IT1145403B - Derivati di 1,2-diidro-2-osso-4-fenil-3-chinolin-carbonitrile dotati di proprieta' anti-infiammatorie - Google Patents
Derivati di 1,2-diidro-2-osso-4-fenil-3-chinolin-carbonitrile dotati di proprieta' anti-infiammatorieInfo
- Publication number
- IT1145403B IT1145403B IT8047580A IT4758080A IT1145403B IT 1145403 B IT1145403 B IT 1145403B IT 8047580 A IT8047580 A IT 8047580A IT 4758080 A IT4758080 A IT 4758080A IT 1145403 B IT1145403 B IT 1145403B
- Authority
- IT
- Italy
- Prior art keywords
- fenyl
- quinolin
- dihydro
- bone
- inflammatory properties
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/007,069 US4232027A (en) | 1979-01-29 | 1979-01-29 | 1,2-Dihydro-2-oxo-4-phenyl-3-quinolinecarbonitrile derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8047580A0 IT8047580A0 (it) | 1980-01-11 |
| IT1145403B true IT1145403B (it) | 1986-11-05 |
Family
ID=21724050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT8047580A IT1145403B (it) | 1979-01-29 | 1980-01-11 | Derivati di 1,2-diidro-2-osso-4-fenil-3-chinolin-carbonitrile dotati di proprieta' anti-infiammatorie |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4232027A (it) |
| JP (1) | JPS55102568A (it) |
| DE (1) | DE3003146A1 (it) |
| FR (1) | FR2447376A1 (it) |
| GB (1) | GB2041361B (it) |
| IT (1) | IT1145403B (it) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0024638A1 (en) * | 1979-08-30 | 1981-03-11 | Byk Gulden Lomberg Chemische Fabrik GmbH | Substituted quinolinone-alkanecarboxylic acids, their preparation, and medicaments containing them |
| JPH03181465A (ja) * | 1989-12-11 | 1991-08-07 | Takeda Chem Ind Ltd | キノリン誘導体 |
| TW384285B (en) * | 1994-03-08 | 2000-03-11 | Takeda Chemical Industries Ltd | Pharmaceutical composition containing quinoline or quinazoline derivatives and novel derivatives therefor |
| EP1667973B1 (en) * | 2003-09-23 | 2013-12-04 | Merck Sharp & Dohme Corp. | Quinoline potassium channel inhibitors |
| UA124474C2 (uk) | 2016-12-22 | 2021-09-22 | Емджен Інк. | БЕНЗІЗОТІАЗОЛЬНІ, ІЗОТІАЗОЛО[3,4-b]ПІРИДИНОВІ, ХІНАЗОЛІНОВІ, ФТАЛАЗИНОВІ, ПІРИДО[2,3-d]ПІРИДАЗИНОВІ Й ПІРИДО[2,3-d]ПІРИМІДИНОВІ ПОХІДНІ ЯК ІНГІБІТОРИ G12C KRAS ДЛЯ ЛІКУВАННЯ РАКУ ЛЕГЕНІ, РАКУ ПІДШЛУНКОВОЇ ЗАЛОЗИ АБО КОЛОРЕКТАЛЬНОГО РАКУ |
| JOP20190272A1 (ar) | 2017-05-22 | 2019-11-21 | Amgen Inc | مثبطات kras g12c وطرق لاستخدامها |
| AU2018329920B2 (en) | 2017-09-08 | 2022-12-01 | Amgen Inc. | Inhibitors of KRAS G12C and methods of using the same |
| MA52496A (fr) | 2018-05-04 | 2021-03-10 | Amgen Inc | Inhibiteurs de kras g12c et leurs procédés d'utilisation |
| JP7266043B2 (ja) | 2018-05-04 | 2023-04-27 | アムジエン・インコーポレーテツド | ＫＲａｓ Ｇ１２Ｃ阻害剤及びそれを使用する方法 |
| AU2019265822A1 (en) | 2018-05-10 | 2020-11-19 | Amgen Inc. | KRAS G12C inhibitors for the treatment of cancer |
| EP3802535B1 (en) | 2018-06-01 | 2022-12-14 | Amgen, Inc | Kras g12c inhibitors and methods of using the same |
| EP4268898A3 (en) * | 2018-06-11 | 2024-01-17 | Amgen Inc. | Kras g12c inhibitors for treating cancer |
| MX2020012261A (es) | 2018-06-12 | 2021-03-31 | Amgen Inc | Inhibidores de kras g12c que comprenden un anillo de piperazina y uso de estos en el tratamiento del cancer. |
| JP2020090482A (ja) | 2018-11-16 | 2020-06-11 | アムジエン・インコーポレーテツド | Ｋｒａｓ ｇ１２ｃ阻害剤化合物の重要な中間体の改良合成法 |
| EP3883565A1 (en) | 2018-11-19 | 2021-09-29 | Amgen Inc. | Kras g12c inhibitors and methods of using the same |
| JP7377679B2 (ja) | 2018-11-19 | 2023-11-10 | アムジエン・インコーポレーテツド | がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法 |
| EP3738593A1 (en) | 2019-05-14 | 2020-11-18 | Amgen, Inc | Dosing of kras inhibitor for treatment of cancers |
| KR20220011670A (ko) | 2019-05-21 | 2022-01-28 | 암젠 인크 | 고체 상태 형태 |
| WO2024102784A1 (en) * | 2022-11-09 | 2024-05-16 | Accutar Biotechnology, Inc. | Substituted quinolinone-8-carbonitrile derivatives having androgen degradation activity and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3210358A (en) * | 1961-08-09 | 1965-10-05 | Geigy Chem Corp | Substituted 4-amino carbostyrils |
| CH471784A (de) * | 1966-01-26 | 1969-04-30 | Bayer Ag | Verfahren zur Herstellung von Carbostyrilderivaten |
| US3763153A (en) * | 1972-02-22 | 1973-10-02 | Squibb & Sons Inc | Benzothiazines |
| US3895006A (en) * | 1974-04-19 | 1975-07-15 | Squibb & Sons Inc | 5-(Substituted amino)alkyl)-2-aryl-3-halo-1,5-benzothiazepin-4(5H)-ones |
| US3994900A (en) * | 1976-01-23 | 1976-11-30 | E. R. Squibb & Sons, Inc. | 6-(Or 8)-[[(substituted amino)alkyl]oxy(or thio)]-3,4-dihydro-4-phenyl-2(1H)-quinolinones |
-
1979
- 1979-01-29 US US06/007,069 patent/US4232027A/en not_active Expired - Lifetime
-
1980
- 1980-01-03 GB GB8000160A patent/GB2041361B/en not_active Expired
- 1980-01-11 IT IT8047580A patent/IT1145403B/it active
- 1980-01-28 JP JP923380A patent/JPS55102568A/ja active Pending
- 1980-01-29 DE DE19803003146 patent/DE3003146A1/de not_active Withdrawn
- 1980-01-29 FR FR8001874A patent/FR2447376A1/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DE3003146A1 (de) | 1980-08-07 |
| GB2041361A (en) | 1980-09-10 |
| US4232027A (en) | 1980-11-04 |
| IT8047580A0 (it) | 1980-01-11 |
| JPS55102568A (en) | 1980-08-05 |
| FR2447376A1 (fr) | 1980-08-22 |
| GB2041361B (en) | 1982-12-08 |
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