PL243307A1 - Process for preparing 5-/e/-/2-bromovinyl/-2'-desoxyuridine and its novel derivatives - Google Patents
Process for preparing 5-/e/-/2-bromovinyl/-2'-desoxyuridine and its novel derivativesInfo
- Publication number
- PL243307A1 PL243307A1 PL24330783A PL24330783A PL243307A1 PL 243307 A1 PL243307 A1 PL 243307A1 PL 24330783 A PL24330783 A PL 24330783A PL 24330783 A PL24330783 A PL 24330783A PL 243307 A1 PL243307 A1 PL 243307A1
- Authority
- PL
- Poland
- Prior art keywords
- desoxyuridine
- bromovinyl
- preparing
- novel derivatives
- derivatives
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU822506A HU187736B (en) | 1982-08-04 | 1982-08-04 | Process for producing /e/ -5-/2-bromovinyl/-2-comma above-deoxyuridine and o-acyl derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
PL243307A1 true PL243307A1 (en) | 1984-11-08 |
PL143289B1 PL143289B1 (en) | 1988-01-30 |
Family
ID=10959738
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL1983243307A PL143289B1 (en) | 1982-08-04 | 1983-08-04 | Process for preparing 5-/e/-/2-bromovinyl/-2'-desoxyuridine and its novel derivatives |
Country Status (12)
Country | Link |
---|---|
AT (1) | AT380688B (en) |
BE (1) | BE897434A (en) |
CH (1) | CH660486A5 (en) |
CS (1) | CS251078B2 (en) |
DE (1) | DE3328238A1 (en) |
FI (1) | FI74289C (en) |
FR (1) | FR2531437B1 (en) |
GB (1) | GB2125399B (en) |
HU (1) | HU187736B (en) |
IT (1) | IT1185759B (en) |
PL (1) | PL143289B1 (en) |
YU (1) | YU162683A (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA005497B1 (en) * | 2001-01-03 | 2005-02-24 | Берлин Хеми Аг | One-day pharmaceutical composition containing brivudine |
DE10109657A1 (en) * | 2001-02-28 | 2002-09-05 | Menarini Ricerche Spa | Process for the preparation of (E) -5- (2-bromovinyl) -2`-deoxyuridine |
CN102432655A (en) * | 2011-10-28 | 2012-05-02 | 河南师范大学 | Method for synthesizing 5-((E)-2-bromovinyl)-2'-deoxyuridine (brivudine) |
EP3792271A1 (en) | 2019-09-13 | 2021-03-17 | Aurobindo Pharma Limited | A process for the preparation of brivudine |
CN115043894A (en) * | 2022-06-22 | 2022-09-13 | 华润双鹤药业股份有限公司 | Brivudine starting material isomer single crystal and preparation method and application thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2721466A1 (en) * | 1977-05-12 | 1978-11-16 | Robugen Gmbh | PROCESS FOR THE PREPARATION OF 2'-DESOXYRIBOFURANOSYL NUCLEOSIDES |
GB1601020A (en) * | 1978-04-24 | 1981-10-21 | Stichting Grega Vzw | 2'-deoxy-5 (2-halogenovinyl)-uridines |
DE3002197A1 (en) * | 1980-01-22 | 1981-07-23 | Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen | 5-Alkyl- and 5-alkenyl-uracil and -cytidine nucleoside derivs. - prepd. e.g. by reaction of 5'-chloro-5'-deoxy cpds. with ammonia |
NZ199764A (en) * | 1981-03-20 | 1984-08-24 | Beecham Group Plc | 5-(2-halogenovinyl)-2'-deoxyuridine derivatives and pharmaceutical compositions |
HU183567B (en) * | 1981-09-07 | 1984-05-28 | Mta Koezponti Kemiai Kutato In | Process for preparing /e/-5-/2-bromo-vinyl/-uridine and derivatives thereof |
EP0082668A1 (en) * | 1981-12-18 | 1983-06-29 | Beecham Group Plc | 5-(2-Halogenovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in treating viral infections |
EP0095294A1 (en) * | 1982-05-22 | 1983-11-30 | Beecham Group Plc | Deoxyuridine compounds, methods for preparing them and their use in medicine |
EP0097039A1 (en) * | 1982-06-16 | 1983-12-28 | Beecham Group Plc | 5-(E-2-halovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them, and their use in treating viral infections |
-
1982
- 1982-08-04 HU HU822506A patent/HU187736B/en unknown
-
1983
- 1983-07-22 CH CH4019/83A patent/CH660486A5/en not_active IP Right Cessation
- 1983-08-01 BE BE1/10845A patent/BE897434A/en not_active IP Right Cessation
- 1983-08-03 FI FI832809A patent/FI74289C/en not_active IP Right Cessation
- 1983-08-03 CS CS835756A patent/CS251078B2/en unknown
- 1983-08-03 FR FR8312777A patent/FR2531437B1/en not_active Expired
- 1983-08-03 IT IT22401/83A patent/IT1185759B/en active
- 1983-08-04 PL PL1983243307A patent/PL143289B1/en unknown
- 1983-08-04 GB GB08321081A patent/GB2125399B/en not_active Expired
- 1983-08-04 YU YU01626/83A patent/YU162683A/en unknown
- 1983-08-04 DE DE3328238A patent/DE3328238A1/en not_active Withdrawn
- 1983-08-04 AT AT0282583A patent/AT380688B/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IT1185759B (en) | 1987-11-18 |
GB8321081D0 (en) | 1983-09-07 |
PL143289B1 (en) | 1988-01-30 |
GB2125399A (en) | 1984-03-07 |
ATA282583A (en) | 1985-11-15 |
IT8322401A0 (en) | 1983-08-03 |
HU187736B (en) | 1986-02-28 |
BE897434A (en) | 1984-02-01 |
FR2531437B1 (en) | 1985-10-25 |
FI832809A (en) | 1984-02-05 |
CH660486A5 (en) | 1987-04-30 |
GB2125399B (en) | 1987-04-01 |
AT380688B (en) | 1986-06-25 |
FR2531437A1 (en) | 1984-02-10 |
CS251078B2 (en) | 1987-06-11 |
DE3328238A1 (en) | 1984-02-23 |
FI74289B (en) | 1987-09-30 |
FI74289C (en) | 1988-01-11 |
YU162683A (en) | 1986-02-28 |
FI832809A0 (en) | 1983-08-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0165537A3 (en) | Process for the preparation of heteroaryloxyacetamides | |
PT80783A (en) | Process for the preparation of benzimidazols bezoxazols and benzothiazols | |
HUT39479A (en) | Process for preparing 4'-dechloro-rebeccamicin | |
PT79818A (en) | Process for the preparation of alpha-acetylamin-ergolines | |
HRP921043B1 (en) | Process for the preparation of hydroxy-4-2h-1-benzothiopyrane-2-ones | |
PT80805A (en) | Process for the preparation of fluoroallylamine derivatives | |
PT80919A (en) | Process for the preparation of 3-arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1h-indoles | |
PL238159A1 (en) | Process for preparing novel /e/-5-/2-bromovinyl/-uridine and its derivatives | |
PL243307A1 (en) | Process for preparing 5-/e/-/2-bromovinyl/-2'-desoxyuridine and its novel derivatives | |
GB2158824B (en) | Process for the preparation of 2-amino-s-triazines | |
DE3570653D1 (en) | Process for the preparation of beta-aminoethylketones | |
DE3364995D1 (en) | Thiophene-2-carboxylic-acid derivatives and process for their preparation | |
PT80634A (en) | Process for the preparation of naftoxazines | |
DE3566249D1 (en) | Process for the preparation of fluoroformiates | |
DE3560035D1 (en) | Process for the preparation of 2-methyl-2-alkenals | |
DE3264631D1 (en) | 4-halogenostilbene derivatives and process for their preparation | |
DE3560314D1 (en) | Process for the preparation of alkylidene and arylidene compounds | |
EP0173202A3 (en) | Process for the preparation of chloro-o-nitroanilines | |
GB2155478B (en) | 1a-hydroxyvitamin d2 analogs and process for preparing same | |
EP0175364A3 (en) | Process for the preparation of alpha-beta-diaminoacrylnitriles | |
PL249198A1 (en) | Process for preparing n-phosphonmethylglycine and its derivatives | |
IL67581A0 (en) | Aminopropylaminobleomycin derivatives and process for preparation thereof | |
ZA857285B (en) | Process for the preparation of lime-nitrogen | |
EP0166214A3 (en) | Process for the preparation of dialkylsuccinylsuccinat | |
DE3564576D1 (en) | Process for the preparation of riboflavin |