JOP20220050A1 - مركبات بيرازول، صياغات منها وطريقة لاستخدام المركبات و/ أو صياغات - Google Patents
مركبات بيرازول، صياغات منها وطريقة لاستخدام المركبات و/ أو صياغاتInfo
- Publication number
- JOP20220050A1 JOP20220050A1 JOP/2022/0050A JOP20220050A JOP20220050A1 JO P20220050 A1 JOP20220050 A1 JO P20220050A1 JO P20220050 A JOP20220050 A JO P20220050A JO P20220050 A1 JOP20220050 A1 JO P20220050A1
- Authority
- JO
- Jordan
- Prior art keywords
- formulations
- compounds
- composition
- compound
- disclosed
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 9
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000009472 formulation Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 150000003217 pyrazoles Chemical class 0.000 title 1
- 102100036342 Interleukin-1 receptor-associated kinase 1 Human genes 0.000 abstract 2
- 101710199015 Interleukin-1 receptor-associated kinase 1 Proteins 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- -1 pyrazole compound Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/255—Tartaric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
يتعلق الاختراع الحالي بتجسيدات مركب بيرازول وفقاً للصيغة I. يتم الكشف أيضاً عن تركيبات تشتمل على المركب، وطريقة لتحضير التركيبة. يمكن أن تشتمل التركيبة على مادة حاملة، مثل بوليمر و/ أو تركيبة يمكن أن تكون عبارة عن صياغة مجففة بالرش. يتم الكشف أيضاً عن طريقة لاستخدام المركب و/ أو التركيبة. يمكن أن يكون المركب و/ أو التركيبة مفيدين لتثبيط بروتين IRAK و/ أو لتحسين، علاج و/ أو الوقاية من مرض أو حالة مرضية مرتبط بـ IRAK في خاضع.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962894547P | 2019-08-30 | 2019-08-30 | |
PCT/US2020/048528 WO2021041898A1 (en) | 2019-08-30 | 2020-08-28 | Pyrazole compounds, formulations thereof, and a method for using the compounds and/or formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
JOP20220050A1 true JOP20220050A1 (ar) | 2023-01-30 |
Family
ID=72473975
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2022/0050A JOP20220050A1 (ar) | 2019-08-30 | 2020-08-28 | مركبات بيرازول، صياغات منها وطريقة لاستخدام المركبات و/ أو صياغات |
Country Status (18)
Country | Link |
---|---|
US (3) | US11370787B2 (ar) |
EP (1) | EP4003990A1 (ar) |
JP (1) | JP2022545542A (ar) |
KR (1) | KR20220054626A (ar) |
CN (1) | CN114364674A (ar) |
AR (1) | AR119857A1 (ar) |
AU (1) | AU2020335903A1 (ar) |
BR (1) | BR112022003564A2 (ar) |
CA (1) | CA3152264A1 (ar) |
CO (1) | CO2022002993A2 (ar) |
CR (1) | CR20220085A (ar) |
EC (1) | ECSP22014379A (ar) |
IL (1) | IL290882A (ar) |
JO (1) | JOP20220050A1 (ar) |
MX (1) | MX2022002292A (ar) |
PE (1) | PE20220970A1 (ar) |
TW (1) | TW202122393A (ar) |
WO (1) | WO2021041898A1 (ar) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20220054626A (ko) * | 2019-08-30 | 2022-05-03 | 리겔 파마슈티칼스, 인크. | 피라졸 화합물, 이의 제형, 및 화합물 및/또는 제형을 사용하는 방법 |
WO2022187303A1 (en) * | 2021-03-03 | 2022-09-09 | Rigel Pharmaceuticals, Inc. | A method for treating a disease or condition using a pyrazole compound or formulation thereof |
TW202346291A (zh) * | 2022-03-23 | 2023-12-01 | 美商雷傑製藥公司 | 作為irak抑制劑的嘧啶—2—基—吡唑化合物 |
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EP1836188A1 (en) | 2004-12-30 | 2007-09-26 | Astex Therapeutics Limited | Pyrazole derivatives as that modulate the activity of cdk, gsk and aurora kinases |
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MX2014003612A (es) | 2011-09-27 | 2014-07-09 | Hoffmann La Roche | Compuestos de pirazol-4-il-heterociclil-carboxamida y metodos de uso. |
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AU2015349899B9 (en) | 2014-11-20 | 2020-06-25 | Merck Patent Gmbh | Heteroaryl compounds as IRAK inhibitors and uses thereof |
EP3286181B1 (en) | 2015-04-22 | 2021-01-27 | Rigel Pharmaceuticals, Inc. | Pyrazole compounds and method for making and using the compounds |
DK3532470T3 (da) * | 2016-10-26 | 2023-02-20 | Rigel Pharmaceuticals Inc | Oxazolderivater til anvendelse som irak-hæmmere og fremgangsmåde til fremstilling deraf |
KR20220054626A (ko) * | 2019-08-30 | 2022-05-03 | 리겔 파마슈티칼스, 인크. | 피라졸 화합물, 이의 제형, 및 화합물 및/또는 제형을 사용하는 방법 |
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2020
- 2020-08-28 KR KR1020227009706A patent/KR20220054626A/ko unknown
- 2020-08-28 AR ARP200102424A patent/AR119857A1/es unknown
- 2020-08-28 JP JP2022513277A patent/JP2022545542A/ja active Pending
- 2020-08-28 BR BR112022003564A patent/BR112022003564A2/pt unknown
- 2020-08-28 WO PCT/US2020/048528 patent/WO2021041898A1/en active Application Filing
- 2020-08-28 PE PE2022000318A patent/PE20220970A1/es unknown
- 2020-08-28 MX MX2022002292A patent/MX2022002292A/es unknown
- 2020-08-28 EP EP20771685.3A patent/EP4003990A1/en active Pending
- 2020-08-28 AU AU2020335903A patent/AU2020335903A1/en active Pending
- 2020-08-28 JO JOP/2022/0050A patent/JOP20220050A1/ar unknown
- 2020-08-28 CR CR20220085A patent/CR20220085A/es unknown
- 2020-08-28 US US17/006,150 patent/US11370787B2/en active Active
- 2020-08-28 CN CN202080061311.2A patent/CN114364674A/zh active Pending
- 2020-08-28 TW TW109129543A patent/TW202122393A/zh unknown
- 2020-08-28 CA CA3152264A patent/CA3152264A1/en active Pending
-
2022
- 2022-02-23 EC ECSENADI202214379A patent/ECSP22014379A/es unknown
- 2022-02-24 IL IL290882A patent/IL290882A/en unknown
- 2022-03-15 CO CONC2022/0002993A patent/CO2022002993A2/es unknown
- 2022-05-18 US US17/747,384 patent/US20220306620A1/en not_active Abandoned
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2023
- 2023-08-24 US US18/237,824 patent/US20230399326A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2022545542A (ja) | 2022-10-27 |
US20230399326A1 (en) | 2023-12-14 |
TW202122393A (zh) | 2021-06-16 |
CN114364674A (zh) | 2022-04-15 |
WO2021041898A1 (en) | 2021-03-04 |
AU2020335903A1 (en) | 2022-03-24 |
BR112022003564A2 (pt) | 2022-05-17 |
KR20220054626A (ko) | 2022-05-03 |
CO2022002993A2 (es) | 2022-04-19 |
MX2022002292A (es) | 2022-06-02 |
EP4003990A1 (en) | 2022-06-01 |
US11370787B2 (en) | 2022-06-28 |
CA3152264A1 (en) | 2021-03-04 |
AR119857A1 (es) | 2022-01-19 |
US20220306620A1 (en) | 2022-09-29 |
PE20220970A1 (es) | 2022-06-10 |
ECSP22014379A (es) | 2022-05-31 |
CR20220085A (es) | 2022-04-19 |
IL290882A (en) | 2022-04-01 |
US20210061798A1 (en) | 2021-03-04 |
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