JOP20200311A1 - مثبطات صغيرة الجزيئات من فئة الكينازات مزدوجة الوجه (jak) - Google Patents

مثبطات صغيرة الجزيئات من فئة الكينازات مزدوجة الوجه (jak)

Info

Publication number
JOP20200311A1
JOP20200311A1 JOP/2020/0311A JOP20200311A JOP20200311A1 JO P20200311 A1 JOP20200311 A1 JO P20200311A1 JO P20200311 A JOP20200311 A JO P20200311A JO P20200311 A1 JOP20200311 A1 JO P20200311A1
Authority
JO
Jordan
Prior art keywords
kinases
small molecule
molecule inhibitors
jak family
methods
Prior art date
Application number
JOP/2020/0311A
Other languages
English (en)
Inventor
Paul J Krawczuk
Mark S Tichenor
Philippe Fernandes
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of JOP20200311A1 publication Critical patent/JOP20200311A1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Health & Medical Sciences (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)

Abstract

مركبات 2-((1r,4r)-4-(إيميدازو[4,5-d]بيرولو[2,3-b]بيريدين-1(6H)-يل)هيكسيل حلقي)أسيتونتريل والتركيبات الدوائية التي تحتوي عليها وطرق صناعتها وطرق استخدامها بما في ذلك طرق علاج حالات المرض والاضطرابات والحالات التي تتدخل بها الكينازات مزدوجة الوجه (JAK).
JOP/2020/0311A 2018-06-15 2019-06-14 مثبطات صغيرة الجزيئات من فئة الكينازات مزدوجة الوجه (jak) JOP20200311A1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862685737P 2018-06-15 2018-06-15
US201962846290P 2019-05-10 2019-05-10
PCT/IB2019/055005 WO2019239387A1 (en) 2018-06-15 2019-06-14 Small molecule inhibitors of the jak family of kinases

Publications (1)

Publication Number Publication Date
JOP20200311A1 true JOP20200311A1 (ar) 2020-11-30

Family

ID=67766195

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2020/0311A JOP20200311A1 (ar) 2018-06-15 2019-06-14 مثبطات صغيرة الجزيئات من فئة الكينازات مزدوجة الوجه (jak)

Country Status (23)

Country Link
US (3) US20200017498A1 (ar)
EP (1) EP3807277A1 (ar)
JP (1) JP2021528391A (ar)
KR (1) KR20210021342A (ar)
CN (1) CN112313233A (ar)
AU (1) AU2019286641A1 (ar)
BR (1) BR112020024744A2 (ar)
CA (1) CA3101438A1 (ar)
CL (1) CL2020003227A1 (ar)
CO (1) CO2020015396A2 (ar)
CR (1) CR20200603A (ar)
EC (1) ECSP20080817A (ar)
IL (1) IL279314A (ar)
JO (1) JOP20200311A1 (ar)
MA (1) MA52900A (ar)
MX (1) MX2020013688A (ar)
NI (1) NI202000100A (ar)
PE (1) PE20212113A1 (ar)
PH (1) PH12020551984A1 (ar)
SG (1) SG11202011691PA (ar)
TW (1) TW202016110A (ar)
UY (1) UY38262A (ar)
WO (1) WO2019239387A1 (ar)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4086256A1 (en) 2016-12-16 2022-11-09 Janssen Pharmaceutica NV Small molecule inhibitors of the jak family of kinases
JOP20190144A1 (ar) 2016-12-16 2019-06-16 Janssen Pharmaceutica Nv إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز
TW202016110A (zh) 2018-06-15 2020-05-01 比利時商健生藥品公司 Ｊａｋ激酶家族之小分子抑制劑
AU2022233254A1 (en) * 2021-03-11 2023-10-26 Janssen Pharmaceutica Nv Lorpucitinib for use in the treatment of jak mediated disorders
CN113292561A (zh) * 2021-05-22 2021-08-24 中国药科大学 一种二吡咯并吡啶结构的化合物、制备方法和医药用途

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6080747A (en) 1999-03-05 2000-06-27 Hughes Institute JAK-3 inhibitors for treating allergic disorders
AU765005B2 (en) 1999-04-23 2003-09-04 Smithkline Beecham Plc Polymorph of 5-(4-(2- (N-methyl-N-( 2-pyridyl)amino) ethoxy)benzyl) thiazolidine-2,4-dione, maleic acid salt
AR033485A1 (es) 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
ES2299720T3 (es) 2002-05-31 2008-06-01 Schering Corporation Formas polimorfas de un inhibidor de xantina-fosfodiesterasa v.
GB0319935D0 (en) 2003-08-26 2003-09-24 Cipla Ltd Polymorphs
US7737279B2 (en) 2005-05-10 2010-06-15 Bristol-Myers Squibb Company 1,6-dihydro-1,3,5,6-tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same
CA2613053C (en) 2005-07-01 2015-11-24 Wyeth Crystalline forms of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile and methods of preparing the same
EP2251341A1 (en) 2005-07-14 2010-11-17 Astellas Pharma Inc. Heterocyclic Janus kinase 3 inhibitors
KR20080026654A (ko) 2005-07-14 2008-03-25 아스텔라스세이야쿠 가부시키가이샤 헤테로시클릭 야누스 키나제 3 억제제
WO2009152133A1 (en) 2008-06-10 2009-12-17 Abbott Laboratories Novel tricyclic compounds
ES2505270T3 (es) 2009-09-03 2014-10-09 Bristol-Myers Squibb Company Inhibidores de JAK2 y su uso para el tratamiento de enfermedades mieloproliferativas y cáncer
SI2506716T1 (sl) 2009-12-01 2017-10-30 Abb Vie Inc. Nove triciklične spojine
US8785639B2 (en) 2009-12-01 2014-07-22 Abbvie Inc. Substituted dihydropyrazolo[3,4-D]pyrrolo[2,3-B]pyridines and methods of use thereof
CA2781578A1 (en) 2010-01-12 2011-07-21 F. Hoffmann-La Roche Ag Tricyclic heterocyclic compounds, compositions and methods of use thereof
EP2534258B1 (en) 2010-02-10 2017-09-20 Genon Biotechnologies OY Dual activity kinase domains and uses thereof
WO2013007765A1 (en) * 2011-07-13 2013-01-17 F. Hoffmann-La Roche Ag Fused tricyclic compounds for use as inhibitors of janus kinases
GB201212081D0 (en) 2012-07-06 2012-08-22 Kalvista Pharmaceuticals Ltd New polymorph
US9475813B2 (en) 2013-02-08 2016-10-25 Nissan Chemical Industries, Ltd. Tricyclic pyrrolopyridine compound, and JAK inhibitor
EP2924026A1 (en) 2014-03-28 2015-09-30 Novartis Tiergesundheit AG Aminosulfonylmethylcyclohexanes as JAK inhibitors
SG11201608542YA (en) 2014-05-14 2016-11-29 Nissan Chemical Ind Ltd Tricyclic compound and jak inhibitor
HUE046130T2 (hu) 2015-05-28 2020-02-28 Theravance Biopharma R&D Ip Llc Naftiridin vegyületek mint jak kináz inhibitorok
WO2017079639A1 (en) 2015-11-04 2017-05-11 Mayo Foundation For Medical Education And Research Methods and materials for treating autoimmune conditions
JOP20190053A1 (ar) 2016-09-23 2019-03-21 Novartis Ag مركبات أزا إندازول للاستخدام في إصابات الأوتار و/ أو الرباط
LT3640251T (lt) 2016-10-24 2022-03-10 Astrazeneca Ab 6,7,8,9-tetrahidro-3h-pirazolo[4,3-f]izochinolino dariniai, tinkami vėžio gydymui
EP4086256A1 (en) 2016-12-16 2022-11-09 Janssen Pharmaceutica NV Small molecule inhibitors of the jak family of kinases
CU24573B1 (es) 2016-12-16 2022-01-13 Pfizer Ácidos carboxílicos de benzimidazoles y 4-aza, 5-aza, 7-aza y 4,7-diaza-benzimidazoles como agonistas receptores de glp-1, útiles para tratar o prevenir enfermedades cardiometabólicas
UA123640C2 (uk) 2016-12-16 2021-05-05 Елі Ліллі Енд Компані Сполука 7-фенілетиламіно-4н-піримідо[4,5-d][1,3]оксазин-2-ону (варіанти) як інгібітор мутантів idh1 та idh2
US20190281874A1 (en) 2016-12-16 2019-09-19 Nestec S.A. Oligosaccharides for flavour generation
MX2019007120A (es) 2016-12-16 2019-09-16 Basf Se Compuestos plaguicidas.
JOP20190144A1 (ar) * 2016-12-16 2019-06-16 Janssen Pharmaceutica Nv إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز
EP3568396B1 (en) 2017-01-11 2020-11-11 Leo Pharma A/S Novel amino-imidazopyridine derivatives as janus kinase inhibitors and pharmaceutical use thereof
BR112019015389A2 (pt) 2017-01-30 2020-03-10 Astrazeneca Ab Moduladores de receptores de estrogênio
CA3059939A1 (en) 2017-04-21 2018-10-25 Kyn Therapeutics Indole ahr inhibitors and uses thereof
TW202016110A (zh) 2018-06-15 2020-05-01 比利時商健生藥品公司 Ｊａｋ激酶家族之小分子抑制劑
WO2020216936A1 (en) 2019-04-24 2020-10-29 Janssen Pharmaceutica Nv Non-clinical liquid formulations of pan-jak inhibitor

Also Published As

Publication number Publication date
EP3807277A1 (en) 2021-04-21
JP2021528391A (ja) 2021-10-21
MA52900A (fr) 2021-04-21
CA3101438A1 (en) 2019-12-19
UY38262A (es) 2019-12-31
NI202000100A (es) 2021-06-30
AU2019286641A1 (en) 2020-12-10
US11066406B2 (en) 2021-07-20
PH12020551984A1 (en) 2021-08-02
US20200017498A1 (en) 2020-01-16
TW202016110A (zh) 2020-05-01
CO2020015396A2 (es) 2021-03-08
BR112020024744A2 (pt) 2021-03-23
KR20210021342A (ko) 2021-02-25
CN112313233A (zh) 2021-02-02
MX2020013688A (es) 2021-02-26
US20210340144A1 (en) 2021-11-04
WO2019239387A1 (en) 2019-12-19
CR20200603A (es) 2021-01-20
US11787807B2 (en) 2023-10-17
CL2020003227A1 (es) 2021-05-14
ECSP20080817A (es) 2021-01-29
IL279314A (en) 2021-01-31
SG11202011691PA (en) 2020-12-30
US20200165250A1 (en) 2020-05-28
PE20212113A1 (es) 2021-11-04

Similar Documents

Publication Publication Date Title
PH12019501355A1 (en) Small molecule inhibitors of the jak family of kinases
PH12019501254A1 (en) Small molecule inhibitors of the jak family of kinases
PH12020551984A1 (en) Small molecule inhibitors of the jak family of kinases
EA202090659A1 (ru) СОСТАВЫ, СОДЕРЖАЩИЕ 6-(2-ГИДРОКСИ-2-МЕТИЛПРОПОКСИ)-4-(6-(6-((6-МЕТОКСИПИРИДИН-3-ИЛ)МЕТИЛ)-3,6-ДИАЗАБИЦИКЛО[3.1.1]ГЕПТАН-3-ИЛ)ПИРИДИН-3-ИЛ)ПИРАЗОЛО[1,5-a]ПИРИДИН-3-КАРБОНИТРИЛ
EA201891067A1 (ru) [1,2,4]ТРИАЗОЛО[1,5-a]ПИРИМИДИН-7-ИЛЬНОЕ СОЕДИНЕНИЕ
EA201991109A1 (ru) ПРОИЗВОДНЫЕ [1,2,4]ТРИАЗОЛО[1,5-a]ПИРИМИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ PDE2
EA201990973A1 (ru) СОЕДИНЕНИЯ [1,2,4]ТРИАЗОЛО[1,5-a]ПИРИМИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ PDE2
EA201991094A1 (ru) СОЕДИНЕНИЯ [1,2,4]ТРИАЗОЛО[1,5-a]ПИРИМИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ PDE2
NZ630580A (en) 6-(4-(1-amino-3-hydroxycyclobutyl)phenyl)-5-phenyl(furo,thieno or pyrrolo) [2, 3-d] pyrimidin-4-one derivatives for the treatment of cancer
EA202190047A1 (ru) Низкомолекулярные ингибиторы киназ семейства jak
EA201991473A1 (ru) Имидазопирролопиридин в качестве ингибиторов киназ семейства jak
EA201991472A1 (ru) Низкомолекулярные ингибиторы киназ семейства jak
AR114969A1 (es) Inhibidores de moléculas pequeñas de la familia de quinasas jak
CR20190283A (es) Imidazopyrrolopyridine as inhibitors of the jak family of kinases
MA50430B1 (fr) Composés d'imidazo[4,5-d]pyrrolo[2,3-b]pyridine comme inhibiteurs de janus kinases