IL65808A - 2-aryl(aralkyl)allylamines,their preparation and pharmaceutical compositions containing them - Google Patents

2-aryl(aralkyl)allylamines,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL65808A
IL65808A IL65808A IL6580882A IL65808A IL 65808 A IL65808 A IL 65808A IL 65808 A IL65808 A IL 65808A IL 6580882 A IL6580882 A IL 6580882A IL 65808 A IL65808 A IL 65808A
Authority
IL
Israel
Prior art keywords
sub
integer
hydrogen
formula
phenyl
Prior art date
Application number
IL65808A
Other languages
English (en)
Other versions
IL65808A0 (en
Original Assignee
Merrell Toraude & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Toraude & Co filed Critical Merrell Toraude & Co
Priority to IL7582982A priority Critical patent/IL75829A/xx
Publication of IL65808A0 publication Critical patent/IL65808A0/xx
Publication of IL65808A publication Critical patent/IL65808A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/62Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, ***e
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40Halogenated unsaturated alcohols
    • C07C33/46Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C07C33/483Monocyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40Halogenated unsaturated alcohols
    • C07C33/46Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C07C33/486Polycyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/20Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/20Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09Geometrical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Indole Compounds (AREA)
  • Purification Treatments By Anaerobic Or Anaerobic And Aerobic Bacteria Or Animals (AREA)
  • Treatment Of Sludge (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pretreatment Of Seeds And Plants (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL65808A 1981-06-01 1982-05-17 2-aryl(aralkyl)allylamines,their preparation and pharmaceutical compositions containing them IL65808A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL7582982A IL75829A (en) 1981-06-01 1982-05-17 Alkoxyphenyl compounds and their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/268,555 US4454158A (en) 1981-06-01 1981-06-01 Allyl amine MAO inhibitors

Publications (2)

Publication Number Publication Date
IL65808A0 IL65808A0 (en) 1982-08-31
IL65808A true IL65808A (en) 1986-12-31

Family

ID=23023513

Family Applications (2)

Application Number Title Priority Date Filing Date
IL65808A IL65808A (en) 1981-06-01 1982-05-17 2-aryl(aralkyl)allylamines,their preparation and pharmaceutical compositions containing them
IL75829A IL75829A0 (en) 1981-06-01 1985-07-17 Alkoxyphenyl compounds and their preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL75829A IL75829A0 (en) 1981-06-01 1985-07-17 Alkoxyphenyl compounds and their preparation

Country Status (18)

Country Link
US (1) US4454158A (xx)
EP (1) EP0067105B1 (xx)
JP (1) JPS5823649A (xx)
KR (1) KR890002756B1 (xx)
AT (1) ATE29875T1 (xx)
AU (2) AU550607B2 (xx)
CA (2) CA1187500A (xx)
DE (1) DE3277371D1 (xx)
DK (1) DK244282A (xx)
ES (4) ES8402810A1 (xx)
GB (2) GB2100255B (xx)
GR (1) GR78033B (xx)
IE (1) IE53456B1 (xx)
IL (2) IL65808A (xx)
MX (1) MX9202950A (xx)
NO (1) NO152837C (xx)
NZ (1) NZ200644A (xx)
ZA (1) ZA823633B (xx)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4699928A (en) * 1984-07-13 1987-10-13 Merrell Dow Pharmaceuticals Inc. Fluoroallylamine derivatives
US4703058A (en) * 1984-12-31 1987-10-27 Merrell Dow Pharmaceuticals Inc. β-methylene furanethanamines and use as anti-hypertensive agents
NZ214697A (en) * 1984-12-31 1988-10-28 Merrell Dow Pharma B-methylene-2- and 3-furanethanamine and pharmaceutical compositions
NZ214698A (en) * 1984-12-31 1988-08-30 Merrell Dow Pharma Thiophene derivatives and pharmaceutical compositions containing such
DE3683604D1 (de) * 1985-12-05 1992-03-05 Merrell Dow Pharma Nichtaromatische fluoralkylamin-mao-inhibitoren.
US4650907A (en) * 1985-12-05 1987-03-17 Merrell Dow Pharmaceuticals Inc. Nonaromatic fluoroallylamine MAO inhibitors
US4822812A (en) * 1987-05-21 1989-04-18 Merrell Dow Pharmaceuticals Inc. β-(Fluoromethylene)-5-hydroxytryptophan and derivatives and their use as prodrugs for MAO inhibition
NZ224982A (en) * 1987-06-16 1990-08-28 Merrell Dow Pharma E-2-(p-fluorophenethyl)-3-fluoroallylamine and its pharmaceutical compositions
US5252608A (en) * 1988-02-25 1993-10-12 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5182297A (en) * 1988-02-25 1993-01-26 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5059714A (en) * 1988-02-25 1991-10-22 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US4943593A (en) * 1988-02-25 1990-07-24 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
CA1338647C (en) * 1988-02-25 1996-10-15 Michael G. Palfreyman Inhibitors of lysyl oxidase
US4965288A (en) * 1988-02-25 1990-10-23 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5120764A (en) * 1988-11-01 1992-06-09 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US4981868A (en) * 1989-07-25 1991-01-01 Merrell Dow Pharmaceutical Pharmaceutically active 3-heteroaryl-2-fluoro-1-olefins
NZ302723A (en) * 1995-03-02 1998-04-27 Scherer Ltd R P Composition comprising monoamine oxidase b inhibitor and a carrier formulated for pre-gastric absorption of the monoamine oxidase b inhibitor
WO2007120528A2 (en) * 2006-03-31 2007-10-25 La Jolla Pharmaceutical Company Inhibitors of semicarbazide-sensitive amine oxidase (ssao) and vap-1 mediated adhesion useful for treatment and prevention of diseases
EP2046794A1 (de) * 2006-07-13 2009-04-15 Basf Se Fungizide azolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
WO2009055002A1 (en) * 2007-10-24 2009-04-30 La Jolla Pharmaceutical Company Combined inhibitors of cyclooxygenase and semicarbazide-sensitive amine oxidase (ssao) (vascular adhesion protein, vap-1)
EP2222160B1 (en) 2007-11-21 2015-03-18 Pharmaxis Ltd. Haloallylamine inhibitors of ssao/vap-1 and uses therefor
PL2844637T3 (pl) 2012-05-02 2018-09-28 Boehringer Ingelheim International Gmbh Podstawione 3-haloalliloaminowe inhibitory ssao i ich zastosowania
WO2015087094A1 (en) * 2013-12-10 2015-06-18 Semmelweis Egyetem New arylalkenylpropargylamine derivatives exhibiting neuroprotective action for the treatment of neurodegenerative diseases
TW202019877A (zh) 2018-08-03 2020-06-01 澳大利亞商法瑪西斯有限公司 離胺醯氧化酶之鹵化烯丙胺碸衍生物抑制劑及其用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2343038A1 (de) * 1973-08-25 1975-03-06 Hoechst Ag 2,3-diaryl-3-halogenallylamine und verfahren zu ihrer herstellung
SE7809127L (sv) * 1978-08-30 1980-03-01 Claesson Alf Allenaminer

Also Published As

Publication number Publication date
ES512699A0 (es) 1984-03-01
ZA823633B (en) 1983-03-30
KR890002756B1 (ko) 1989-07-27
IE53456B1 (en) 1988-11-23
EP0067105A3 (en) 1984-02-22
ATE29875T1 (de) 1987-10-15
ES8503639A1 (es) 1985-04-16
ES8507461A1 (es) 1985-10-01
AU8423882A (en) 1983-02-03
CA1187500A (en) 1985-05-21
ES523873A0 (es) 1985-10-01
AU5180586A (en) 1986-06-12
US4454158A (en) 1984-06-12
GB2152039B (en) 1986-04-30
GB2100255A (en) 1982-12-22
NZ200644A (en) 1986-06-11
GB8428858D0 (en) 1984-12-27
MX9202950A (es) 1992-07-01
US4454158B1 (xx) 1992-12-22
NO152837C (no) 1985-11-27
KR830010044A (ko) 1983-12-24
NO821799L (no) 1982-12-02
IL75829A0 (en) 1985-11-29
GB2152039A (en) 1985-07-31
EP0067105A2 (en) 1982-12-15
ES8503638A1 (es) 1985-04-16
DK244282A (da) 1982-12-02
DE3277371D1 (en) 1987-10-29
NO152837B (no) 1985-08-19
ES523875A0 (es) 1985-04-16
AU550607B2 (en) 1986-03-27
IL65808A0 (en) 1982-08-31
ES523874A0 (es) 1985-04-16
AU576281B2 (en) 1988-08-18
CA1204759A (en) 1986-05-20
ES8402810A1 (es) 1984-03-01
JPS5823649A (ja) 1983-02-12
GR78033B (xx) 1984-09-26
GB2100255B (en) 1985-10-23
JPH0422898B2 (xx) 1992-04-20
EP0067105B1 (en) 1987-09-23
IE821246L (en) 1982-12-01

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Legal Events

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KB Patent renewed
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