FI940280A - Menetelmä demetyyliepypodofyylilotoksiinin valmistamiseksi - Google Patents
Menetelmä demetyyliepypodofyylilotoksiinin valmistamiseksi Download PDFInfo
- Publication number
- FI940280A FI940280A FI940280A FI940280A FI940280A FI 940280 A FI940280 A FI 940280A FI 940280 A FI940280 A FI 940280A FI 940280 A FI940280 A FI 940280A FI 940280 A FI940280 A FI 940280A
- Authority
- FI
- Finland
- Prior art keywords
- demethylepipodophyllotoxin
- beta
- alkylidene
- react
- ester
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI912025 | 1991-07-23 | ||
ITMI912025A IT1250692B (it) | 1991-07-23 | 1991-07-23 | Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi. |
EP9201605 | 1992-07-15 | ||
PCT/EP1992/001605 WO1993002094A1 (en) | 1991-07-23 | 1992-07-15 | A process for the preparation of demethylepypodophyllotoxin |
Publications (3)
Publication Number | Publication Date |
---|---|
FI940280A0 FI940280A0 (fi) | 1994-01-20 |
FI940280A true FI940280A (fi) | 1994-01-20 |
FI110782B FI110782B (fi) | 2003-03-31 |
Family
ID=11360401
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI940280A FI110782B (fi) | 1991-07-23 | 1994-01-20 | Demetyyliepipodofyllotoksiini-beeta-D-glukosidit, menetelmä niiden valmistamiseksi, beeta-D-glukoosijohdannaiset ja menetelmät demetyyliepipodofyllotoksiini-beeta-D-glukoosin dimeerien valmistamiseksi |
Country Status (16)
Country | Link |
---|---|
US (1) | US5688925A (fi) |
EP (1) | EP0595888B1 (fi) |
JP (1) | JP3231765B2 (fi) |
AT (1) | ATE159026T1 (fi) |
AU (1) | AU666322B2 (fi) |
CA (1) | CA2113894C (fi) |
DE (1) | DE69222643T2 (fi) |
DK (1) | DK0595888T3 (fi) |
ES (1) | ES2107546T3 (fi) |
FI (1) | FI110782B (fi) |
GR (1) | GR3025729T3 (fi) |
IL (1) | IL102610A (fi) |
IT (1) | IT1250692B (fi) |
MX (1) | MX9204334A (fi) |
WO (1) | WO1993002094A1 (fi) |
ZA (1) | ZA925515B (fi) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2191733T3 (es) * | 1995-12-04 | 2003-09-16 | Nippon Kayaku Kk | Procedimiento para producir etoposido. |
AU728986B2 (en) * | 1997-06-02 | 2001-01-25 | Bristol-Myers Squibb Company | Process for preparing etoposide |
CN1376159A (zh) | 1998-09-10 | 2002-10-23 | 加拿大植原药物公司 | 抗肿瘤药亿妥谱赛的制造方法 |
FR2791681B1 (fr) * | 1999-03-29 | 2001-06-22 | Pf Medicament | Nouveau procede de preparation de l'etoposide |
GB0019124D0 (en) * | 2000-08-03 | 2000-09-27 | Pfizer | Novel process |
US20080161251A1 (en) | 2005-01-21 | 2008-07-03 | Astex Therapeutics Limited | Pharmaceutical Compounds |
WO2008044045A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
EP2073803B1 (en) | 2006-10-12 | 2018-09-19 | Astex Therapeutics Limited | Pharmaceutical combinations |
RS57350B1 (sr) | 2011-10-03 | 2018-08-31 | Mx Adjuvac Ab | Nanočestice, postupak dobijanja i njihova primena kao nosača amfipatičnih ili hidrofobnih molekula u medicini, uključujući i terapiju kancera, kao i prehrambenih jedinjenja |
US9907846B2 (en) | 2013-04-01 | 2018-03-06 | Mx Adjuvac Ab | Nanoparticles, composed of sterol and saponin from Quillaja saponaria Molina for use in pharmaceutical compositions |
EP3616688A1 (en) | 2018-08-27 | 2020-03-04 | Centre National de la Recherche Scientifique - CNRS | Preparation of nanosuspension comprising nanocrystals of active pharmaceutical ingredients with little or no stabilizing agents |
EP3669890A1 (en) | 2018-12-18 | 2020-06-24 | Croda International PLC | Filamentous nanoparticles having vaccine adjuvant effect |
CN113121618A (zh) * | 2021-04-07 | 2021-07-16 | 梯尔希(南京)药物研发有限公司 | 两种依托泊苷杂质的制备方法 |
CN115197281B (zh) * | 2021-04-09 | 2024-06-14 | 四川汇宇制药股份有限公司 | 依托泊苷中间体的制备方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3374317D1 (en) * | 1982-11-26 | 1987-12-10 | Nippon Kayaku Kk | Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof |
JPS60246393A (ja) * | 1984-05-22 | 1985-12-06 | Nippon Kayaku Co Ltd | エトポシドの新規製造法 |
IL77334A (en) * | 1985-12-16 | 1991-04-15 | Univ Bar Ilan | Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor |
DK39886D0 (da) * | 1986-01-27 | 1986-01-27 | Hans Goeran Magnusson | Hydroxybeskyttelsesgrupper |
US4904768A (en) * | 1987-08-04 | 1990-02-27 | Bristol-Myers Company | Epipodophyllotoxin glucoside 4'-phosphate derivatives |
US4965348A (en) * | 1989-05-19 | 1990-10-23 | Bristol-Myers Company | Dimeric epipodophyllotoxin glucoside derivatives |
US5036055A (en) * | 1989-06-07 | 1991-07-30 | Bristol-Myers Company | Acylated derivatives of etoposide |
DE3935016A1 (de) * | 1989-10-20 | 1991-04-25 | Behringwerke Ag | Glycosyl-etoposid-prodrugs, verfahren zu ihrer herstellung und ihre anwendung in kombination mit funktionalisiertem tumorspezifischen enzym-konjugaten |
FR2658824B1 (fr) * | 1990-02-27 | 1992-07-03 | Pf Medicament | Tris acetyl-2",3",4' ethylidene-4",6" beta-d-glucopyranosides, leur preparation et leur utilisation pour la preparation d'ethylidene beta-d-glucopyranoside de demethyl-4' epipodophyllotoxine. |
US5081234A (en) * | 1990-04-30 | 1992-01-14 | Bristol-Myers Squibb Co. | 4'-demethylepipodophyllotoxin glycosides |
CN1025918C (zh) * | 1990-06-07 | 1994-09-14 | 国家医药管理局上海医药工业研究院 | 抗肿瘤药表鬼臼毒吡喃糖甙的合成新工艺 |
-
1991
- 1991-07-23 IT ITMI912025A patent/IT1250692B/it active IP Right Grant
-
1992
- 1992-07-15 WO PCT/EP1992/001605 patent/WO1993002094A1/en active IP Right Grant
- 1992-07-15 CA CA002113894A patent/CA2113894C/en not_active Expired - Fee Related
- 1992-07-15 ES ES92915482T patent/ES2107546T3/es not_active Expired - Lifetime
- 1992-07-15 JP JP50258193A patent/JP3231765B2/ja not_active Expired - Fee Related
- 1992-07-15 AU AU23265/92A patent/AU666322B2/en not_active Ceased
- 1992-07-15 DE DE69222643T patent/DE69222643T2/de not_active Expired - Fee Related
- 1992-07-15 AT AT92915482T patent/ATE159026T1/de not_active IP Right Cessation
- 1992-07-15 EP EP92915482A patent/EP0595888B1/en not_active Expired - Lifetime
- 1992-07-15 DK DK92915482.1T patent/DK0595888T3/da active
- 1992-07-22 ZA ZA925515A patent/ZA925515B/xx unknown
- 1992-07-22 IL IL102610A patent/IL102610A/xx not_active IP Right Cessation
- 1992-07-23 MX MX9204334A patent/MX9204334A/es unknown
-
1994
- 1994-01-20 FI FI940280A patent/FI110782B/fi not_active IP Right Cessation
-
1995
- 1995-05-15 US US08/441,210 patent/US5688925A/en not_active Expired - Fee Related
-
1997
- 1997-12-22 GR GR970403378T patent/GR3025729T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JP3231765B2 (ja) | 2001-11-26 |
DE69222643D1 (de) | 1997-11-13 |
ZA925515B (en) | 1993-04-28 |
ATE159026T1 (de) | 1997-10-15 |
IL102610A (en) | 1997-03-18 |
FI940280A0 (fi) | 1994-01-20 |
CA2113894C (en) | 2003-12-16 |
AU666322B2 (en) | 1996-02-08 |
EP0595888A1 (en) | 1994-05-11 |
MX9204334A (es) | 1993-02-01 |
WO1993002094A1 (en) | 1993-02-04 |
AU2326592A (en) | 1993-02-23 |
ITMI912025A1 (it) | 1993-01-24 |
JPH06509334A (ja) | 1994-10-20 |
GR3025729T3 (en) | 1998-03-31 |
DE69222643T2 (de) | 1998-02-05 |
ES2107546T3 (es) | 1997-12-01 |
DK0595888T3 (da) | 1998-05-18 |
US5688925A (en) | 1997-11-18 |
ITMI912025A0 (it) | 1991-07-23 |
EP0595888B1 (en) | 1997-10-08 |
CA2113894A1 (en) | 1993-02-04 |
FI110782B (fi) | 2003-03-31 |
IT1250692B (it) | 1995-04-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MA | Patent expired |