IN2014CN04183A - - Google Patents

Info

Publication number
IN2014CN04183A
IN2014CN04183A IN4183CHN2014A IN2014CN04183A IN 2014CN04183 A IN2014CN04183 A IN 2014CN04183A IN 4183CHN2014 A IN4183CHN2014 A IN 4183CHN2014A IN 2014CN04183 A IN2014CN04183 A IN 2014CN04183A
Authority
IN
India
Prior art keywords
antibodies
csf
relates
human anti
nucleic acid
Prior art date
Application number
Inventor
Martin Hegen
Deborah Ann Young
Heath M Guay
Joannopoulos Kyriaki Dunussi
Sudhakar Sridharan
Annette Diehl
Gail Comer
Margot Mary OTOOLE
Jean Elizabeth Beebe
Robert Fogel
Marek Honczarenko
David Beidler
Padmalatha Sunkara Reddy
Schack David Johannes Von
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IN2014CN04183A publication Critical patent/IN2014CN04183A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243—Colony Stimulating Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

Abstract

The present invention relates to antibodies and antigen binding portions thereof that specifically bind to a M CSF preferably human M CSF and that function to inhibit a M CSF. The invention also relates to human anti M CSF antibodies and antigen binding portions thereof. The invention also relates to antibodies that are chimeric bispecific derivatized single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti M CSF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti M CSF antibodies compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti M CSF antibodies. The invention also relates to transgenic animals and transgenic plants comprising nucleic acid molecules of the present invention.
IN4183CHN2014 2011-11-08 2012-11-02 IN2014CN04183A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161557175P 2011-11-08 2011-11-08
PCT/IB2012/056125 WO2013068902A1 (en) 2011-11-08 2012-11-02 Methods of treating inflammatory disorders using anti-m-csf antibodies

Publications (1)

Publication Number Publication Date
IN2014CN04183A true IN2014CN04183A (en) 2015-07-17

Family

ID=47216377

Family Applications (1)

Application Number Title Priority Date Filing Date
IN4183CHN2014 IN2014CN04183A (en) 2011-11-08 2012-11-02

Country Status (14)

Country Link
US (1) US20140286959A1 (en)
EP (1) EP2776467A1 (en)
JP (1) JP2013100281A (en)
KR (1) KR20140076602A (en)
CN (1) CN104271599A (en)
AU (1) AU2012335247A1 (en)
BR (1) BR112014011115A2 (en)
CA (1) CA2856149A1 (en)
HK (1) HK1205522A1 (en)
IL (1) IL232190A0 (en)
IN (1) IN2014CN04183A (en)
MX (1) MX2014005570A (en)
RU (1) RU2014114015A (en)
WO (1) WO2013068902A1 (en)

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CA2907973A1 (en) 2013-04-12 2014-10-16 Morphosys Ag Antibodies targeting m-csf
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CN105985435B (en) 2015-01-30 2019-10-15 嘉和生物药业有限公司 The mutant antibodies and its encoding gene of full source of people HER2 antibody and application
EP4169942A1 (en) 2016-03-11 2023-04-26 Scholar Rock, Inc. Tgfbeta1-binding immunoglobulins and use thereof
SG10201606949QA (en) 2016-08-19 2018-03-28 Singapore Health Serv Pte Ltd Immunosuppressive composition for use in treating immunological disorders
PE20191661A1 (en) * 2017-01-06 2019-11-11 Scholar Rock Inc INHIBITORS OF TGF BETA1 ISOFORM-SPECIFIC CONTEXT-PERMISIVES AND USE OF THE SAME
WO2018183366A1 (en) 2017-03-28 2018-10-04 Syndax Pharmaceuticals, Inc. Combination therapies of csf-1r or csf-1 antibodies and a t-cell engaging therapy
JP2020520943A (en) 2017-05-19 2020-07-16 シンダックス ファーマシューティカルズ， インコーポレイテッド Combination therapy

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Also Published As

Publication number Publication date
RU2014114015A (en) 2015-12-20
KR20140076602A (en) 2014-06-20
HK1205522A1 (en) 2015-12-18
MX2014005570A (en) 2014-05-30
EP2776467A1 (en) 2014-09-17
AU2012335247A1 (en) 2014-05-29
BR112014011115A2 (en) 2017-06-13
IL232190A0 (en) 2014-06-30
CN104271599A (en) 2015-01-07
US20140286959A1 (en) 2014-09-25
CA2856149A1 (en) 2013-05-16
JP2013100281A (en) 2013-05-23
WO2013068902A1 (en) 2013-05-16

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