IT1194795B - Procedimento per la eliminazione del gruppo n-formile da peptidi n-formilati e da esteri di peptidi n-formilati - Google Patents

Procedimento per la eliminazione del gruppo n-formile da peptidi n-formilati e da esteri di peptidi n-formilati

Info

Publication number
IT1194795B
IT1194795B IT21674/81A IT2167481A IT1194795B IT 1194795 B IT1194795 B IT 1194795B IT 21674/81 A IT21674/81 A IT 21674/81A IT 2167481 A IT2167481 A IT 2167481A IT 1194795 B IT1194795 B IT 1194795B
Authority
IT
Italy
Prior art keywords
formilated
formile
peptid
peptides
elimination
Prior art date
Application number
IT21674/81A
Other languages
English (en)
Other versions
IT8121674A0 (it
IT8121674A1 (it
Inventor
Vincenzo Giobbio
Giorgio Ornato
Livio Buracchi
Alberto Mangia
Original Assignee
Pierrel Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierrel Spa filed Critical Pierrel Spa
Publication of IT8121674A0 publication Critical patent/IT8121674A0/it
Priority to IT21674/81A priority Critical patent/IT1194795B/it
Priority to FI821412A priority patent/FI821412L/fi
Priority to US06/372,216 priority patent/US4434097A/en
Priority to ES511760A priority patent/ES511760A0/es
Priority to YU00938/82A priority patent/YU93882A/xx
Priority to CA000402109A priority patent/CA1244406A/en
Priority to CH2642/82A priority patent/CH648566A5/it
Priority to NL8201821A priority patent/NL8201821A/nl
Priority to DE3216512A priority patent/DE3216512C2/de
Priority to SE8202787A priority patent/SE8202787L/
Priority to BE2/59692A priority patent/BE893074A/fr
Priority to GB8213232A priority patent/GB2098220B/en
Priority to AT0183082A priority patent/ATA183082A/de
Priority to DK208082A priority patent/DK208082A/da
Priority to JP57079805A priority patent/JPS5810546A/ja
Priority to NZ200583A priority patent/NZ200583A/en
Priority to ZA823232A priority patent/ZA823232B/xx
Priority to NO821585A priority patent/NO821585L/no
Priority to AU83612/82A priority patent/AU537275B2/en
Priority to PT74892A priority patent/PT74892B/pt
Priority to GR68142A priority patent/GR75497B/el
Priority to KR8202080A priority patent/KR840001342B1/ko
Priority to FR8208355A priority patent/FR2505829B1/fr
Publication of IT8121674A1 publication Critical patent/IT8121674A1/it
Application granted granted Critical
Publication of IT1194795B publication Critical patent/IT1194795B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C07K1/124—Hydrazinolysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IT21674/81A 1981-05-13 1981-05-13 Procedimento per la eliminazione del gruppo n-formile da peptidi n-formilati e da esteri di peptidi n-formilati IT1194795B (it)

Priority Applications (23)

Application Number Priority Date Filing Date Title
IT21674/81A IT1194795B (it) 1981-05-13 1981-05-13 Procedimento per la eliminazione del gruppo n-formile da peptidi n-formilati e da esteri di peptidi n-formilati
FI821412A FI821412L (fi) 1981-05-13 1982-04-23 Foerfarande foer avlaegsning av formylgruppen fraon n-formylpeptider och deras estrar
US06/372,216 US4434097A (en) 1981-05-13 1982-04-26 Process for the removal of the formyl group from N-formyl peptides and esters thereof
ES511760A ES511760A0 (es) 1981-05-13 1982-04-28 Procedimiento para eliminar el grupo n-formilo de peptidos n-formilo de peptidos n-formilados o de esteres de peptidos n-formilados.
YU00938/82A YU93882A (en) 1981-05-13 1982-04-29 Process for the separation of the formyl group of n-peptides and esters thereof
CA000402109A CA1244406A (en) 1981-05-13 1982-04-30 Process for the removal of the formyl group from n- formyl peptides and esters thereof
CH2642/82A CH648566A5 (it) 1981-05-13 1982-04-30 Procedimento per la eliminazione del gruppo n-formile da peptidi n-formilati e da esteri di peptidi n-formilati.
NL8201821A NL8201821A (nl) 1981-05-13 1982-05-03 Werkwijze voor het verwijderen van de formylgroep van n-formylpeptiden en esters daarvan.
DE3216512A DE3216512C2 (de) 1981-05-13 1982-05-03 Verfahren zur Abspaltung der Formylgruppe aus Estern von N↑α↑-Formylpeptiden mit primären und sekundären Alkoholen
SE8202787A SE8202787L (sv) 1981-05-13 1982-05-04 Forfarande for avlegsnande av formylgruppen fran n-formylpeptider och estrar derav
BE2/59692A BE893074A (fr) 1981-05-13 1982-05-05 Werkwijze voor het verwijderen van de formulgroep van n-formyl-peptiden en esters daarvan
GB8213232A GB2098220B (en) 1981-05-13 1982-05-07 Removal of formyl groups from n-formyl peptides
AT0183082A ATA183082A (de) 1981-05-13 1982-05-10 Verfahren zur entfernung der formylgruppe aus einem ester eines n-formylierten peptids
DK208082A DK208082A (da) 1981-05-13 1982-05-10 Fremgangsmaade til fjernelse af formylgruppen fra n-formylpeptider og estere deraf
JP57079805A JPS5810546A (ja) 1981-05-13 1982-05-11 Ｎ−ホルミルペプチドエステルからホルミル基を除去する方法
NZ200583A NZ200583A (en) 1981-05-13 1982-05-11 A method of removing formyl groups from formulated peptides or esters of peptides
ZA823232A ZA823232B (en) 1981-05-13 1982-05-11 Process for the removal of the formyl group from n-formyl peptides and esters thereof
PT74892A PT74892B (en) 1981-05-13 1982-05-12 Process for the removal of the formyl group from n-formyl peptides and esters thereof
AU83612/82A AU537275B2 (en) 1981-05-13 1982-05-12 Removal of n-formyl protecting group from peptides with hydrazine or hydrazides
NO821585A NO821585L (no) 1981-05-13 1982-05-12 Fremgangsmaate ved fjerning av formylgruppen fra n-formylpeptider og estere derav
GR68142A GR75497B (it) 1981-05-13 1982-05-13
KR8202080A KR840001342B1 (ko) 1981-05-13 1982-05-13 N-포밀 펩타이드로부터 포밀그룹 제거방법
FR8208355A FR2505829B1 (fr) 1981-05-13 1982-05-13 Procede pour l'elimination du groupe n-formyle de peptides n-formyles et d'esters de peptides n-formyles

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21674/81A IT1194795B (it) 1981-05-13 1981-05-13 Procedimento per la eliminazione del gruppo n-formile da peptidi n-formilati e da esteri di peptidi n-formilati

Publications (3)

Publication Number Publication Date
IT8121674A0 IT8121674A0 (it) 1981-05-13
IT8121674A1 IT8121674A1 (it) 1982-11-13
IT1194795B true IT1194795B (it) 1988-09-28

Family

ID=11185195

Family Applications (1)

Application Number Title Priority Date Filing Date
IT21674/81A IT1194795B (it) 1981-05-13 1981-05-13 Procedimento per la eliminazione del gruppo n-formile da peptidi n-formilati e da esteri di peptidi n-formilati

Country Status (23)

Country Link
US (1) US4434097A (it)
JP (1) JPS5810546A (it)
KR (1) KR840001342B1 (it)
AT (1) ATA183082A (it)
AU (1) AU537275B2 (it)
BE (1) BE893074A (it)
CA (1) CA1244406A (it)
CH (1) CH648566A5 (it)
DE (1) DE3216512C2 (it)
DK (1) DK208082A (it)
ES (1) ES511760A0 (it)
FI (1) FI821412L (it)
FR (1) FR2505829B1 (it)
GB (1) GB2098220B (it)
GR (1) GR75497B (it)
IT (1) IT1194795B (it)
NL (1) NL8201821A (it)
NO (1) NO821585L (it)
NZ (1) NZ200583A (it)
PT (1) PT74892B (it)
SE (1) SE8202787L (it)
YU (1) YU93882A (it)
ZA (1) ZA823232B (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4555362A (en) * 1983-06-20 1985-11-26 G. D. Searle & Co. Method and intermediates for producing α-L-aspartyl-L-phenylalanine
IT1190395B (it) * 1985-09-30 1988-02-16 Lark Spa Procedimento per la rimozione del gruppo formile da un estere di n-formil peptide o di n-formil amminoacido
DE60334912D1 (de) * 2002-05-24 2010-12-23 Medtronic Inc Polypeptid-spaltungsprozess

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1543610A1 (de) * 1966-08-27 1969-07-31 Hoechst Ag Verfahren zur Herstellung von Aminosaeuren und Peptiden und deren Derivaten
US3933781A (en) * 1973-11-05 1976-01-20 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters
JPS5823380B2 (ja) * 1974-12-05 1983-05-14 味の素株式会社 ホルミルキノ ダツリホウ
JPS5223001A (en) * 1975-08-14 1977-02-21 Ajinomoto Co Inc Process for elimination of formyl group

Also Published As

Publication number Publication date
ES8302633A1 (es) 1983-02-01
PT74892A (en) 1982-06-01
DE3216512A1 (de) 1982-12-23
KR840001342B1 (ko) 1984-09-19
CA1244406A (en) 1988-11-08
FR2505829A1 (fr) 1982-11-19
FR2505829B1 (fr) 1985-10-25
BE893074A (fr) 1982-08-30
NO821585L (no) 1982-11-15
US4434097A (en) 1984-02-28
GB2098220A (en) 1982-11-17
ZA823232B (en) 1983-03-30
GR75497B (it) 1984-07-24
FI821412L (fi) 1982-11-14
NZ200583A (en) 1984-12-14
JPS5810546A (ja) 1983-01-21
AU537275B2 (en) 1984-06-14
IT8121674A0 (it) 1981-05-13
PT74892B (en) 1984-08-02
CH648566A5 (it) 1985-03-29
SE8202787L (sv) 1982-11-14
KR830010053A (ko) 1983-12-24
GB2098220B (en) 1984-08-15
DK208082A (da) 1982-11-14
IT8121674A1 (it) 1982-11-13
YU93882A (en) 1985-08-31
ES511760A0 (es) 1983-02-01
DE3216512C2 (de) 1986-09-11
AU8361282A (en) 1982-11-18
ATA183082A (de) 1989-04-15
JPS616080B2 (it) 1986-02-24
NL8201821A (nl) 1982-12-01
FI821412A0 (fi) 1982-04-23

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