EP1719532A3 - Osteogenic devices and methods of use thereof for repair of bones - Google Patents

Osteogenic devices and methods of use thereof for repair of bones Download PDF

Info

Publication number
EP1719532A3
EP1719532A3 EP06017297A EP06017297A EP1719532A3 EP 1719532 A3 EP1719532 A3 EP 1719532A3 EP 06017297 A EP06017297 A EP 06017297A EP 06017297 A EP06017297 A EP 06017297A EP 1719532 A3 EP1719532 A3 EP 1719532A3
Authority
EP
European Patent Office
Prior art keywords
defects
repair
methods
devices
bones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06017297A
Other languages
German (de)
French (fr)
Other versions
EP1719532A2 (en
Inventor
David C. Rueger
Marjorie M. Tucker
An-Cheng Chang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stryker Corp
Original Assignee
Stryker Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stryker Corp filed Critical Stryker Corp
Publication of EP1719532A2 publication Critical patent/EP1719532A2/en
Publication of EP1719532A3 publication Critical patent/EP1719532A3/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A61L31/047—Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Prostheses (AREA)

Abstract

Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with enhanced stability using less osteogenic protein than devices in the art. Defects susceptible to repair with the instant invention include, but are not limited to critical size defects, non-critical size defects, non-union fractures, fractures, osteochondral defects, subchondral defects, and defects resulting from degenerative diseases such as osteochondritis dissecans.
EP06017297A 1997-03-20 1998-03-20 Osteogenic devices and methods of use thereof for repair of bones Withdrawn EP1719532A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/822,186 US7041641B2 (en) 1997-03-20 1997-03-20 Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
EP98913183A EP0968012B1 (en) 1997-03-20 1998-03-20 Osteogenic devices and methods of use thereof for repair of bone

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP98913183A Division EP0968012B1 (en) 1997-03-20 1998-03-20 Osteogenic devices and methods of use thereof for repair of bone
EP98913183.4 Division 1998-09-24

Publications (2)

Publication Number Publication Date
EP1719532A2 EP1719532A2 (en) 2006-11-08
EP1719532A3 true EP1719532A3 (en) 2011-07-20

Family

ID=25235396

Family Applications (3)

Application Number Title Priority Date Filing Date
EP06017296A Withdrawn EP1719531A3 (en) 1997-03-20 1998-03-20 Osteogenic devices and methods of use thereof for repair of bones
EP06017297A Withdrawn EP1719532A3 (en) 1997-03-20 1998-03-20 Osteogenic devices and methods of use thereof for repair of bones
EP98913183A Expired - Lifetime EP0968012B1 (en) 1997-03-20 1998-03-20 Osteogenic devices and methods of use thereof for repair of bone

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP06017296A Withdrawn EP1719531A3 (en) 1997-03-20 1998-03-20 Osteogenic devices and methods of use thereof for repair of bones

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP98913183A Expired - Lifetime EP0968012B1 (en) 1997-03-20 1998-03-20 Osteogenic devices and methods of use thereof for repair of bone

Country Status (11)

Country Link
US (3) US7041641B2 (en)
EP (3) EP1719531A3 (en)
JP (4) JP4477702B2 (en)
AT (1) ATE338569T1 (en)
AU (1) AU751451B2 (en)
CA (1) CA2284098C (en)
DE (1) DE69835810T2 (en)
DK (1) DK0968012T3 (en)
ES (1) ES2273412T3 (en)
PT (1) PT968012E (en)
WO (1) WO1998041246A2 (en)

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US7410947B2 (en) 2008-08-12
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US8354376B2 (en) 2013-01-15
EP0968012A2 (en) 2000-01-05

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