IL99682A - הכנת לקטולוזה גבישית המכילה פחות מ-%1 של מים - Google Patents

הכנת לקטולוזה גבישית המכילה פחות מ-%1 של מים

Info

Publication number: IL99682A
Authority: IL; Israel
Prior art keywords: lactulose; water content; evaporation; preparation; free
Prior art date: 1990-10-12

Application number

IL9968291A

Other languages

English (en)

Other versions

IL99682A0 (en

Original Assignee

Duphar Int Res

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-10-12

Filing date

1991-10-09

Publication date

1995-08-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8205141&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL99682(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1991-10-09 Application filed by Duphar Int Res filed Critical Duphar Int Res

1992-08-18 Publication of IL99682A0 publication Critical patent/IL99682A0/xx

1995-08-31 Publication of IL99682A publication Critical patent/IL99682A/he

Links

229960000511 lactulose Drugs 0.000 title claims abstract description 44
PFCRQPBOOFTZGQ-UHFFFAOYSA-N lactulose keto form Natural products OCC(=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O PFCRQPBOOFTZGQ-UHFFFAOYSA-N 0.000 title claims abstract description 44
JCQLYHFGKNRPGE-FCVZTGTOSA-N lactulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-FCVZTGTOSA-N 0.000 title claims abstract description 43
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 12
238000002360 preparation method Methods 0.000 title claims abstract description 8
239000013078 crystal Substances 0.000 claims abstract description 13
238000000034 method Methods 0.000 claims abstract description 13
238000001704 evaporation Methods 0.000 claims abstract description 11
230000008020 evaporation Effects 0.000 claims abstract description 11
239000000843 powder Substances 0.000 claims abstract description 10
239000007787 solid Substances 0.000 claims abstract description 10
238000003756 stirring Methods 0.000 claims abstract description 5
239000000725 suspension Substances 0.000 claims abstract description 3
239000000470 constituent Substances 0.000 claims description 2
239000000243 solution Substances 0.000 description 9
239000006188 syrup Substances 0.000 description 6
235000020357 syrup Nutrition 0.000 description 6
239000007864 aqueous solution Substances 0.000 description 4
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
238000002156 mixing Methods 0.000 description 3
239000000047 product Substances 0.000 description 3
239000000126 substance Substances 0.000 description 3
239000003463 adsorbent Substances 0.000 description 2
239000007900 aqueous suspension Substances 0.000 description 2
239000000969 carrier Substances 0.000 description 2
238000002425 crystallisation Methods 0.000 description 2
230000008025 crystallization Effects 0.000 description 2
238000001035 drying Methods 0.000 description 2
239000000463 material Substances 0.000 description 2
238000001694 spray drying Methods 0.000 description 2
239000005995 Aluminium silicate Substances 0.000 description 1
239000005909 Kieselgur Substances 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
230000000274 adsorptive effect Effects 0.000 description 1
230000032683 aging Effects 0.000 description 1
230000001476 alcoholic effect Effects 0.000 description 1
235000012211 aluminium silicate Nutrition 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
239000003610 charcoal Substances 0.000 description 1
239000007795 chemical reaction product Substances 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
235000005911 diet Nutrition 0.000 description 1
230000000378 dietary effect Effects 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
239000000835 fiber Substances 0.000 description 1
239000006260 foam Substances 0.000 description 1
235000013305 food Nutrition 0.000 description 1
208000007386 hepatic encephalopathy Diseases 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
238000006317 isomerization reaction Methods 0.000 description 1
NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
239000008101 lactose Substances 0.000 description 1
229920005610 lignin Polymers 0.000 description 1
238000003801 milling Methods 0.000 description 1
239000000203 mixture Substances 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
238000000746 purification Methods 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
238000010583 slow cooling Methods 0.000 description 1
230000008023 solidification Effects 0.000 description 1
238000007711 solidification Methods 0.000 description 1
229920003002 synthetic resin Polymers 0.000 description 1
239000000057 synthetic resin Substances 0.000 description 1
MLGCXEBRWGEOQX-UHFFFAOYSA-N tetradifon Chemical compound C1=CC(Cl)=CC=C1S(=O)(=O)C1=CC(Cl)=C(Cl)C=C1Cl MLGCXEBRWGEOQX-UHFFFAOYSA-N 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/04—Disaccharides
- C—CHEMISTRY; METALLURGY
- C13—SUGAR INDUSTRY
- C13K—SACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
- C13K13/00—Sugars not otherwise provided for in this class
- C13K13/005—Lactulose

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Saccharide Compounds (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Fats And Perfumes (AREA)
Detergent Compositions (AREA)
Enzymes And Modification Thereof (AREA)
Cephalosporin Compounds (AREA)

IL9968291A 1990-10-12 1991-10-09 הכנת לקטולוזה גבישית המכילה פחות מ-%1 של מים IL99682A (he)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP90202712		1990-10-12

Publications (2)

Publication Number	Publication Date
IL99682A0 IL99682A0 (en)	1992-08-18
IL99682A true IL99682A (he)	1995-08-31

Family

ID=8205141

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9968291A IL99682A (he)	1990-10-12	1991-10-09	הכנת לקטולוזה גבישית המכילה פחות מ-%1 של מים

Country Status (28)

Country	Link
US (1)	US5326405A (he)
EP (1)	EP0480519B1 (he)
JP (1)	JP2741812B2 (he)
KR (1)	KR100203247B1 (he)
AT (1)	ATE138922T1 (he)
AU (1)	AU634098B2 (he)
BG (1)	BG60867B1 (he)
CA (1)	CA2053079A1 (he)
CZ (1)	CZ284664B6 (he)
DE (1)	DE69120013T2 (he)
DK (1)	DK0480519T3 (he)
ES (1)	ES2087963T3 (he)
FI (1)	FI101794B (he)
GR (1)	GR3020254T3 (he)
HK (1)	HK174796A (he)
HU (1)	HU209472B (he)
IE (1)	IE76458B1 (he)
IL (1)	IL99682A (he)
NO (1)	NO175861C (he)
NZ (1)	NZ240165A (he)
PL (1)	PL291974A1 (he)
RO (1)	RO112295B1 (he)
RU (1)	RU2034931C1 (he)
SG (1)	SG43680A1 (he)
SI (1)	SI9111632B (he)
SK (1)	SK279153B6 (he)
YU (1)	YU48208B (he)
ZA (1)	ZA918087B (he)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0670075B2 (ja) *	1990-08-28	1994-09-07	ホクレン農業協同組合連合会	１―ケストース結晶およびその製造方法
JP3022699B2 (ja) *	1993-02-02	2000-03-21	森永乳業株式会社	ラクチュロース無水物の製造法
IT1271449B (it) *	1993-04-28	1997-05-28	Inalco Spa	Procedimento per la preparazione di lattulosio cristallino da sciroppi commerciali
GB9508691D0 (en)	1995-04-28	1995-06-14	Pafra Ltd	Stable compositions
DE19536792A1 (de) *	1995-10-02	1997-04-03	Basf Ag	Verfahren zur Stofftrennung aus einem flüssigen Gemisch durch Kristallisation
GB9827423D0 (en) *	1998-12-11	1999-02-03	Relax Limited	Method of drying a solution
WO2003101218A1 (fr) *	2002-06-04	2003-12-11	Morinaga Milk Industry Co., Ltd.	Procede pour produire une composition pulverulente contenant du lactulose, composition pulverulente contenant du lactulose obtenue par ce procede et additif alimentaire
US7256202B2 (en) *	2003-12-31	2007-08-14	Halow George M	Composition and method for treatment of hepatic encephalopathy
HU229363B1 (hu)	2007-06-29	2013-11-28	Magyar Tejgazdasagi Kiserleti Intezet Kft	Kalciumban dúsított túrósavó-por, eljárás annak elõállítására és felhasználására élelmiszerekben
ES2720080T3 (es)	2007-11-14	2019-07-17	Fresenius Kabi Austria Gmbh	Procedimiento continúo para la preparación de lactulosa cristalina
RU2455012C1 (ru) *	2011-01-11	2012-07-10	Учреждение Российской академии медицинских наук Научно-исследовательский институт медицинских проблем Севера Сибирского отделения РАМН	Способ энтеральной детоксикации при лечении иммунных нарушений
RU2541398C2 (ru) *	2013-07-02	2015-02-10	Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кемеровский технологический институт пищевой промышленности"	Способ получения сухой лактулозы с помощью распылительной сушки

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS61104800A (ja) *	1984-10-26	1986-05-23	日研化学株式会社	ラクツロ−ス結晶含有粉末の製造方法
IT1223398B (it) *	1987-12-01	1990-09-19	Sirac Spa	Procedimento per la preparazione di lattulosio cristallino ad alta purezza
US5004057A (en) *	1988-01-20	1991-04-02	Eastman Christensen Company	Drill bit with improved steerability
IL89624A0 (en) *	1988-03-18	1989-09-10	Duphar Int Res	Preparation of solid lactulose
JP2628368B2 (ja) *	1989-01-28	1997-07-09	森永乳業株式会社	高純度ラクチュロース粉末の製造法ならびにラクチュロースを含むビフイズス菌製剤の製造法

1991
- 1991-10-04 DE DE69120013T patent/DE69120013T2/de not_active Revoked
- 1991-10-04 AT AT91202591T patent/ATE138922T1/de not_active IP Right Cessation
- 1991-10-04 ES ES91202591T patent/ES2087963T3/es not_active Expired - Lifetime
- 1991-10-04 SG SG1995001934A patent/SG43680A1/en unknown
- 1991-10-04 DK DK91202591.3T patent/DK0480519T3/da active
- 1991-10-04 EP EP91202591A patent/EP0480519B1/en not_active Revoked
- 1991-10-07 YU YU163291A patent/YU48208B/sh unknown
- 1991-10-07 SI SI9111632A patent/SI9111632B/sl unknown
- 1991-10-08 BG BG95284A patent/BG60867B1/bg unknown
- 1991-10-08 RO RO148509A patent/RO112295B1/ro unknown
- 1991-10-08 HU HU913185A patent/HU209472B/hu not_active IP Right Cessation
- 1991-10-09 SK SK3077-91A patent/SK279153B6/sk unknown
- 1991-10-09 NZ NZ240165A patent/NZ240165A/en unknown
- 1991-10-09 ZA ZA918087A patent/ZA918087B/xx unknown
- 1991-10-09 IL IL9968291A patent/IL99682A/he not_active IP Right Cessation
- 1991-10-09 FI FI914757A patent/FI101794B/fi active
- 1991-10-09 CA CA002053079A patent/CA2053079A1/en not_active Abandoned
- 1991-10-09 AU AU85661/91A patent/AU634098B2/en not_active Ceased
- 1991-10-09 US US07/773,506 patent/US5326405A/en not_active Expired - Fee Related
- 1991-10-09 NO NO913952A patent/NO175861C/no not_active IP Right Cessation
- 1991-10-09 JP JP3326281A patent/JP2741812B2/ja not_active Expired - Lifetime
- 1991-10-09 RU SU915001847A patent/RU2034931C1/ru active
- 1991-10-09 KR KR1019910017661A patent/KR100203247B1/ko not_active IP Right Cessation
- 1991-10-09 CZ CS913077A patent/CZ284664B6/cs not_active IP Right Cessation
- 1991-10-09 PL PL29197491A patent/PL291974A1/xx unknown
- 1991-10-16 IE IE357091A patent/IE76458B1/en not_active IP Right Cessation
1996
- 1996-06-18 GR GR960401633T patent/GR3020254T3/el unknown
- 1996-09-19 HK HK174796A patent/HK174796A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
US5326405A (en)	1994-07-05
IE76458B1 (en)	1997-10-22
EP0480519A1 (en)	1992-04-15
NO913952D0 (no)	1991-10-09
SK279153B6 (sk)	1998-07-08
YU48208B (sh)	1997-08-22
IL99682A0 (en)	1992-08-18
IE913570A1 (en)	1992-04-22
EP0480519B1 (en)	1996-06-05
NO913952L (no)	1992-04-13
BG60867B1 (bg)	1996-05-31
FI914757A0 (fi)	1991-10-09
GR3020254T3 (en)	1996-09-30
CZ284664B6 (cs)	1999-01-13
ATE138922T1 (de)	1996-06-15
DK0480519T3 (da)	1996-06-24
FI914757A (fi)	1992-04-13
HU913185D0 (en)	1992-01-28
ES2087963T3 (es)	1996-08-01
DE69120013D1 (de)	1996-07-11
RU2034931C1 (ru)	1995-05-10
SI9111632A (en)	1997-12-31
NZ240165A (en)	1993-03-26
CS307791A3 (en)	1992-04-15
RO112295B1 (ro)	1997-07-30
AU634098B2 (en)	1993-02-11
BG95284A (bg)	1993-12-24
CA2053079A1 (en)	1992-04-13
JPH04262800A (ja)	1992-09-18
JP2741812B2 (ja)	1998-04-22
HU209472B (en)	1994-06-28
AU8566191A (en)	1992-04-16
NO175861C (no)	1994-12-21
KR920008058A (ko)	1992-05-27
YU163291A (sh)	1996-01-08
NO175861B (he)	1994-09-12
DE69120013T2 (de)	1996-10-24
KR100203247B1 (ko)	1999-06-15
FI101794B1 (fi)	1998-08-31
SG43680A1 (en)	1997-11-14
SI9111632B (sl)	1998-08-31
HUT59691A (en)	1992-06-29
FI101794B (fi)	1998-08-31
ZA918087B (en)	1992-07-29
PL291974A1 (en)	1992-06-15
HK174796A (en)	1996-09-27

Legal Events

Date	Code	Title
1998-03-10	KB	Patent renewed
2002-02-10	KB	Patent renewed
2006-08-01	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
US5326405A (en)	1994-07-05	Solid lactulose
FI91261C (fi)	1996-01-31	Kiteinen, kidevedetön laktitoli ja menetelmä sen valmistamiseksi sekä sen käyttö
US5003061A (en)	1991-03-26	Method for preparing high-purity crystalline lactulose
DE3883608T2 (de)	1994-02-03	Verfahren zur Herstellung von Maltosepulver.
US4634472A (en)	1987-01-06	Enrichment of fructose syrups
US4594110A (en)	1986-06-10	Process for preparing lactose products
KR100762289B1 (ko)	2007-10-04	말티톨의 결정화 방법
EP1310504A4 (en)	2004-02-25	PROCESS FOR PRODUCING CRYSTALLINE TAGATOSIS
FR2791703B1 (fr)	2001-06-15	Procede de preparation d'un dextrose cristallin alpha anhydre de haute purete
EP0622374B1 (en)	1997-12-03	Process for the preparation of crystalline lactulose from commercial syrups
RU2347818C1 (ru)	2009-02-27	Способ получения фруктозосодержащего сиропа
JPH0517239B2 (he)	1993-03-08
FI92489B (fi)	1994-08-15	Menetelmä erittäin puhtaan kiteisen laktuloosin valmistamiseksi
ES2720080T3 (es)	2019-07-17	Procedimiento continúo para la preparación de lactulosa cristalina