IL54842A - 1-piperidino-phthalazine derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

1-piperidino-phthalazine derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number: IL54842A
Authority: IL; Israel
Prior art keywords: piperidino; preparation; pharmaceutical compositions; compositions containing; phthalazine derivatives
Prior art date: 1977-06-03

Application number

IL54842A

Other languages

English (en)

Other versions

IL54842A0 (en

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-06-03

Filing date

1978-06-01

Publication date

1982-01-31

1978-06-01 Application filed by Pfizer filed Critical Pfizer

1978-08-31 Publication of IL54842A0 publication Critical patent/IL54842A0/xx

1982-01-31 Publication of IL54842A publication Critical patent/IL54842A/xx

Links

YSKBWCJNIRPTNF-UHFFFAOYSA-N 1-piperidin-1-ylphthalazine Chemical class C1CCCCN1C1=NN=CC2=CC=CC=C12 YSKBWCJNIRPTNF-UHFFFAOYSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

IL54842A 1977-06-03 1978-06-01 1-piperidino-phthalazine derivatives,their preparation and pharmaceutical compositions containing them IL54842A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB2358277		1977-06-03

Publications (2)

Publication Number	Publication Date
IL54842A0 IL54842A0 (en)	1978-08-31
IL54842A true IL54842A (en)	1982-01-31

Family

ID=10198020

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL54842A IL54842A (en)	1977-06-03	1978-06-01	1-piperidino-phthalazine derivatives,their preparation and pharmaceutical compositions containing them

Country Status (29)

Country	Link
US (1)	US4289772A (xx)
JP (1)	JPS5416488A (xx)
AR (2)	AR222013A1 (xx)
AT (2)	AT362792B (xx)
AU (1)	AU505373B1 (xx)
BE (1)	BE867727A (xx)
CA (1)	CA1111850A (xx)
DD (1)	DD137355A5 (xx)
DE (1)	DE2824064A1 (xx)
DK (1)	DK248078A (xx)
EG (1)	EG13527A (xx)
ES (4)	ES470470A1 (xx)
FI (1)	FI781753A (xx)
FR (1)	FR2392986A1 (xx)
GB (1)	GB2000136B (xx)
GR (1)	GR74402B (xx)
HU (1)	HU179745B (xx)
IL (1)	IL54842A (xx)
IN (3)	IN148482B (xx)
IT (1)	IT1094944B (xx)
LU (1)	LU79761A1 (xx)
NL (1)	NL7806016A (xx)
NO (1)	NO781935L (xx)
NZ (1)	NZ187453A (xx)
PL (3)	PL116437B1 (xx)
PT (1)	PT68126A (xx)
SE (1)	SE7806519L (xx)
SU (2)	SU856383A3 (xx)
ZA (1)	ZA783183B (xx)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4370328A (en) *	1977-11-03	1983-01-25	Pfizer Inc.	Cardiac stimulant 1-(3- or 4-substituted piperidino)phthalazines
IL59619A0 (en) *	1979-03-28	1980-06-30	Pfizer	Phthalazine derivatives,their preparation and pharmaceutical compositions containing them
IL62200A (en) *	1980-03-01	1984-09-30	Wyeth John & Brother Ltd	Piperidine derivatives,their preparation and pharmaceutical compositions containing them
GB8320958D0 (en) *	1983-08-03	1983-09-07	Pfizer Ltd	Quinazoline cardiac stimulants
US5001125A (en) *	1984-03-26	1991-03-19	Janssen Pharmaceutica N.V.	Anti-virally active pyridazinamines
US4882354A (en) *	1987-12-16	1989-11-21	Norwich Eaton Pharmaceuticals, Inc.	N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents
US5300515A (en) *	1991-01-31	1994-04-05	Kyorin Pharmaceutical Co., Ltd.	Carbamic acid derivatives and method for preparing the same
JP3169188B2 (ja) *	1991-01-31	2001-05-21	杏林製薬株式会社	カルバミン酸誘導体及びその製造方法
EP0621267A1 (en) *	1993-04-07	1994-10-26	Shell Internationale Researchmaatschappij B.V.	Spiropiperidine derivatives and their use as fungicides
US5728712A (en) *	1995-05-19	1998-03-17	Chiroscience Limited	3,4-disubstituted-phenylsulphonamides and their therapeutic use
WO1998007430A1 (fr) *	1996-08-20	1998-02-26	Eisai Co., Ltd.	Medicament contre les defaillances de l'erection, renfermant un compose a base de pyridazine fondue
US20030186963A1 (en)	2001-09-14	2003-10-02	Dorwald Florencio Zaragoza	Substituted piperidines
ES2355139T3 (es) *	2002-08-16	2011-03-23	Janssen Pharmaceutica Nv	Compuestos de piperidinilo que unen selectivamente a receptores de integrinas.
US20040224986A1 (en) *	2002-08-16	2004-11-11	Bart De Corte	Piperidinyl targeting compounds that selectively bind integrins
US20060019975A1 (en) *	2004-07-23	2006-01-26	Pfizer Inc	Novel piperidyl derivatives of quinazoline and isoquinoline
TW200630337A (en)	2004-10-14	2006-09-01	Euro Celtique Sa	Piperidinyl compounds and the use thereof
EP2258359A3 (en)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation with sabcomelin
JP2009506069A (ja)	2005-08-26	2009-02-12	ブレインセルス，インコーポレイティド	ムスカリン性受容体調節による神経発生
CA2625153A1 (en)	2005-10-21	2007-04-26	Braincells, Inc.	Modulation of neurogenesis by pde inhibition
US20070112017A1 (en)	2005-10-31	2007-05-17	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
EP1981868A2 (en) *	2006-01-27	2008-10-22	Pfizer Products Inc.	Aminophthalazine derivative compounds
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
WO2007110449A1 (en)	2006-03-29	2007-10-04	Euro-Celtique S.A.	Benzenesulfonamide compounds and their use
TW200815353A (en)	2006-04-13	2008-04-01	Euro Celtique Sa	Benzenesulfonamide compounds and their use
TW200812963A (en)	2006-04-13	2008-03-16	Euro Celtique Sa	Benzenesulfonamide compounds and the use thereof
US7678808B2 (en)	2006-05-09	2010-03-16	Braincells, Inc.	5 HT receptor mediated neurogenesis
EP2377531A2 (en)	2006-05-09	2011-10-19	Braincells, Inc.	Neurogenesis by modulating angiotensin
EP1903037A1 (de) *	2006-09-07	2008-03-26	Bayer Schering Pharma Aktiengesellschaft	1-(Het)aryl-3-[hetaryl-piperidin-4-yl]-thioharnstoffe als Modulatoren des EP2-Rezeptors
EP1900731A1 (de) *	2006-09-07	2008-03-19	Bayer Schering Pharma Aktiengesellschaft	N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren
WO2008030651A1 (en)	2006-09-08	2008-03-13	Braincells, Inc.	Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
US8399486B2 (en)	2007-04-09	2013-03-19	Purdue Pharma L.P.	Benzenesulfonyl compounds and the use thereof
CA2695211A1 (en)	2007-08-07	2009-02-12	F. Hoffmann-La Roche Ag	Pyrrolidine aryl-ether as nk3 receptor antagonists
EP2190815B1 (en)	2007-08-22	2011-08-10	F. Hoffmann-La Roche AG	Pyrrolidine aryl-ether as nk3 receptor antagonists
CA2699464A1 (en) *	2007-09-14	2009-03-19	F. Hoffmann-La Roche Ag	Piperidine derivatives as nk3 receptor antagonists
US8765736B2 (en)	2007-09-28	2014-07-01	Purdue Pharma L.P.	Benzenesulfonamide compounds and the use thereof
US20100216805A1 (en)	2009-02-25	2010-08-26	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
AR077014A1 (es)	2009-06-19	2011-07-27	Lilly Co Eli	Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
WO2013106547A1 (en)	2012-01-10	2013-07-18	President And Fellows Of Harvard College	Beta-cell replication promoting compounds and methods of their use
CN113087654B (zh) *	2021-04-15	2022-12-23	苏州昊帆生物股份有限公司	哌啶-4-丁胺的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1094044A (en) *	1965-07-12	1967-12-06	Vantorex Ltd	Phthalazine derivatives
GB1199768A (en)	1966-10-31	1970-07-22	Pfizer & Co C	Nitrogen Heterocycles and process for their preparation
GB1293565A (en)	1969-05-03	1972-10-18	Aspro Nicholas Ltd	Aminophthalazines and pharmaceutical compositions thereof
GB1460389A (en)	1974-07-25	1977-01-06	Pfizer Ltd	4-substituted quinazoline cardiac stimulants

1978
- 1978-05-15 IN IN364/DEL/78A patent/IN148482B/en unknown
- 1978-06-01 FI FI781753A patent/FI781753A/fi not_active Application Discontinuation
- 1978-06-01 IT IT24106/78A patent/IT1094944B/it active
- 1978-06-01 GB GB7826202A patent/GB2000136B/en not_active Expired
- 1978-06-01 IL IL54842A patent/IL54842A/xx unknown
- 1978-06-01 BE BE188257A patent/BE867727A/xx unknown
- 1978-06-01 NZ NZ187453A patent/NZ187453A/xx unknown
- 1978-06-01 GR GR56414A patent/GR74402B/el unknown
- 1978-06-01 PT PT68126A patent/PT68126A/pt unknown
- 1978-06-01 DE DE19782824064 patent/DE2824064A1/de not_active Ceased
- 1978-06-01 JP JP6627978A patent/JPS5416488A/ja active Granted
- 1978-06-02 AU AU36839/78A patent/AU505373B1/en not_active Expired
- 1978-06-02 PL PL1978217897A patent/PL116437B1/pl unknown
- 1978-06-02 NO NO781935A patent/NO781935L/no unknown
- 1978-06-02 DK DK248078A patent/DK248078A/da not_active Application Discontinuation
- 1978-06-02 DD DD78205751A patent/DD137355A5/xx unknown
- 1978-06-02 CA CA304,700A patent/CA1111850A/en not_active Expired
- 1978-06-02 SU SU782624349A patent/SU856383A3/ru active
- 1978-06-02 FR FR7816545A patent/FR2392986A1/fr active Granted
- 1978-06-02 PL PL1978217896A patent/PL116420B1/pl unknown
- 1978-06-02 ZA ZA00783183A patent/ZA783183B/xx unknown
- 1978-06-02 NL NL7806016A patent/NL7806016A/xx not_active Application Discontinuation
- 1978-06-02 ES ES470470A patent/ES470470A1/es not_active Expired
- 1978-06-02 SE SE7806519A patent/SE7806519L/xx unknown
- 1978-06-02 AR AR272434A patent/AR222013A1/es active
- 1978-06-02 HU HU78PI629A patent/HU179745B/hu unknown
- 1978-06-02 LU LU79761A patent/LU79761A1/fr unknown
- 1978-06-02 AT AT0400878A patent/AT362792B/de not_active IP Right Cessation
- 1978-06-02 PL PL1978207337A patent/PL113208B1/pl unknown
- 1978-06-03 EG EG354/78A patent/EG13527A/xx active
1979
- 1979-03-01 ES ES478199A patent/ES478199A1/es not_active Expired
- 1979-03-01 ES ES478201A patent/ES478201A1/es not_active Expired
- 1979-03-01 ES ES478200A patent/ES478200A1/es not_active Expired
- 1979-06-18 SU SU792777649A patent/SU862826A3/ru active
- 1979-12-13 US US06/103,342 patent/US4289772A/en not_active Expired - Lifetime
1980
- 1980-02-12 AR AR279935A patent/AR223999A1/es active
- 1980-05-20 IN IN368/DEL/80A patent/IN149550B/en unknown
- 1980-06-10 AT AT0305080A patent/AT363096B/de not_active IP Right Cessation
1981
- 1981-01-13 IN IN19/DEL/81A patent/IN149973B/en unknown

Also Published As

Publication number	Publication date
AR223999A1 (es)	1981-10-15
IN149973B (xx)	1982-06-19
SU862826A3 (ru)	1981-09-07
LU79761A1 (fr)	1980-01-22
JPS5538351B2 (xx)	1980-10-03
SE7806519L (sv)	1978-12-04
DE2824064A1 (de)	1978-12-14
ES478200A1 (es)	1980-01-01
IN149550B (xx)	1982-01-16
ATA400878A (de)	1980-11-15
PL116420B1 (en)	1981-06-30
US4289772A (en)	1981-09-15
ZA783183B (en)	1979-06-27
PL207337A1 (pl)	1979-06-04
AT363096B (de)	1981-07-10
AR222013A1 (es)	1981-04-15
AU505373B1 (en)	1979-11-15
BE867727A (fr)	1978-12-01
EG13527A (en)	1981-12-31
PL116437B1 (en)	1981-06-30
IL54842A0 (en)	1978-08-31
ATA305080A (de)	1980-12-15
HU179745B (en)	1982-12-28
DD137355A5 (de)	1979-08-29
GR74402B (xx)	1984-06-28
AT362792B (de)	1981-06-10
JPS5416488A (en)	1979-02-07
GB2000136B (en)	1982-01-06
FI781753A (fi)	1978-12-04
NZ187453A (en)	1980-12-19
ES478199A1 (es)	1980-01-16
FR2392986A1 (fr)	1978-12-29
PL113208B1 (en)	1980-11-29
ES470470A1 (es)	1979-09-01
IT1094944B (it)	1985-08-10
IT7824106A0 (it)	1978-06-01
NO781935L (no)	1978-12-05
ES478201A1 (es)	1980-02-01
PT68126A (en)	1978-07-01
CA1111850A (en)	1981-11-03
NL7806016A (nl)	1978-12-05
IN148482B (xx)	1981-03-07
DK248078A (da)	1978-12-04
FR2392986B1 (xx)	1982-07-16
GB2000136A (en)	1979-01-04
SU856383A3 (ru)	1981-08-15

Publication	Publication Date	Title
IL54842A (en)	1982-01-31	1-piperidino-phthalazine derivatives,their preparation and pharmaceutical compositions containing them
IL56155A (en)	1982-09-30	Substituted alkanoylanilide derivatives,their preparation and pharmaceutical compositions comprising them
DE2861316D1 (en)	1982-01-14	Thienothiazine derivatives, their preparation and compositions containing them
DE2862355D1 (en)	1984-01-19	Amine derivatives, their preparation and pharmaceutical compositions containing them
IL56206A0 (en)	1979-03-12	New 1,2-benzothiazine-1,1-doxide derivatives, their preparation and pharmaceutical compositions containing them
IL55183A0 (en)	1978-09-29	Novel imidazoquinazoline derivatives, their preparation and pharmaceutical compositions containing them
IL55845A (en)	1982-07-30	Quinazoline derivatives,their preparation and pharmaceutical compositions containing them
IL56017A (en)	1983-03-31	5-cyano-prostacyclin derivatives,their manufacture and pharmaceutical compositions containing them
IL55765A (en)	1982-08-31	Dehydropyridine derivatives,their preparation and pharmaceutical compositions containing them
IL56284A (en)	1983-03-31	7-(2-thiazolyl-2-alkoxyiminoacetamido)-cephalosporin derivatives,their preparation and pharmaceutical compositions containing them
IL54438A (en)	1981-10-30	Substituted anisole derivatives,their preparation and pharmaceutical compositions containing them
IL54535A0 (en)	1978-07-31	Novel -lactam derivatives, their preparation and pharmaceutical compositions containing them
IL53857A0 (en)	1978-04-30	New aminoalkoxyphenyl derivatives, their preparation and pharmaceutical compositions containing them
IL55813A0 (en)	1978-12-17	Movel triazile derivatives, their preparation and pharmaceutical compositions containing them
IL55254A (en)	1983-03-31	Bis-isoquinolinium compounds,their preparation and pharmaceutical compositions containing them
IL55153A (en)	1983-07-31	Piperazine derivatives,their preparation and pharmaceutical compositions containing them
IL55894A (en)	1981-09-13	1-alkylenedithia (or oxathia) benzyl-4-heteroaryl-piperazine derivatives,their preparation and pharmaceutical compositions containing them
IL53766A0 (en)	1978-04-30	4-diphenylmethylene-1-hydroxybenzyl-piperidine derivatives, their preparation and pharmaceutical compositions containing them
IL55857A (en)	1982-07-30	Benzodioxanylcarbonyl-piperazinoquinazoline derivatives,their preparation and pharmaceutical compositions containing them
IL53861A0 (en)	1978-04-30	Novel n-aralkylaniline derivatives, their preparation and pharmaceutical compositions containing them
IL55120A0 (en)	1978-09-29	New 3-pyridazine derivatives,their preparation and pharmaceutical compositions containing them
IL55095A0 (en)	1978-09-29	Novel piperidino-propanol derivatives,their preparation and pharmaceutical compositions containing them
IL54899A (en)	1982-05-31	Pyridazinylhydrazones,their preparation and pharmaceutical compositions containing them
IL54677A (en)	1981-02-27	N1-carboxylic acyl-n2-phenyl-2-hydroxy-1,3-diaminopropane derivatives, their preparation and pharmaceutical compositions containing them
IL53948A0 (en)	1978-04-30	New thiazinoindole derivatives, their preparation and pharmaceutical compositions containing them