IT8323762A0 - Derivati glicosilati dell'insulina. - Google Patents

Derivati glicosilati dell'insulina.

Info

Publication number: IT8323762A0
Authority: IT; Italy
Prior art keywords: insulin; glycosylated derivatives; glycosylated; derivatives
Prior art date: 1982-11-17

Application number

IT8323762A

Other languages

English (en)

Other versions

IT1207992B (it

Inventor

James C Mcrea

Sung Wan Kim

Seo Young Jeong

Original Assignee

Salt Lake City Utah U S A A

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-11-17

Filing date

1983-11-17

Publication date

1983-11-17

1983-11-17 Application filed by Salt Lake City Utah U S A A filed Critical Salt Lake City Utah U S A A

1983-11-17 Publication of IT8323762A0 publication Critical patent/IT8323762A0/it

1989-06-01 Application granted granted Critical

1989-06-01 Publication of IT1207992B publication Critical patent/IT1207992B/it

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
- H01B11/00—Communication cables or conductors
- H01B11/02—Cables with twisted pairs or quads
- H01B11/04—Cables with twisted pairs or quads with pairs or quads mutually positioned to reduce cross-talk
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
- H01B13/00—Apparatus or processes specially adapted for manufacturing conductors or cables
- H01B13/02—Stranding-up
- H01B13/04—Mutually positioning pairs or quads to reduce cross-talk
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Diabetes (AREA)
Biotechnology (AREA)
Endocrinology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Manufacturing & Machinery (AREA)
Zoology (AREA)
Toxicology (AREA)
Hematology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Obesity (AREA)
Bioinformatics & Cheminformatics (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IT8323762A 1982-11-17 1983-11-17 Derivati glicosilati dell'insulina. IT1207992B (it)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/442,362 US4444683A (en)	1982-11-17	1982-11-17	Glycosylated insulin derivatives

Publications (2)

Publication Number	Publication Date
IT8323762A0 true IT8323762A0 (it)	1983-11-17
IT1207992B IT1207992B (it)	1989-06-01

Family

ID=23756525

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT8323762A IT1207992B (it)	1982-11-17	1983-11-17	Derivati glicosilati dell'insulina.

Country Status (8)

Country	Link
US (2)	US4444683A (it)
EP (2)	EP0125299B1 (it)
JP (1)	JPH0613556B2 (it)
AT (2)	ATE105296T1 (it)
CA (1)	CA1216578A (it)
DE (2)	DE3382749T2 (it)
IT (1)	IT1207992B (it)
WO (1)	WO1984001896A1 (it)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE8102194L (sv) *	1981-04-06	1982-10-07	Pharmacia Ab	Terapeutiskt aktiv organisk forening och farmaceutisk beredning innehallande denna
DE3790635B4 (de) *	1986-10-13	2007-11-22	Novartis Ag	Verfahren zur Herstellung eines Peptidalkohols und Ausgangsverbindungen dafür
HU906340D0 (en) *	1986-10-13	1991-04-29	Sandoz Ag	Synthesis in solid phase for producing peptonic alcohols
US4885163A (en) *	1987-02-24	1989-12-05	Eli Lilly And Company	Topical use of IGF-II for wound healing
DE3829798A1 (de) *	1988-09-02	1990-03-08	Bosch Gmbh Robert	Kraftstoffeinspritzpumpe fuer brennkraftmaschinen
US5218092A (en) *	1988-09-29	1993-06-08	Kyowa Hakko Kogyo Co., Ltd.	Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
DK111489D0 (da) *	1989-03-08	1989-03-08	Novo Nordisk As	Peptider
JP2648584B2 (ja) *	1990-02-16	1997-09-03	株式会社ディ・ディ・エス研究所	グリコシル−蛋白誘導体
JP3318602B2 (ja) *	1997-11-10	2002-08-26	独立行政法人産業技術総合研究所	糖鎖付加型ヘパリン結合性タンパク質、その製造方法およびそれを含有する医薬組成物
US6323311B1 (en)	1999-09-22	2001-11-27	University Of Utah Research Foundation	Synthesis of insulin derivatives
US7316999B2 (en) *	2000-06-02	2008-01-08	Novo Nordisk A/S	Glucose dependent release of insulin from glucose sensing insulin derivatives
US7176278B2 (en)	2001-08-30	2007-02-13	Biorexis Technology, Inc.	Modified transferrin fusion proteins
US7317000B2 (en) *	2001-12-02	2008-01-08	Novo Nordisk A/S	Glucose-dependent insulins
ATE409546T1 (de) *	2004-12-06	2008-10-15	Vetrox Ag	Vorrichtung zum schleifen von harten oberflächen, insbesondere von glasflächen
WO2007047922A2 (en) *	2005-10-19	2007-04-26	Smartcells, Inc.	Polymer-drug conjugates
KR100829257B1 (ko) *	2006-06-22	2008-05-14	부경대학교 산학협력단	인간 섬유육종세포에서 메트릭스 메탈로프로테이나제-9의발현 및 활성을 억제하는 카복시화 글루코사민 화합물 및이를 함유한 메트릭스 메탈로프로테이나제-9 억제제
JP2008214256A (ja) *	2007-03-02	2008-09-18	Yaizu Suisankagaku Industry Co Ltd	双頭型配糖化合物の製造方法及び双頭型配糖化合物並びに該双頭型配糖化合物を含有する糖鎖認識タンパク質結合剤
US8940690B2 (en)	2009-01-28	2015-01-27	National Institutes Of Health (Nih)	Synthetic conjugates and uses thereof
AU2010208381A1 (en)	2009-01-28	2011-08-04	Smartcells, Inc.	Exogenously triggered controlled release materials and uses thereof
KR20140054404A (ko)	2009-01-28	2014-05-08	스마트쎌스, 인크.	결정질 인슐린-접합체
MX2011007929A (es)	2009-01-28	2011-08-17	Smartcells Inc	Sistemas basados en conjugados para entrega farmacologica controlada.
JP2012520879A (ja)	2009-03-20	2012-09-10	スマートセルズ・インコーポレイテツド	末端官能基化コンジュゲートおよびその用途
EP2408470A4 (en)	2009-03-20	2012-08-29	Smartcells Inc	SOLUBLE NONDEPOT INSULIN CONJUGATE AND ITS USE
US8933207B2 (en)	2010-07-28	2015-01-13	Smartcells, Inc.	Drug-ligand conjugates, synthesis thereof, and intermediates thereto
WO2012015692A2 (en)	2010-07-28	2012-02-02	Smartcells, Inc.	Recombinantly expressed insulin polypeptides and uses thereof
US9068013B2 (en)	2010-07-28	2015-06-30	Smart Cells, Inc.	Recombinant lectins, binding-site modified lectins and uses thereof
WO2014088836A1 (en)	2012-12-03	2014-06-12	Merck Sharp & Dohme Corp.	O-glycosylated carboxy terminal portion (ctp) peptide-based insulin and insulin analogues
BR112016007176A2 (pt)	2013-10-04	2018-01-23	Merck Sharp & Dohme	conjugado, composição, usos de um conjugado e de uma composição, e, método para tratar um indivíduo que tem diabete

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3591574A (en) *	1968-05-29	1971-07-06	American Home Prod	Tri-n-phenylglycyl derivatives of insulin
US3723617A (en) *	1968-12-31	1973-03-27	Smith Kline French Lab	Anti-inflammatory compositions containing acylated-{62 -d-glucopyranosides and methods of using them
US3847890A (en) *	1971-11-01	1974-11-12	A Green	Acidic monosaccharide-substituted proteins
US3755569A (en) *	1972-07-25	1973-08-28	American Home Prod	Acyl substituted insulins
US4152513A (en) *	1977-06-01	1979-05-01	University Of Delaware	Preparation of alkyl glycosides of amino sugars
DE3220427A1 (de) *	1982-05-29	1983-12-01	Behringwerke Ag, 3550 Marburg	Ss-d-galactosederivate, verfahren zu ihrer herstellung und ihre verwendung

1982
- 1982-11-17 US US06/442,362 patent/US4444683A/en not_active Expired - Lifetime
1983
- 1983-11-15 DE DE3382749T patent/DE3382749T2/de not_active Expired - Fee Related
- 1983-11-15 AT AT8888120072T patent/ATE105296T1/de active
- 1983-11-15 JP JP59500051A patent/JPH0613556B2/ja not_active Expired - Lifetime
- 1983-11-15 WO PCT/US1983/001780 patent/WO1984001896A1/en active IP Right Grant
- 1983-11-15 EP EP83903886A patent/EP0125299B1/en not_active Expired
- 1983-11-15 EP EP88120072A patent/EP0312127B1/en not_active Expired - Lifetime
- 1983-11-15 DE DE8383903886T patent/DE3380199D1/de not_active Expired
- 1983-11-15 AT AT83903886T patent/ATE44649T1/de not_active IP Right Cessation
- 1983-11-16 CA CA000441330A patent/CA1216578A/en not_active Expired
- 1983-11-17 IT IT8323762A patent/IT1207992B/it active
1984
- 1984-02-06 US US06/532,697 patent/US4478746A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE3380199D1 (en)	1989-08-24
US4444683A (en)	1984-04-24
DE3382749D1 (de)	1994-06-09
EP0312127B1 (en)	1994-05-04
CA1216578A (en)	1987-01-13
ATE44649T1 (de)	1989-08-15
EP0312127A3 (en)	1991-09-25
IT1207992B (it)	1989-06-01
EP0312127A2 (en)	1989-04-19
EP0125299A4 (en)	1986-02-13
EP0125299A1 (en)	1984-11-21
EP0125299B1 (en)	1989-07-19
ATE105296T1 (de)	1994-05-15
JPS59502065A (ja)	1984-12-13
WO1984001896A1 (en)	1984-05-24
JPH0613556B2 (ja)	1994-02-23
DE3382749T2 (de)	1994-09-29
US4478746A (en)	1984-10-23

Publication	Publication Date	Title
IT8323762A0 (it)	1983-11-17	Derivati glicosilati dell'insulina.
IT8521865A0 (it)	1985-08-05	Derivati di etilendiamminomonoammidi.
DK236185A (da)	1985-11-30	Stabiliseret insulin-formulering
IT8123771A0 (it)	1981-09-03	Derivati dell'acido carbammico.
IT8222784A0 (it)	1982-08-09	Processo per la preparazione di derivati dell'insulina.
IT1167478B (it)	1987-05-13	Derivati dell'acido ursodesossicolico
IT1157220B (it)	1987-02-11	Derivati dell'n-fenilpirazolo
IT8123109A0 (it)	1981-07-24	Derivati dell'acido chenodesossicolico.
IT8220295A0 (it)	1982-03-19	Derivati dell'acido ascorbico.
IT1199212B (it)	1988-12-30	Derivati dell'1,2-ditiolano,loro preparazione e loro impiego come medicamenti
IT8322629A0 (it)	1983-08-24	Derivati di benzammidi.
IT8467795A1 (it)	1986-02-08	Diastereoisomeri di derivati dell'acido glicirretinico.
IT8124627A0 (it)	1981-10-22	Procedimento per la preparazione di derivati dell' 11-dodecen-1-ile.
IT8419778A0 (it)	1984-02-23	Derivati di benzammidi.
IT1233243B (it)	1992-03-24	Derivati dell'isochinolina.
IT1214436B (it)	1990-01-18	Derivati dell'eteroprostaglandina e procedimenti per la loro preparazione.
IT1155457B (it)	1987-01-28	Procedimento per l apreparazione di derivati dell'ossadiazolidina
IT8620380A0 (it)	1986-05-09	Derivati dell'acido ottenoico.
IT1151092B (it)	1986-12-17	Derivati dell'amikacina
IT8121046A0 (it)	1981-04-10	Derivati dell'acido benzaminoetilfenossicicloesilacetico.
IT8221166A0 (it)	1982-05-10	Derivati dell'acido 5-inosinico.
IT8223761A0 (it)	1982-10-15	Derivati dell'acido pirrolidin-2-carbossilico.
KR860007343U (ko)	1986-07-12	주사용 수액세트
IT8224393A0 (it)	1982-11-24	Derivati dell'acido ursodesossicoli co
IT8025251A0 (it)	1980-10-09	Derivati dell'acido ossayohimban-carbossilico.