約1000mgのコラーゲンマトリクス;および 少なくとも約20mgのフィブリンのり、 を含む、デバイス。 23.約40mgのフィブリンのりをさらに含む、請求項22に記載のデバイス。 24.局所性の骨形成または軟骨形成を誘導するためのデバイスであって、以下 : 約1.2mgの骨形成タンパク質; 約1000mgのβ−リン酸三カルシウム;および 少なくとも約40mgのフィブリンのり、 を含む、デバイス。 25.約220mgのフィブリンのりをさらに含む、請求項22または24に記載の デバイス。 26.前記フィブリンのりが哺乳動物フィブリノーゲンとトロンビンとの混合物 である、請求項22または24に記載のデバイス。 27.前記トロンビン含量が約2.0U〜約25Uである、請求項26に記載のデバ イス。 28.前記トロンビン含量が約5.0U〜約25Uである、請求項26に記載のデバ イス。 29.前記トロンビン含量が約2.5U〜約5.0Uである、請求項26に記載のデバ イス。 30.約20mg〜約180mgのフィブリノーゲン含量をさらに含む、請求項26に記 載のデバイス。 31.骨形成タンパク質およびキャリアを含む局所性の骨形成または軟骨形成を 誘導するためのデバイスであって、該キャリアが50部(w/w)のマトリクスに対し て1部(w/w)の結合剤を含む、デバイス。 32.前記キャリアが25部(w/w)のマトリクスに対して1部(w/w)の結合剤を含 む、請求項31に記載のデバイス。 33.前記キャリアが10部(w/w)のマトリクスに対して1部(w/w)の結合剤を含 む、請求項31に記載のデバイス。 34.前記キャリアが5部(w/w)のマトリクスに対して1部(w/w)の結合剤を含 む、請求項31に記載のデバイス。 35.前記キャリアが5部(w/w)未満のマトリクスを含む、請求項31に記載 のデバイス。 36.骨形成タンパク質およびキャリアを含む局所性の骨形成または軟骨形成を 誘導するためのデバイスであって、該キャリアが1部(w/w)のマトリクスに対し て10部(w/w)の結合剤を含む、デバイス。 37.前記キャリアが10部(w/w)未満の結合剤を含む、請求項36に記載のデバ イス。 38.生理食塩水をさらに含む、請求項19、22、24、31、または36に 記載のデバイス。 39.骨欠損、軟骨欠損または骨軟骨欠損の修復のために局所性の骨形成または 軟骨形成を誘導するための方法であって、以下の工程: 請求項1、19、22、24、31、または36に記載のデバイスを欠損部位 に提供する工程、 を包含する、方法。 40.前記骨形成が軟骨内骨形成である、請求項39に記載の方法。 41.前記軟骨形成が関節軟骨形成である、請求項39に記載の方法。 42.前記欠損部位が、以下:重症サイズ欠損、非重症サイズ欠損、分節非癒合 欠損、非癒合性骨折、骨折、骨軟骨欠損、および肋軟骨下欠損からなる群より選 択される、請求項39に記載の方法。 43.前記欠損部位に提供される骨形成デバイスの容積が該欠損部位を満たすの に充分である、請求項39に記載の方法。 44.局所性の骨形成または軟骨形成を誘導するためのデバイスであって、以下 : 骨形成タンパク質OP-1; コラーゲンマトリクス;および カルボキシメチルセルロース、 を含むデバイス。 45.局所性の骨形成または軟骨形成を誘導するためのデバイスであって、以下 : 骨形成タンパク質OP-1; コラーゲンマトリクス;および フィブリンのり、 を含むデバイス。 46.請求項1に記載のデバイスを用いる局所性の骨形成または軟骨形成を誘導 するためのキットであって、以下: (a)骨形成タンパク質およびマトリクス物質を収容するように適合されている 第一の容器;および (b)結合剤を収容するように適合されている第二の容器、 を含み、ここで、該骨形成タンパク質およびマトリクス物質が部分(a)の該第一 の容器に提供され、そして該結合剤が部分(b)の該第二の容器に提供される、キ ット。 47.湿潤剤を収容するように適合されている第三の容器をさらに含む、請求項 46に記載のキット。 48.前記第一の容器および前記第二の容器が同一である、請求項46に記載の キット。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/822,186 | 1997-03-20 | ||
US08/822,186 US7041641B2 (en) | 1997-03-20 | 1997-03-20 | Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects |
PCT/US1998/006043 WO1998041246A2 (en) | 1997-03-20 | 1998-03-20 | Osteogenic devices and methods of use thereof for repair of bone |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009040036A Division JP2009131649A (ja) | 1997-03-20 | 2009-02-23 | 骨の修復のための骨形成デバイスおよびその使用 |
Publications (2)
Publication Number | Publication Date |
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JP2001516262A true JP2001516262A (ja) | 2001-09-25 |
JP4477702B2 JP4477702B2 (ja) | 2010-06-09 |
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Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
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JP54086898A Expired - Fee Related JP4477702B2 (ja) | 1997-03-20 | 1998-03-20 | 骨の修復のための骨形成デバイスおよびその使用 |
JP2009040036A Ceased JP2009131649A (ja) | 1997-03-20 | 2009-02-23 | 骨の修復のための骨形成デバイスおよびその使用 |
JP2012095395A Pending JP2012161635A (ja) | 1997-03-20 | 2012-04-19 | 骨の修復のための骨形成デバイスおよびその使用 |
JP2014168198A Withdrawn JP2014221427A (ja) | 1997-03-20 | 2014-08-21 | 骨の修復のための骨形成デバイスおよびその使用 |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
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JP2009040036A Ceased JP2009131649A (ja) | 1997-03-20 | 2009-02-23 | 骨の修復のための骨形成デバイスおよびその使用 |
JP2012095395A Pending JP2012161635A (ja) | 1997-03-20 | 2012-04-19 | 骨の修復のための骨形成デバイスおよびその使用 |
JP2014168198A Withdrawn JP2014221427A (ja) | 1997-03-20 | 2014-08-21 | 骨の修復のための骨形成デバイスおよびその使用 |
Country Status (11)
Country | Link |
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US (3) | US7041641B2 (ja) |
EP (3) | EP1719532A3 (ja) |
JP (4) | JP4477702B2 (ja) |
AT (1) | ATE338569T1 (ja) |
AU (1) | AU751451B2 (ja) |
CA (1) | CA2284098C (ja) |
DE (1) | DE69835810T2 (ja) |
DK (1) | DK0968012T3 (ja) |
ES (1) | ES2273412T3 (ja) |
PT (1) | PT968012E (ja) |
WO (1) | WO1998041246A2 (ja) |
Cited By (5)
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JP2009541358A (ja) * | 2006-06-22 | 2009-11-26 | バイオサーフェス エンジニアリング テクノロジーズ,インク. | 骨形成を強化するためにbmp−2増幅因子/共活性化因子を送達するための組成物および方法 |
JP2010520788A (ja) * | 2007-03-08 | 2010-06-17 | ウォーソー・オーソペディック・インコーポレーテッド | 骨間隙充填剤 |
JP2010522617A (ja) * | 2007-03-26 | 2010-07-08 | バクスター・インターナショナル・インコーポレイテッド | 軟部組織増強のための注入可能な空隙の充填剤 |
JP2011511808A (ja) * | 2008-02-07 | 2011-04-14 | バイオミメティック セラピューティクス, インコーポレイテッド | 仮骨延長のための組成物および方法 |
JP2018199725A (ja) * | 2006-12-29 | 2018-12-20 | オステオキューシー | Sostもしくはwiseアンタゴニストまたはアゴニストの投与による骨成長を変化させる方法 |
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US20010016646A1 (en) * | 1998-03-20 | 2001-08-23 | David C. Rueger | Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects |
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WO2005018429A2 (en) * | 2003-08-20 | 2005-03-03 | Histogenics Corporation | Acellular matrix implanted into an articular cartilage or osteochondral lesion protected with a biodegradable polymer modified to have extended polymerization time and methods for preparation and use thereof |
US20080227696A1 (en) * | 2005-02-22 | 2008-09-18 | Biosurface Engineering Technologies, Inc. | Single branch heparin-binding growth factor analogs |
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JP2018199725A (ja) * | 2006-12-29 | 2018-12-20 | オステオキューシー | Sostもしくはwiseアンタゴニストまたはアゴニストの投与による骨成長を変化させる方法 |
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JP2011511808A (ja) * | 2008-02-07 | 2011-04-14 | バイオミメティック セラピューティクス, インコーポレイテッド | 仮骨延長のための組成物および方法 |
JP2015180705A (ja) * | 2008-02-07 | 2015-10-15 | バイオミメティック セラピューティクス, インコーポレイテッド | 仮骨延長のための組成物および方法 |
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CA2284098A1 (en) | 1998-09-24 |
EP0968012B1 (en) | 2006-09-06 |
DK0968012T3 (da) | 2006-12-27 |
EP1719532A2 (en) | 2006-11-08 |
WO1998041246A2 (en) | 1998-09-24 |
JP2009131649A (ja) | 2009-06-18 |
EP1719531A3 (en) | 2011-07-20 |
US20090060976A1 (en) | 2009-03-05 |
DE69835810T2 (de) | 2007-10-11 |
WO1998041246A3 (en) | 1998-10-22 |
EP1719532A3 (en) | 2011-07-20 |
ES2273412T3 (es) | 2007-05-01 |
US7041641B2 (en) | 2006-05-09 |
ATE338569T1 (de) | 2006-09-15 |
EP1719531A2 (en) | 2006-11-08 |
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