IT1237518B - Eparine supersolfatate - Google Patents

Eparine supersolfatate

Info

Publication number
IT1237518B
IT1237518B IT02250489A IT2250489A IT1237518B IT 1237518 B IT1237518 B IT 1237518B IT 02250489 A IT02250489 A IT 02250489A IT 2250489 A IT2250489 A IT 2250489A IT 1237518 B IT1237518 B IT 1237518B
Authority
IT
Italy
Prior art keywords
heparins
super
heparin
sulfated
sulfated heparins
Prior art date
Application number
IT02250489A
Other languages
English (en)
Other versions
IT8922504A1 (it
IT8922504A0 (it
Inventor
Renato Conti
Paolo Casati
Original Assignee
Renato Conti
Paolo Casati
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Renato Conti, Paolo Casati filed Critical Renato Conti
Publication of IT8922504A0 publication Critical patent/IT8922504A0/it
Priority to IT02250489A priority Critical patent/IT1237518B/it
Priority to IE422590A priority patent/IE904225A1/en
Priority to DE69016383T priority patent/DE69016383T2/de
Priority to JP2315683A priority patent/JPH03210302A/ja
Priority to ES90122309T priority patent/ES2068969T3/es
Priority to EP90122309A priority patent/EP0432537B1/en
Priority to AT90122309T priority patent/ATE117697T1/de
Priority to PT95961A priority patent/PT95961B/pt
Priority to US07/618,051 priority patent/US5164378A/en
Publication of IT8922504A1 publication Critical patent/IT8922504A1/it
Application granted granted Critical
Publication of IT1237518B publication Critical patent/IT1237518B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • Veterinary Medicine (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT02250489A 1989-11-24 1989-11-24 Eparine supersolfatate IT1237518B (it)

Priority Applications (9)

Application Number Priority Date Filing Date Title
IT02250489A IT1237518B (it) 1989-11-24 1989-11-24 Eparine supersolfatate
ES90122309T ES2068969T3 (es) 1989-11-24 1990-11-22 Heparinas supersulfatadas.
DE69016383T DE69016383T2 (de) 1989-11-24 1990-11-22 Supersulfatierte Heparine.
JP2315683A JPH03210302A (ja) 1989-11-24 1990-11-22 過硫酸化ヘパリン
IE422590A IE904225A1 (en) 1989-11-24 1990-11-22 Supersulfated heparins
EP90122309A EP0432537B1 (en) 1989-11-24 1990-11-22 Supersulfated heparins
AT90122309T ATE117697T1 (de) 1989-11-24 1990-11-22 Supersulfatierte heparine.
PT95961A PT95961B (pt) 1989-11-24 1990-11-22 Processo para a preparacao de heparinas supersulfatadas
US07/618,051 US5164378A (en) 1989-11-24 1990-11-26 Supersulfated heparins

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT02250489A IT1237518B (it) 1989-11-24 1989-11-24 Eparine supersolfatate

Publications (3)

Publication Number Publication Date
IT8922504A0 IT8922504A0 (it) 1989-11-24
IT8922504A1 IT8922504A1 (it) 1991-05-24
IT1237518B true IT1237518B (it) 1993-06-08

Family

ID=11197161

Family Applications (1)

Application Number Title Priority Date Filing Date
IT02250489A IT1237518B (it) 1989-11-24 1989-11-24 Eparine supersolfatate

Country Status (9)

Country Link
US (1) US5164378A (it)
EP (1) EP0432537B1 (it)
JP (1) JPH03210302A (it)
AT (1) ATE117697T1 (it)
DE (1) DE69016383T2 (it)
ES (1) ES2068969T3 (it)
IE (1) IE904225A1 (it)
IT (1) IT1237518B (it)
PT (1) PT95961B (it)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1244373B (it) * 1991-01-18 1994-07-08 Sclavo Spa Composizioni farmaceutiche per uso orale contenenti eparina a basso peso molecolare, loro preparazione ed uso
SE9101155D0 (sv) * 1991-04-18 1991-04-18 Kabi Pharmacia Ab Novel heparin derivatives
US5514665A (en) * 1993-12-30 1996-05-07 University Of British Columbia Method of preventing or reducing the risk of infection by bacterial pathogens utilizing simple and conjugated dextrans
US5783568A (en) * 1994-06-10 1998-07-21 Sugen, Inc. Methods for treating cancer and other cell proliferative diseases
US6217863B1 (en) 1995-10-30 2001-04-17 Massachusetts Institute Of Technology Rationally designed polysaccharide lyases derived from heparinase I
IT1285546B1 (it) * 1996-01-16 1998-06-18 Alfa Wassermann Spa Uso del dermatano solfato a basso peso molecolare e delle specialita' medicinali che lo contengono nella terapia e nella prevenzione della
IT1290814B1 (it) * 1997-03-24 1998-12-11 Istituto Scient Di Chimica E B Glicosaminoglicani aventi elevata attivita' antitrombotica
US7056504B1 (en) 1998-08-27 2006-06-06 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase I and II
WO2000012726A2 (en) 1998-08-27 2000-03-09 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase i and ii
US6597996B1 (en) 1999-04-23 2003-07-22 Massachusetts Institute Of Technology Method for indentifying or characterizing properties of polymeric units
CA2402160C (en) * 2000-03-08 2012-02-14 Massachusetts Institute Of Technology Heparinase iii and uses thereof
ES2640975T3 (es) 2000-09-12 2017-11-07 Massachusetts Institute Of Technology Métodos y productos relacionados con heparina de peso molecular bajo
JP2004523479A (ja) 2000-10-18 2004-08-05 マサチューセッツ　インスティテュート　オブ　テクノロジー 多糖の肺送達に関する方法および産物
EP1238670A1 (en) * 2001-03-07 2002-09-11 Bruce Daniels Composition and method for treating and preventing cardiovascular disease and hypertension.
EP2284535A1 (en) 2002-03-11 2011-02-16 Momenta Pharmaceuticals, Inc. Low molecular weight heparins
JP2006501815A (ja) * 2002-04-25 2006-01-19 モメンタ ファーマシューティカルズ インコーポレイテッド 粘膜送達のための方法および製品
GB0306615D0 (en) * 2003-03-22 2003-04-30 Astrazeneca Ab New use
WO2007019554A2 (en) * 2005-08-08 2007-02-15 Momenta Pharmaceuticals, Inc. Polysaccharides for delivery of active agents
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
WO2011090948A1 (en) * 2010-01-19 2011-07-28 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
US9068957B2 (en) 2011-02-21 2015-06-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
EP3398971A4 (en) * 2015-12-30 2019-09-25 Shenzhen Hepalink Pharmaceutical Group Co., Ltd. OLIGOSACCHARIDE OF SULPHATED HEPARIN AND PREPARATION METHOD AND APPLICATION THEREOF

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2599172A (en) * 1948-11-29 1952-06-03 Searle & Co Sulfuric acid esters of hyaluronic acid and processes for the production thereof
FR1714M (fr) * 1960-12-29 1963-02-25 Chugai Pharmaceutical Co Ltd Sulfates de polysaccharides faiblement polymérisés.
DE1418844A1 (de) * 1961-05-24 1969-05-08 Hoechst Ag Verfahren zur Herstellung von gegebenenfalls Phosphatgruppen enthaltenden Polysacchariden
US3454560A (en) * 1966-03-01 1969-07-08 Seikagaku Kogyo Co Ltd Process for the production of chondroitin polysulfate
US3506642A (en) * 1967-07-03 1970-04-14 Canada Packers Ltd Stable orally active heparinoid complexes
IT1083903B (it) * 1977-08-09 1985-05-25 Lobo Srl Oligo-eteropolisaccaridi con attivita' eparinosimili,procedimento per il loro ottenimento e relative composizioni terapeutiche
SE7811306L (sv) * 1978-11-01 1980-05-02 Rothman Gunnvor Antikoagulationsmedel samt sett for dess framstellning
JPS57134419A (en) * 1981-02-12 1982-08-19 Eisai Co Ltd Stable anticoagulant of blood
DE3244214A1 (de) * 1982-11-30 1984-05-30 B. Braun Melsungen Ag, 3508 Melsungen Verfahren zur reinigung und fraktionierung von heparin
CA1218986A (en) * 1982-12-28 1987-03-10 Annamaria Naggi Process for the depolymerisation and sulfatation of polysaccharides
US4948881A (en) * 1982-12-28 1990-08-14 Sanofi Process for the depolymerization and sulfation of polysaccharides
FR2538404B1 (it) * 1982-12-28 1985-08-23 Anic Spa
FR2548672A1 (fr) * 1983-07-04 1985-01-11 Pharmuka Lab Oligosaccharides sulfates et leur utilisation comme medicaments
JPS6049001A (ja) * 1983-08-30 1985-03-18 Eisai Co Ltd アンチトロンビン３低親和性ヘパリン
FR2584728B1 (fr) * 1985-07-12 1987-11-20 Choay Sa Procede de sulfatation de glycosaminoglycanes et de leurs fragments
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
DE3734815A1 (de) * 1987-10-14 1989-04-27 Luitpold Werk Chem Pharm Polyschwefelsaeureester von bis-aldonsaeureamiden und deren derivaten, verfahren zu ihrer herstellung und arzneimittel
DE3744119A1 (de) * 1987-12-24 1989-07-06 Basf Ag Verwendung von polysulfatierten heparinen
EP0423151B1 (en) * 1988-06-03 1993-09-22 ITALFARMACO S.p.A. Glycosaminoglycan salts, processes for the preparation thereof and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
DE69016383T2 (de) 1995-07-13
PT95961B (pt) 1996-12-31
EP0432537B1 (en) 1995-01-25
DE69016383D1 (de) 1995-03-09
PT95961A (pt) 1991-09-13
IT8922504A1 (it) 1991-05-24
US5164378A (en) 1992-11-17
ES2068969T3 (es) 1995-05-01
EP0432537A2 (en) 1991-06-19
EP0432537A3 (en) 1991-11-13
ATE117697T1 (de) 1995-02-15
JPH03210302A (ja) 1991-09-13
IT8922504A0 (it) 1989-11-24
IE904225A1 (en) 1991-06-05

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Legal Events

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0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19951219