WO2008019290A3 - Human antibodies to erbb 2 - Google Patents

Human antibodies to erbb 2 Download PDF

Info

Publication number
WO2008019290A3
WO2008019290A3 PCT/US2007/075078 US2007075078W WO2008019290A3 WO 2008019290 A3 WO2008019290 A3 WO 2008019290A3 US 2007075078 W US2007075078 W US 2007075078W WO 2008019290 A3 WO2008019290 A3 WO 2008019290A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibodies
erbb2
relates
nucleic acid
acid molecules
Prior art date
Application number
PCT/US2007/075078
Other languages
French (fr)
Other versions
WO2008019290A2 (en
Inventor
Sue Cartilage
Jianying Dong
Original Assignee
Astrazeneca Ab
Sue Cartilage
Jianying Dong
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2009523054A priority Critical patent/JP5638804B2/en
Application filed by Astrazeneca Ab, Sue Cartilage, Jianying Dong filed Critical Astrazeneca Ab
Priority to AU2007281774A priority patent/AU2007281774A1/en
Priority to ES07813707.2T priority patent/ES2613957T3/en
Priority to BRPI0714728-7A priority patent/BRPI0714728A2/en
Priority to MX2009001291A priority patent/MX2009001291A/en
Priority to CA002659631A priority patent/CA2659631A1/en
Priority to EP07813707.2A priority patent/EP2054444B1/en
Priority to US12/376,196 priority patent/US8350011B2/en
Publication of WO2008019290A2 publication Critical patent/WO2008019290A2/en
Publication of WO2008019290A3 publication Critical patent/WO2008019290A3/en
Priority to IL196701A priority patent/IL196701A0/en
Priority to NO20090424A priority patent/NO20090424L/en
Priority to US13/710,883 priority patent/US8858942B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to ErbB2, preferably human ErbB2. In another embodiment, the antibodies or antigen-binding portions thereof inhibit ErbB2. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins or portions thereof derived from human anti-ErbB2 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-ErbB2 antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
PCT/US2007/075078 2006-08-04 2007-08-02 Human antibodies to erbb 2 WO2008019290A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
CA002659631A CA2659631A1 (en) 2006-08-04 2007-08-02 Antibodies to erbb2
AU2007281774A AU2007281774A1 (en) 2006-08-04 2007-08-02 Human antibodies to ErbB 2
ES07813707.2T ES2613957T3 (en) 2006-08-04 2007-08-02 Antibodies against ERBB2
BRPI0714728-7A BRPI0714728A2 (en) 2006-08-04 2007-08-02 targeted binding agent, antibody, composition, isolated cell line isolated nucleic acid molecule, vector, host cell, methods for making a targeted binding agent, for isolating an antibody or antigen binding portion thereof, for making an antibody human monoclonal construct, to treat, prevent or alleviate the symptoms of a disorder, to inhibit the proliferation of a cancer cell, to inhibit an erbb2 activity in an erbb2 expressing cell, and to modulate an erbb2 activity in an erbb2 expressing cell. and non-human transgenic animal or transgenic plant
MX2009001291A MX2009001291A (en) 2006-08-04 2007-08-02 Human antibodies to erbb 2.
JP2009523054A JP5638804B2 (en) 2006-08-04 2007-08-02 Antibodies against ErbB2
EP07813707.2A EP2054444B1 (en) 2006-08-04 2007-08-02 Antibodies to erbb2
US12/376,196 US8350011B2 (en) 2006-08-04 2007-08-02 Antibodies to ErbB2
IL196701A IL196701A0 (en) 2006-08-04 2009-01-25 HUMAN ANTIBODIES TO ErbB2
NO20090424A NO20090424L (en) 2006-08-04 2009-01-28 Human antibodies to ErbB2
US13/710,883 US8858942B2 (en) 2006-08-04 2012-12-11 Antibodies directed to ERBB2

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83551406P 2006-08-04 2006-08-04
US60/835,514 2006-08-04

Related Child Applications (3)

Application Number Title Priority Date Filing Date
EP12154574.3A Previously-Filed-Application EP2511301B1 (en) 2006-08-04 2007-08-02 Human antibodies to erbb 2
US12/376,196 A-371-Of-International US8350011B2 (en) 2006-08-04 2007-08-02 Antibodies to ErbB2
US13/710,883 Continuation US8858942B2 (en) 2006-08-04 2012-12-11 Antibodies directed to ERBB2

Publications (2)

Publication Number Publication Date
WO2008019290A2 WO2008019290A2 (en) 2008-02-14
WO2008019290A3 true WO2008019290A3 (en) 2008-04-03

Family

ID=38925686

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/075078 WO2008019290A2 (en) 2006-08-04 2007-08-02 Human antibodies to erbb 2

Country Status (22)

Country Link
US (2) US8350011B2 (en)
EP (2) EP2054444B1 (en)
JP (1) JP5638804B2 (en)
KR (1) KR20090058512A (en)
CN (1) CN101522717A (en)
AU (1) AU2007281774A1 (en)
BR (1) BRPI0714728A2 (en)
CA (1) CA2659631A1 (en)
CY (1) CY1120065T1 (en)
DK (1) DK2511301T3 (en)
ES (2) ES2661952T3 (en)
HU (1) HUE038454T2 (en)
IL (1) IL196701A0 (en)
LT (1) LT2511301T (en)
MX (1) MX2009001291A (en)
NO (1) NO20090424L (en)
PL (1) PL2511301T3 (en)
PT (1) PT2511301T (en)
RU (1) RU2009107494A (en)
SI (1) SI2511301T1 (en)
WO (1) WO2008019290A2 (en)
ZA (1) ZA200900753B (en)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8557243B2 (en) 2008-01-03 2013-10-15 The Scripps Research Institute EFGR antibodies comprising modular recognition domains
SG10201605629VA (en) 2008-01-03 2016-08-30 Scripps Research Inst Antibody targeting through a modular recognition domain
US8574577B2 (en) 2008-01-03 2013-11-05 The Scripps Research Institute VEGF antibodies comprising modular recognition domains
US8454960B2 (en) 2008-01-03 2013-06-04 The Scripps Research Institute Multispecific antibody targeting and multivalency through modular recognition domains
US8557242B2 (en) 2008-01-03 2013-10-15 The Scripps Research Institute ERBB2 antibodies comprising modular recognition domains
WO2009102421A2 (en) 2008-02-14 2009-08-20 Bristol-Myers Squibb Company Targeted therapeutics based on engineered proteins that bind egfr
JP2011520961A (en) 2008-05-22 2011-07-21 ブリストル−マイヤーズ スクイブ カンパニー Scaffold domain protein based on multivalent fibronectin
GB0812277D0 (en) * 2008-07-04 2008-08-13 Fusion Antibodies Ltd Antibody and uses thereof
AU2009308707A1 (en) 2008-10-31 2010-05-06 Biogen Idec Ma Inc. LIGHT targeting molecules and uses thereof
TWI496582B (en) 2008-11-24 2015-08-21 必治妥美雅史谷比公司 Bispecific egfr/igfir binding molecules
CN101633695B (en) * 2009-04-15 2012-12-12 北京天广实生物技术股份有限公司 Preparation method of anti-erbB2 functional antibody based on erbB2 protein extracellular C-terminal functional epitope characteristics
CN101591396B (en) * 2009-04-15 2013-01-09 北京天广实生物技术股份有限公司 Anti-erbB2 human antibody MIL-5 and application thereof
CN102167742B (en) * 2010-02-25 2014-05-14 上海百迈博制药有限公司 Human monoclonal antibody against HER2, preparation method and purpose thereof
KR20130108069A (en) 2010-04-15 2013-10-02 알퍼 바이오테크, 엘엘씨 Monoclonal antibodies against her2 antigens, and uses therefor
US9562089B2 (en) 2010-05-26 2017-02-07 Bristol-Myers Squibb Company Fibronectin based scaffold proteins having improved stability
EP2575880B1 (en) 2010-05-27 2019-01-16 Genmab A/S Monoclonal antibodies against her2 epitope
WO2011147986A1 (en) 2010-05-27 2011-12-01 Genmab A/S Monoclonal antibodies against her2
AU2016201799B2 (en) * 2010-05-27 2017-09-07 Genmab A/S Monoclonal antibodies aganst HER2 epitope
CN101928345B (en) * 2010-06-21 2012-08-29 中国科学技术大学 Human source antibody and humanization remolding method thereof
US20120100166A1 (en) 2010-07-15 2012-04-26 Zyngenia, Inc. Ang-2 Binding Complexes and Uses Thereof
EA036314B1 (en) 2010-08-20 2020-10-26 Новартис Аг Antibodies for epidermal growth factor receptor 3 (her3)
JP6385060B2 (en) * 2011-03-07 2018-09-05 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト In vivo selection of therapeutically active antibodies
AU2012245116A1 (en) 2011-04-20 2013-11-07 Genmab A/S Bispecific antibodies against HER2 and CD3
CN103857699B (en) 2011-05-24 2016-08-31 泽恩格尼亚股份有限公司 Multivalence and unit price polyspecific complex and application thereof
CN102492039B (en) * 2011-11-21 2015-03-11 无锡天演生物技术有限公司 Fully humanized antihuman HER2 monoclonal antibody
BR112014022692A8 (en) 2012-03-14 2021-07-20 Regeneron Pharma multispecific antigen binding molecule
KR101505157B1 (en) 2012-05-08 2015-03-24 주식회사 종근당 Anti-ErbB2 Antibody Variants
EP2956485A2 (en) * 2013-02-13 2015-12-23 Laboratoire Français du Fractionnement et des Biotechnologies Highly galactosylated anti-her2 antibodies and uses thereof
CA2907181C (en) 2013-03-15 2023-10-17 Viktor Roschke Multivalent and monovalent multispecific complexes and their uses
KR101453462B1 (en) * 2013-05-16 2014-10-23 앱클론(주) Antibodies Capable of Binding Specifically to HER2
US9738726B2 (en) 2013-06-11 2017-08-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services HER2-specific monoclonal antibodies and conjugates thereof
WO2015066543A1 (en) * 2013-11-01 2015-05-07 Board Of Regents, The University Of Texas System Targeting her2 and her3 with bispecific antibodies in cancerous cells
JP2017512765A (en) * 2014-04-11 2017-05-25 メディミューン，エルエルシー Bispecific HER2 antibody
TWI695011B (en) * 2014-06-18 2020-06-01 美商梅爾莎納醫療公司 Monoclonal antibodies against her2 epitope and methods of use thereof
KR101515535B1 (en) 2015-01-28 2015-05-06 주식회사 종근당 Anti-ErbB2 Antibody Variants
NZ737726A (en) 2015-07-06 2023-03-31 Regeneron Pharma Multispecific antigen-binding molecules and uses thereof
WO2017054141A1 (en) * 2015-09-29 2017-04-06 北京天成新脉生物技术有限公司 Her2 linear epitope neutralizing activity monoclonal antibody and use thereof
RU2640259C2 (en) * 2015-12-09 2017-12-27 Федеральное государственное бюджетное учреждение науки Институт теоретической и экспериментальной биофизики Российской академии наук (ИТЭБ РАН) Mat40 antibody binding with domain i of extracellular part of epidermal her2/cd340 growth factor receptor, and its application for cancer treatment
SG11201804839WA (en) 2015-12-14 2018-07-30 Macrogenics Inc Bispecific molecules having immunoreactivity with pd-1 and ctla-4, and methods of use thereof
SG10201601719RA (en) 2016-03-04 2017-10-30 Agency Science Tech & Res Anti-LAG-3 Antibodies
AU2017239018A1 (en) * 2016-03-24 2018-08-16 Bayer As Radio-pharmaceutical complexes
US11352446B2 (en) 2016-04-28 2022-06-07 Regeneron Pharmaceuticals, Inc. Methods of making multispecific antigen-binding molecules
SG10201603721TA (en) 2016-05-10 2017-12-28 Agency Science Tech & Res Anti-CTLA-4 Antibodies
AU2018224094A1 (en) 2017-02-24 2019-09-19 Macrogenics, Inc. Bispecific binding molecules that are capable of binding CD137 and tumor antigens, and uses thereof
AU2018385409A1 (en) 2017-12-12 2020-07-02 Macrogenics Inc. Bispecific CD 16-binding molecules and their use in the treatment of disease
JP7337079B2 (en) 2018-02-15 2023-09-01 マクロジェニクス，インコーポレーテッド Mutant CD3 binding domains and their use in combination therapy for the treatment of disease
US11168128B2 (en) 2020-02-26 2021-11-09 Vir Biotechnology, Inc. Antibodies against SARS-CoV-2 and methods of using the same
US11883432B2 (en) 2020-12-18 2024-01-30 Century Therapeutics, Inc. Chimeric antigen receptor system with adaptable receptor specificity

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997000271A1 (en) * 1995-06-14 1997-01-03 The Regents Of The University Of California Novel high affinity human antibodies to tumor antigens
WO1999055367A1 (en) * 1998-04-24 1999-11-04 The Regents Of The University Of California INTERNALIZING ErbB2 ANTIBODIES
WO2003006509A2 (en) * 2001-07-10 2003-01-23 Universita Degli Studi Di Napoli Federico Ii Human mini-antibody cytotoxic for tumor cells which express the erbb2 receptor

Family Cites Families (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4510245A (en) 1982-11-18 1985-04-09 Chiron Corporation Adenovirus promoter system
US4740461A (en) 1983-12-27 1988-04-26 Genetics Institute, Inc. Vectors and methods for transformation of eucaryotic cells
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
CA1319120C (en) 1985-04-01 1993-06-15 John Henry Kenten Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same
US4968615A (en) 1985-12-18 1990-11-06 Ciba-Geigy Corporation Deoxyribonucleic acid segment from a virus
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US7838216B1 (en) * 1986-03-05 2010-11-23 The United States Of America, As Represented By The Department Of Health And Human Services Human gene related to but distinct from EGF receptor gene
US4959455A (en) 1986-07-14 1990-09-25 Genetics Institute, Inc. Primate hematopoietic growth factors IL-3 and pharmaceutical compositions
US4912040A (en) 1986-11-14 1990-03-27 Genetics Institute, Inc. Eucaryotic expression system
US4968603A (en) 1986-12-31 1990-11-06 The Regents Of The University Of California Determination of status in neoplastic disease
US5750172A (en) 1987-06-23 1998-05-12 Pharming B.V. Transgenic non human mammal milk
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
US5824311A (en) 1987-11-30 1998-10-20 Trustees Of The University Of Pennsylvania Treatment of tumors with monoclonal antibodies against oncogene antigens
JP3040121B2 (en) 1988-01-12 2000-05-08 ジェネンテク，インコーポレイテッド Methods of treating tumor cells by inhibiting growth factor receptor function
GB8809129D0 (en) 1988-04-18 1988-05-18 Celltech Ltd Recombinant dna methods vectors and host cells
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
US5959177A (en) 1989-10-27 1999-09-28 The Scripps Research Institute Transgenic plants expressing assembled secretory antibodies
US5183884A (en) 1989-12-01 1993-02-02 United States Of America Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor
US5633076A (en) 1989-12-01 1997-05-27 Pharming Bv Method of producing a transgenic bovine or transgenic bovine embryo
US6673986B1 (en) 1990-01-12 2004-01-06 Abgenix, Inc. Generation of xenogeneic antibodies
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
WO1991010741A1 (en) 1990-01-12 1991-07-25 Cell Genesys, Inc. Generation of xenogeneic antibodies
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5151510A (en) 1990-04-20 1992-09-29 Applied Biosystems, Inc. Method of synethesizing sulfurized oligonucleotide analogs
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
WO1992020791A1 (en) 1990-07-10 1992-11-26 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
DE69133557D1 (en) 1990-08-29 2007-03-15 Pharming Intellectual Pty Bv HOMOLOGOUS RECOMBINATION IN MAMMALIAN CELLS
ES2108048T3 (en) 1990-08-29 1997-12-16 Genpharm Int PRODUCTION AND USE OF LOWER TRANSGENIC ANIMALS CAPABLE OF PRODUCING HETEROLOGICAL ANTIBODIES.
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
EP0564531B1 (en) 1990-12-03 1998-03-25 Genentech, Inc. Enrichment method for variant proteins with altered binding properties
ES2330052T3 (en) 1991-03-01 2009-12-03 Dyax Corporation CHEMICAL PROTEIN THAT INCLUDES MICRO-PROTEINS THAT HAVE TWO OR MORE DISULFURENT BRIDGES AND RELATIONSHIPS OF THE SAME.
EP0580737B1 (en) 1991-04-10 2004-06-16 The Scripps Research Institute Heterodimeric receptor libraries using phagemids
IL101943A0 (en) 1991-05-24 1992-12-30 Genentech Inc Structure,production and use of heregulin
JP4124480B2 (en) 1991-06-14 2008-07-23 ジェネンテック・インコーポレーテッド Immunoglobulin variants
DE4122599C2 (en) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid for screening antibodies
WO1993004169A1 (en) 1991-08-20 1993-03-04 Genpharm International, Inc. Gene targeting in animal cells using isogenic dna constructs
DK0605522T3 (en) 1991-09-23 2000-01-17 Medical Res Council Process for producing humanized antibodies
US5298256A (en) 1992-04-28 1994-03-29 Corint, Ltd. Desmopressin buccal patch composition
AU687346B2 (en) 1992-06-30 1998-02-26 Oncologix, Inc. A combination of anti-erbB-2 monoclonal antibodies and method of using
CA2140638C (en) 1992-07-24 2010-05-04 Raju Kucherlapati Generation of xenogeneic antibodies
US6710174B2 (en) 2001-09-13 2004-03-23 Isis Pharmaceuticals, Inc. Antisense inhibition of vascular endothelial growth factor receptor-1 expression
US20040014051A1 (en) 2002-07-18 2004-01-22 Isis Pharmaceuticals Inc. Antisense modulation of breast cancer-1 expression
CA2103323A1 (en) 1992-11-24 1994-05-25 Gregory D. Plowman Her4 human receptor tyrosine kinase
CA2150262C (en) 1992-12-04 2008-07-08 Kaspar-Philipp Holliger Multivalent and multispecific binding proteins, their manufacture and use
EP0804070B1 (en) 1993-03-09 2000-05-24 Genzyme Corporation Process of isolation of proteins from milk
AU6527894A (en) 1993-03-30 1994-10-24 Trustees Of The University Of Pennsylvania, The Prevention of tumors with monoclonal antibodies against (neu)
US5827690A (en) 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
IL112969A (en) 1994-03-17 2001-05-20 Baxter Int Pharmaceutical compositions for the treatment of cancer comprising allogenic lymphocytes or their combination with a t-cell activator
IT1274034B (en) 1994-07-26 1997-07-14 Applied Pharma Res PHARMACEUTICAL COMPOSITIONS BASED ON RUBBER TO BE CHEWED AND PROCEDURE FOR THEIR PREPARATION
US5643763A (en) 1994-11-04 1997-07-01 Genpharm International, Inc. Method for making recombinant yeast artificial chromosomes by minimizing diploid doubling during mating
US6046037A (en) 1994-12-30 2000-04-04 Hiatt; Andrew C. Method for producing immunoglobulins containing protection proteins in plants and their use
US6091001A (en) 1995-03-29 2000-07-18 Abgenix, Inc. Production of antibodies using Cre-mediated site-specific recombination
US6130364A (en) 1995-03-29 2000-10-10 Abgenix, Inc. Production of antibodies using Cre-mediated site-specific recombination
WO1996033266A1 (en) 1995-04-21 1996-10-24 Cell Genesys, Inc. Generation of large genomic dna deletions
CA2219361C (en) 1995-04-27 2012-02-28 Abgenix, Inc. Human antibodies derived from immunized xenomice
EP0823941A4 (en) 1995-04-28 2001-09-19 Abgenix Inc Human antibodies derived from immunized xenomice
US5783186A (en) 1995-12-05 1998-07-21 Amgen Inc. Antibody-induced apoptosis
WO1997034631A1 (en) 1996-03-18 1997-09-25 Board Of Regents, The University Of Texas System Immunoglobin-like domains with increased half lives
US5714352A (en) 1996-03-20 1998-02-03 Xenotech Incorporated Directed switch-mediated DNA recombination
US5994619A (en) 1996-04-01 1999-11-30 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus Production of chimeric bovine or porcine animals using cultured inner cell mass cells
US6277368B1 (en) 1996-07-25 2001-08-21 The Regents Of The University Of California Cancer immunotherapy using autologous tumor cells combined with cells expressing a membrane cytokine
US5916771A (en) 1996-10-11 1999-06-29 Abgenix, Inc. Production of a multimeric protein by cell fusion method
ATE229810T1 (en) 1996-10-11 2003-01-15 Univ California CANCER IMMUNOTHERAPY USING TUMOR CELLS COMBINED WITH LYMPHOCYTE MIXTURES
BR9712410A (en) * 1996-10-18 1999-10-19 Genentech Inc Isolated antibody, composition, nucleic acid, vector, host cell, method for making an anti-erbb2 antibody, method for determining the presence of erbb2, kit, method for inducing cell death and manufactured article
EP1500329B1 (en) 1996-12-03 2012-03-21 Amgen Fremont Inc. Human antibodies that specifically bind human TNF alpha
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
CN1304572C (en) 1997-05-05 2007-03-14 萨诺费－阿文蒂斯德国有限公司 Modified antisense nucleotides complementary to section of human Ha-Ras gene
AU7383298A (en) 1997-05-13 1998-12-08 Regents Of The University Of California, The Novel antiangiogenic peptide agents and their therapeutic and diagnostic use
EP1724282B1 (en) 1997-05-21 2013-05-15 Merck Patent GmbH Method for the production of non-immunogenic proteins
US6344476B1 (en) 1997-05-23 2002-02-05 Bayer Corporation Inhibition of p38 kinase activity by aryl ureas
AU9794698A (en) 1997-10-10 1999-05-03 Regents Of The University Of California, The Enhanced immunogenic cell populations prepared using h2 receptor antagonists
EP1060193A2 (en) 1998-03-03 2000-12-20 Abgenix, Inc. Cd147 binding molecules as therapeutics
US6485925B1 (en) 1998-04-01 2002-11-26 The United States Of America As Represented By The Department Of Health And Human Services Anthrax lethal factor is a MAPK kinase protease
US20020029391A1 (en) 1998-04-15 2002-03-07 Claude Geoffrey Davis Epitope-driven human antibody production and gene expression profiling
US6413773B1 (en) 1998-06-01 2002-07-02 The Regents Of The University Of California Phosphatidylinositol 3-kinase inhibitors as stimulators of endocrine differentiation
CA2341029A1 (en) 1998-08-17 2000-02-24 Abgenix, Inc. Generation of modified molecules with increased serum half-lives
US6451316B1 (en) 1998-10-05 2002-09-17 University Of Conneticut Health Center Methods for generating antigen-reactive T cells in vitro
EP1051432B1 (en) 1998-12-08 2007-01-24 Biovation Limited Method for reducing immunogenicity of proteins
EP2154535A1 (en) 1998-12-10 2010-02-17 Bristol-Myers Squibb Company Protein scaffolds for antibody mimics and other binding proteins
ES2340745T3 (en) 1998-12-23 2010-06-08 Pfizer Inc. HUMAN MONOCLONAL ANTIBODIES AGAINST CTLA-4.
WO2000057705A1 (en) 1999-03-31 2000-10-05 University Of Pittsburgh Of The Commonwealth System Of Higher Education In vitro induction of antigen-specific t-cells using dendritic cell-tumor cell or dendritic cell-viral cell derived immunogens
JP4387625B2 (en) * 1999-07-02 2009-12-16 ジェネンテック・インコーポレーテッド Compound binding to HER2
US6517529B1 (en) 1999-11-24 2003-02-11 Radius International Limited Partnership Hemodialysis catheter
US7306801B2 (en) * 2000-05-15 2007-12-11 Health Research, Inc. Methods of therapy for cancers characterized by overexpression of the HER2 receptor protein
ATE378403T1 (en) 2000-11-30 2007-11-15 Medarex Inc TRANSCHROMOSOMAL TRANSGENIC RODENTS FOR PRODUCING HUMAN ANTIBODIES
ES2649037T3 (en) 2000-12-12 2018-01-09 Medimmune, Llc Molecules with prolonged half-lives, compositions and uses thereof
GB0101686D0 (en) 2001-01-23 2001-03-07 Cancer Res Campaign Tech Cyclin dependent kinase inhibitors
CA2508763C (en) 2001-05-11 2012-01-24 Kirin Beer Kabushiki Kaisha Human antibody producing mouse and method for producing human antibody using the same
ATE395413T1 (en) 2001-12-03 2008-05-15 Amgen Fremont Inc ANTIBODIES CATEGORIZATION BASED ON BINDING PROPERTIES
US6716627B2 (en) 2001-12-20 2004-04-06 Isis Pharmaceuticals, Inc. Antisense modulation of mucin 1, transmembrane expression
EP3960855A1 (en) * 2001-12-28 2022-03-02 Chugai Seiyaku Kabushiki Kaisha Method for stabilizing proteins
US7135174B2 (en) * 2002-01-07 2006-11-14 Amgen Fremont, Inc. Antibodies directed to PDGFD and uses thereof
AU2003208946A1 (en) * 2002-02-28 2003-09-16 Eli Lilly And Company Anti-interleukin-1 beta analogs
US20030225098A1 (en) 2002-03-21 2003-12-04 Hirst Gavin C. Kinase inhibitors
GB0209891D0 (en) 2002-04-30 2002-06-05 Glaxo Group Ltd Novel compounds
US8034334B2 (en) 2002-09-06 2011-10-11 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Immunotherapy with in vitro-selected antigen-specific lymphocytes after non-myeloablative lymphodepleting chemotherapy
EP2316831B1 (en) 2002-11-21 2013-03-06 Novartis AG 2-(morpholin-4-yl)pyrimidines as phosphotidylinositol (PI) 3-kinase inhibitors and their use in the treatment of cancer
JP2006315964A (en) * 2005-05-10 2006-11-24 Chugai Pharmaceut Co Ltd Method for antibody stabilization
US7777008B2 (en) * 2006-06-19 2010-08-17 Tolerx, Inc. ILT3 binding molecules and uses therefor
US9209965B2 (en) 2014-01-14 2015-12-08 Microsemi Semiconductor Ulc Network interface with clock recovery module on line card

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997000271A1 (en) * 1995-06-14 1997-01-03 The Regents Of The University Of California Novel high affinity human antibodies to tumor antigens
WO1999055367A1 (en) * 1998-04-24 1999-11-04 The Regents Of The University Of California INTERNALIZING ErbB2 ANTIBODIES
WO2003006509A2 (en) * 2001-07-10 2003-01-23 Universita Degli Studi Di Napoli Federico Ii Human mini-antibody cytotoxic for tumor cells which express the erbb2 receptor

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
AGUS D B ET AL: "CLINICAL ACTIVITY IN A PHASE I TRIAL OF HER-2-TARGETED RHUMAB 2C4 (PERTUZUMAB) IN PATIENTS WITH ADVANCED SOLID MALIGNANCIES (AST)", PROGRAM/PROCEEDINGS - AMERICAN SOCIETY OF CLINICAL ONCOLOGY, THE SOCIETY, US, vol. 22, 2003, pages 192,ABSTRACT771, XP009070506, ISSN: 1081-0641 *
DATABASE EMBL [online] 8 January 1998 (1998-01-08), "Homo sapiens mRNA for immunoglobulin kappa heavy chain", XP002465475, retrieved from EBI accession no. EMBL:Y14735 Database accession no. Y14735 *
DATABASE EMBL [online] 8 January 1998 (1998-01-08), "Homo sapiens mRNA for immunoglobulin kappa light chain", XP002465474, retrieved from EBI accession no. EMBL:Y14736 Database accession no. Y14736 *
KUDO TOSHIO ET AL: "Production of a human monoclonal antibody to a synthetic peptide by active in vivo immunization using a SCID mouse grafted with human lymphocytes", TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, vol. 171, no. 4, 1993, pages 327 - 338, XP002465609, ISSN: 0040-8727 *
PATERSON TREVOR ET AL: "Variation in IgG1 heavy chain allotype does not contribute to differences in biological activity of two human anti-Rhesus (D) monoclonal antibodies", IMMUNOTECHNOLOGY (SHANNON), vol. 4, no. 1, June 1998 (1998-06-01), pages 37 - 47, XP004127385, ISSN: 1380-2933, DOI: doi:10.1016/S1380-2933(98)00005-0 *
ROSS J S ET AL: "TARGETED THERAPIES FOR CANCER 2004", AMERICAN JOURNAL OF CLINICAL PATHOLOGY, PHILADELPHIA, PA, US, vol. 122, no. 4, October 2004 (2004-10-01), pages 598 - 609, XP009071882, ISSN: 0002-9173 *

Also Published As

Publication number Publication date
US8350011B2 (en) 2013-01-08
PL2511301T3 (en) 2018-05-30
SI2511301T1 (en) 2018-05-31
WO2008019290A2 (en) 2008-02-14
US8858942B2 (en) 2014-10-14
EP2511301A2 (en) 2012-10-17
ES2613957T3 (en) 2017-05-29
NO20090424L (en) 2009-03-03
CN101522717A (en) 2009-09-02
DK2511301T3 (en) 2018-03-12
JP5638804B2 (en) 2014-12-10
US20100158926A1 (en) 2010-06-24
CY1120065T1 (en) 2018-12-12
RU2009107494A (en) 2010-09-10
HUE038454T2 (en) 2018-10-29
KR20090058512A (en) 2009-06-09
ES2661952T3 (en) 2018-04-04
EP2511301A3 (en) 2013-05-01
LT2511301T (en) 2018-04-10
JP2009545325A (en) 2009-12-24
CA2659631A1 (en) 2008-02-14
ZA200900753B (en) 2010-09-29
EP2054444A2 (en) 2009-05-06
BRPI0714728A2 (en) 2013-05-14
MX2009001291A (en) 2009-03-10
US20130089544A1 (en) 2013-04-11
IL196701A0 (en) 2011-08-01
EP2054444B1 (en) 2016-11-02
AU2007281774A1 (en) 2008-02-14
PT2511301T (en) 2018-03-08
EP2511301B1 (en) 2017-12-06

Similar Documents

Publication Publication Date Title
WO2008019290A3 (en) Human antibodies to erbb 2
WO2006116269A3 (en) Antibodies to myostatin
WO2005067620A3 (en) ANTIBODIES TO MAdCAM
WO2005030124A3 (en) Antibodies to m-csf
AP1918A (en) Antibodies to CD40
WO2003085089A3 (en) Human monoclonal antibodies to interleukin-5 and methods and compositions comprising same
WO2008060331A3 (en) Antibodies to sars coronavirus
AP2072A (en) Antibodies to insulin-like growth factor I receptor
PH12014501872A1 (en) P-cadherin antibodies

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200780037095.2

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07813707

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2659631

Country of ref document: CA

Ref document number: 750/DELNP/2009

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 2007281774

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2009523054

Country of ref document: JP

Ref document number: MX/A/2009/001291

Country of ref document: MX

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2007281774

Country of ref document: AU

Date of ref document: 20070802

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 1020097004290

Country of ref document: KR

REEP Request for entry into the european phase

Ref document number: 2007813707

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2007813707

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 575282

Country of ref document: NZ

ENP Entry into the national phase

Ref document number: 2009107494

Country of ref document: RU

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 12376196

Country of ref document: US

ENP Entry into the national phase

Ref document number: PI0714728

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20090203