CN1090031C - Ace－抑制剂在治疗消化不良症中的新用途 - Google Patents
Ace－抑制剂在治疗消化不良症中的新用途 Download PDFInfo
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- CN1090031C CN1090031C CN96199635A CN96199635A CN1090031C CN 1090031 C CN1090031 C CN 1090031C CN 96199635 A CN96199635 A CN 96199635A CN 96199635 A CN96199635 A CN 96199635A CN 1090031 C CN1090031 C CN 1090031C
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Abstract
一种使用ACE-抑制剂以及包括此类化合物的药物制剂预防和治疗未知原因的消化不良症的方法。
Description
发明领域
本发明涉及ACE-抑制剂在预防和/或治疗未知原因的消化不良症中的用途，涉及对上述消化不良症有效的药物的制备。
发明背景
肠胃道功能失调是很普遍的疾患，占据了很大数量的临床病例。每年有大约30％的西方人患过从轻度消化不良到严重疼痛的功能性消化不良症。这些病症可由器官疾病引起(例如消化道溃疡)，但更常见的是无任何原因(即通过各种诊断方法证明上消化道无器官病理反应)。临床实践中通常将后一种症状-综合征称为“无溃疡性消化不良”，“功能性消化不良”，或“非器官性消化不良”。对未知原因的消化不良的通用治疗方法包括各种药理原则，例如中和胃酸或影响消化道壁的能动性，有的方法效果值得怀疑，有的具有严重的副作用。
由消化道溃疡引起的消化不良可通过服用抗酸剂和胃酸分泌抑制剂治疗。无粘膜病理作用的溃疡样消化不良症通常具有相似的治疗反应。因此，该消化不良症的亚群体(与酸相关的消化不良)被定义为可通过服用中和制剂，或用质子注入抑制剂来抑制胃酸产生，或组胺H2-受体拮抗剂以缓和病情的亚群。但是前一种治疗方法持续时间短，并且中和药物必须每天中重复给药。后一种治疗方法的缺点是费用很高，以及对消化道生理过程产生不利影响，和使用抗胃酸药物会增加肠道和/或全身感染的危险。激肽类药物(如西沙必利)或抗胆碱能化合物也可用于治疗消化不良症，通常药效差异大，副作用发生频率高。现有治疗消化不良症的药物都有这样那样的缺点。
本发明涉及一种通过药理学影响血管紧张肽原酶-血管紧张肽***(RAS)治疗未知原因的消化不良的新方法。在先技术
本领域影响血管紧张肽原酶-血管紧张肽***(RAS)的化合物是已知的，并已用它们治疗心血管疾病，特别是动脉高血压和心脑衰竭。首先，通过抑制合成血管紧张肽的酶或阻断效应物部位的相应受体可影响RAS。现已发现血管紧张肽原酶拮抗剂，血管紧张肽转化酶(ACE)抑制剂，和血管紧张肽II-受体(AII-受体)拮抗剂。除心血管作用外，某些上述化合物已在专利文献中对其非特异性“肠胃失调症”产生作用方面要求保护。
本发明的详细描述
现已令人惊喜地发现在使用血管紧张肽转化酶(ACE)抑制剂治疗高血压时减轻了未知原因的消化不良症(如“非溃疡性消化不良”，功能性消化不良或“非器官性消化不良”)的发生频率和严重程度，并可以预防这些疾病。本发明描述一种通过使用ACE-抑制剂影响血管紧张肽II合成治疗未知原因的消化不良的新方法。
ACE-抑制剂可以中性形式或以盐的形式被口服，直肠给药或肠胃外给药。尽管对消化不良症的作用是通过口服途径确定的，但显然ACE-抑制剂的作用是***作用。不依赖于给药途径。
治疗消化不良症时ACE-抑制剂的剂量取决于疾病的严重程度和患者的状况诸因素。口服，直肠给药和肠胃外给药的剂量范围优选每天从0.01到50mg。
可用于预防或治疗消化不良症的ACE-抑制剂的例子包括：
阿拉普利
alatriopril
altiopril calcium
ancovenin
贝那普利
贝那普利盐酸盐
benazeprilat
benzazepril
benzoylcaptopril
卡托普利
卡托普利-半胱氨酸
卡托普利-谷胱甘肽
ceranapril
ceranopril
ceronapril
西拉普利
西拉普利拉
converstatin
地拉普利
地拉普利-二乙溴乙酰脲
依那普利
依那普利拉
enalkiren
enapril
epicaptopril
foroxymithine
fosfenopril
fosenopril
fosenopril sodium
福辛普利
福辛普利钠
福辛普利拉
福辛普利酸
glycopril
hemorphiin-4
idrapril
米达普利
吲哚普利
吲哚普利拉
libenzapril
赖诺普利
lyciumin A
lyciumin B
mixanpril
莫西普利
莫西普利拉
moveltipril
muracein A
muracein B
muracein C
喷托普利
培哚普利
培哚普利拉
pivalopril
匹伏普利
喹那普利
喹那普利盐酸盐
喹那普利拉
雷米普利
雷米普利拉
螺普利
螺普利盐酸盐
螺普利拉
spiropril
spiropril hydrochloride
temocapril
temocapril hydrochloride
teprotide
群多普利
群多普利拉
伏巴普利
扎比普利
扎比普利拉
佐芬普利
佐芬普利拉
可以使用上面所列化合物的外消旋形式，或纯的、基本上纯的对映体形式。药物制剂
可使用常规药物制剂。药物制剂可为注射溶液，口服溶液，直肠溶液，悬浮液，口服或舌下片剂，或胶囊。
药物制剂含0.001mg到100mg，优选0.1到50mg活性物质。
病例报告
男性，37岁，快艇制造业雇员，长期感觉腹部不适，特别是在经济衰退期。对该患者进行了单盲试验。两星期使用安慰剂，另两星期使用ACE-抑制剂依那普利(每天一次2.5mg)。使用依那普利期间，患者感觉到有明显的好转，所使用安慰剂期间需更少的抗酸剂。
Claims (1)
1.依那普利或其生理学上可接受的盐在制备预防和/或治疗功能性消化不良的药物中的用途。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9600120-1 | 1996-01-15 | ||
| SE9600120A SE9600120D0 (sv) | 1996-01-15 | 1996-01-15 | Novel medical use |
| SE96001201 | 1996-01-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1207685A CN1207685A (zh) | 1999-02-10 |
| CN1090031C true CN1090031C (zh) | 2002-09-04 |
Family
ID=20401013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96199635A Expired - Fee Related CN1090031C (zh) | 1996-01-15 | 1996-12-20 | Ace－抑制剂在治疗消化不良症中的新用途 |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US5977159A (zh) |
| EP (1) | EP0876158B1 (zh) |
| JP (1) | JP2001501908A (zh) |
| KR (1) | KR19990076973A (zh) |
| CN (1) | CN1090031C (zh) |
| AT (1) | ATE218885T1 (zh) |
| AU (1) | AU710846B2 (zh) |
| BR (1) | BR9612483A (zh) |
| CA (1) | CA2240199A1 (zh) |
| CZ (1) | CZ222398A3 (zh) |
| DE (1) | DE69621834T2 (zh) |
| DK (1) | DK0876158T3 (zh) |
| EE (1) | EE03517B1 (zh) |
| ES (1) | ES2175182T3 (zh) |
| HK (1) | HK1014870A1 (zh) |
| HU (1) | HUP9901353A3 (zh) |
| ID (1) | ID16186A (zh) |
| IL (1) | IL125195A (zh) |
| IS (1) | IS4778A (zh) |
| MX (1) | MX9805506A (zh) |
| MY (1) | MY129782A (zh) |
| NO (1) | NO983234L (zh) |
| NZ (1) | NZ325973A (zh) |
| PL (1) | PL327818A1 (zh) |
| PT (1) | PT876158E (zh) |
| RU (1) | RU2203092C2 (zh) |
| SE (1) | SE9600120D0 (zh) |
| SI (1) | SI0876158T1 (zh) |
| SK (1) | SK282781B6 (zh) |
| TR (1) | TR199801298T2 (zh) |
| UA (1) | UA49861C2 (zh) |
| WO (1) | WO1997026014A1 (zh) |
| ZA (1) | ZA9783B (zh) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2340206A1 (en) * | 1998-08-26 | 2000-03-09 | Queen's University At Kingston | Use of anti-pressor agents for vascular remodeling in genital dysfunction |
| US6730775B1 (en) | 1999-03-23 | 2004-05-04 | University Of Southern California | Methods for limiting scar and adhesion formation |
| US6747008B1 (en) | 2000-06-19 | 2004-06-08 | University Of Southern California | Methods for treating and preventing alopecia |
| AU2002308522A1 (en) * | 2001-05-01 | 2002-11-11 | University Of Southern California | Methods for inhibiting tumor cell proliferation |
| WO2003075842A2 (en) * | 2002-03-08 | 2003-09-18 | Teva Pharmeceuticals Usa, Inc. | Stable formulations of angiotensin converting enzyme (ace) inhibitors |
| US20030215526A1 (en) * | 2002-03-08 | 2003-11-20 | Scott Stofik | Stable formulations of angiotensin converting enzyme (ACE) inhibitors |
| US6869963B2 (en) * | 2003-07-11 | 2005-03-22 | Sandoz Ag | Stable pharmaceutical compositions containing an ACE inhibitor |
| US20050271657A1 (en) * | 2004-06-08 | 2005-12-08 | Australian Stem Cell Centre Ltd. | Intermittent treatment regime for organ failure |
| US7776831B2 (en) | 2006-02-01 | 2010-08-17 | Weg Stuart L | Use of antifungal compositions to treat upper gastrointestinal conditions |
| US20090227507A1 (en) * | 2008-03-10 | 2009-09-10 | University Of Southern California | Angiotensin (1-7) Dosage Forms and Uses Thereof |
| WO2010022249A2 (en) * | 2008-08-20 | 2010-02-25 | Ensemble Discovery Corporation | Macrocyclic compounds for inhibition of tumor necrosis factor alpha |
| WO2010110439A1 (ja) * | 2009-03-27 | 2010-09-30 | カルピス株式会社 | 自律神経活動調節用組成物および自律神経を調節する方法 |
| UA108742C2 (uk) | 2009-09-23 | 2015-06-10 | Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK9200258U4 (da) * | 1992-03-11 | 1993-07-23 | Merck & Co Inc | Farmaceutisk præparat indeholdende enalapril til brug mod hypertension |
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1996
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- 1996-12-20 EE EE9800203A patent/EE03517B1/xx not_active IP Right Cessation
- 1996-12-20 HU HU9901353A patent/HUP9901353A3/hu unknown
- 1996-12-20 CA CA002240199A patent/CA2240199A1/en not_active Abandoned
- 1996-12-20 WO PCT/SE1996/001733 patent/WO1997026014A1/en not_active Application Discontinuation
- 1996-12-20 KR KR1019980705101A patent/KR19990076973A/ko not_active Application Discontinuation
- 1996-12-20 AU AU13237/97A patent/AU710846B2/en not_active Ceased
- 1996-12-20 US US08/793,059 patent/US5977159A/en not_active Expired - Fee Related
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1997
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- 1997-01-14 MY MYPI97000128A patent/MY129782A/en unknown
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1998
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- 1998-07-07 MX MX9805506A patent/MX9805506A/es not_active IP Right Cessation
- 1998-07-14 NO NO983234A patent/NO983234L/no not_active Application Discontinuation
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1999
- 1999-01-04 HK HK99100001A patent/HK1014870A1/xx not_active IP Right Cessation
Non-Patent Citations (3)
| Title |
|---|
| CHEMICAL ABSTRACTS 1987.1.1 Shiromani,P.K.等"Effect of moistusr on the physical and chemical stability of granulations and table * |
| INDIAN 1990.1.1 Dhume等"Comparison of the effects of catopril and enalapril on oxyphenbuta zone and ethanol-induced g * |
| J PHYSIOL PHARMACOL.,VOL.34(3) 1990.1.1 Dhume等"Comparison of the effects of catopril and enalapril on oxyphenbuta zone and ethanol-induced g * |
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