IT1185759B - PROCEDURE FOR THE PREPARATION OF 5- (E) - (2-BROMOVINYL) -2 '- DYOXYXIERS AND ITS DERIVATIVES, AND DERIVATIVES OF 5- (E) - (2 - BROMOVINYL) -2'-DESOXYURURIDINE - Google Patents

PROCEDURE FOR THE PREPARATION OF 5- (E) - (2-BROMOVINYL) -2 '- DYOXYXIERS AND ITS DERIVATIVES, AND DERIVATIVES OF 5- (E) - (2 - BROMOVINYL) -2'-DESOXYURURIDINE

Info

Publication number
IT1185759B
IT1185759B IT22401/83A IT2240183A IT1185759B IT 1185759 B IT1185759 B IT 1185759B IT 22401/83 A IT22401/83 A IT 22401/83A IT 2240183 A IT2240183 A IT 2240183A IT 1185759 B IT1185759 B IT 1185759B
Authority
IT
Italy
Prior art keywords
bromovinyl
derivatives
dyoxyxiers
desoxyururidine
procedure
Prior art date
Application number
IT22401/83A
Other languages
Italian (it)
Other versions
IT8322401A0 (en
Inventor
Anna Szabolos
Laszlo Otvos
Janos Sagi
Helga Todos
Zoltan Ratonyi
Tibor Gal
Lajos Voroshazy
Ivan Daroczy
Dieter Barwolf
Jurgen Refschalager
Hellmut Just
Original Assignee
Magyar Tudomanyos Akademia
Akad Wissenschaften Ddr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Magyar Tudomanyos Akademia, Akad Wissenschaften Ddr filed Critical Magyar Tudomanyos Akademia
Publication of IT8322401A0 publication Critical patent/IT8322401A0/en
Application granted granted Critical
Publication of IT1185759B publication Critical patent/IT1185759B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT22401/83A 1982-08-04 1983-08-03 PROCEDURE FOR THE PREPARATION OF 5- (E) - (2-BROMOVINYL) -2 '- DYOXYXIERS AND ITS DERIVATIVES, AND DERIVATIVES OF 5- (E) - (2 - BROMOVINYL) -2'-DESOXYURURIDINE IT1185759B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU822506A HU187736B (en) 1982-08-04 1982-08-04 Process for producing /e/ -5-/2-bromovinyl/-2-comma above-deoxyuridine and o-acyl derivatives

Publications (2)

Publication Number Publication Date
IT8322401A0 IT8322401A0 (en) 1983-08-03
IT1185759B true IT1185759B (en) 1987-11-18

Family

ID=10959738

Family Applications (1)

Application Number Title Priority Date Filing Date
IT22401/83A IT1185759B (en) 1982-08-04 1983-08-03 PROCEDURE FOR THE PREPARATION OF 5- (E) - (2-BROMOVINYL) -2 '- DYOXYXIERS AND ITS DERIVATIVES, AND DERIVATIVES OF 5- (E) - (2 - BROMOVINYL) -2'-DESOXYURURIDINE

Country Status (12)

Country Link
AT (1) AT380688B (en)
BE (1) BE897434A (en)
CH (1) CH660486A5 (en)
CS (1) CS251078B2 (en)
DE (1) DE3328238A1 (en)
FI (1) FI74289C (en)
FR (1) FR2531437B1 (en)
GB (1) GB2125399B (en)
HU (1) HU187736B (en)
IT (1) IT1185759B (en)
PL (1) PL143289B1 (en)
YU (1) YU162683A (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA005497B1 (en) * 2001-01-03 2005-02-24 Берлин Хеми Аг One-day pharmaceutical composition containing brivudine
DE10109657A1 (en) * 2001-02-28 2002-09-05 Menarini Ricerche Spa Process for the preparation of (E) -5- (2-bromovinyl) -2`-deoxyuridine
CN102432655A (en) * 2011-10-28 2012-05-02 河南师范大学 Method for synthesizing 5-((E)-2-bromovinyl)-2'-deoxyuridine (brivudine)
EP3792271A1 (en) 2019-09-13 2021-03-17 Aurobindo Pharma Limited A process for the preparation of brivudine
CN115043894A (en) * 2022-06-22 2022-09-13 华润双鹤药业股份有限公司 Brivudine starting material isomer single crystal and preparation method and application thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2721466A1 (en) * 1977-05-12 1978-11-16 Robugen Gmbh PROCESS FOR THE PREPARATION OF 2'-DESOXYRIBOFURANOSYL NUCLEOSIDES
GB1601020A (en) * 1978-04-24 1981-10-21 Stichting Grega Vzw 2'-deoxy-5 (2-halogenovinyl)-uridines
DE3002197A1 (en) * 1980-01-22 1981-07-23 Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen 5-Alkyl- and 5-alkenyl-uracil and -cytidine nucleoside derivs. - prepd. e.g. by reaction of 5'-chloro-5'-deoxy cpds. with ammonia
NZ199764A (en) * 1981-03-20 1984-08-24 Beecham Group Plc 5-(2-halogenovinyl)-2'-deoxyuridine derivatives and pharmaceutical compositions
HU183567B (en) * 1981-09-07 1984-05-28 Mta Koezponti Kemiai Kutato In Process for preparing /e/-5-/2-bromo-vinyl/-uridine and derivatives thereof
EP0082668A1 (en) * 1981-12-18 1983-06-29 Beecham Group Plc 5-(2-Halogenovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in treating viral infections
EP0095294A1 (en) * 1982-05-22 1983-11-30 Beecham Group Plc Deoxyuridine compounds, methods for preparing them and their use in medicine
EP0097039A1 (en) * 1982-06-16 1983-12-28 Beecham Group Plc 5-(E-2-halovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them, and their use in treating viral infections

Also Published As

Publication number Publication date
GB8321081D0 (en) 1983-09-07
PL243307A1 (en) 1984-11-08
PL143289B1 (en) 1988-01-30
GB2125399A (en) 1984-03-07
ATA282583A (en) 1985-11-15
IT8322401A0 (en) 1983-08-03
HU187736B (en) 1986-02-28
BE897434A (en) 1984-02-01
FR2531437B1 (en) 1985-10-25
FI832809A (en) 1984-02-05
CH660486A5 (en) 1987-04-30
GB2125399B (en) 1987-04-01
AT380688B (en) 1986-06-25
FR2531437A1 (en) 1984-02-10
CS251078B2 (en) 1987-06-11
DE3328238A1 (en) 1984-02-23
FI74289B (en) 1987-09-30
FI74289C (en) 1988-01-11
YU162683A (en) 1986-02-28
FI832809A0 (en) 1983-08-03

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