IL65814A - 3-phenylalkylaminoalkyl-3-benzazepine and 1,3-benzodiazepine derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

3-phenylalkylaminoalkyl-3-benzazepine and 1,3-benzodiazepine derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number: IL65814A
Authority: IL; Israel
Prior art keywords: phenylalkylaminoalkyl; benzazepine; preparation; pharmaceutical compositions; compositions containing
Prior art date: 1981-05-19

Application number

IL65814A

Other languages

English (en)

Other versions

IL65814A0 (en

Original Assignee

Thomae Gmbh Dr K

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-05-19

Filing date

1982-05-18

Publication date

1986-02-28

1982-05-18 Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K

1982-08-31 Publication of IL65814A0 publication Critical patent/IL65814A0/xx

1986-02-28 Publication of IL65814A publication Critical patent/IL65814A/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

IL65814A 1981-05-19 1982-05-18 3-phenylalkylaminoalkyl-3-benzazepine and 1,3-benzodiazepine derivatives,their preparation and pharmaceutical compositions containing them IL65814A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19813119874 DE3119874A1 (de)	1981-05-19	1981-05-19	"benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"

Publications (2)

Publication Number	Publication Date
IL65814A0 IL65814A0 (en)	1982-08-31
IL65814A true IL65814A (en)	1986-02-28

Family

ID=6132690

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL65814A IL65814A (en)	1981-05-19	1982-05-18	3-phenylalkylaminoalkyl-3-benzazepine and 1,3-benzodiazepine derivatives,their preparation and pharmaceutical compositions containing them

Country Status (29)

Country	Link
EP (1)	EP0065229B1 (es)
JP (1)	JPS57193462A (es)
KR (3)	KR890001544B1 (es)
AR (1)	AR231130A1 (es)
AT (1)	ATE14725T1 (es)
AU (1)	AU551509B2 (es)
BG (1)	BG60412B2 (es)
CA (1)	CA1185239A (es)
CS (2)	CS251760B2 (es)
DD (1)	DD202872A5 (es)
DE (2)	DE3119874A1 (es)
DK (1)	DK156720C (es)
ES (5)	ES512285A0 (es)
FI (1)	FI77856C (es)
GB (1)	GB2099425B (es)
GR (1)	GR76458B (es)
HK (1)	HK43388A (es)
HU (1)	HU186584B (es)
IE (1)	IE53016B1 (es)
IL (1)	IL65814A (es)
MX (1)	MX9202743A (es)
NO (1)	NO159166C (es)
NZ (1)	NZ200659A (es)
PL (1)	PL136914B1 (es)
PT (1)	PT74919B (es)
SU (1)	SU1160935A3 (es)
UA (1)	UA8038A1 (es)
YU (1)	YU44674B (es)
ZA (1)	ZA823413B (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3242599A1 (de) *	1982-11-18	1984-05-24	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel
DE3343801A1 (de) *	1983-12-03	1985-06-13	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue indolderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3418271A1 (de) *	1984-05-17	1985-11-21	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3418270A1 (de) *	1984-05-17	1985-11-21	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0204349A3 (de) *	1985-06-01	1990-01-03	Dr. Karl Thomae GmbH	Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE3717561A1 (de) *	1987-05-25	1988-12-08	Thomae Gmbh Dr K	Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3541811A1 (de) *	1985-11-27	1987-06-04	Thomae Gmbh Dr K	Neue cyclische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3736866A1 (de) *	1987-10-30	1989-05-11	Thomae Gmbh Dr K	Mittel zur behandlung des bluthochdrucks und der herzinsuffizienz
FR2624117B1 (fr) *	1987-12-08	1991-02-22	Synthelabo	Derives de hydroxy-3 (methoxy-4 phenyl)-2 (methylamino-2 ethyl)-5 dihydro-2,3 5h-benzothiazepine-1,5 one-4, leur preparation et leur application en therapeutique
JP2699511B2 (ja) *	1988-01-29	1998-01-19	武田薬品工業株式会社	置換アミン類
JP2807577B2 (ja) *	1990-06-15	1998-10-08	エーザイ株式会社	環状アミド誘導体
FR2681862B1 (fr) *	1991-09-27	1993-11-12	Adir Cie	Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
FR2705675B1 (fr) *	1993-05-27	1996-05-03	Smithkline Beecham Labo Pharma	Nouveaux composés, leur procédé de préparation et leur utilisation en tant que médicaments.
WO1994027971A1 (en) *	1993-05-27	1994-12-08	Smithkline Beecham Laboratoires Pharmaceutiques	Anti-arrhythmic n-substituted 3-benzazepines or isoquinolines
SE9303274D0 (sv) *	1993-10-07	1993-10-07	Astra Ab	Novel phenylethyl and phenylproplamines
DE10018401A1 (de)	2000-04-13	2001-10-25	Boehringer Ingelheim Pharma	Verwendung von Bradycardica bei der Behandlung von mit Hypertrophie einhergehenden Myocarderkrankungen und neue Arzneimittelkombinationen
WO2002098865A2 (fr)	2001-06-07	2002-12-12	Neuro3D	Inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations de ces inhibiteurs
CN102718665B (zh) *	2003-08-29	2015-09-16	三井化学株式会社	农园艺用杀虫剂的制备中间体
FR2868775B1 (fr) *	2004-04-13	2008-04-11	Servier Lab	Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868776B1 (fr) *	2004-04-13	2008-04-18	Servier Lab	Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868777B1 (fr)	2004-04-13	2006-05-26	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2870537A1 (fr) *	2004-05-19	2005-11-25	Servier Lab	Nouveau procede de synthese du (1s)-4,5-dimethoxy-1-(methyl aminomethyl-)-benzocyclobutane et de ses sels d'addition, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2882556B1 (fr) *	2005-02-28	2007-05-04	Servier Lab	Forme cristalline gamma d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882554B1 (fr) *	2005-02-28	2007-05-04	Servier Lab	Forme critalline beta d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882555B1 (fr) *	2005-02-28	2007-05-04	Servier Lab	Forme cristalline gamma du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882553B1 (fr) *	2005-02-28	2007-05-04	Servier Lab	Forme cristalline beta du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
EP1762179A1 (en)	2005-09-07	2007-03-14	Boehringer Ingelheim Vetmedica Gmbh	Method for improving diagnostic quality in echocardiography
FR2891827B1 (fr) *	2005-10-11	2007-12-28	Servier Lab	Forme cristalline deltad du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2891826B1 (fr) *	2005-10-11	2007-12-28	Servier Lab	Forme cristalline 6 du chlorhydrate de l'ivabradine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2920773B1 (fr) *	2007-09-11	2009-10-23	Servier Lab	Derives de 1,2,4,5-tetrahydro-3h-benzazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2935381B1 (fr) *	2008-08-29	2010-12-17	Servier Lab	Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine
FR2941695B1 (fr) *	2009-02-04	2011-02-18	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2943667B1 (fr) *	2009-03-31	2011-05-06	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
ME00986B (me) *	2009-03-31	2012-06-20	Servier Lab	Novi postupak sinteze ivabradina i njegovih adicionih soli sa farmaceutski prihvatljivom kiselinom
FR2956401B1 (fr) *	2010-02-17	2012-02-03	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
RU2014109079A (ru)	2011-08-12	2015-09-20	Бёрингер Ингельхайм Ветмедика Гмбх	Фармацевтическая композиция с маскированным вкусом
EP2953612A1 (en)	2013-02-11	2015-12-16	Boehringer Ingelheim Vetmedica GmbH	Kit-of-parts
FR3003859B1 (fr) *	2013-03-26	2015-03-13	Servier Lab	"procede de synthese de derives de la 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one et application a la synthese de l'ivabradine"
HU230826B1 (hu) *	2014-11-19	2018-07-30	Richter Gedeon Nyrt.	Eljárás benzazepin származékok előállítására

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3474090A (en) *	1966-12-22	1969-10-21	American Cyanamid Co	3-aminoalkyl-1,3-benzodiazepin-2-ones
US3780023A (en) *	1972-06-30	1973-12-18	J Suh	2-aralkylamino-4,5-dihydro-3h-1,3-benzodiazepines
US4210749A (en) *	1974-11-12	1980-07-01	Pennwalt Corporation	Substituted 1,2,4,5-tetrahydro-3H,3 benzazepines
DE2639718A1 (de)	1976-09-03	1978-03-16	Thomae Gmbh Dr K	Neue phenylaethylamine
ZA786230B (en) *	1977-12-21	1979-10-31	Smithkline Corp	8 and/or 9 substituted 2-benzazepine compounds
ZA792785B (en)	1978-07-07	1980-08-27	Smithkline Corp	Mercapto substituted-2,3,4,5-tetrahydro-1h-3-benzazepines
ES484553A1 (es) *	1978-10-05	1980-05-16	Hoechst Ag	Un metodo para preparar 4-fenil-1,3-benzodiazepinas
DE2850078A1 (de) *	1978-11-18	1980-05-29	Basf Ag	Aminopropanolderivate des 6-hydroxy-2,3,4,5-tetrahydro-1h-1- benzazepin-2-ons

1981
- 1981-05-19 DE DE19813119874 patent/DE3119874A1/de not_active Withdrawn
1982
- 1982-05-06 AT AT82103931T patent/ATE14725T1/de not_active IP Right Cessation
- 1982-05-06 DE DE8282103931T patent/DE3265206D1/de not_active Expired
- 1982-05-06 EP EP82103931A patent/EP0065229B1/de not_active Expired
- 1982-05-12 CS CS823456A patent/CS251760B2/cs unknown
- 1982-05-13 SU SU823435639A patent/SU1160935A3/ru active
- 1982-05-13 UA UA3435639A patent/UA8038A1/uk unknown
- 1982-05-17 PL PL1982236474A patent/PL136914B1/pl unknown
- 1982-05-17 DK DK222382A patent/DK156720C/da not_active IP Right Cessation
- 1982-05-17 DD DD82239912A patent/DD202872A5/de not_active IP Right Cessation
- 1982-05-17 FI FI821724A patent/FI77856C/fi not_active IP Right Cessation
- 1982-05-18 ZA ZA823413A patent/ZA823413B/xx unknown
- 1982-05-18 CA CA000403172A patent/CA1185239A/en not_active Expired
- 1982-05-18 JP JP57083915A patent/JPS57193462A/ja active Granted
- 1982-05-18 YU YU1051/82A patent/YU44674B/xx unknown
- 1982-05-18 NO NO821645A patent/NO159166C/no not_active IP Right Cessation
- 1982-05-18 HU HU821581A patent/HU186584B/hu unknown
- 1982-05-18 IL IL65814A patent/IL65814A/xx not_active IP Right Cessation
- 1982-05-18 AR AR289434A patent/AR231130A1/es active
- 1982-05-18 PT PT74919A patent/PT74919B/pt unknown
- 1982-05-18 IE IE1194/82A patent/IE53016B1/en not_active IP Right Cessation
- 1982-05-18 GB GB8214503A patent/GB2099425B/en not_active Expired
- 1982-05-18 ES ES512285A patent/ES512285A0/es active Granted
- 1982-05-18 NZ NZ200659A patent/NZ200659A/en unknown
- 1982-05-18 AU AU83794/82A patent/AU551509B2/en not_active Expired
- 1982-05-19 GR GR68197A patent/GR76458B/el unknown
- 1982-05-19 KR KR8202240A patent/KR890001544B1/ko active
- 1982-05-19 KR KR1019890001999A patent/KR890001545B1/ko not_active IP Right Cessation
- 1982-11-29 ES ES517758A patent/ES517758A0/es active Granted
- 1982-11-29 ES ES517753A patent/ES8308309A1/es not_active Expired
- 1982-11-29 ES ES517756A patent/ES8308310A1/es not_active Expired
- 1982-11-29 ES ES517757A patent/ES8308311A1/es not_active Expired
1988
- 1988-06-09 HK HK433/88A patent/HK43388A/xx not_active IP Right Cessation
1989
- 1989-02-20 KR KR1019890001998A patent/KR890001550B1/ko not_active IP Right Cessation
1991
- 1991-12-27 CS CS914102A patent/CS410291A3/cs unknown
1992
- 1992-06-09 MX MX9202743A patent/MX9202743A/es unknown
1994
- 1994-01-25 BG BG98418A patent/BG60412B2/bg unknown

Also Published As

Publication number	Publication date
FI77856B (fi)	1989-01-31
UA8038A1 (uk)	1995-12-26
PT74919B (de)	1985-05-16
DE3119874A1 (de)	1982-12-09
ES517756A0 (es)	1983-08-16
HU186584B (en)	1985-08-28
CA1185239A (en)	1985-04-09
GB2099425B (en)	1985-02-06
ATE14725T1 (de)	1985-08-15
ES8306726A1 (es)	1983-06-01
PL236474A1 (en)	1983-06-20
ES517757A0 (es)	1983-08-16
CS251760B2 (en)	1987-08-13
GR76458B (es)	1984-08-10
PT74919A (de)	1982-06-01
GB2099425A (en)	1982-12-08
AU8379482A (en)	1982-11-25
ES8308312A1 (es)	1983-08-16
KR830010077A (ko)	1983-12-26
PL136914B1 (en)	1986-04-30
NO821645L (no)	1982-11-22
IE53016B1 (en)	1988-05-11
FI77856C (fi)	1989-05-10
DK222382A (da)	1982-11-20
KR890001545B1 (ko)	1989-05-08
FI821724A0 (fi)	1982-05-17
NZ200659A (en)	1985-05-31
ES517753A0 (es)	1983-08-16
DD202872A5 (de)	1983-10-05
MX9202743A (es)	1992-06-30
ES8308310A1 (es)	1983-08-16
YU105182A (en)	1986-12-31
EP0065229A1 (de)	1982-11-24
ZA823413B (en)	1984-01-25
KR890001544B1 (ko)	1989-05-08
AU551509B2 (en)	1986-05-01
HK43388A (en)	1988-06-17
DK156720B (da)	1989-09-25
NO159166C (no)	1988-12-07
CS410291A3 (en)	1992-08-12
AR231130A1 (es)	1984-09-28
JPH0136829B2 (es)	1989-08-02
ES517758A0 (es)	1983-08-16
ES8308311A1 (es)	1983-08-16
BG60412B2 (bg)	1995-02-28
NO159166B (no)	1988-08-29
DK156720C (da)	1990-02-19
EP0065229B1 (de)	1985-08-07
IL65814A0 (en)	1982-08-31
SU1160935A3 (ru)	1985-06-07
ES512285A0 (es)	1983-06-01
ES8308309A1 (es)	1983-08-16
YU44674B (en)	1990-12-31
IE821194L (en)	1982-11-19
DE3265206D1 (en)	1985-09-12
KR890001550B1 (ko)	1989-05-08
JPS57193462A (en)	1982-11-27

Legal Events

Date	Code	Title	Description
2000-08-31	KB	Patent renewed
2002-07-25	EXP	Patent expired

Publication	Publication Date	Title
IL65814A (en)	1986-02-28	3-phenylalkylaminoalkyl-3-benzazepine and 1,3-benzodiazepine derivatives,their preparation and pharmaceutical compositions containing them
IL65257A0 (en)	1983-12-30	Arylcyclo-butanealkylamine derivatives,their preparation and pharmaceutical compositions containing them
IL73706A0 (en)	1985-03-31	2,2'-iminobisethanol derivatives,their preparation and pharmaceutical compositions containing them
IL65803A0 (en)	1982-08-31	Cyclobutene-dione derivatives,their preparation and pharmaceutical compositions containing them
IL66099A0 (en)	1982-09-30	N-aryl-piperazinealkanamides,their preparation and pharmaceutical compositions containing them
IL66501A0 (en)	1982-12-31	Benzazepine-2-one derivatives,their manufacture and pharmaceutical compositions containing them
IL65076A (en)	1984-12-31	3,4-dihydro-5h-2,3-benzo-diazepine derivatives,their preparation and pharmaceutical compositions containing them
IL76405A0 (en)	1986-01-31	1,3-diacyl-2-oxyindole derivatives,their preparation and pharmaceutical compositions containing them
IL64777A0 (en)	1982-03-31	3-aminopropoxyaryl derivatives,their preparation and pharmaceutical compositions containing them
IL66408A0 (en)	1982-11-30	Amino-pyridazine derivatives,their preparation and pharmaceutical compositions containing them
IL66683A0 (en)	1982-12-31	Benzo-heterocycles,their preparation and pharmaceutical compositions containing them
IL67180A0 (en)	1983-03-31	Morphinate derivatives,their preparation and pharmaceutical compositions containing them
IL66471A (en)	1986-02-28	9'-thiaergotaman-3',6',18-trione derivatives,their preparation and pharmaceutical compositions containing them
IL65051A0 (en)	1982-04-30	Azepine derivatives,their preparation and pharmaceutical compositions containing them
DE3275296D1 (en)	1987-03-05	Azabicyclo-(3,3,1)-nonylbenzamide derivatives, processes for their preparation, and pharmaceutical compositions containing them
IL65327A0 (en)	1982-05-31	Acylquinolinone derivatives,their preparation and pharmaceutical compositions containing them
IL66424A (en)	1985-10-31	3-amino-pyridazine derivatives,their preparation and pharmaceutical compositions containing them
IL65852A (en)	1986-04-29	2-aminoalkylenethioquinoline derivatives,their preparation and pharmaceutical compositions comprising them
IL66238A0 (en)	1982-11-30	Benzothiazolesulfonamide derivatives,their preparation and pharmaceutical compositions containing them
IL65422A0 (en)	1982-07-30	2-piperazino-pyrimidine derivatives,their preparation and pharmaceutical compositions containing them
IL62229A (en)	1987-10-30	3-substituted-5-amino-1,2,4-triazole derivatives,their preparation and pharmaceutical compositions containing them
IL74270A0 (en)	1985-05-31	1,2,4-triazole derivatives,their preparation and pharmaceutical compositions containing them
IL76312A (en)	1991-06-10	Xenocoumacins and derivatives thereof,their preparation and pharmaceutical compositions containing them
IL73278A0 (en)	1985-01-31	Pharmaceutical compositions containing 1,2-dithiolan derivatives,certain such derivatives and their preparation
DE3268487D1 (en)	1986-02-27	2,3,4-trinor-m-inter-phenylene-prostaglandin derivatives, their preparation and pharmaceutical compositions