IT1277392B1 - Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina - Google Patents

Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina

Info

Publication number
IT1277392B1
IT1277392B1 IT95MI001671A ITMI951671A IT1277392B1 IT 1277392 B1 IT1277392 B1 IT 1277392B1 IT 95MI001671 A IT95MI001671 A IT 95MI001671A IT MI951671 A ITMI951671 A IT MI951671A IT 1277392 B1 IT1277392 B1 IT 1277392B1
Authority
IT
Italy
Prior art keywords
pct
adenosine
triazole
receptor
herocyclic
Prior art date
Application number
IT95MI001671A
Other languages
English (en)
Inventor
Pier Giovanni Baraldi
Barbara Cacciari
Monica Viziano
Silvio Dionisotti
Ennio Ongini
Original Assignee
Schering Plough S P A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Plough S P A filed Critical Schering Plough S P A
Publication of ITMI951671A0 publication Critical patent/ITMI951671A0/it
Priority to IT95MI001671A priority Critical patent/IT1277392B1/it
Priority to CA002227991A priority patent/CA2227991C/en
Priority to ES96924840T priority patent/ES2153118T3/es
Priority to EP96924840A priority patent/EP0856003B1/en
Priority to PCT/EP1996/002881 priority patent/WO1997005138A1/en
Priority to DK96924840T priority patent/DK0856003T3/da
Priority to US09/006,698 priority patent/US5935964A/en
Priority to DE69611377T priority patent/DE69611377T2/de
Priority to AT96924840T priority patent/ATE198334T1/de
Priority to PT96924840T priority patent/PT856003E/pt
Publication of ITMI951671A1 publication Critical patent/ITMI951671A1/it
Application granted granted Critical
Publication of IT1277392B1 publication Critical patent/IT1277392B1/it
Priority to GR20010400134T priority patent/GR3035309T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
IT95MI001671A 1995-07-28 1995-07-28 Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina IT1277392B1 (it)

Priority Applications (11)

Application Number Priority Date Filing Date Title
IT95MI001671A IT1277392B1 (it) 1995-07-28 1995-07-28 Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina
US09/006,698 US5935964A (en) 1995-07-28 1996-07-02 1,2,4-triazolo 1,5-c! pyrimidine heterocyclic analogues having antagonistic activity on adenosine A2a receptor
ES96924840T ES2153118T3 (es) 1995-07-28 1996-07-02 Analogos heterociclicos de 1,2,4-triazolo 1,5-c)pirimidina que tienen una actividad antagonista sobre los receptores de adenosina a 2a?.
EP96924840A EP0856003B1 (en) 1995-07-28 1996-07-02 1,2,4-TRIAZOLO 1,5-c]PYRIMIDINE HETEROCYCLIC ANALOGUES HAVING ANTAGONISTIC ACTIVITY ON ADENOSINE A 2a? RECEPTOR
PCT/EP1996/002881 WO1997005138A1 (en) 1995-07-28 1996-07-02 1,2,4-TRIAZOLO[1,5-c]PYRIMIDINE HETEROCYCLIC ANALOGUES HAVING ANTAGONISTIC ACTIVITY ON ADENOSINE A2a RECEPTOR
DK96924840T DK0856003T3 (da) 1995-07-28 1996-07-02 Heterocykliske analoger af 1,2,4-triazolo[1,5-c]pyrimidin med antagonistisk virkning på adenosin A2a-receptorer
CA002227991A CA2227991C (en) 1995-07-28 1996-07-02 1,2,4-triazolo[1,5-c]pyrimidine heterocyclic analogues having antagonistic activity on adenosine a2a receptor
DE69611377T DE69611377T2 (de) 1995-07-28 1996-07-02 1,2,4-triazolo[1,5-c]pyrimidin-heterocyclische analoge mit antagonistischer aktivität auf dem adenosine a2a rezeptor
AT96924840T ATE198334T1 (de) 1995-07-28 1996-07-02 1,2,4-triazolo(1,5-c)pyrimidin-heterocyclische analoge mit antagonistischer aktivität auf dem adenosine a2a rezeptor
PT96924840T PT856003E (pt) 1995-07-28 1996-07-02 Analogos heterociclicos 1,2,4-triazolo¬1,5-c|pirimidina tendo actividade antagonista noreceptor a2a de adenosina
GR20010400134T GR3035309T3 (en) 1995-07-28 2001-01-26 1,2,4-TRIAZOLO 1,5-c]PYRIMIDINE HETEROCYCLIC ANALOGUES HAVING ANTAGONISTIC ACTIVITY ON ADENOSINE A 2a? RECEPTOR

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95MI001671A IT1277392B1 (it) 1995-07-28 1995-07-28 Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina

Publications (3)

Publication Number Publication Date
ITMI951671A0 ITMI951671A0 (it) 1995-07-28
ITMI951671A1 ITMI951671A1 (it) 1997-01-28
IT1277392B1 true IT1277392B1 (it) 1997-11-10

Family

ID=11372092

Family Applications (1)

Application Number Title Priority Date Filing Date
IT95MI001671A IT1277392B1 (it) 1995-07-28 1995-07-28 Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina

Country Status (11)

Country Link
US (1) US5935964A (it)
EP (1) EP0856003B1 (it)
AT (1) ATE198334T1 (it)
CA (1) CA2227991C (it)
DE (1) DE69611377T2 (it)
DK (1) DK0856003T3 (it)
ES (1) ES2153118T3 (it)
GR (1) GR3035309T3 (it)
IT (1) IT1277392B1 (it)
PT (1) PT856003E (it)
WO (1) WO1997005138A1 (it)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100513062B1 (ko) * 1998-04-03 2005-09-05 가부시키 가이샤 오오쯔카 세이야쿠 고우죠우 트리아조로푸린 유도체, 그 유도체를 함유하는 의약조성물, 아데노신 에이3 수용체 친화제 및 천식치료제
US6686366B1 (en) 1998-06-02 2004-02-03 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6878716B1 (en) 1998-06-02 2005-04-12 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptor and uses thereof
MXPA00011889A (es) 1998-06-02 2003-04-25 Osi Pharm Inc Composiciones de pirrolo (2,3d) piridina y su uso.
US6921825B2 (en) 1998-09-16 2005-07-26 King Pharmaceuticuals Research & Development, Inc. Adenosine A3 receptor modulators
US6448253B1 (en) 1998-09-16 2002-09-10 King Pharmaceuticals Research And Development, Inc. Adenosine A3 receptor modulators
CA2385865A1 (en) * 1999-09-28 2001-04-05 Takashi Okamura Triazolopurine derivatives, pharmaceutical compositions containing the derivatives, and adenosine a3 receptor affinitive agents
US6664252B2 (en) 1999-12-02 2003-12-16 Osi Pharmaceuticals, Inc. 4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof
US6680322B2 (en) 1999-12-02 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US7160890B2 (en) 1999-12-02 2007-01-09 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
MXPA02005357A (es) 1999-12-02 2003-05-19 Osi Pharm Inc Compuestos especificos para los receptores a1, a2a y y a3 de adenosina y usos de los mismos.
ATE293627T1 (de) * 2000-05-26 2005-05-15 Schering Corp Adenosin a2a rezeptor antagonisten
US6673802B2 (en) 2000-12-01 2004-01-06 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6680324B2 (en) 2000-12-01 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
MXPA04002389A (es) * 2001-09-13 2004-05-31 Schering Corp Combinacion de un antagonista del receptor de adenosian a2a y un antidepresivo o ansiolitico.
AU2002340184B2 (en) 2001-10-15 2005-10-06 Schering Corporation Imidazo (4,3-E)-1,2,4-triazolo(1,5-C) pyrimidines as adenosine A2A receptor antagonists
DK1450811T3 (da) 2001-11-30 2010-02-15 Osi Pharm Inc Forbindelser specifikke af adenosin A1- og A3-receptorer og anvendelser heraf
EP1453836B1 (en) 2001-11-30 2007-03-28 Schering Corporation BICYCLIC [1,2,4] -TRIAZOLE ADENOSINE A2a RECEPTOR ANTAGONISTS
DE60234951D1 (de) * 2001-11-30 2010-02-11 Schering Corp Adenosin a2a rezeptor antagonisten
AR038366A1 (es) 2001-11-30 2005-01-12 Schering Corp Compuestos de 1,2,4-triazolo [1,5-c] pirimidinas sustituidas, antagonistas del receptor de adenosina a2a, composiciones farmaceuticas, el uso de dichos compuestos para la manufactura de un medicamento para el tratamiento de enfermedades del sistema nervioso central y un kit que comprende combinacion
JP4440642B2 (ja) 2001-12-20 2010-03-24 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド ピリミジンＡ２ｂ選択的アンタゴニスト化合物、それらの合成、及び使用
US20030229067A1 (en) 2001-12-20 2003-12-11 Arlindo Castelhano Pyrrolopyrimidine A2b selective antagonist compounds, their synthesis and use
MXPA03008967A (es) * 2002-02-01 2004-02-12 King Pharmaceuticals Res & Dev Antagonistas receptores de 8-heteroarilo xantina adenosina a-2b.
WO2003101455A2 (en) * 2002-05-30 2003-12-11 King Pharmaceuticals Research & Development, Inc. Pharmaceutically active compounds having a tricyclic pyrazolotriazolopyrimidine ring structure and methods of use
US20060106040A1 (en) * 2002-12-19 2006-05-18 Michael Grzelak Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders
BR0317436A (pt) 2002-12-19 2005-11-16 Schering Corp Usos de antagonistas do receptor a2a de adenosina
PL1622912T3 (pl) 2003-04-23 2009-11-30 Schering Corp 2-ALKINYLO i 2-ALKENYLO-PIRAZOLO-[4,3-E]-1,2,4-TRIAZOLO-[1,5-C]-PIRYMIDYNY JAKO ANTAGONIŚCI RECEPTORA ADENOZYNOWEGO A2A
TW200538118A (en) 2004-04-21 2005-12-01 Schering Corp Pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists
AR057817A1 (es) 2005-09-19 2007-12-19 Schering Corp Antagonistas del receptor a2a de 2-heteroaril-pirazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pirimidin adenosina. composiciones farmaceuticas
AR056080A1 (es) 2005-09-23 2007-09-19 Schering Corp 7-[2-[4-(6-fluoro-3-metil-1,2-benciosoxazol-5-il)-1-piperazinil]etil]-2-(1-propinil)-7h-pirazol-[4,3-e]-[1,2,4]-triazol-[1,5-c] -pirimidin-5-amine
ES2273599B1 (es) 2005-10-14 2008-06-01 Universidad De Barcelona Compuestos para el tratamiento de la fibrilacion auricular.
WO2007143705A2 (en) 2006-06-06 2007-12-13 Intra-Cellular Therapies, Inc. Organic compounds
US7723343B2 (en) 2007-03-30 2010-05-25 King Pharmaceuticals Research And Development, Inc. Adenosine A2A receptor antagonists
JP5701608B2 (ja) 2007-12-06 2015-04-15 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 有機化合物
WO2009111449A1 (en) 2008-03-04 2009-09-11 Schering Corporation 1,2,4-triazolo[4,3-c]pyrimidin-3-one and pyrazolo [4,3-e] -1,2,4-triazolo [4,3-c] pyrimidin-3-one compounds for use as adenosine a2a receptor antagonists
JP5710493B2 (ja) 2008-12-06 2015-04-30 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 有機化合物
MX2011005934A (es) 2008-12-06 2011-12-16 Intra Cellular Therapies Inc Compuestos organicos.
MX2011005935A (es) 2008-12-06 2011-12-16 Intra Cellular Therapies Inc Compuestos organicos.
WO2011101861A1 (en) 2010-01-29 2011-08-25 Msn Laboratories Limited Process for preparation of dpp-iv inhibitors
US9371327B2 (en) 2010-05-31 2016-06-21 Intra-Cellular Therapies, Inc. PDE1 inhibitor compounds
WO2011153136A1 (en) 2010-05-31 2011-12-08 Intra-Cellular Therapies, Inc. Organic compounds
AU2011306358B2 (en) * 2010-09-24 2014-08-14 Impetis Biosciences Ltd. Fused tricyclic compounds as adenosine receptor antagonist
WO2014101120A1 (en) 2012-12-28 2014-07-03 Merck Sharp & Dohme Corp. Heterobicyclo-substituted-7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties
US9546175B2 (en) 2014-08-07 2017-01-17 Intra-Cellular Therapies, Inc. Organic compounds
CA2967944C (en) 2014-11-18 2020-11-17 Merck Sharp & Dohme Corp. Aminopyrazine compounds with a2a antagonist properties
EP3253390B1 (en) 2015-02-06 2022-04-13 Merck Sharp & Dohme Corp. Aminoquinazoline compounds as a2a antagonist
EP3307067B1 (en) 2015-06-11 2022-11-02 Merck Sharp & Dohme LLC Aminopyrazine compounds with a2a antagonist properties
WO2017008205A1 (en) 2015-07-10 2017-01-19 Merck Sharp & Dohme Corp. Substituted aminoquinazoline compounds as a2a antagonist
EP3723754A4 (en) 2017-12-13 2021-05-19 Merck Sharp & Dohme Corp. IMIDAZO [1,2-C] QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES
DE102019116986A1 (de) 2019-06-24 2020-12-24 Helmholtz-Zentrum Dresden-Rossendorf E. V. Deuterierte 7-(3-(4-(2-([18F]Fluor)ethoxy)phenyl)propyl)-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amin-Derivate
CN111072676B (zh) * 2019-12-12 2021-07-16 广东东阳光药业有限公司 含氮稠合三环衍生物及其用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1264901B1 (it) * 1993-06-29 1996-10-17 Schering Plough S P A Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina
DE69428977T2 (de) * 1993-07-27 2002-07-11 Kyowa Hakko Kogyo Kk Arzneimittel gegen Parkinsonsche Krankheit

Also Published As

Publication number Publication date
EP0856003A1 (en) 1998-08-05
PT856003E (pt) 2001-04-30
EP0856003B1 (en) 2000-12-27
ITMI951671A0 (it) 1995-07-28
GR3035309T3 (en) 2001-04-30
ES2153118T3 (es) 2001-02-16
CA2227991A1 (en) 1997-02-13
DE69611377T2 (de) 2001-04-26
WO1997005138A1 (en) 1997-02-13
DE69611377D1 (de) 2001-02-01
CA2227991C (en) 2001-09-11
DK0856003T3 (da) 2001-01-22
ITMI951671A1 (it) 1997-01-28
US5935964A (en) 1999-08-10
ATE198334T1 (de) 2001-01-15

Similar Documents

Publication Publication Date Title
IT1277392B1 (it) Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina
DE69329727D1 (de) Neue imidazol derivate, ihre herstellung und therapeutische verwendung
ITMI931396A0 (it) Analoghi eterociclici di 1,2,4-triazolo[15-c]pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina
DE69622031D1 (de) INDOLDERIVATE ALS cGMP-PDE INHIBITOREN
DE69609602T2 (de) Pyrazolderivate und verfahren zu deren herstellung
HUP9901820A2 (hu) 4-Amino-pirimidin-származékok, ezeket tartalmazó gyógyszerkészítmények, alkalmazásuk és eljárás előállításukra
DE69427991D1 (de) 4,6-dianilino-pyrimidin derivate, deren herstellung und deren verwendung als tyrosin-kinase inhibitoren
BG103785A (en) Pyrrolo[2,3-d]pyrimidines and their application as tyrosine kinase inhibitors
HU9701083D0 (en) 1h-imidazo[4,5-c]quinolin-5n-oxide derivatives for producing 1- and 2-substituted 1h-imidazo[4,5-c]-quinolin-4-amine derivatives
DE69401716D1 (de) Imidazo [1,2-a] pyrasin-4-on-derivate welche als ampa und nmda receptor antagonisten dienen
HU9502495D0 (en) Xanthine derivatives as adenosine a1 receptor antagonists
GR3034354T3 (en) IMIDAZO 1,2-a]QUINOXALIN-4-AMINES ACTIVE AS ADENOSINE ANTAGONISTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF
EP0167922A3 (en) Pyrrolo û1,2-b¨ û1,2,5¨ triazepines, a process and intermediates for their preparation and their use as medicaments
EP0462468A3 (en) 9-amino-2-phenylbicyclo(3.3.1)nonane and 9-amino-2-phenylbicyclo(3.3.1)-non-2-ene and therapeutic agents containing them
ES2188155T3 (es) N-ariloxietilindolilalquilaminas para el tratamiento de la depresion.

Legal Events

Date Code Title Description
0001 Granted