JP2001120972A - Liquid mixer - Google Patents
Liquid mixerInfo
- Publication number
- JP2001120972A JP2001120972A JP29922299A JP29922299A JP2001120972A JP 2001120972 A JP2001120972 A JP 2001120972A JP 29922299 A JP29922299 A JP 29922299A JP 29922299 A JP29922299 A JP 29922299A JP 2001120972 A JP2001120972 A JP 2001120972A
- Authority
- JP
- Japan
- Prior art keywords
- liquid
- liquids
- narrow groove
- plates
- mixer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】この発明は、科学分析や化学
合成などの分野において微小量の液体を混合するのに用
いられる液体混合器に係り、特に微小量の液体の混合を
簡潔な構造で行えるようにするための技術に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a liquid mixer used for mixing a minute amount of liquid in the fields of scientific analysis and chemical synthesis, and more particularly to a method for mixing minute amounts of liquid with a simple structure. So as to relate to the technology.
【０００２】[0002]
【従来の技術】一般に液体を混合する場合、混合対象の
液体を大型容器に入れて攪拌することによって混ぜ合わ
せたり、或いは、混合対象の各液体を一緒にして流す流
路中に障害物を配してカルマン渦を発生させることによ
って混ぜ合わせたりしている。しかし、最近は、例えば
科学分析や化学合成の分野においては、廃液の量を減ら
す等のために微小量の液体を混合する必要性が生じてお
り、図７および図８に示す超小型の液体混合器によって
液体の混合を行うことが試みられている〔A.Manz,Proce
edings of the μTAS '98 Workshop,pp.235-240(1988)
参照〕．2. Description of the Related Art In general, when mixing liquids, the liquids to be mixed are placed in a large container and mixed by stirring, or obstacles are arranged in a flow path in which the liquids to be mixed flow together. And they mix by generating Karman vortices. However, recently, for example, in the field of scientific analysis and chemical synthesis, it has become necessary to mix a small amount of liquid in order to reduce the amount of waste liquid. Attempts have been made to mix liquids with mixers [A. Manz, Proceed.
edings of the μTAS '98 Workshop, pp.235-240 (1988)
reference〕.
【０００３】この超小型の液体混合器は、図７の断面図
に示すように、面同士を合わせて上下に積層された３枚
のプレート５１〜５３を備え、図８に示すように、中央
のプレート５２の表面（上面）にＡ液を４分割する液体
分割用細溝５４と、Ａ，Ｂ両液の混合を行う液体混合用
細溝５６とが形成されているとともに、裏面（下面）に
Ｂ液を４分割する液体分割用細溝５５が形成されてい
る。なお、図８において、実線はプレート５２の表面に
形成された溝を、破線はプレート５２の裏面に形成され
た溝を、それぞれ示す。As shown in the sectional view of FIG. 7, this ultra-small liquid mixer is provided with three plates 51 to 53 which are stacked one on top of the other with the surfaces facing each other, and as shown in FIG. On the surface (upper surface) of the plate 52, there are formed a liquid dividing narrow groove 54 for dividing the liquid A into four, and a liquid mixing narrow groove 56 for mixing both the A and B liquids, and the back surface (lower surface). Is formed with a liquid dividing narrow groove 55 for dividing the liquid B into four parts. In FIG. 8, a solid line indicates a groove formed on the front surface of the plate 52, and a broken line indicates a groove formed on the back surface of the plate 52.
【０００４】この液体混合器を使ってＡ液とＢ液を混合
する場合は、Ａ液導入口５７から導入されるＡ液と、Ｂ
液導入口５８から導入されるＢ液が、両液体分割用細溝
５４，５６により分岐されるに従ってそれぞれが４分割
された後、液体混合用細溝５６において、図８の中の丸
の内に平面視した状態を図示したように、順に２層から
４層を経て最終的に８層と水平（横）方向に順に重ねら
れてゆく。４層のＡ液と４層のＢ液とが横並びに交互に
積層された最終的な８層の状態においては、Ａ，Ｂ両液
が薄層で交互に隣接しているので、両液の間で速やかに
拡散が進行し、両液は十分に混合されて導出口５９から
流出することになる。When the liquid A and the liquid B are mixed by using this liquid mixer, the liquid A introduced from the liquid A inlet 57 and the liquid B
The liquid B introduced from the liquid inlet 58 is divided into four parts as the liquid B is branched by the two liquid dividing grooves 54 and 56, and then the liquid B is introduced into the liquid mixing narrow groove 56 by a plane in a circle in FIG. As shown in the drawing, the state is sequentially stacked from two layers to four layers, and finally to eight layers in the horizontal (lateral) direction. In a final eight-layer state in which four layers of the liquid A and four layers of the liquid B are alternately stacked side by side, the two liquids A and B are alternately adjacent in a thin layer. Diffusion proceeds rapidly between the two, and the two liquids are sufficiently mixed and flow out from the outlet 59.
【０００５】[0005]
【発明が解決しようとする課題】しかしながら、上記の
液体混合器は、プレート５１〜５３を３枚も積層しなけ
ればならない複雑な構造であるので、生産性が悪く、コ
ストが嵩むという問題がある。However, the above-mentioned liquid mixer has a complicated structure in which three plates 51 to 53 must be stacked, so that the productivity is low and the cost is high. .
【０００６】この発明は、上記の事情に鑑み、簡潔な構
造で微小量の液体の混合を行うことができる液体混合器
を提供することを課題とする。In view of the above circumstances, an object of the present invention is to provide a liquid mixer capable of mixing a very small amount of liquid with a simple structure.
【０００７】[0007]
【課題を解決するための手段】前記課題を解決するため
に、この発明に係る液体混合器は、面同士が密着して重
ね合わされて接合された２枚のプレートを備え、これら
プレートの重ね合わせ面に、個別の液体導入口からそれ
ぞれ導入された混合対象の各液体をプレートの厚み方向
に積層する液体積層用細溝が形成されているとともに、
この液体積層用細溝の後段には厚み方向に積層された積
層液体を面方向に分割する液体分割用細溝と、この液体
分割用細溝で分割された分割液体をプレートの厚み方向
に再び積層する液体再積層用細溝とが直列接続された形
態で液体導出口へ向かって繰り返し形成されている。In order to solve the above-mentioned problems, a liquid mixer according to the present invention comprises two plates which are superposed and joined in close contact with each other. On the surface, liquid lamination narrow grooves for laminating each liquid to be mixed respectively introduced from individual liquid introduction ports in the thickness direction of the plate are formed,
Subsequent to the liquid laminating narrow groove, a liquid dividing narrow groove that divides the layered liquid laminated in the thickness direction in the plane direction, and the divided liquid divided by the liquid dividing narrow groove is again placed in the thickness direction of the plate. The liquid re-stacking thin grooves to be stacked are repeatedly formed toward the liquid outlet in a form of being connected in series.
【０００８】〔作用〕次に、この発明の液体混合器にお
ける作用を説明する。この発明の液体混合器により液体
の混合が行われる場合、先ず液体導入口から導入された
混合対象の各液体が液体積層用細溝によってプレートの
厚み方向（溝の深さ方向）に積層される。次に液体積層
用細溝で積層された積層液体が液体分割用細溝で面方向
（溝の幅方向）に分割される。液体分割用細溝による分
割は、面方向の分割であるので分割の前後で積層液体の
幅寸法は短くなるが、積層液体における液の積層数は変
わらず分割前後と同一である。ついで、液体分割用細溝
で分割された分割液体は、液体再積層用細溝によってプ
レートの厚み方向に再び積層される。再積層により同層
数の分割液体がプレートの厚み方向に積み重ねられるこ
とになるので、再積層後は液の積層数が倍になる。[Operation] Next, the operation of the liquid mixer of the present invention will be described. When liquids are mixed by the liquid mixer of the present invention, first, each liquid to be mixed introduced from the liquid introduction port is laminated in the thickness direction of the plate (the depth direction of the groove) by the liquid lamination narrow groove. . Next, the laminated liquid laminated by the liquid laminating narrow groove is divided in the plane direction (groove width direction) by the liquid dividing narrow groove. Since the division by the narrow groove for liquid division is a division in the plane direction, the width dimension of the laminated liquid becomes shorter before and after the division, but the number of layers of the liquid in the laminated liquid does not change and remains the same before and after the division. Next, the divided liquid divided by the liquid dividing narrow groove is stacked again in the thickness direction of the plate by the liquid re-stacking narrow groove. Since the same number of divided liquids are stacked in the thickness direction of the plate by the re-lamination, the number of liquids to be laminated is doubled after the re-lamination.
【０００９】その後、同様に、液体分割用細溝による液
体の分割と液体再積層用細溝による液体の再積層とが繰
り返し行われ、その都度、積層液体における各液体の積
層数が倍に増加してゆく。この結果、混合対象の各液体
はプレートの厚み方向に繰り返し多段に積み重ねられて
薄層で互いに隣接したかたちとなるので、各液体同士の
間で速やかに拡散が進行し、両液は十分に混合されて液
体導出口から流れ出ることになる。Thereafter, similarly, the division of the liquid by the narrow groove for liquid division and the re-lamination of the liquid by the narrow groove for liquid re-lamination are repeated, and each time the number of layers of each liquid in the laminated liquid is doubled. I will do it. As a result, the liquids to be mixed are repeatedly stacked in multiple layers in the thickness direction of the plate and formed in a thin layer adjacent to each other, so that diffusion between the liquids proceeds rapidly, and the two liquids are sufficiently mixed. Then, the liquid flows out from the liquid outlet.
【００１０】そして、この発明の液体混合器の場合、液
体積層用細溝と液体分割用細溝および液体再積層用細溝
が全て２枚のプレートの合わせ面に形成されているの
で、プレートが２枚だけの簡潔な構造で微小量の液体の
混合が行える。従来の液体混合器の場合、液体分割用細
溝がプレートの表面と裏面の両面に別れて形成されてい
て、このプレートの表と裏の両側にそれぞれ別のプレー
トを積層しなければならず、必然的にプレートの数が３
枚の複雑な構造とならざるを得なかったのである。In the case of the liquid mixer of the present invention, the narrow groove for laminating the liquid, the narrow groove for dividing the liquid and the narrow groove for re-laminating the liquid are all formed on the mating surface of the two plates. A small amount of liquid can be mixed with only two simple structures. In the case of the conventional liquid mixer, narrow grooves for liquid division are formed separately on both the front and back surfaces of the plate, and different plates must be stacked on both the front and back sides of this plate, Inevitably three plates
It had to be a complicated structure.
【００１１】[0011]
【発明の実施の形態】続いて、この発明の一実施例を図
面を参照しながら説明する。図１は実施例に係る液体混
合器の外観を示す斜視図、図２は実施例の液体混合器に
おける流路構成を示す流路系統図、図３は実施例の液体
混合器の上側のプレートの重ね合わせ面を示す平面図、
図４は実施例の液体混合器の下側のプレートの重ね合わ
せ面を示す平面図である。Next, an embodiment of the present invention will be described with reference to the drawings. FIG. 1 is a perspective view showing an appearance of a liquid mixer according to an embodiment, FIG. 2 is a flow path diagram showing a flow path configuration in the liquid mixer of the embodiment, and FIG. 3 is an upper plate of the liquid mixer of the embodiment. Plan view showing a superimposed surface of
FIG. 4 is a plan view showing a superposed surface of the lower plate of the liquid mixer of the embodiment.
【００１２】実施例の液体混合器は、図１に示すよう
に、面同士が密着して重ね合わされて接合された上下２
枚の長方形プレート１，２からなるチップ型の混合器で
ある。実施例の場合、上側のプレート１には、一方の混
合対象液であるＡ液を導入するための液体導入口３およ
び他方の混合対象液であるＢ液を導入するための液体導
入口４と、Ａ，Ｂ両液が混ぜ合わされた混合液を導出す
るための液体導出口５とがプレート１を厚み方向に貫通
するようにして形成されている。As shown in FIG. 1, the liquid mixer according to the embodiment has upper and lower surfaces which are closely attached to each other and are joined together.
This is a chip-type mixer composed of two rectangular plates 1 and 2. In the case of the embodiment, the upper plate 1 has a liquid inlet 3 for introducing one of the liquids A to be mixed and a liquid inlet 4 for introducing the other liquid B to be mixed. , A and B are formed so as to penetrate the plate 1 in the thickness direction with a liquid outlet 5 for extracting a mixed liquid obtained by mixing the two liquids.
【００１３】図３に示すように、上側のプレート１の重
ね合わせ面１ａの（図３で見て）左端側には、液体導入
口３，４から導入されたＡ液とＢ液をプレートの厚み方
向（溝の深さ方向）に積層する液体積層用細溝６と、こ
の液体積層用細溝６に液体導入口３を接続する接続用細
溝６ａとが形成されている。また、図４に示すように、
下側のプレート２の重ね合わせ面２ａの（図４で見て）
左端側には、液体積層用細溝６に液体導入口４を接続す
る接続用細溝６ｂが形成されている。As shown in FIG. 3, the liquid A and the liquid B introduced from the liquid inlets 3 and 4 are placed on the left end of the superposed surface 1a of the upper plate 1 (as viewed in FIG. 3). A thin groove 6 for liquid lamination laminated in the thickness direction (depth direction of the groove) and a thin groove 6a for connecting the liquid inlet 3 to the narrow groove 6 for liquid lamination are formed. Also, as shown in FIG.
Of the overlapping surface 2a of the lower plate 2 (see FIG. 4)
On the left end side, a connecting narrow groove 6b for connecting the liquid inlet 4 to the liquid laminating narrow groove 6 is formed.
【００１４】さらに、両プレート１，２の重ね合わせ面
１ａ，２ａには、液体積層用細溝６の後段において、図
２に示すように、積層液体を面方向（溝の幅方向）に等
しく二分する液体分割用細溝７ａ〜７ｅと、液体分割用
細溝７ａ〜７ｅで二分された分割液体をプレートの厚み
方向に再び積層する液体再積層用細溝８ａ〜８ｅとが液
体導出口５へ向かって直列接続された形態で繰り返し形
成されている。Further, on the superposed surfaces 1a and 2a of the plates 1 and 2, after the narrow groove 6 for laminating the liquid, as shown in FIG. The liquid outlet 5 includes liquid dividing thin grooves 7a to 7e to be bisected, and liquid re-laminating narrow grooves 8a to 8e to re-stack the divided liquids divided by the liquid dividing narrow grooves 7a to 7e in the thickness direction of the plate. It is formed repeatedly in the form of being connected in series toward.
【００１５】各液体分割用細溝７ａ〜７ｅは、それぞ
れ、図３および図４に示すように、２枚のプレート１，
２の重ね合わせ面１ａ，２ａに別れて形成された分岐細
溝７ａ１〜７ａ３，７ｂ１〜７ｂ３，７ｃ１〜７ｃ３，
７ｄ１〜７ｄ３，７ｅ１〜７ｅ３からなる構成となって
おり、また各液体再積層用細溝８ａ〜８ｅはプレート
１，２の重ね合わせ面１ａ，２ａに交互に出現する構成
となっている。なお、図２においては、実線がプレート
１の重ね合わせ面１ａの方に形成された細溝を示し、破
線がプレート２の重ね合わせ面２ａの方に形成された細
溝を示している。As shown in FIGS. 3 and 4, each of the liquid dividing narrow grooves 7a to 7e has two plates 1 and 2, respectively.
Branch narrow grooves 7a1 to 7a3, 7b1 to 7b3, 7c1 to 7c3 formed separately on the two overlapping surfaces 1a and 2a.
7d1 to 7d3, 7e1 to 7e3, and the narrow grooves 8a to 8e for liquid re-lamination alternately appear on the overlapping surfaces 1a and 2a of the plates 1 and 2. In FIG. 2, a solid line indicates a narrow groove formed on the overlapping surface 1 a of the plate 1, and a broken line indicates a narrow groove formed on the overlapping surface 2 a of the plate 2.
【００１６】また、液体再積層用細溝８ｅの末端は、接
続用細溝６ｃを介して液体導出口５に連通している。し
たがって、実施例では、液体導入口３および接続用細溝
６ａがＡ液導入流路を構成し、液体導入口４および接続
用細溝６ｂがＢ液導入流路を構成するとともに、接続用
細溝６ｃおよび液体導出口５が混合液導出流路を構成し
ていることになる。The end of the liquid restacking narrow groove 8e communicates with the liquid outlet 5 through the connecting narrow groove 6c. Therefore, in the embodiment, the liquid inlet 3 and the connecting narrow groove 6a constitute a liquid A introduction channel, the liquid inlet 4 and the connecting narrow groove 6b constitute a liquid B introducing passage, and the connection narrow groove. The groove 6c and the liquid outlet 5 constitute a mixed liquid outlet channel.
【００１７】実施例の液体混合器の場合、液体導入口
３，４および液体導出口５はそれぞれ直径１ｍｍの小孔
である。プレート１，２は、それぞれ縦：１０〜１５ｍ
ｍ，横：約５０〜６０ｍｍで厚み数ｍｍの平板である。
また、各接続用細溝６ａ〜６ｃや液体分割用細溝７ａ〜
７ｅの各分岐細溝は、幅５０μｍ，深さ２０μｍであ
り、液体積層用細溝６および液体再積層用細溝８ａ〜８
ｅは幅１００μｍ，深さ２０μｍである。この発明にお
いては、普通、各細溝は断面積が１ｍｍ2 以下の微小容
積溝である。したがって、実施例の液体混合器はＡ，Ｂ
両液を僅かな量でも混合できる。In the case of the liquid mixer of the embodiment, the liquid inlets 3, 4 and the liquid outlet 5 are small holes each having a diameter of 1 mm. Plates 1 and 2 each have a length of 10 to 15 m
m, width: about 50 to 60 mm and a thickness of several mm.
In addition, each of the connecting narrow grooves 6a to 6c and the liquid dividing narrow grooves 7a to 7c.
Each of the branch narrow grooves 7e has a width of 50 μm and a depth of 20 μm, and has a narrow groove 6 for liquid lamination and a narrow groove 8a to 8 for liquid relamination.
e is 100 μm in width and 20 μm in depth. In the present invention, each narrow groove is usually a minute volume groove having a sectional area of 1 mm 2 or less. Therefore, the liquid mixer of the embodiment is A, B
Both liquids can be mixed in a small amount.
【００１８】また、上下の各プレート１，２の板基材に
は、ガラス板やシリコン（Ｓｉ）板あるいはプラスチッ
ク板の他に金属板などの中から用途や混合対象の液体の
種類などに応じて適当な板基材が選ばれる。例えば、細
溝の中の混合液に適当な光を照射して反射光ないし透過
光を検出することにより液の分光分析を行うような場合
は、プレート１，２として透明板（例えば無色透明のガ
ラス板）が用いられる。The base material of each of the upper and lower plates 1 and 2 may be selected from glass plates, silicon (Si) plates, plastic plates, metal plates and the like, depending on the application and the type of liquid to be mixed. A suitable plate substrate is selected. For example, in a case where the liquid mixture in the narrow groove is irradiated with an appropriate light and the reflected light or the transmitted light is detected to perform the spectral analysis of the liquid, the plates 1 and 2 are transparent plates (for example, a colorless transparent plate). Glass plate) is used.
【００１９】実施例の液体混合器により液体の混合を実
行する際には、Ａ液やＢ液の送液が必要となる。この送
液は、シリンジポンプのような物理式送液方法や、電気
泳動や電気浸透流などの電気式送液方法を用いて行われ
る。電気泳動による送液の場合、例えば液体導入口３，
４と液体導出口５に電極をセットして電圧を印加するこ
とによって液体を移動させる。なお、電気泳動による送
液では溶質が電荷を持っている必要があるが、電気浸透
流による送液では溶質が電荷を持っていなくてもよい。When liquids are mixed by the liquid mixer of the embodiment, liquid A or liquid B needs to be sent. This liquid sending is performed using a physical liquid sending method such as a syringe pump or an electric liquid sending method such as electrophoresis or electroosmotic flow. In the case of liquid transfer by electrophoresis, for example, liquid inlet 3,
The liquid is moved by setting electrodes to the liquid outlet 4 and the liquid outlet 5 and applying a voltage. It should be noted that the solute needs to have an electric charge in liquid transfer by electrophoresis, but does not have to have an electric charge in liquid transfer by electroosmotic flow.
【００２０】続いて、実施例の液体混合器の製造方法に
ついて説明する。実施例の液体混合器を製造する場合、
上側のプレート１に用いる板基材の重ね合わせ面となる
表面に対して接続用細溝、液体積層用細溝、液体分割用
細溝、および、液体再積層用細溝となる部分以外の領域
を覆うマスクを施しておいてから、エッチング処理を施
した後、マスクを除去することにより各細溝を掘り込み
形成し、さらにサンドブラスト法によりスルホールを板
基材に穿設して液体導入口３，４および液体導出口５を
形成し、上側のプレート１を作製する。Next, a method of manufacturing the liquid mixer of the embodiment will be described. When manufacturing the liquid mixer of the embodiment,
A region other than a portion serving as a connecting narrow groove, a liquid laminating narrow groove, a liquid dividing narrow groove, and a liquid re-laminating narrow groove with respect to a surface serving as an overlapping surface of a plate base material used for the upper plate 1. After applying a mask covering the substrate, the etching process is performed, and then the mask is removed to dig each narrow groove, and further, a through hole is formed in the plate base material by a sand blast method to form a liquid inlet 3. , 4 and the liquid outlet 5 are formed, and the upper plate 1 is manufactured.
【００２１】一方、下側のプレート２に用いる板基材の
重ね合わせ面となる表面に対しても接続用細溝、液体分
割用細溝、および、液体再積層用細溝となる部分以外の
領域を覆うマスクを施しておいてから、エッチング処理
を施した後、マスクを除去することにより各細溝を掘り
込み形成し、下側のプレート２を作製する。ついで作製
した両プレート１，２を重ね合わせ面で貼り合わせて水
密状態に接合すれば、実施例の液体混合器が完成する。
貼り合わせ方法としては、板基材が例えばガラス基板や
石英基板の場合は、重ね合わせ面１ａ，２ａをフッ酸系
の薬剤で少し溶解してプレート１，２を重ね合わせて接
合すればよい。或いは、接着剤を重ね合わせ面１ａ，２
ａに薄く塗布してプレート１，２を重ね合わせて接合し
てもよい。このように、実施例の液体混合器は、いわゆ
るフォトリソグラフィ技術やマイクロマシニング技術を
利用してプレート１，２を簡単に作製して貼り合わす程
度のことで容易に完成させられるのである。On the other hand, the surface other than the portion which becomes the connecting narrow groove, the liquid dividing narrow groove, and the liquid re-laminating narrow groove is also formed on the surface which becomes the overlapping surface of the plate base material used for the lower plate 2. After applying a mask covering the region and performing an etching process, the mask is removed to dig and form each narrow groove, and the lower plate 2 is manufactured. Then, the prepared two plates 1 and 2 are bonded to each other on a superposed surface and joined in a watertight state, whereby the liquid mixer of the embodiment is completed.
As a bonding method, when the plate base is, for example, a glass substrate or a quartz substrate, the plates 1 and 2 may be overlapped and joined by slightly dissolving the overlapping surfaces 1a and 2a with a hydrofluoric acid-based chemical. Alternatively, the adhesive is superposed on the surfaces 1a and 2a.
a, and the plates 1 and 2 may be overlapped and joined. As described above, the liquid mixer of the embodiment can be easily completed by simply manufacturing and bonding the plates 1 and 2 using the so-called photolithography technology or micromachining technology.
【００２２】次に、上述した構成を有する実施例の液体
混合器により液体の混合を実行する時のプロセスを図面
を参照しながら説明する。混合対象のＡ液を液体導入口
３から接続用細溝６ａへ導入するとともに、混合対象の
Ｂ液を液体導入口４から接続用細溝６ｂへ導入する。Ａ
液は接続用細溝６ａから同一の重ね合わせ面１ａに形成
された液体積層用細溝６へそのまま流れ込む一方、液体
積層用細溝６には他方の重ね合わせ面２ａに形成された
接続用細溝６ｂからＢ液が流れ込む。液体積層用細溝６
と接続用細溝６ｂは異なる重ね合わせ面に形成されてい
て、両者の間には段差があるので、Ｂ液はＡ液の下側に
層をなすようにして流れ込んでゆく結果、液体積層用細
溝６では、図２に示すように、Ａ，Ｂ両液がプレートの
厚み方向に積層された２層の積層液体となる。なお、液
体積層用細溝６は接続用細溝６ａ，６ｂの倍の幅である
ので流速は変化せずに液流は乱れることなくＡ，Ｂ両液
の積層はスムースに進む。Next, a process of mixing liquids by the liquid mixer of the embodiment having the above-described configuration will be described with reference to the drawings. The liquid A to be mixed is introduced from the liquid inlet 3 into the connecting narrow groove 6a, and the liquid B to be mixed is introduced from the liquid inlet 4 into the connecting narrow groove 6b. A
The liquid flows directly from the connecting narrow groove 6a into the liquid laminating narrow groove 6 formed on the same overlapping surface 1a, while the liquid flows into the liquid laminating narrow groove 6 through the connecting narrow groove formed on the other overlapping surface 2a. The liquid B flows from the groove 6b. Groove for liquid lamination 6
And the connecting thin groove 6b are formed on different overlapping surfaces, and there is a step between the two, so that the solution B flows in a layer below the solution A, and as a result, In the narrow groove 6, as shown in FIG. 2, both the liquids A and B become a two-layer laminated liquid laminated in the thickness direction of the plate. Since the narrow groove 6 for liquid lamination has twice the width of the narrow grooves 6a and 6b for connection, the flow of the liquids A and B proceeds smoothly without disturbing the liquid flow without changing the flow velocity.
【００２３】次に、２層の積層液体は液体分割用細溝７
ａによりプレートの面方向（溝の幅方向）に等しく２分
割された分割液体となる。２層の積層液体が分岐細溝７
ａ１と分岐細溝７ａ２，７ａ３との２つの経路に従って
分かれるのである。分割はプレートの面方向（溝の幅方
向）に対して行われるので、分割液体の幅は半分になる
が、分割液体の積層数は変化なく２層のままである。そ
して、二つの分割液体は液体再積層用細溝８ａでプレー
トの厚み方向に再び積層され、図２に示すように、Ａ，
Ｂ両液がプレートの厚み方向に交互に積層された４層の
積層液体となる。液体再積層用細溝８ａの深さは同じで
あるので各層の厚みは半分となるが、液体再積層用細溝
８ａの幅は分岐細溝７ａ１〜７ａ３の幅の倍であるので
流速は変化せずに液流は乱れることなく分割液体の積層
はスムースに進む。Next, the two-layer laminated liquid is applied to the liquid dividing narrow grooves 7.
Due to a, the divided liquid is divided equally into two in the plane direction of the plate (width direction of the groove). The two-layered liquid is branched into narrow grooves 7
a1 and branching narrow grooves 7a2 and 7a3. Since the division is performed in the plane direction of the plate (the width direction of the groove), the width of the divided liquid is halved, but the number of layers of the divided liquid remains unchanged at two layers. Then, the two divided liquids are again laminated in the thickness direction of the plate by the liquid re-lamination narrow groove 8a, and as shown in FIG.
B Both liquids become a four-layer laminated liquid alternately laminated in the thickness direction of the plate. Since the depth of the liquid re-layering narrow groove 8a is the same, the thickness of each layer becomes half, but the width of the liquid re-layering narrow groove 8a is twice the width of the branch narrow grooves 7a1 to 7a3, so that the flow velocity changes. Without disturbing the liquid flow, the lamination of the divided liquids proceeds smoothly.
【００２４】引き続き、上と同様、積層液体は液体分割
用細溝７ｂにより２分割された後、液体再積層用細溝８
ｂで再び積層され、図２に示すように、Ａ，Ｂ両液が交
互に積層された８層の積層液体となり、さらに８層の積
層液体は、同様、液体分割用細溝７ｃにより２分割され
た後、液体再積層用細溝８ｃで再び積層され、図２に示
すように、Ａ，Ｂ両液が交互に積層された１６層の積層
液体となる。又さらに、１６層の積層液体は液体分割用
細溝７ｄにより２分割された後、液体再積層用細溝８ｄ
で再び積層され、図２に示すように、Ａ，Ｂ両液が交互
に積層された３２層の積層液体となり、最後に、３２層
の積層液体が、これまでと同様、液体分割用細溝７ｅに
より２分割された後、液体再積層用細溝８ｅで再び積層
され、図２に示すように、Ａ，Ｂ両液が交互に積層され
た６４層の積層液体となる。もちろん、各再積層用細溝
の深さは同じであるので、積層の都度、各層の厚みは半
分となってゆく。Subsequently, similarly to the above, the laminated liquid is divided into two by the liquid dividing narrow groove 7b, and then the liquid re-laminating narrow groove 8 is formed.
As shown in FIG. 2, the liquid A and the liquid B are alternately laminated to form an eight-layer laminated liquid, and the eight-layer laminated liquid is similarly divided into two by the liquid dividing narrow groove 7c. After that, the liquid is laminated again in the liquid re-lamination narrow groove 8c, and as shown in FIG. 2, a 16-layer laminated liquid in which both A and B liquids are alternately laminated. Further, after the 16 layers of the laminated liquid are divided into two by the liquid dividing narrow grooves 7d, the liquid re-laminating narrow grooves 8d are formed.
As shown in FIG. 2, the two liquids A and B are alternately laminated to form a laminated liquid of 32 layers. Finally, the laminated liquid of 32 layers is formed into a narrow groove for liquid division as before. After being divided into two by 7e, the liquid is again laminated by the liquid re-lamination narrow groove 8e, and as shown in FIG. 2, a liquid of 64 layers in which both A and B liquids are alternately laminated becomes a laminated liquid. Of course, since the depth of each re-lamination narrow groove is the same, the thickness of each layer becomes half each time lamination.
【００２５】したがって、液体再積層用細溝８ｅを過ぎ
るとＡ液とＢ液は６４層の薄層で互いに隣接しているの
で、Ａ，Ｂ両液の間で拡散が速やかに進行し、両液は十
分に混合されて液体導出口５から流出してくることとな
る。なお、積層の途中でもＡ，Ｂ両液の間で拡散は進行
するので、Ａ液とＢ液は、図示した層を境として完全に
２液に分離した状態となっているわけではない。Therefore, after passing through the narrow groove 8e for liquid re-lamination, the liquid A and the liquid B are adjacent to each other in a thin layer of 64 layers, so that the diffusion between the liquids A and B proceeds rapidly, The liquid is sufficiently mixed and flows out from the liquid outlet 5. Since the diffusion proceeds between the A and B liquids even during the lamination, the A liquid and the B liquid are not necessarily completely separated into two liquids at the illustrated layer.
【００２６】そして、従来の液体混合器だと、液分割用
細溝が１枚のプレートの表裏両面に別れて形成されてい
て、このプレートの両側にそれぞれプレートを積層する
必要があって必然的にプレートが３枚の複雑な構造とな
らざるを得なかったのであるが、実施例の液体混合器で
は、必要な各細溝が２枚のプレートの合わせ面１ａ，２
ａに全て形成されているので、プレート１，２の２枚だ
けの簡潔な構造で液体の混合が十分に行える。In the conventional liquid mixer, narrow grooves for liquid division are formed separately on the front and back surfaces of one plate, and it is necessary to laminate the plates on both sides of this plate, which is inevitable. However, in the liquid mixer of the embodiment, each required narrow groove is formed by the mating surfaces 1a and 2 of the two plates.
a, liquid mixing can be sufficiently performed with a simple structure of only two plates 1 and 2.
【００２７】この発明は、上記実施の形態に限られるこ
とはなく、下記のように変形実施することができる。 （１）実施例では、Ａ液とＢ液の２種類の液体を混合す
る構成であったが、この発明の液体混合器により混合さ
れる液体の種類数は２種類に限らず３種類以上の液体を
混合する構成であってもよい。例えば、図５に示すよう
に、Ｃ液の液体導入口９を設けるとともに、液体積層用
細溝６におけるＢ液の合流点より下流側で液体導入口９
を液体積層用細溝６と結合する接続用細溝６ｄを設けれ
ば、Ａ液〜Ｃ液の３種類の液体を混合することができ
る。この場合、積層の都度、積層数は３層，６層，１２
層，２４層，４８層，９６層と増加してゆく。The present invention is not limited to the above embodiment, but can be modified as follows. (1) In the embodiment, the two kinds of liquids of the liquid A and the liquid B are mixed. However, the number of liquids mixed by the liquid mixer of the present invention is not limited to two but may be three or more. A configuration in which liquids are mixed may be used. For example, as shown in FIG. 5, a liquid inlet 9 for the liquid C is provided, and the liquid inlet 9 is provided downstream of the junction of the liquid B in the narrow groove 6 for liquid lamination.
Is provided with the connecting narrow groove 6d for coupling the liquid with the liquid laminating narrow groove 6, three types of liquids of liquid A to liquid C can be mixed. In this case, the number of laminations is 3, 6, 12
Layers, 24 layers, 48 layers, and 96 layers.
【００２８】（２）実施例の液体混合器において、図６
に示すように、接続用細溝６ａ，６ｂや各分岐細溝７ａ
１，７ａ３，・・・７ｅ１，７ｅ３の合流点での上下の
溝の重なり部分の寸法を長くした他は同様の構成である
液体混合器も、液体の積層がよりスムースに行われるの
で、有用な変形例である。(2) In the liquid mixer of the embodiment, FIG.
As shown in FIG. 3, the connecting narrow grooves 6a and 6b and the branch narrow grooves 7a
1, 7a3,..., 7e1 and 7e3 are also useful because a liquid mixer having the same configuration except that the size of the overlapping portion of the upper and lower grooves at the confluence point is lengthened is such that the liquids are stacked more smoothly. This is a simple modification.
【００２９】（３）実施例の液体混合器において、下側
のプレート２の重ね合わせ面２ａに形成されていた分岐
細溝７ａ３，７ｃ３，７ｅ３および分岐細溝７ｂ１，７
ｄ１の先端側の一定部分だけは重ね合わせ面２ａに形成
されている必要があるが、その他の細溝部分が下側のプ
レート１の重ね合わせ面１ａに形成されている他は実施
例と同様の構成の液体混合器が、変形例として挙げられ
る。つまり、液体が積層される合流点のところでは分岐
細溝が上下のプレート１，２に別れているよう構成され
ていればよいのである。(3) In the liquid mixer of the embodiment, the branch narrow grooves 7a3, 7c3, 7e3 and the branch narrow grooves 7b1, 7 formed on the overlapping surface 2a of the lower plate 2 are formed.
It is necessary that only a certain portion on the leading end side of d1 be formed on the overlapping surface 2a, but the same as the embodiment except that other narrow groove portions are formed on the overlapping surface 1a of the lower plate 1. The liquid mixer having the configuration described above is a modified example. That is, it is only necessary that the branch narrow groove is divided into the upper and lower plates 1 and 2 at the junction where the liquids are stacked.
【００３０】（４）実施例の液体混合器では液体積層用
細溝や液体再積層用細溝は直線状であったが、これらの
細溝の形状は、Ｓ字状に屈曲を繰り返す形状や渦巻き状
などの形状であってもよい。(4) In the liquid mixer of the embodiment, the narrow groove for liquid lamination and the narrow groove for liquid re-lamination are linear. The shape may be a spiral shape or the like.
【００３１】（５）実施例では、液体導入口３，４およ
び液体導出口５は上側のプレート１の外面に開いていた
が、液体導入口３，４および液体導出口５は下側のプレ
ート２の外面に開いていてもよいし、上下のプレート
１，２の外面に分かれて開いていてもよい。(5) In the embodiment, the liquid inlets 3, 4 and the liquid outlet 5 are open on the outer surface of the upper plate 1, but the liquid inlets 3, 4 and the liquid outlet 5 are connected to the lower plate. 2 may be open on the outer surface, or may be open on the outer surfaces of the upper and lower plates 1 and 2 separately.
【００３２】[0032]
【発明の効果】以上に詳述したように、この発明の液体
混合器によれば、２枚のプレートの合わせ面に混合対象
の各液体をプレートの厚み方向（溝の深さ方向）に積層
する液体積層用細溝が形成されているとともに、その後
段に積層液体を面方向（溝の幅方向）に分割する液体分
割用細溝と、分割液体をプレートの厚み方向に再び積層
する液体再積層用細溝とが直列接続状態となるようにし
て繰り返し形成されていて、必要な細溝が２枚のプレー
トの合わせ面に存在する構成を備えており、これら各細
溝により混合対象の各液体がプレートの厚み方向に繰り
返し積層されるので液同士が薄層で隣接し速やかに拡散
が進行して微小な量の液体が旨く混合される。また、プ
レートが２枚だけの簡潔な構造で微小量の液体の混合が
行えるので、生産性や価格面で有利で利用価値が高い。As described above in detail, according to the liquid mixer of the present invention, the liquids to be mixed are stacked on the mating surface of the two plates in the thickness direction of the plates (the depth direction of the grooves). A liquid dividing thin groove for dividing the laminated liquid in the surface direction (the width direction of the groove) is formed in the subsequent stage, and a liquid re-circulating groove for dividing the divided liquid again in the thickness direction of the plate. The thin grooves for lamination are repeatedly formed so as to be in a series connection state, and a configuration is provided in which the necessary thin grooves are present on the mating surface of the two plates. Since the liquids are repeatedly laminated in the thickness direction of the plate, the liquids are adjacent to each other in a thin layer, and the diffusion proceeds quickly, so that a minute amount of the liquid is mixed well. In addition, since a minute amount of liquid can be mixed with a simple structure having only two plates, it is advantageous in terms of productivity and price and has high utility value.
【図１】実施例に係る液体混合器の外観を示す斜視図で
ある。FIG. 1 is a perspective view illustrating an appearance of a liquid mixer according to an embodiment.
【図２】実施例の液体混合器における流路構成を示す流
路系統図である。FIG. 2 is a flow path diagram showing a flow path configuration in the liquid mixer of the embodiment.
【図３】実施例の液体混合器の上側のプレートの重ね合
わせ面を示す平面図である。FIG. 3 is a plan view showing a superposed surface of an upper plate of the liquid mixer of the embodiment.
【図４】実施例の液体混合器の下側のプレートの重ね合
わせ面を示す平面図である。FIG. 4 is a plan view showing a superposed surface of a lower plate of the liquid mixer of the embodiment.
【図５】変形例の液体混合器における液体導入区間の流
路構成を示す部分流路系統図である。FIG. 5 is a partial flow system diagram showing a flow structure of a liquid introduction section in a liquid mixer of a modified example.
【図６】変形例の液体混合器において液体が積層される
合流点での細溝の重なり状態を示す部分平面図である。FIG. 6 is a partial plan view showing an overlapping state of narrow grooves at a junction where liquids are stacked in a liquid mixer of a modified example.
【図７】従来の液体混合器の構成を示す概略図である。FIG. 7 is a schematic diagram showing a configuration of a conventional liquid mixer.
【図８】従来の液体混合器における流路構成を示す流路
系統図である。FIG. 8 is a flow path diagram showing a flow path configuration in a conventional liquid mixer.
１ …上側のプレート １ａ …重ね合わせ面 ２ …下側のプレート ２ａ …重ね合わせ面 ３，４ …液体導入口 ５ …液体導出口 ６ …液体積層用細溝 ７ａ〜７ｅ…液体分割用細溝 ８ａ〜８ｅ…液体再積層用細溝 DESCRIPTION OF SYMBOLS 1 ... Upper plate 1a ... Overlapping surface 2 ... Lower plate 2a ... Overlapping surface 3, 4 ... Liquid inlet 5 ... Liquid outlet 6 ... Liquid laminating narrow groove 7a-7e ... Liquid dividing narrow groove 8a -8e: Narrow groove for liquid re-lamination
Claims (1)
た２枚のプレートを備え、これらプレートの重ね合わせ
面に、個別の液体導入口からそれぞれ導入された混合対
象の各液体をプレートの厚み方向に積層する液体積層用
細溝が形成されているとともに、この液体積層用細溝の
後段には厚み方向に積層された積層液体を面方向に分割
する液体分割用細溝と、この液体分割用細溝で分割され
た分割液体をプレートの厚み方向に再び積層する液体再
積層用細溝とが直列接続された形態で液体導出口へ向か
って繰り返し形成されていることを特徴とする液体混合
器。1. A plate comprising two plates which are brought into close contact with each other and joined together, and each of the liquids to be mixed introduced from an individual liquid inlet is placed on the overlapping surface of these plates. A thin groove for liquid lamination laminated in the thickness direction is formed, and a narrow groove for liquid division that divides the laminated liquid laminated in the thickness direction in a plane direction, at a subsequent stage of the narrow groove for liquid lamination, A liquid characterized by being repeatedly formed toward a liquid outlet in a form in which liquid re-laminating narrow grooves for laminating the divided liquid divided by the dividing narrow grooves in the thickness direction of the plate are connected in series. Mixer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29922299A JP2001120972A (en) | 1999-10-21 | 1999-10-21 | Liquid mixer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29922299A JP2001120972A (en) | 1999-10-21 | 1999-10-21 | Liquid mixer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2001120972A true JP2001120972A (en) | 2001-05-08 |
Family
ID=17869742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP29922299A Pending JP2001120972A (en) | 1999-10-21 | 1999-10-21 | Liquid mixer |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2001120972A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003001077A (en) * | 2001-06-15 | 2003-01-07 | Minolta Co Ltd | Mixing method, mixing structure, micromixer and microchip provided with mixing structure |
| WO2006001195A1 (en) * | 2004-06-24 | 2006-01-05 | The University Of Tokyo | Micromixer and fluid mixing method |
| JP2006006166A (en) * | 2004-06-24 | 2006-01-12 | Univ Of Tokyo | Cell separator and method for separating cell |
| JP2006320878A (en) * | 2005-05-20 | 2006-11-30 | Univ Of Tokyo | Fluid mixing apparatus |
| JP2008221208A (en) * | 2007-02-14 | 2008-09-25 | Univ Nagoya | Mixing device/method of fluid and mold configuration |
| JP2008290038A (en) * | 2007-05-28 | 2008-12-04 | Hitachi Plant Technologies Ltd | Fluid mixing apparatus and method for producing mixed fluid |
| JP2016538115A (en) * | 2013-11-25 | 2016-12-08 | エルジー・ケム・リミテッド | Fine channel reactor |
-
1999
- 1999-10-21 JP JP29922299A patent/JP2001120972A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003001077A (en) * | 2001-06-15 | 2003-01-07 | Minolta Co Ltd | Mixing method, mixing structure, micromixer and microchip provided with mixing structure |
| WO2006001195A1 (en) * | 2004-06-24 | 2006-01-05 | The University Of Tokyo | Micromixer and fluid mixing method |
| JP2006007063A (en) * | 2004-06-24 | 2006-01-12 | Univ Of Tokyo | Micro-mixer and fluid mixing method |
| JP2006006166A (en) * | 2004-06-24 | 2006-01-12 | Univ Of Tokyo | Cell separator and method for separating cell |
| JP2006320878A (en) * | 2005-05-20 | 2006-11-30 | Univ Of Tokyo | Fluid mixing apparatus |
| JP4590558B2 (en) * | 2005-05-20 | 2010-12-01 | 国立大学法人 東京大学 | Fluid mixing device |
| JP2008221208A (en) * | 2007-02-14 | 2008-09-25 | Univ Nagoya | Mixing device/method of fluid and mold configuration |
| JP2013139034A (en) * | 2007-02-14 | 2013-07-18 | Nagoya Univ | Mixing device/method of fluid and mold construction |
| JP2008290038A (en) * | 2007-05-28 | 2008-12-04 | Hitachi Plant Technologies Ltd | Fluid mixing apparatus and method for producing mixed fluid |
| JP2016538115A (en) * | 2013-11-25 | 2016-12-08 | エルジー・ケム・リミテッド | Fine channel reactor |
| US10232338B2 (en) | 2013-11-25 | 2019-03-19 | Lg Chem, Ltd. | Micro-channel reactor |
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