IT1251158B - 13-diidro-3'-(2-alcossi-4-morfolinil)antracicline - Google Patents
13-diidro-3'-(2-alcossi-4-morfolinil)antraciclineInfo
- Publication number
- IT1251158B IT1251158B ITMI912222A ITMI912222A IT1251158B IT 1251158 B IT1251158 B IT 1251158B IT MI912222 A ITMI912222 A IT MI912222A IT MI912222 A ITMI912222 A IT MI912222A IT 1251158 B IT1251158 B IT 1251158B
- Authority
- IT
- Italy
- Prior art keywords
- hydrogen
- hydroxy
- anthracyclines
- morpholinyl
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Glicosidi antraciclinici di formula A: (FORMULA ) dove R1 è un atomo di idrogeno, un gruppo idrossi o metossi; R2 o R3 rappresenta un gruppo idrossile e l'altro di R2 e R3 rappresenta un atomo di idrogeno; R4 è idrogeno o idrossi; sia R5 che R6 rappresentano idrogeno oppure uno di R5 e R6 rappresenta idrogeno e l'altro di R5 e R6 idrossi; R7 rappresenta un residuo alchilico inferiore lineare o ramificato o un residuo benzilico e loro sali farmaceuticamente accettabili sono agenti antitumorali.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909019933A GB9019933D0 (en) | 1990-09-12 | 1990-09-12 | 13-dihydro-3'-(2-alkoxy-4-morphlinyl)anthracyclines |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI912222A0 ITMI912222A0 (it) | 1991-08-07 |
ITMI912222A1 ITMI912222A1 (it) | 1992-03-13 |
IT1251158B true IT1251158B (it) | 1995-05-04 |
Family
ID=10682082
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI912222A IT1251158B (it) | 1990-09-12 | 1991-08-07 | 13-diidro-3'-(2-alcossi-4-morfolinil)antracicline |
Country Status (4)
Country | Link |
---|---|
JP (1) | JP3068258B2 (it) |
DE (1) | DE4126475B4 (it) |
GB (2) | GB9019933D0 (it) |
IT (1) | IT1251158B (it) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2240495B1 (en) | 2008-02-01 | 2015-07-15 | Genentech, Inc. | Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods |
AU2009270988A1 (en) | 2008-07-15 | 2010-01-21 | Genentech, Inc. | Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds |
US8470984B2 (en) | 2010-12-02 | 2013-06-25 | Nerviano Medical Sciences S.R.L. | Process for the preparation of morpholinyl anthracycline derivatives |
JP2016517871A (ja) * | 2013-04-29 | 2016-06-20 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | 新規モルホリニルアントラサイクリン誘導体 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4464529A (en) * | 1982-07-20 | 1984-08-07 | Sri International | Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin |
JPS59212499A (ja) * | 1983-05-13 | 1984-12-01 | アドリヤ・ラボラトリ−ズ・インコ−ポレ−テツド | 抗腫瘍性抗生物質アントラサイクリンの4−デメトキシ−3′−デアミノ−3′(4−モリホリニル)誘導体 |
GB2172594B (en) * | 1985-03-22 | 1988-06-08 | Erba Farmitalia | New morpholino derivatives of daunorubicin and doxorubicin |
GB8905668D0 (en) * | 1989-03-13 | 1989-04-26 | Erba Carlo Spa | New 3'-(4-morpholinyl)-and 3'-(2-methoxy-4-morpholinyl)-anthracycline derivatives |
-
1990
- 1990-09-12 GB GB909019933A patent/GB9019933D0/en active Pending
-
1991
- 1991-08-07 IT ITMI912222A patent/IT1251158B/it active IP Right Grant
- 1991-08-08 GB GB9117175A patent/GB2247885B/en not_active Expired - Lifetime
- 1991-08-08 JP JP3199562A patent/JP3068258B2/ja not_active Expired - Fee Related
- 1991-08-09 DE DE4126475A patent/DE4126475B4/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
GB9019933D0 (en) | 1990-10-24 |
GB9117175D0 (en) | 1991-09-25 |
JPH04247096A (ja) | 1992-09-03 |
GB2247885B (en) | 1994-02-09 |
GB2247885A (en) | 1992-03-18 |
ITMI912222A0 (it) | 1991-08-07 |
DE4126475B4 (de) | 2005-09-15 |
JP3068258B2 (ja) | 2000-07-24 |
DE4126475A1 (de) | 1992-03-19 |
ITMI912222A1 (it) | 1992-03-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970728 |