IT1185759B - Procedimento per la preparazione della 5-(e)-(2-bromovinil)-2'--desossiuri dina e dei suoi derivati,e derivati della 5-(e)-(2--bromovinil)-2'-desossiuridina - Google Patents
Procedimento per la preparazione della 5-(e)-(2-bromovinil)-2'--desossiuri dina e dei suoi derivati,e derivati della 5-(e)-(2--bromovinil)-2'-desossiuridinaInfo
- Publication number
- IT1185759B IT1185759B IT22401/83A IT2240183A IT1185759B IT 1185759 B IT1185759 B IT 1185759B IT 22401/83 A IT22401/83 A IT 22401/83A IT 2240183 A IT2240183 A IT 2240183A IT 1185759 B IT1185759 B IT 1185759B
- Authority
- IT
- Italy
- Prior art keywords
- bromovinyl
- derivatives
- dyoxyxiers
- desoxyururidine
- procedure
- Prior art date
Links
- -1 2-BROMOVINYL Chemical class 0.000 title 2
- 238000000034 method Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU822506A HU187736B (en) | 1982-08-04 | 1982-08-04 | Process for producing /e/ -5-/2-bromovinyl/-2-comma above-deoxyuridine and o-acyl derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8322401A0 IT8322401A0 (it) | 1983-08-03 |
IT1185759B true IT1185759B (it) | 1987-11-18 |
Family
ID=10959738
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT22401/83A IT1185759B (it) | 1982-08-04 | 1983-08-03 | Procedimento per la preparazione della 5-(e)-(2-bromovinil)-2'--desossiuri dina e dei suoi derivati,e derivati della 5-(e)-(2--bromovinil)-2'-desossiuridina |
Country Status (12)
Country | Link |
---|---|
AT (1) | AT380688B (it) |
BE (1) | BE897434A (it) |
CH (1) | CH660486A5 (it) |
CS (1) | CS251078B2 (it) |
DE (1) | DE3328238A1 (it) |
FI (1) | FI74289C (it) |
FR (1) | FR2531437B1 (it) |
GB (1) | GB2125399B (it) |
HU (1) | HU187736B (it) |
IT (1) | IT1185759B (it) |
PL (1) | PL143289B1 (it) |
YU (1) | YU162683A (it) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA005497B1 (ru) * | 2001-01-03 | 2005-02-24 | Берлин Хеми Аг | Применение фармацевтической композиции, содержащей бривудин, для лечения герпесвирусных инфекций |
DE10109657A1 (de) * | 2001-02-28 | 2002-09-05 | Menarini Ricerche Spa | Verfahren zur Herstellung von (E)-5-(2-Bromvinyl)-2`-desoxyuridin |
CN102432655A (zh) * | 2011-10-28 | 2012-05-02 | 河南师范大学 | 一种合成5-((e)-2-溴乙烯基)-2′-脱氧尿嘧啶核苷(溴呋啶)的方法 |
EP3792271A1 (en) | 2019-09-13 | 2021-03-17 | Aurobindo Pharma Limited | A process for the preparation of brivudine |
CN115043894A (zh) * | 2022-06-22 | 2022-09-13 | 华润双鹤药业股份有限公司 | 一种溴夫定起始物料异构体单晶及其制备方法和应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2721466A1 (de) * | 1977-05-12 | 1978-11-16 | Robugen Gmbh | Verfahren zur herstellung von 2'-desoxyribofuranosylnucleosiden |
GB1601020A (en) * | 1978-04-24 | 1981-10-21 | Stichting Grega Vzw | 2'-deoxy-5 (2-halogenovinyl)-uridines |
DE3002197A1 (de) * | 1980-01-22 | 1981-07-23 | Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen | 5-alkylsubstituierte pyrimidin-nukleoside, verfahren zu deren herstellung und daraus hergestellte virostatische und cytostatische mittel |
NZ199764A (en) * | 1981-03-20 | 1984-08-24 | Beecham Group Plc | 5-(2-halogenovinyl)-2'-deoxyuridine derivatives and pharmaceutical compositions |
HU183567B (en) * | 1981-09-07 | 1984-05-28 | Mta Koezponti Kemiai Kutato In | Process for preparing /e/-5-/2-bromo-vinyl/-uridine and derivatives thereof |
EP0082668A1 (en) * | 1981-12-18 | 1983-06-29 | Beecham Group Plc | 5-(2-Halogenovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in treating viral infections |
EP0095294A1 (en) * | 1982-05-22 | 1983-11-30 | Beecham Group Plc | Deoxyuridine compounds, methods for preparing them and their use in medicine |
EP0097039A1 (en) * | 1982-06-16 | 1983-12-28 | Beecham Group Plc | 5-(E-2-halovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them, and their use in treating viral infections |
-
1982
- 1982-08-04 HU HU822506A patent/HU187736B/hu unknown
-
1983
- 1983-07-22 CH CH4019/83A patent/CH660486A5/de not_active IP Right Cessation
- 1983-08-01 BE BE1/10845A patent/BE897434A/fr not_active IP Right Cessation
- 1983-08-03 FI FI832809A patent/FI74289C/fi not_active IP Right Cessation
- 1983-08-03 CS CS835756A patent/CS251078B2/cs unknown
- 1983-08-03 FR FR8312777A patent/FR2531437B1/fr not_active Expired
- 1983-08-03 IT IT22401/83A patent/IT1185759B/it active
- 1983-08-04 PL PL1983243307A patent/PL143289B1/pl unknown
- 1983-08-04 GB GB08321081A patent/GB2125399B/en not_active Expired
- 1983-08-04 YU YU01626/83A patent/YU162683A/xx unknown
- 1983-08-04 DE DE3328238A patent/DE3328238A1/de not_active Withdrawn
- 1983-08-04 AT AT0282583A patent/AT380688B/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
GB8321081D0 (en) | 1983-09-07 |
PL243307A1 (en) | 1984-11-08 |
PL143289B1 (en) | 1988-01-30 |
GB2125399A (en) | 1984-03-07 |
ATA282583A (de) | 1985-11-15 |
IT8322401A0 (it) | 1983-08-03 |
HU187736B (en) | 1986-02-28 |
BE897434A (fr) | 1984-02-01 |
FR2531437B1 (fr) | 1985-10-25 |
FI832809A (fi) | 1984-02-05 |
CH660486A5 (de) | 1987-04-30 |
GB2125399B (en) | 1987-04-01 |
AT380688B (de) | 1986-06-25 |
FR2531437A1 (fr) | 1984-02-10 |
CS251078B2 (en) | 1987-06-11 |
DE3328238A1 (de) | 1984-02-23 |
FI74289B (fi) | 1987-09-30 |
FI74289C (fi) | 1988-01-11 |
YU162683A (en) | 1986-02-28 |
FI832809A0 (fi) | 1983-08-03 |
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