JOP20200145B1 - تركيبة عقار ذو إطلاق متأخر - Google Patents
تركيبة عقار ذو إطلاق متأخرInfo
- Publication number
- JOP20200145B1 JOP20200145B1 JOP/2020/0145A JOP20200145A JOP20200145B1 JO P20200145 B1 JOP20200145 B1 JO P20200145B1 JO P20200145 A JOP20200145 A JO P20200145A JO P20200145 B1 JOP20200145 B1 JO P20200145B1
- Authority
- JO
- Jordan
- Prior art keywords
- polymeric material
- core
- layer
- delayed release
- drug
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/606—Salicylic acid; Derivatives thereof having amino groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A—HUMAN NECESSITIES
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A—HUMAN NECESSITIES
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
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- A—HUMAN NECESSITIES
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/288—Compounds of unknown constitution, e.g. material from plants or animals
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2893—Tablet coating processes
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Zoology (AREA)
- Botany (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Laminated Bodies (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- General Preparation And Processing Of Foods (AREA)
- Grain Derivatives (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
يتم الحصول على عقار ذو إطلاق متأخر إلى القولون من تركيبة ذات إطلاق متأخر تشتمل على جزء رئيسي وطبقة تغليف لهذا الجزء الرئيسي. يشتمل الجزء الرئيسي على عقار وتشتمل طبقة التغليف على طبقة خارجية وطبقة واحدة على الأقل ما بين الجزء الرئيسي والطبقة الخارجية التي يتم إختيارها من المجموعة التي تتكون من طبقة عازلة وطبقة داخلية. حيث تشتمل الطبقة الخارجية المذكورة على مزيج من مواد أولى بوليميرية والتي هي عرضة لهجوم البَكْتِيريَا الموجودة في القُولُون ويكون للمواد البوليميرية الثانية ذات درجة حموضة بدرجة تصل إلى حوالي 5 أو أعلى من ذلك، تشتمل الطبقة الداخلية على مواد بوليميرية ثالثة والتي هي قابلٌ للذوَبان في السوائل المعوية أو سوائل الجهاز الهضمي ويجري إختيار المواد البوليميرية الثالثة من حمض بولي كربوكسيلية مُحيدة بشكل جزئي على الأقل وبوليمر غير أيونية. وفي التجسيدات التي تكون فيها المواد البوليميرية الثالثة هي بوليمرات غير أيونية، تشتمل الطبقة الداخلية على أحد العوامل المنظمة على الأقل وقاعدة. تشتمل الطبقة العازلة على بوليمر غير أيوني الذي يكون قابلٌ للذوَبان في السوائل المعوية أو سوائل الجهاز الهضمي، حيث تطبق الطبقة الخارجية مباشرة على الطبقة الداخلية أو الطبقة العازلة بإستخدام مستحضر غطاء التغليف الذي يتم تشكيله من مزج المواد البوليميرية الأولى في وسط مائي مع مادة بوليمرية ثانية في وسط عضوي. وتتضمن مزايا التركيبات وفقاً للإختراع الحالي على مواد تسريع تحلل العقار عندما يتعرض لظروف القولون مما يخفض أو يزيل تأثير الطعام و/أو الكحول على تحرر العقار بعد تناوله.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12166110.2A EP2659881B1 (en) | 2012-04-30 | 2012-04-30 | A delayed release drug formulation |
Publications (2)
Publication Number | Publication Date |
---|---|
JOP20200145A1 JOP20200145A1 (ar) | 2022-10-30 |
JOP20200145B1 true JOP20200145B1 (ar) | 2023-09-17 |
Family
ID=46025554
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2020/0144A JOP20200144A1 (ar) | 2012-04-30 | 2012-04-30 | تركيبة عقار ذو إطلاق متأخر |
JOP/2013/0111A JO3574B1 (ar) | 2012-04-30 | 2013-04-21 | تركيبة عقار ذو إطلاق متأخر |
JOP/2020/0148A JOP20200148B1 (ar) | 2012-04-30 | 2020-06-09 | تركيبة عقار ذو إطلاق متأخر |
JOP/2020/0147A JOP20200147B1 (ar) | 2012-04-30 | 2020-06-09 | تركيبة عقار ذو إطلاق متأخر |
JOP/2020/0145A JOP20200145B1 (ar) | 2012-04-30 | 2020-06-09 | تركيبة عقار ذو إطلاق متأخر |
JOP/2020/0146A JOP20200146B1 (ar) | 2012-04-30 | 2020-06-09 | تركيبة عقار ذو إطلاق متأخر |
Family Applications Before (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2020/0144A JOP20200144A1 (ar) | 2012-04-30 | 2012-04-30 | تركيبة عقار ذو إطلاق متأخر |
JOP/2013/0111A JO3574B1 (ar) | 2012-04-30 | 2013-04-21 | تركيبة عقار ذو إطلاق متأخر |
JOP/2020/0148A JOP20200148B1 (ar) | 2012-04-30 | 2020-06-09 | تركيبة عقار ذو إطلاق متأخر |
JOP/2020/0147A JOP20200147B1 (ar) | 2012-04-30 | 2020-06-09 | تركيبة عقار ذو إطلاق متأخر |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2020/0146A JOP20200146B1 (ar) | 2012-04-30 | 2020-06-09 | تركيبة عقار ذو إطلاق متأخر |
Country Status (40)
Country | Link |
---|---|
US (6) | US9364440B2 (ar) |
EP (6) | EP3187171A1 (ar) |
JP (2) | JP6621661B2 (ar) |
KR (6) | KR102198621B1 (ar) |
CN (5) | CN110200949B (ar) |
AR (1) | AR090898A1 (ar) |
AU (4) | AU2013255914B2 (ar) |
BR (3) | BR122019022551B1 (ar) |
CA (4) | CA2871017A1 (ar) |
CL (2) | CL2014002796A1 (ar) |
CO (2) | CO7151506A2 (ar) |
CR (4) | CR20190245A (ar) |
CU (1) | CU24304B1 (ar) |
CY (4) | CY1120215T1 (ar) |
DK (5) | DK2659881T3 (ar) |
EA (2) | EA032514B1 (ar) |
ES (5) | ES2655622T3 (ar) |
GE (4) | GEP201706753B (ar) |
HR (2) | HRP20180068T1 (ar) |
HU (5) | HUE036187T2 (ar) |
JO (6) | JOP20200144A1 (ar) |
LT (5) | LT2659881T (ar) |
ME (2) | ME03641B (ar) |
MX (3) | MX366677B (ar) |
MY (3) | MY169161A (ar) |
NO (1) | NO2659881T3 (ar) |
NZ (3) | NZ725409A (ar) |
PE (3) | PE20150129A1 (ar) |
PH (2) | PH12014502340B1 (ar) |
PL (5) | PL2659881T3 (ar) |
PT (5) | PT2659881T (ar) |
RS (5) | RS56839B1 (ar) |
SA (2) | SA115370043B1 (ar) |
SG (2) | SG11201406798WA (ar) |
SI (5) | SI2659881T1 (ar) |
TN (2) | TN2014000442A1 (ar) |
TR (3) | TR201903569T4 (ar) |
TW (3) | TWI705833B (ar) |
UY (1) | UY34772A (ar) |
WO (2) | WO2013164316A1 (ar) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CU24342B1 (es) * | 2012-04-30 | 2018-05-08 | Tillotts Pharma Ag | Formulación de fármaco de liberación retardada |
EP3187171A1 (en) * | 2012-04-30 | 2017-07-05 | Tillotts Pharma AG | A delayed release drug formulation |
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- 2018-01-15 HR HRP20180068TT patent/HRP20180068T1/hr unknown
- 2018-02-27 CY CY20181100237T patent/CY1120215T1/el unknown
- 2018-06-26 HR HRP20180965TT patent/HRP20180965T1/hr unknown
- 2018-08-06 CY CY20181100815T patent/CY1120492T1/el unknown
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2019
- 2019-04-16 CY CY20191100417T patent/CY1121609T1/el unknown
- 2019-12-16 CY CY20191101316T patent/CY1122475T1/el unknown
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2020
- 2020-03-18 US US16/823,094 patent/US11534406B2/en active Active
- 2020-06-09 JO JOP/2020/0148A patent/JOP20200148B1/ar active
- 2020-06-09 JO JOP/2020/0147A patent/JOP20200147B1/ar active
- 2020-06-09 JO JOP/2020/0145A patent/JOP20200145B1/ar active
- 2020-06-09 JO JOP/2020/0146A patent/JOP20200146B1/ar active
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