JP2001501908A - 消化不良症候の治療のためのａｃｅ阻害剤の新規な医療への使用 - Google Patents
消化不良症候の治療のためのａｃｅ阻害剤の新規な医療への使用Info
- Publication number
- JP2001501908A JP2001501908A JP09525898A JP52589897A JP2001501908A JP 2001501908 A JP2001501908 A JP 2001501908A JP 09525898 A JP09525898 A JP 09525898A JP 52589897 A JP52589897 A JP 52589897A JP 2001501908 A JP2001501908 A JP 2001501908A
- Authority
- JP
- Japan
- Prior art keywords
- treatment
- hydrochloride
- medicament
- prevention
- dyspepsia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 201000006549 dyspepsia Diseases 0.000 title claims abstract description 27
- 239000005541 ACE inhibitor Substances 0.000 title claims abstract description 12
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 title claims abstract description 12
- 238000011282 treatment Methods 0.000 title claims description 17
- 208000024891 symptom Diseases 0.000 title claims description 10
- 150000001875 compounds Chemical class 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims abstract description 5
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- 230000002265 prevention Effects 0.000 claims description 6
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- FAKRSMQSSFJEIM-RQJHMYQMSA-N captopril Chemical compound SC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O FAKRSMQSSFJEIM-RQJHMYQMSA-N 0.000 claims description 4
- 239000002552 dosage form Substances 0.000 claims description 3
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- 238000004519 manufacturing process Methods 0.000 claims description 3
- NVXFXLSOGLFXKQ-JMSVASOKSA-N (2s)-1-[(2r,4r)-5-ethoxy-2,4-dimethyl-5-oxopentanoyl]-2,3-dihydroindole-2-carboxylic acid Chemical compound C1=CC=C2N(C(=O)[C@H](C)C[C@@H](C)C(=O)OCC)[C@H](C(O)=O)CC2=C1 NVXFXLSOGLFXKQ-JMSVASOKSA-N 0.000 claims description 2
- PHASTBJLWIZXKB-KKSFZXQISA-N (2s)-2-[[(2s)-1-[carboxymethyl(2,3-dihydro-1h-inden-2-yl)amino]-1-oxopropan-2-yl]amino]-4-phenylbutanoic acid Chemical compound C([C@H](N[C@@H](C)C(=O)N(CC(O)=O)C1CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 PHASTBJLWIZXKB-KKSFZXQISA-N 0.000 claims description 2
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- XRKXJJYSKUIIEN-UHFFFAOYSA-N 2-[cyclopentyl-[3-(2,2-dimethylpropanoylsulfanyl)-2-methylpropanoyl]amino]acetic acid Chemical compound CC(C)(C)C(=O)SCC(C)C(=O)N(CC(O)=O)C1CCCC1 XRKXJJYSKUIIEN-UHFFFAOYSA-N 0.000 claims description 2
- XPCFTKFZXHTYIP-PMACEKPBSA-N Benazepril Chemical compound C([C@@H](C(=O)OCC)N[C@@H]1C(N(CC(O)=O)C2=CC=CC=C2CC1)=O)CC1=CC=CC=C1 XPCFTKFZXHTYIP-PMACEKPBSA-N 0.000 claims description 2
- NEEBNBLVYKFVTK-VGMNWLOBSA-N Captopril-cysteine disulfide Chemical compound OC(=O)[C@@H](N)CSSC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O NEEBNBLVYKFVTK-VGMNWLOBSA-N 0.000 claims description 2
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- IVBOFTGCTWVBLF-GOSISDBHSA-N benzyl 2-[[(2s)-2-(acetylsulfanylmethyl)-3-(1,3-benzodioxol-5-yl)propanoyl]amino]acetate Chemical compound O=C([C@H](CC=1C=C2OCOC2=CC=1)CSC(=O)C)NCC(=O)OCC1=CC=CC=C1 IVBOFTGCTWVBLF-GOSISDBHSA-N 0.000 claims description 2
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- RLAWWYSOJDYHDC-BZSNNMDCSA-N lisinopril Chemical compound C([C@H](N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 RLAWWYSOJDYHDC-BZSNNMDCSA-N 0.000 claims description 2
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- ODAIHABQVKJNIY-PEDHHIEDSA-N perindoprilat Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(O)=O)[C@H]21 ODAIHABQVKJNIY-PEDHHIEDSA-N 0.000 claims description 2
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- IBBLRJGOOANPTQ-JKVLGAQCSA-N quinapril hydrochloride Chemical compound Cl.C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 IBBLRJGOOANPTQ-JKVLGAQCSA-N 0.000 claims description 2
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- TVTJZMHAIQQZTL-WATAJHSMSA-M sodium;(2s,4s)-4-cyclohexyl-1-[2-[[(1s)-2-methyl-1-propanoyloxypropoxy]-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylate Chemical compound [Na+].C([P@@](=O)(O[C@H](OC(=O)CC)C(C)C)CC(=O)N1[C@@H](C[C@H](C1)C1CCCCC1)C([O-])=O)CCCC1=CC=CC=C1 TVTJZMHAIQQZTL-WATAJHSMSA-M 0.000 claims description 2
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Abstract
(57)【要約】
ＡＣＥ阻害剤及びこれらの化合物を含む医薬製剤を使用する原因が不明の消化不良症侯の予防及び／又は治療の方法。
Description
【発明の詳細な説明】
消化不良症侯の治療のためのＡＣＥ阻害剤
の新規な医療への使用
発明の技術分野
本発明は、原因が不明の消化不良症候の予防及び／又は治療のためのＡＣＥ阻
害剤の使用及びそのような消化不良症侯に効果を有する医薬の製造に関する。
発明の背景
胃腸管の機能障害は普遍的でありそして極めて多くの医療相談の原因である。
年間基準で西側諸国人口の３０％は中程度の消化不良から激しい痛みにまで亘る
そのような機能性消化不良症侯を経験している。症侯学によれば臓器疾患（例え
ば消化性潰瘍疾患）が原因であるか又は、より一般的には、いずれの既知の原因
にも因果関係を求め得ない（すなわち種々の診断方法により証明されるような上
部消化管における器官病理の欠如）ことがある。定型的な診断標準においては後
者の症状−症侯群を一般に「非潰瘍性消化不良」、「機能性消化不良」、又は「
非器官性消化不良」と呼称する。原因が不明の消化不良に対する現在の治療法は
種々の薬理学的理論、例えば胃の酸性の中和又は消化管壁の運動性に変化を与え
ることなどによるものを含むが、それらの中には効果が疑わしくそして時には重
い副作用を伴うものがある。
消化性潰瘍による消化不良は制酸剤又は胃酸分泌の抑制剤を服用することによ
り治療することができる。潰瘍様消化不良症侯も粘膜病理を伴うことがなく、通
常同じ治療に対して好反応を示す。この消化不良症侯（酸関連消化不良）の亜集
団は従って中和剤の服用又はプロトンポンプ阻害剤もしくはヒスタミンＨ2受容
休アンタゴニストの使用による胃酸生産の抑制と関連する症侯軽減により限定さ
れる。しかしながら、前者の治療は持続時間が短くそして中和剤を一日の間に反
復して投与しなければならない。
後者の治療は費用がかかることそして制酸された胃の状態は腸及び／又は全身感
染の危険を高めることから、消化管生理に対して悪影響を及ぼすという欠点があ
る。消化管運動改善剤(prokinetic drugs)(例えばシサプリド)又は抗コリン作動
性化合物は消化不良症侯を治療するために使用される他の薬剤であるが、通常効
果は変動性であり、そして高頻度で副作用を現わす。消化不良症侯の治療に利用
可能な薬剤処方は幾つかの欠点により損なわれることになる。
本発明はレニン−アンギオテンシン系（RAS）についての薬理学的干渉による
原因が不明の消化不良を治療する新しい方法に関する。
先行技術
レニン−アンギオテンシン系（RAS）に干渉する化合物はこの技術分野でよく
知られており、そし心臓血管系疾患、特に動脈高血圧症及び心不全の治療に使用
される。原理的に、ＲＡＳはアンギオテンシンを合成する酵素の阻害により又は
対応する受容体のエフェクター部位における遮断により干渉される。レニンアン
タゴニスト、アンギオテンシン転換酵素（ＡＣＥ）の阻害剤及びアンギオテンシ
ンII受容体（ＡII受容体）アンタゴニストが現在利用可能である。心臓血管系効
果のほかに、これらの化合物のあるものは特定化されていない「胃腸疾患」に対
して効果を発揮したと云われている。
発明の詳細な説明
驚くべきことに、アンギオテンシン転換酵素（ACE）阻害剤の使用による抗高
血圧症治療は、原因が不明の消化不良症侯（例えば「非潰瘍性消化不良」、「機
能性消化不良」、又は「非器官性消化不良」）の頻度及び重症度を減らしそして
これらの症侯に対して予防的に作用することができることを見いだした。本発明
はアンギオテンシンIIの合成を妨げるＡＣＥ阻害剤の投与による原因不明の消化
不良症侯を治療する新しい方法を開示する。ＡＣＥ阻害剤は中性形体又は塩の形
体で経口的に、直腸内に又は非経
口的に投与することができる。消化不良症侯に対する効果が経口経路により確立
されている限り、ＡＣＥ阻害剤の作用は全身作用であり、これは投与方式により
左右されないと考えられる。
消化不良症侯の治療のために投与されるＡＣＥ阻害剤の用量は、病気の重症度
及び患者の状態によって変動するであろう。経口、直腸内並びに静脈内投与の場
合の投与量範囲は好ましくは一日当たり0.01〜50mgの範囲であろう。
消化不良症侯の予防及び治療に使用することができるＡＣＥ阻害剤の例は下記
のとおりである。
アラセプリル
アラトリオプリル
アルチオプリルカルシウム
アンコベニン
ベナゼプリル
塩酸ベナゼプリル
ベナゼプリラット
ベンザゼプリル
ベンゾイルカプトプリル
カプトプリル
カプトプリル−システイン
カプトプリル−グルタチオン
セラナプリル
セラノプリル
セロナプリル
シラザプリル
シラザプリラット
コンベルスタチン
デラプリル
デラプリル二酸
エナラプリル
エナラプリラット
エナルキレン
エナプリル
エピカプトプリル
ホロキシミチン
ホスフェノブリル
ホセノプリル
ホセノプリルナトリウム
ホシノプリル
ホシノプリルナトリウム
ホシノプリラット
ホシノプリル酸
グリコプリル
ヘモルフィン−４
イドラプリル
イミダプリル
インドラプリル
インドラプリラット
リベンザプリル
リシノプリル
リシウミンＡ
リシウミンＢ
ミキサンプリル
モエキシプリル
モエキシプリラット
モベルチプリル
ムラセインＡ
ムラセインＢ
ムラセインＣ
ペントプリル
ペリンドプリル
ペリンドプリラット
ピバロプリル
ピボプリル
キナプリル
塩酸キナプリル
キナプリラット
ラミプリル
ラミプリラット
スピラプリル
塩酸スピラプリル
スピラプリラット
スピロプリル
塩酸スピロプリル
テモカプリル
塩酸テモカプリル
テプロチド
トランドラプリル
トランドラプリラット
ウチバプリル
ザビシプリル
ザビシプリラット
ゾフェノプリル
ゾフェノプリラット
ありうる場合については、上の表に挙げた化合物はラセミ形体又は純粋なもし
くは実質的に純粋なエナチオマーの形体で使用することができる。
医薬組成物
慣用的な医薬剤型を使用することができる。医薬剤型は注射溶液、経口溶液、
直腸用溶液、懸濁液、経口用もしくは舌下用錠剤又はカプセルの形体とすること
ができる。
この医薬製剤は活性物質の0.001mg〜100mg、好ましくは0.1〜50mgを含有する
。
事例研究報告
事例：自営でヨットの製作に携わる３７歳の男性は長い間、そして特に経済的
後退期の年において腹部不快感に苦しんできた。この患者は単一盲検試験を受け
た。２週間の間プラセボの投与を受けそして別の２週間の間ＡＣＥ阻害剤のエナ
ラプリル（毎日１回2.5mg）の投与を受けた。エナラプリル治療の間、患者は明
らかな症侯軽減が認められそしてプラセボ期間に比べてその制酸剤の消費が減少
した。
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フロントページの続き
(81)指定国 ＥＰ(ＡＴ，ＢＥ，ＣＨ，ＤＥ，
ＤＫ，ＥＳ，ＦＩ，ＦＲ，ＧＢ，ＧＲ，ＩＥ，ＩＴ，Ｌ
Ｕ，ＭＣ，ＮＬ，ＰＴ，ＳＥ)，ＯＡ(ＢＦ，ＢＪ，ＣＦ
，ＣＧ，ＣＩ，ＣＭ，ＧＡ，ＧＮ，ＭＬ，ＭＲ，ＮＥ，
ＳＮ，ＴＤ，ＴＧ)，ＡＰ(ＫＥ，ＬＳ，ＭＷ，ＳＤ，Ｓ
Ｚ，ＵＧ)，ＥＡ(ＡＭ，ＡＺ，ＢＹ，ＫＧ，ＫＺ，ＭＤ
，ＲＵ，ＴＪ，ＴＭ)，ＡＬ，ＡＭ，ＡＴ，ＡＵ，ＡＺ
，ＢＡ，ＢＢ，ＢＧ，ＢＲ，ＢＹ，ＣＡ，ＣＨ，ＣＮ，
ＣＵ，ＣＺ，ＤＥ，ＤＫ，ＥＥ，ＥＳ，ＦＩ，ＧＢ，Ｇ
Ｅ，ＨＵ，ＩＬ，ＩＳ，ＪＰ，ＫＥ，ＫＧ，ＫＰ，ＫＲ
，ＫＺ，ＬＣ，ＬＫ，ＬＲ，ＬＳ，ＬＴ，ＬＵ，ＬＶ，
ＭＤ，ＭＧ，ＭＫ，ＭＮ，ＭＷ，ＭＸ，ＮＯ，ＮＺ，Ｐ
Ｌ，ＰＴ，ＲＯ，ＲＵ，ＳＤ，ＳＥ，ＳＧ，ＳＩ，ＳＫ
，ＴＪ，ＴＭ，ＴＲ，ＴＴ，ＵＡ，ＵＧ，ＵＳ，ＵＺ，
ＶＮ
Claims (1)
- 【特許請求の範囲】 １．ＡＣＥ阻害剤又はそれらの生理学的に許容し得る塩の、原因が不明の消化不 良症侯の予防及び／又は治療のための医薬の製造のための使用。 ２．アラセプリル アラトリオプリル アルチオプリルカルシウム アンコベニン べナゼプリル 塩酸ベナゼプリル ベナゼプリラット ベンザゼプリル ベンゾイルカプトプリル カプトプリル カプトプリル−システイン カプトプリル−グルタチオン セラナプリル セラノプリル セロナプリル シラザプリル シラザプリラット コンベルスタチン デラプリル デラプリル二酸 エナラプリル エナラプリラット エナルキレン エナプリル エピカプトプリル ホロキシミチン ホスフェノプリル ホセノプリル ホセノプリルナトリウム ホシノプリル ホシノプリルナトリウム ホシノプリラット ホシノプリル酸 グリコプリル ヘモルフィン−４ イドラプリル イミダプリル インドラプリル インドラプリラット リベンザプリル リシノプリル リシウミンＡ リシウミンＢ ミキサンプリル モエキシプリル モエキシプリラット モベルチプリル ムラセインＡ ムラセインＢ ムラセインＣ ペントプリル ペリンドプリル ペリンドプリラット ピバロプリル ピボプリル キナプリル 塩酸キナプリル キナプリラット ラミプリル ラミプリラット スピラプリル 塩酸スピラプリル スピラプリラット スピロプリル 塩酸スピロプリル テモカプリル 塩酸テモカプリル テプロチド トランドラプリル トランドラプリラット ウチバプリル ザビシプリル ザビシプリラット ゾフェノプリル ゾフェノプリラット からなる群より選ばれるＡＣＥ阻害剤の請求項１に記載の使用。 ３．活性成分が請求項１又は２のいずれかの項に記載の化合物である、原因が不 明の消化不良症侯の予防及び／又は治療における使用に適当な医 薬製剤。 ４．単位剤形になった請求項１又は２に記載の医薬、又は請求項３に記載の医薬 製剤。 ５．医薬的に許容し得る担体と一緒に活性成分からなる請求項１又は２に記載の 医薬、又は請求項３〜４に記載の医薬製剤。 ６．活性成分として請求項２に記載の化合物を含む請求項３〜５に記載の医薬製 剤。 ７．原因が不明の消化不良症侯の予防又は治療が必要な人間を含む哺乳動物に請 求項１に記載の化合物の有効な量を投与する、前記宿主における前記症侯の予防 又は治療の方法。 ８．請求項２に記載の化合物の投与を特徴とする請求項７に記載の方法。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9600120-1 | 1996-01-15 | ||
| SE9600120A SE9600120D0 (sv) | 1996-01-15 | 1996-01-15 | Novel medical use |
| PCT/SE1996/001733 WO1997026014A1 (en) | 1996-01-15 | 1996-12-20 | Novel medical use of an ace-inhibitor for treatment of dyspeptic symptoms |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2001501908A true JP2001501908A (ja) | 2001-02-13 |
Family
ID=20401013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP09525898A Abandoned JP2001501908A (ja) | 1996-01-15 | 1996-12-20 | 消化不良症候の治療のためのａｃｅ阻害剤の新規な医療への使用 |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US5977159A (ja) |
| EP (1) | EP0876158B1 (ja) |
| JP (1) | JP2001501908A (ja) |
| KR (1) | KR19990076973A (ja) |
| CN (1) | CN1090031C (ja) |
| AT (1) | ATE218885T1 (ja) |
| AU (1) | AU710846B2 (ja) |
| BR (1) | BR9612483A (ja) |
| CA (1) | CA2240199A1 (ja) |
| CZ (1) | CZ222398A3 (ja) |
| DE (1) | DE69621834T2 (ja) |
| DK (1) | DK0876158T3 (ja) |
| EE (1) | EE03517B1 (ja) |
| ES (1) | ES2175182T3 (ja) |
| HK (1) | HK1014870A1 (ja) |
| HU (1) | HUP9901353A3 (ja) |
| ID (1) | ID16186A (ja) |
| IL (1) | IL125195A (ja) |
| IS (1) | IS4778A (ja) |
| MX (1) | MX9805506A (ja) |
| MY (1) | MY129782A (ja) |
| NO (1) | NO983234L (ja) |
| NZ (1) | NZ325973A (ja) |
| PL (1) | PL327818A1 (ja) |
| PT (1) | PT876158E (ja) |
| RU (1) | RU2203092C2 (ja) |
| SE (1) | SE9600120D0 (ja) |
| SI (1) | SI0876158T1 (ja) |
| SK (1) | SK282781B6 (ja) |
| TR (1) | TR199801298T2 (ja) |
| UA (1) | UA49861C2 (ja) |
| WO (1) | WO1997026014A1 (ja) |
| ZA (1) | ZA9783B (ja) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5677937B2 (ja) * | 2009-03-27 | 2015-02-25 | カルピス株式会社 | 自律神経活動調節用組成物および自律神経を調節する方法 |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2340206A1 (en) * | 1998-08-26 | 2000-03-09 | Queen's University At Kingston | Use of anti-pressor agents for vascular remodeling in genital dysfunction |
| US6730775B1 (en) | 1999-03-23 | 2004-05-04 | University Of Southern California | Methods for limiting scar and adhesion formation |
| US6747008B1 (en) | 2000-06-19 | 2004-06-08 | University Of Southern California | Methods for treating and preventing alopecia |
| AU2002308522A1 (en) * | 2001-05-01 | 2002-11-11 | University Of Southern California | Methods for inhibiting tumor cell proliferation |
| WO2003075842A2 (en) * | 2002-03-08 | 2003-09-18 | Teva Pharmeceuticals Usa, Inc. | Stable formulations of angiotensin converting enzyme (ace) inhibitors |
| US20030215526A1 (en) * | 2002-03-08 | 2003-11-20 | Scott Stofik | Stable formulations of angiotensin converting enzyme (ACE) inhibitors |
| US6869963B2 (en) * | 2003-07-11 | 2005-03-22 | Sandoz Ag | Stable pharmaceutical compositions containing an ACE inhibitor |
| US20050271657A1 (en) * | 2004-06-08 | 2005-12-08 | Australian Stem Cell Centre Ltd. | Intermittent treatment regime for organ failure |
| US7776831B2 (en) | 2006-02-01 | 2010-08-17 | Weg Stuart L | Use of antifungal compositions to treat upper gastrointestinal conditions |
| US20090227507A1 (en) * | 2008-03-10 | 2009-09-10 | University Of Southern California | Angiotensin (1-7) Dosage Forms and Uses Thereof |
| WO2010022249A2 (en) * | 2008-08-20 | 2010-02-25 | Ensemble Discovery Corporation | Macrocyclic compounds for inhibition of tumor necrosis factor alpha |
| UA108742C2 (uk) | 2009-09-23 | 2015-06-10 | Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK9200258U4 (da) * | 1992-03-11 | 1993-07-23 | Merck & Co Inc | Farmaceutisk præparat indeholdende enalapril til brug mod hypertension |
-
1996
- 1996-01-15 SE SE9600120A patent/SE9600120D0/xx unknown
- 1996-12-20 IL IL12519596A patent/IL125195A/en not_active IP Right Cessation
- 1996-12-20 ES ES96944722T patent/ES2175182T3/es not_active Expired - Lifetime
- 1996-12-20 DK DK96944722T patent/DK0876158T3/da active
- 1996-12-20 CZ CZ982223A patent/CZ222398A3/cs unknown
- 1996-12-20 PL PL96327818A patent/PL327818A1/xx unknown
- 1996-12-20 DE DE69621834T patent/DE69621834T2/de not_active Expired - Fee Related
- 1996-12-20 SK SK879-98A patent/SK282781B6/sk unknown
- 1996-12-20 JP JP09525898A patent/JP2001501908A/ja not_active Abandoned
- 1996-12-20 RU RU98113650/14A patent/RU2203092C2/ru not_active IP Right Cessation
- 1996-12-20 PT PT96944722T patent/PT876158E/pt unknown
- 1996-12-20 CN CN96199635A patent/CN1090031C/zh not_active Expired - Fee Related
- 1996-12-20 NZ NZ325973A patent/NZ325973A/en unknown
- 1996-12-20 EP EP96944722A patent/EP0876158B1/en not_active Expired - Lifetime
- 1996-12-20 BR BR9612483A patent/BR9612483A/pt unknown
- 1996-12-20 UA UA98063020A patent/UA49861C2/uk unknown
- 1996-12-20 SI SI9630497T patent/SI0876158T1/xx unknown
- 1996-12-20 AT AT96944722T patent/ATE218885T1/de not_active IP Right Cessation
- 1996-12-20 TR TR1998/01298T patent/TR199801298T2/xx unknown
- 1996-12-20 EE EE9800203A patent/EE03517B1/xx not_active IP Right Cessation
- 1996-12-20 HU HU9901353A patent/HUP9901353A3/hu unknown
- 1996-12-20 CA CA002240199A patent/CA2240199A1/en not_active Abandoned
- 1996-12-20 WO PCT/SE1996/001733 patent/WO1997026014A1/en not_active Application Discontinuation
- 1996-12-20 KR KR1019980705101A patent/KR19990076973A/ko not_active Application Discontinuation
- 1996-12-20 AU AU13237/97A patent/AU710846B2/en not_active Ceased
- 1996-12-20 US US08/793,059 patent/US5977159A/en not_active Expired - Fee Related
-
1997
- 1997-01-06 ZA ZA9783A patent/ZA9783B/xx unknown
- 1997-01-14 MY MYPI97000128A patent/MY129782A/en unknown
- 1997-01-15 ID IDP970100A patent/ID16186A/id unknown
-
1998
- 1998-06-19 IS IS4778A patent/IS4778A/is unknown
- 1998-07-07 MX MX9805506A patent/MX9805506A/es not_active IP Right Cessation
- 1998-07-14 NO NO983234A patent/NO983234L/no not_active Application Discontinuation
-
1999
- 1999-01-04 HK HK99100001A patent/HK1014870A1/xx not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5677937B2 (ja) * | 2009-03-27 | 2015-02-25 | カルピス株式会社 | 自律神経活動調節用組成物および自律神経を調節する方法 |
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