IL59316A - Phenylpyrimidobenzazepine derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

Phenylpyrimidobenzazepine derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL59316A
IL59316A IL59316A IL5931680A IL59316A IL 59316 A IL59316 A IL 59316A IL 59316 A IL59316 A IL 59316A IL 5931680 A IL5931680 A IL 5931680A IL 59316 A IL59316 A IL 59316A
Authority
IL
Israel
Prior art keywords
hydrogen
lower alkyl
hydroxy
group
phenylpyrimidobenzazepine
Prior art date
Application number
IL59316A
Other versions
IL59316A0 (en
Original Assignee
Sparamedica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sparamedica Ag filed Critical Sparamedica Ag
Publication of IL59316A0 publication Critical patent/IL59316A0/en
Publication of IL59316A publication Critical patent/IL59316A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/34—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/16—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Pyrimido-2-benzazepines of the formula <IMAGE> wherein A is one of the groups <IMAGE> R<1> is hydrogen, chlorine, bromine, lower alkyl, the group NR<4>R<5>, the group -CH2-CO-R<7>, the group -NH(CH2)mNR<8>R<9>, hydroxy, lower alkoxy, mercapto or lower alkyl mercapto, R<2> is hydrogen, amino or di-lower alkyl amino, R<3> is hydrogen, lower acyloxy or hydroxy, X is hydrogen, halogen, trifluoromethyl, ethyl alpha -hydroxy ethyl or acetyl, Y is hydrogen or halogen, R<4> and R<5> each are hydrogen or lower alkyl or, together complete a five to seven membered heterocyclic ring, R<7> is hydroxy, lower alkoxy or NR<8>R<9>, R<8> and R<9> each are hydrogen or lower alkyl, n is 0 or 1 and m is 1 to 7, with certain provisos, and pharmaceutically acceptable acid addition salts thereof, exhibit pharmacological utility as anxiolytics and sedatives.
IL59316A 1979-02-07 1980-02-05 Phenylpyrimidobenzazepine derivatives,their preparation and pharmaceutical compositions containing them IL59316A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1011879A 1979-02-07 1979-02-07
US1670979A 1979-03-01 1979-03-01
CH51080 1980-01-22

Publications (2)

Publication Number Publication Date
IL59316A0 IL59316A0 (en) 1980-05-30
IL59316A true IL59316A (en) 1983-07-31

Family

ID=27172162

Family Applications (1)

Application Number Title Priority Date Filing Date
IL59316A IL59316A (en) 1979-02-07 1980-02-05 Phenylpyrimidobenzazepine derivatives,their preparation and pharmaceutical compositions containing them

Country Status (26)

Country Link
EP (1) EP0014470B1 (en)
AT (1) ATE14225T1 (en)
AU (1) AU535233B2 (en)
CA (1) CA1138863A (en)
DD (1) DD149066A5 (en)
DE (2) DE3070847D1 (en)
ES (1) ES8101590A1 (en)
FI (1) FI68832C (en)
FR (1) FR2450833A1 (en)
GB (1) GB2043636B (en)
HU (1) HU182662B (en)
IE (1) IE49630B1 (en)
IL (1) IL59316A (en)
IN (1) IN151574B (en)
IT (1) IT1140535B (en)
LU (1) LU82143A1 (en)
MC (1) MC1314A1 (en)
MT (1) MTP864B (en)
NL (1) NL8000715A (en)
NO (1) NO153138C (en)
NZ (1) NZ192803A (en)
PT (1) PT70794B (en)
RO (1) RO79168A (en)
SE (1) SE8000964L (en)
SU (1) SU1181547A3 (en)
YU (1) YU32380A (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU547557B2 (en) * 1980-08-05 1985-10-24 F. Hoffmann-La Roche & Co. Pyrimido (4,5-d)(2)benzazepines
EP0273697A3 (en) * 1986-12-30 1989-11-29 Merck & Co. Inc. 2-benzazepines with 5- and 6- membered heterocyclic rings
US5013333A (en) * 1990-04-13 1991-05-07 Tennant Company Unattended air cleaning system for surface maintenance machine
AU2005245386B2 (en) * 2004-05-07 2008-11-27 Amgen Inc. Nitrogenated heterocyclic derivatives as protein kinase modulators and use for the treatment of angiogenesis and cancer
AU2005243175B2 (en) 2004-05-14 2011-12-01 Millennium Pharmaceuticals, Inc. Compounds and methods for inhibiting mitotic progression by inhibition of Aurora kinase
EP2054413A2 (en) 2006-08-09 2009-05-06 Millennium Pharmaceuticals, Inc. Pyridobenzazepine compounds and methods for inhibiting mitotic progression
CL2007003244A1 (en) 2006-11-16 2008-04-04 Millennium Pharm Inc COMPOUNDS DERIVED FROM PIRIMIDO [5,4-D] [2] BENZAZEPINA; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUND; AND USE OF THE COMPOUND FOR THE TREATMENT OF CANCER.
US20100183601A1 (en) 2008-12-22 2010-07-22 Millennium Pharmaceuticals, Inc. Combination of Aurora Kinase Inhibitors and Anti-CD20 Antibodies
JO3635B1 (en) 2009-05-18 2020-08-27 Millennium Pharm Inc Solid pharmaceutical compositions and processes for their production
JP2013520424A (en) 2010-02-19 2013-06-06 ミレニアム ファーマシューティカルズ， インコーポレイテッド Sodium 4-{[9-chloro-7- (2-fluoro-6-methoxyphenyl) -5H-pyrimido [5,4-d] [2] benzoazepin-2-yl] amino} -2-methoxybenzoate Crystal form
US20130303519A1 (en) 2012-03-20 2013-11-14 Millennium Pharmaceuticals, Inc. Methods of treating cancer using aurora kinase inhibitors
CN105209042B (en) 2013-03-22 2019-03-08 米伦纽姆医药公司 The combination of 1/2 inhibitor of catalytic MTORC and selective aurora A kinase inhibitor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947585A (en) * 1974-06-03 1976-03-30 Ciba-Geigy Corporation Pyrazolobenzazepines

Also Published As

Publication number Publication date
LU82143A1 (en) 1981-09-10
SU1181547A3 (en) 1985-09-23
DE3070847D1 (en) 1985-08-14
MTP864B (en) 1981-04-29
FI68832C (en) 1985-11-11
CA1138863A (en) 1983-01-04
FI800367A (en) 1980-08-08
IE800227L (en) 1980-08-07
GB2043636B (en) 1983-05-11
IN151574B (en) 1983-05-28
FI68832B (en) 1985-07-31
IT8019740A0 (en) 1980-02-06
AU535233B2 (en) 1984-03-08
PT70794B (en) 1981-06-11
YU32380A (en) 1983-12-31
NO153138C (en) 1986-01-22
FR2450833A1 (en) 1980-10-03
HU182662B (en) 1984-02-28
RO79168A (en) 1982-06-25
MC1314A1 (en) 1981-03-10
EP0014470A2 (en) 1980-08-20
EP0014470B1 (en) 1985-07-10
NL8000715A (en) 1980-08-11
FR2450833B1 (en) 1983-06-10
GB2043636A (en) 1980-10-08
ES488311A0 (en) 1980-12-16
PT70794A (en) 1980-03-01
SE8000964L (en) 1980-08-08
EP0014470A3 (en) 1982-02-10
IE49630B1 (en) 1985-11-13
DE3004381A1 (en) 1980-09-04
NO800316L (en) 1980-08-08
ATE14225T1 (en) 1985-07-15
IT1140535B (en) 1986-10-01
ES8101590A1 (en) 1980-12-16
IL59316A0 (en) 1980-05-30
NO153138B (en) 1985-10-14
AU5529680A (en) 1980-08-14
DD149066A5 (en) 1981-06-24
NZ192803A (en) 1984-08-24

Similar Documents

Publication Publication Date Title
AU557691B2 (en) 2-penem antibiotics and their oxa-aza-, and carba analogues
IL57648A (en) 2-substituted-5,9-dimethyl-2&#39;-hydroxy-6,7-benzomorphanes,their preparation and pharmaceutical compositions containing them
IL59316A (en) Phenylpyrimidobenzazepine derivatives,their preparation and pharmaceutical compositions containing them
PL263885A1 (en) Method of obtaining novel derivatives of dihydrobenzofurane and chromate carbonamide
ES477785A1 (en) 2-Phenylimino-imidazolidines and salts thereof
AU554959B2 (en) Triazolo(4,3-a) quinazolin-5-ones
FI871637A (en) FOERFARANDE FOER FRAMSTAELLNING AV 1,5-BENZOTIAZEPINDERIVAT.
MX9204457A (en) COMPOUNDS OF 6-OXO-AZEPINOIDOL, AS WELL AS PROCEDURES AND INTERMEDIATE PRODUCTS FOR ITS PREPARATION, AND MEDICINES CONTAINING THESE COMPOUNDS.
SE8004129L (en) NEW TETRAHYDROPYRIDIN-4-YL-INDOLD DERIVATIVES AND SALTS THEREOF, PREPARATION AND USE THEREOF AS A MEDICINAL PRODUCT AND COMPOSITIONS CONTAINING THESE COMPOUNDS
SE8008189L (en) COMPOUNDS WITH ANTIALLERGIC AND ANTIULCEROS EFFECTS, SUCH 1-OXO-1H-TIAZOLO (3,2-A) PYRIMIDIN-2-CARBOXAMIDES AND INTERMEDIATES FOR THESE
ES474694A1 (en) 7-Amino-5H-benzocycloheptene derivatives and their salts, a process for their preparation, their use as medicines and pharmaceutical compositions containing them.
ES460807A1 (en) 4,5,6,7-Tetrahalo-isoindolin-1-one derivatives
ES8605247A1 (en) Substituted arylsulfonyl guanidines.
ES8705454A1 (en) Imidazoalkylcarboxylic-acid derivatives, process for their preparation and their use in the preparation of pharmaceutically active compounds.
ES479005A1 (en) 4-Amino-6,7-dimethoxy quinazoline derivatives, process for their preparation, their use and a pharmaceutical composition.
ES8104172A1 (en) Basically substituted phenols, process for their preparation, pharmaceutical preparations containing these compounds and their use.
ES8307812A1 (en) Beta-lactam antibacterial agents, their preparation and use.