CO4290417A1 - Nuevas benzoilguanidinas como medicamentos y su preparacion . - Google Patents

Nuevas benzoilguanidinas como medicamentos y su preparacion .

Info

Publication number
CO4290417A1
CO4290417A1 CO94050176A CO94050176A CO4290417A1 CO 4290417 A1 CO4290417 A1 CO 4290417A1 CO 94050176 A CO94050176 A CO 94050176A CO 94050176 A CO94050176 A CO 94050176A CO 4290417 A1 CO4290417 A1 CO 4290417A1
Authority
CO
Colombia
Prior art keywords
pct
benzoylguanidines
medicines
preparation
new
Prior art date
Application number
CO94050176A
Other languages
English (en)
Inventor
Otto Roos
Georg Speck
Walter Losel
Arndts Dietrich
Bechtel Wolf-Dietric
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of CO4290417A1 publication Critical patent/CO4290417A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1. COMPUESTOS DE LA FORMULA EN LA QUE REPRESENTAN: A UNO DE LOS GRUPOS CmH2m-NR4 - CmH2m-NR4-CpH2p-NR4´- NR4-CmH2m-NR4´ R1 R´-SO2- o R´-NH-SO2- (R´ ES IGUAL A ALQUILO C- C5, ALQUILO C1-C5, SUSTITUIDO CON HALOGENO O FENI- LO, PUDIENDO TENER EL RADICAL FENILO HASTA TRES SUSTITUYENTES TOMADOS DEL GRUPO FORMADO POR HALO- GENO, ALQUILO C1-C4 O ALCOXI C1-C4), F, Cl O CF3; R2 UN RADICAL DE LAS FORMULAS EN LAS QUE R3, R4 Y R5´, QUE PUEDEN SER IGUALES O DIFERENTES, SIGNIFICAN HIDROGENO, ALQUILO C1-C4, R4 Y R4, SIG- NIFICAN TAMBIEN FENILO, BENCILO Y CILCOALQUILO C3- C7, R5 Y R6, QUE PUEDEN SER IGUALES O DIFERENTES, SIG- NIFICAN HIDROGENO, METILO, METOXI, HIDROXI, O HA- LOGENO, R7 SIGNIFICA HIDROGENO, ALQUILO C1-C4, BENCILO O BENCILOXI, R8 Y R9, QUE PUEDEN SER IGUALES O DIFERENTES SIG- NIFICAN HIDROGENO, METILO, METOXI, HIDROXI O HALO- GENO, R7 SIGNIFICA HIDROGENO, ALQUILO C1-C4, BENCILO O BENCILOXI, R8 Y R9, QUE PUEDEN SER IGUALES O DIFERENTES, SIG- NIFICAN HIDROGENO, ALQUILO C1-C4, FENILO O HALOGE- NO, R10, SIGNIFICA HIDROGENO O ALQUILO C1-C6, QUE TAM- BIEN PUEDE ESTAR SUSTITUIDO CON FENILO O CON FENI- LOS SUSTITUIDO CON METILO, METOXI O HALOGENO, R11 Y R12, QUE PUEDEN SER IGUALES O DIFERENTES, SIGNIFICAN HIDROGENO, METILO, METOXI, FENILO, BEN- CILO, NITRO, CIANO, HALOGENO, TRIFLUOROMETILO, AMINO O CARBAMOILO, R13 SIGNIFICA HIDROGENO, ALQUILO C1-C4, QUE TAM- BIEN PUEDE ESTAR SUSTITUIDO CON FENILO, FENOXI O BENCILOXI, O SIGNIFICA HALOGENO, E y G, QUE PUEDEN SER IGUALES O DIFERENTES, SIG- NIFICAN N o CH, Y m SIGNIFICA 2, 3, 4, 5 o 6, n SIGNIFICA 0, o 1 y p SIGNIFICA 2, 3 o 4, PUDIENDO PRESENTARSE LOS COMPUESTOS DE LA FORMULA I COMO BASES O COMO SALES, Y EVENTUALMENTE EN FOR- MA DE LOS ESTEROISOMEROS INDIVIDUALES O ISOMEROS CIS-TRANS O DE LAS MEZCLAS DE TALES ISOMEROS.
CO94050176A 1993-11-04 1994-11-02 Nuevas benzoilguanidinas como medicamentos y su preparacion . CO4290417A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4337611A DE4337611A1 (de) 1993-11-04 1993-11-04 Neue Benzoylguanidine, ihre Herstellung und ihre Verwendung in Arzneimitteln

Publications (1)

Publication Number Publication Date
CO4290417A1 true CO4290417A1 (es) 1996-04-17

Family

ID=6501758

Family Applications (1)

Application Number Title Priority Date Filing Date
CO94050176A CO4290417A1 (es) 1993-11-04 1994-11-02 Nuevas benzoilguanidinas como medicamentos y su preparacion .

Country Status (21)

Country Link
US (1) US5783576A (es)
EP (1) EP0733046B1 (es)
JP (1) JPH09504535A (es)
KR (1) KR100359676B1 (es)
CN (1) CN1056609C (es)
AT (1) ATE202563T1 (es)
AU (1) AU687911B2 (es)
CA (1) CA2175838A1 (es)
CO (1) CO4290417A1 (es)
DE (2) DE4337611A1 (es)
DK (1) DK0733046T3 (es)
ES (1) ES2157993T3 (es)
GR (1) GR3036642T3 (es)
HK (1) HK1010722A1 (es)
NZ (1) NZ274849A (es)
PL (1) PL180302B1 (es)
PT (1) PT733046E (es)
RU (1) RU2136659C1 (es)
TW (1) TW400319B (es)
WO (1) WO1995012584A1 (es)
ZA (1) ZA948670B (es)

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DE19601303A1 (de) * 1996-01-16 1997-07-17 Boehringer Ingelheim Kg Neuartige Benzoylguanidin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Herstellung von Arzneimitteln
WO1999048870A1 (en) * 1998-03-23 1999-09-30 Aventis Pharmaceuticals Products Inc. Piperididinyl and n-amidinopiperidinyl derivatives
US6239279B1 (en) * 1998-12-16 2001-05-29 Smithkline Beecham Corporation Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives
EP1182194A4 (en) 1999-06-03 2004-02-11 Takeda Chemical Industries Ltd PERNASAL COMPOSITIONS
US6156758A (en) * 1999-09-08 2000-12-05 Isis Pharmaceuticals, Inc. Antibacterial quinazoline compounds
CN100537571C (zh) * 2002-04-19 2009-09-09 细胞基因组公司 咪唑并[1,2-а]吡嗪-8-基胺,其制备方法及使用方法
US7312341B2 (en) * 2002-09-09 2007-12-25 Cgi Pharmaceuticals, Inc. 6-aryl-imidazo[1,2-a] pyrazin-8-ylamines, method of making, and method of use thereof
WO2004072080A1 (en) * 2003-02-10 2004-08-26 Cellular Genomics, Inc. Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of hsp90 complex activity
US7405295B2 (en) * 2003-06-04 2008-07-29 Cgi Pharmaceuticals, Inc. Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
US20060183746A1 (en) * 2003-06-04 2006-08-17 Currie Kevin S Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
US7393848B2 (en) * 2003-06-30 2008-07-01 Cgi Pharmaceuticals, Inc. Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of Bruton's tyrosine kinase by such compounds
US7259164B2 (en) * 2003-08-11 2007-08-21 Cgi Pharmaceuticals, Inc. Certain substituted imidazo[1,2-a]pyrazines, as modulators of kinase activity
AU2004276341B2 (en) * 2003-09-23 2011-04-14 Vertex Pharmaceuticals Incorporated Pyrazolopyrrole derivatives as protein kinase inhibitors
CN102267978A (zh) * 2005-01-14 2011-12-07 Cgi药学股份有限公司 作为激酶活性调节剂的1,3-二芳基取代的脲
US7777040B2 (en) * 2005-05-03 2010-08-17 Cgi Pharmaceuticals, Inc. Certain substituted ureas, as modulators of kinase activity
US7709468B2 (en) 2005-09-02 2010-05-04 Abbott Laboratories Imidazo based heterocycles
US20090221612A1 (en) 2008-02-13 2009-09-03 Mitchell Scott A Certain substituted amides, method of making, and method of use thereof
TWI529172B (zh) 2008-12-08 2016-04-11 吉李德康乃狄克公司 作爲脾臟酪胺酸激酶（Ｓｙｋ）抑制劑之咪唑並吡化合物
ES2744541T3 (es) 2008-12-08 2020-02-25 Gilead Connecticut Inc Inhibidores de imidazopirazina Syk
US8450321B2 (en) 2008-12-08 2013-05-28 Gilead Connecticut, Inc. 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor
TW201200518A (en) * 2010-03-10 2012-01-01 Kalypsys Inc Heterocyclic inhibitors of histamine receptors for the treatment of disease
MX350010B (es) 2010-03-11 2017-08-23 Gilead Connecticut Inc Inhibidores syk de imidazopiridinas.
SI3027618T1 (sl) 2013-07-30 2021-01-29 Kronos Bio, Inc. Polimorf SYK inhibitorjev
MX2016001480A (es) 2013-07-30 2017-01-05 Gilead Connecticut Inc Formulacion de inhibidores de syk.
KR20160090903A (ko) 2013-12-04 2016-08-01 길리애드 사이언시즈, 인코포레이티드 암을 치료하는 방법
US9290505B2 (en) 2013-12-23 2016-03-22 Gilead Sciences, Inc. Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
UY35898A (es) 2013-12-23 2015-07-31 Gilead Sciences Inc ?compuestos inhibidores de syk y composiciones que los comprenden?.
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DE3929582A1 (de) * 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
CZ284456B6 (cs) * 1992-02-15 1998-12-16 Hoechst Aktiengesellschaft Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje
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Also Published As

Publication number Publication date
AU687911B2 (en) 1998-03-05
ATE202563T1 (de) 2001-07-15
GR3036642T3 (en) 2001-12-31
PT733046E (pt) 2001-10-30
TW400319B (en) 2000-08-01
DE59409794D1 (de) 2001-08-02
RU2136659C1 (ru) 1999-09-10
US5783576A (en) 1998-07-21
ES2157993T3 (es) 2001-09-01
DK0733046T3 (da) 2001-09-03
CN1056609C (zh) 2000-09-20
DE4337611A1 (de) 1995-05-11
ZA948670B (en) 1995-07-04
NZ274849A (en) 1998-08-26
PL314188A1 (en) 1996-09-02
JPH09504535A (ja) 1997-05-06
KR960705789A (ko) 1996-11-08
AU7993794A (en) 1995-05-23
CN1134146A (zh) 1996-10-23
EP0733046A1 (de) 1996-09-25
CA2175838A1 (en) 1995-05-11
WO1995012584A1 (de) 1995-05-11
EP0733046B1 (de) 2001-06-27
PL180302B1 (pl) 2001-01-31
KR100359676B1 (ko) 2003-04-16
HK1010722A1 (en) 1999-06-25

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