IL164803A0 - Means and methods for the production of adenovirusvectors - Google Patents
Means and methods for the production of adenovirusvectorsInfo
- Publication number
- IL164803A0 IL164803A0 IL16480303A IL16480303A IL164803A0 IL 164803 A0 IL164803 A0 IL 164803A0 IL 16480303 A IL16480303 A IL 16480303A IL 16480303 A IL16480303 A IL 16480303A IL 164803 A0 IL164803 A0 IL 164803A0
- Authority
- IL
- Israel
- Prior art keywords
- methods
- complementing cell
- orf6
- adenovirusvectors
- production
- Prior art date
Links
- 239000013598 vector Substances 0.000 abstract 3
- 101150029662 E1 gene Proteins 0.000 abstract 1
- 108700026244 Open Reading Frames Proteins 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/861—Adenoviral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
- C12N2810/6009—Vectors comprising as targeting moiety peptide derived from defined protein from viruses dsDNA viruses
- C12N2810/6018—Adenoviridae
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- AIDS & HIV (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL0200280 | 2002-04-25 | ||
PCT/EP2003/050125 WO2003104467A1 (en) | 2002-04-25 | 2003-04-24 | Means and methods for the production of adenovirus vectors |
Publications (1)
Publication Number | Publication Date |
---|---|
IL164803A0 true IL164803A0 (en) | 2005-12-18 |
Family
ID=29728828
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL16480303A IL164803A0 (en) | 2002-04-25 | 2003-04-24 | Means and methods for the production of adenovirusvectors |
IL164803A IL164803A (en) | 2002-04-25 | 2004-10-24 | Means and methods for the production of adenovirus vectors |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL164803A IL164803A (en) | 2002-04-25 | 2004-10-24 | Means and methods for the production of adenovirus vectors |
Country Status (23)
Country | Link |
---|---|
US (2) | US7468181B2 (ja) |
EP (1) | EP1497438B1 (ja) |
JP (1) | JP4495587B2 (ja) |
KR (1) | KR101021387B1 (ja) |
CN (1) | CN100497639C (ja) |
AT (1) | ATE447037T1 (ja) |
AU (1) | AU2003271737B2 (ja) |
BR (1) | BR0308783A (ja) |
CA (1) | CA2477954C (ja) |
DE (1) | DE60329835D1 (ja) |
DK (1) | DK1497438T3 (ja) |
EA (1) | EA010828B1 (ja) |
ES (1) | ES2335657T3 (ja) |
HK (1) | HK1068371A1 (ja) |
IL (2) | IL164803A0 (ja) |
MX (1) | MXPA04008891A (ja) |
NO (1) | NO332108B1 (ja) |
NZ (1) | NZ534866A (ja) |
PL (1) | PL215165B1 (ja) |
PT (1) | PT1497438E (ja) |
SI (1) | SI1497438T1 (ja) |
WO (1) | WO2003104467A1 (ja) |
ZA (1) | ZA200406942B (ja) |
Families Citing this family (115)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69638058D1 (de) | 1995-06-15 | 2009-11-26 | Crucell Holland Bv | Verpackungssysteme für humane rekombinante Adenoviren zur Gentherapie |
US6929946B1 (en) * | 1998-11-20 | 2005-08-16 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
US6492169B1 (en) | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
US6913922B1 (en) * | 1999-05-18 | 2005-07-05 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
US20050232900A1 (en) * | 1999-05-18 | 2005-10-20 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
JP4495587B2 (ja) * | 2002-04-25 | 2010-07-07 | クルセル ホランド ベー ヴェー | 組換えアデノウイルスベクターおよびその使用 |
PL208588B1 (pl) | 2002-04-25 | 2011-05-31 | Crucell Holland Bv | Rekombinowane adenowirusy, wyizolowane kwasy nukleinowe, komórki pakujące oraz sposoby zwiększania stabilności i/lub pojemności upakowania rekombinowanego adenowirusa |
EP1539937A4 (en) * | 2002-08-22 | 2006-07-26 | Merck & Co Inc | METHODS OF PROPAGATION OF ADENOVIRUS AND VIRUS SO OBTAINED |
US20070036721A1 (en) * | 2003-09-23 | 2007-02-15 | Uab Resarch Foundation | Methods and compositions for in vivo inflammation monitoring |
NZ548495A (en) | 2004-02-23 | 2009-05-31 | Crucell Holland Bv | Virus purification methods |
BRPI0518933A2 (pt) | 2004-11-16 | 2008-12-16 | Crucell Holland B V E Aeras Gl | adenovÍrus recombinante defeituoso de replicaÇço, vetor de polinucleotÍdeo recombinante, vacina multivalente da tuberculose, e, uso do antÍgeno tb10.4 de mycobacterium |
DK1869171T4 (en) | 2005-04-11 | 2016-01-18 | Crucell Holland Bv | Virus cleaning using ultrafiltration |
EP1998804B1 (en) * | 2006-03-27 | 2014-04-16 | Crucell Holland B.V. | Compositions comprising a recombinant adenovirus and an adjuvant |
JP5770633B2 (ja) * | 2008-11-03 | 2015-08-26 | クルセル ホランド ベー ヴェー | アデノウイルスベクターの産生方法 |
AU2010305768B2 (en) | 2009-10-15 | 2015-05-14 | Crucell Holland B.V. | Process for adenovirus purification from high cell density cultures |
BR112012008516B1 (pt) | 2009-10-15 | 2021-10-19 | Janssen Vaccines & Prevention B.V. | Método para purificar partículas de adenovírus a partir de uma suspensão de célula |
AU2010314842A1 (en) | 2009-11-09 | 2012-05-31 | Genvec, Inc. | Methods of propagating monkey adenoviral vectors |
AU2011214262B2 (en) | 2010-02-15 | 2015-05-21 | Crucell Holland B.V. | Method for the production of Ad26 adenoviral vectors |
AP3390A (en) | 2010-09-20 | 2015-08-31 | Crucell Holland Bv | Therapeutic vaccination against active tuberculosis |
CA2809463C (en) | 2010-09-27 | 2021-05-25 | Crucell Holland B.V. | Heterologous prime boost vaccination regimen against malaria |
WO2012082918A1 (en) | 2010-12-14 | 2012-06-21 | The Goverment Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Adenovirus serotype 26 and serotype 35 filovirus vaccines |
US20140155469A1 (en) | 2011-04-19 | 2014-06-05 | The Research Foundation Of State University Of New York | Adeno-associated-virus rep sequences, vectors and viruses |
EP2780034A1 (en) | 2011-11-14 | 2014-09-24 | Crucell Holland B.V. | Heterologous prime-boost immunization using measles virus-based vaccines |
CA2857087C (en) | 2011-11-28 | 2021-05-25 | Crucell Holland B.V. | Influenza virus vaccines and uses thereof |
US8932607B2 (en) | 2012-03-12 | 2015-01-13 | Crucell Holland B.V. | Batches of recombinant adenovirus with altered terminal ends |
SI2825640T1 (sl) | 2012-03-12 | 2016-08-31 | Crucell Holland B.V. | Šarže rekombinantnega adenovirusa s spremenjenimi konci |
CN104334188B (zh) | 2012-03-22 | 2016-08-24 | 克鲁塞尔荷兰公司 | 抗rsv疫苗 |
US9125870B2 (en) | 2012-03-22 | 2015-09-08 | Crucell Holland B.V. | Vaccine against RSV |
US9476061B2 (en) | 2012-05-24 | 2016-10-25 | Janssen Vaccines & Prevention B.V. | Adenoviral vectors for transduction of vascular tissue |
EP2971008B1 (en) | 2013-03-14 | 2018-07-25 | Salk Institute for Biological Studies | Oncolytic adenovirus compositions |
PL2988780T3 (pl) | 2013-04-25 | 2019-06-28 | Janssen Vaccines & Prevention B.V. | Stabilizowane rozpuszczalne prefuzyjne polipeptydy F RSV |
AP2015008893A0 (en) | 2013-06-17 | 2015-12-31 | Crucell Holland Bv | Stabilized soluble pre-fusion rsv f polypeptides |
EP3046536B1 (en) | 2013-09-19 | 2018-11-28 | Janssen Vaccines & Prevention B.V. | Improved adenovirus formulations |
SI3188753T1 (sl) | 2014-09-03 | 2020-07-31 | Bavarian Nordic A/S | Metode in sestave za induciranje zaščitne imunosti proti okužbi s filovirusom |
CA2960096A1 (en) | 2014-09-03 | 2016-03-10 | Bavarian Nordic A/S | Methods and compositions for enhancing immune responses |
PT3197489T (pt) | 2014-09-26 | 2021-04-30 | Beth Israel Deaconess Medical Ct Inc | Métodos e composições para induzir a imunidade protetora contra a infeção pelo vírus da imunodeficiência humana |
LT3215187T (lt) | 2014-11-04 | 2018-12-27 | Janssen Vaccines & Prevention B.V. | Terapinės hpv16 vakcinos |
AU2016249798B2 (en) | 2015-04-14 | 2022-05-26 | Janssen Vaccines And Prevention B.V. | Recombinant adenovirus expressing two transgenes with a bidirectional promoter |
CN104846013B (zh) * | 2015-04-15 | 2018-11-09 | 广州恩宝生物医药科技有限公司 | 一种复制缺陷型人55型腺病毒载体及其制备方法和应用 |
EA039065B1 (ru) | 2015-07-07 | 2021-11-29 | Янссен Вэксинс Энд Превеншн Б.В. | Вакцина против rsv |
JP6840718B2 (ja) | 2015-07-07 | 2021-03-10 | ヤンセン ファッシンズ アンド プリベンション ベーフェーJanssen Vaccines & Prevention B.V. | 安定化された可溶性融合前rsv fポリペプチド |
SG10202001501QA (en) | 2015-08-20 | 2020-04-29 | Janssen Vaccines & Prevention Bv | Therapeutic hpv18 vaccines |
WO2017060329A1 (en) | 2015-10-06 | 2017-04-13 | Janssen Vaccines & Prevention B.V. | Methods for preventing plastic-induced degradation of biologicals |
JP7171433B2 (ja) * | 2015-10-30 | 2022-11-15 | ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ | Her-2発現固形腫瘍の処置のための組成物および方法 |
JP6510149B2 (ja) | 2015-12-15 | 2019-05-08 | ヤンセン ファッシンズ アンド プリベンション ベーフェーJanssen Vaccines & Prevention B.V. | ヒト免疫不全ウイルス抗原、ベクター、組成物、およびその使用方法 |
EP3390428B1 (en) | 2016-02-23 | 2019-09-25 | Salk Institute for Biological Studies | High throughput assay for measuring adenovirus replication kinetics |
KR102471633B1 (ko) | 2016-02-23 | 2022-11-25 | 솔크 인스티튜트 포 바이올로지칼 스터디즈 | 바이러스 동역학에 미치는 영향 최소화를 위한 치료용 아데노바이러스의 외인성 유전자 발현 |
PE20190433A1 (es) | 2016-04-05 | 2019-03-21 | Janssen Vaccines And Prevention B V | Vacuna contra vrs |
ES2858315T3 (es) | 2016-04-05 | 2021-09-30 | Janssen Vaccines & Prevention Bv | Proteína F de prefusión de VRS soluble estabilizada para uso en la profilaxis de la infección por VRS |
JP7053491B2 (ja) | 2016-05-02 | 2022-04-12 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | 治療用hpvワクチン組み合わせ |
BR112018072865A2 (pt) | 2016-05-12 | 2019-04-30 | Janssen Vaccines & Prevention B.V. | promotor bidirecional potente e equilibrado |
IL264119B2 (en) | 2016-05-30 | 2023-04-01 | Janssen Vaccines Prevention B V | f proteins of rsv are stabilized before fusion |
BR112018075785A2 (pt) | 2016-06-16 | 2019-04-02 | Janssen Vaccines & Prevention B.V. | formulação de vacina para o hiv |
MX2018015540A (es) | 2016-06-20 | 2019-04-11 | Janssen Vaccines & Prevention Bv | Promotor bidireccional potente y equilibrado. |
JP7229151B2 (ja) | 2016-07-14 | 2023-02-27 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | Hpvワクチン |
EP3484507A1 (en) | 2016-07-15 | 2019-05-22 | Janssen Vaccines & Prevention B.V. | Methods and compositions for inducing protective immunity against a marburg virus infection |
EP3484505A1 (en) | 2016-07-15 | 2019-05-22 | Janssen Vaccines & Prevention B.V. | Methods and compositions for inducing protective immunity against a marburg virus infection |
US10307477B2 (en) | 2016-09-02 | 2019-06-04 | Janssen Vaccines & Prevention B.V. | Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment |
IL294832A (en) | 2016-09-15 | 2022-09-01 | Janssen Vaccines Prevention B V | HIV envelope proteins with trimer-stabilizing mutations |
AU2017375633C1 (en) | 2016-12-12 | 2023-04-27 | Salk Institute For Biological Studies | Tumor-targeting synthetic adenoviruses and uses thereof |
CN110268061A (zh) | 2017-02-09 | 2019-09-20 | 扬森疫苗与预防公司 | 用于表达异源基因的有效的短启动子 |
EP3606553A1 (en) | 2017-04-06 | 2020-02-12 | Janssen Vaccines & Prevention B.V. | Mva-bn and ad26.zebov or ad26.filo prime-boost regimen |
TW202333779A (zh) | 2017-05-08 | 2023-09-01 | 美商磨石生物公司 | 阿爾法病毒新抗原載體 |
JP2020519663A (ja) | 2017-05-17 | 2020-07-02 | ヤンセン ファッシンズ アンド プリベンション ベーフェーJanssen Vaccines & Prevention B.V. | Rsv感染に対する防御免疫を誘導するための方法及び組成物 |
WO2018210871A1 (en) | 2017-05-17 | 2018-11-22 | Janssen Vaccines & Prevention B.V. | Methods and compositions for inducing protective immunity against rsv infection |
NZ759833A (en) | 2017-05-26 | 2023-01-27 | Epicentrx Inc | Recombinant adenoviruses carrying transgenes |
WO2018229711A1 (en) | 2017-06-15 | 2018-12-20 | Janssen Vaccines & Prevention B.V. | Poxvirus vectors encoding hiv antigens, and methods of use thereof |
CA3069052A1 (en) | 2017-07-19 | 2019-01-24 | Janssen Vaccines & Prevention B.V. | Trimer stabilizing hiv envelope protein mutations |
WO2019018724A1 (en) | 2017-07-21 | 2019-01-24 | Janssen Vaccines & Prevention B.V. | METHODS FOR SAFE INDUCTION OF MULTICLADED CROSS-IMMUNITY AGAINST HUMAN IMMUNODEFICIENCY VIRUS INFECTION IN HUMAN BEINGS |
CN111163799A (zh) | 2017-07-28 | 2020-05-15 | 扬森疫苗与预防公司 | 用于异源repRNA免疫接种的方法和组合物 |
AU2018333566A1 (en) | 2017-09-15 | 2020-02-27 | Janssen Vaccines & Prevention B.V. | Method for the safe induction of immunity against RSV |
US20190083620A1 (en) | 2017-09-18 | 2019-03-21 | Janssen Vaccines & Prevention B.V. | Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment |
CA3077630A1 (en) | 2017-10-31 | 2019-05-09 | Janssen Vaccines & Prevention B.V. | Adenovirus vectors and uses thereof |
CN111295391B (zh) | 2017-10-31 | 2023-12-05 | 扬森疫苗与预防公司 | 腺病毒及其用途 |
MA50502A (fr) | 2017-10-31 | 2020-09-09 | Janssen Vaccines & Prevention Bv | Adénovirus et utilisations associées |
MX2020004492A (es) | 2017-10-31 | 2020-11-24 | Janssen Vaccines & Prevention Bv | Adenovirus y usos de los mismos. |
WO2019099970A1 (en) | 2017-11-20 | 2019-05-23 | Janssen Pharmaceuticals Inc. | Method of providing safe administration of adenoviral vectors encoding a zika virus antigen |
MA51312A (fr) | 2017-12-19 | 2020-10-28 | Bavarian Nordic As | Méthodes et compositions permettant d'induire une réponse immunitaire contre le virus de l'hépatite b (vhb) |
US20220153871A1 (en) | 2018-01-04 | 2022-05-19 | Iconic Therapeutics, Inc. | Anti-Tissue Factor Antibodies, Antibody-Drug Conjugates, and Related Methods |
BR112021000274A2 (pt) | 2018-07-20 | 2021-04-06 | Janssen Vaccines & Prevention B.V. | Vetor adenoviral recombinante expressando antígeno de zika com produtividade melhorada |
US11517618B2 (en) | 2018-09-25 | 2022-12-06 | Janssen Vaccines & Prevention B.V. | Method of inducing an immune response against human immunodeficiency virus by co-localized administration of vaccine components |
US20220193219A1 (en) | 2019-05-15 | 2022-06-23 | Janssen Vaccines & Prevention B.V. | Prophylactic treatment of respiratory syncytial virus infection with an adenovirus based vaccine |
US20220273787A1 (en) | 2019-05-15 | 2022-09-01 | Janssen Vaccines & Prevention B.V. | Co-administration of seasonal influenza vaccine and an adenovirus based respiratory syncytial virus vaccine |
WO2020237052A1 (en) | 2019-05-22 | 2020-11-26 | Janssen Vaccines & Prevention B.V. | Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment |
CA3140019A1 (en) | 2019-05-30 | 2020-12-03 | Gritstone Bio, Inc. | Modified adenoviruses |
CA3156471A1 (en) | 2019-10-03 | 2021-04-08 | Janssen Vaccines & Prevention B.V. | ADENOVIRUS VECTORS AND THEIR USES |
WO2021209897A1 (en) | 2020-04-13 | 2021-10-21 | Janssen Biotech, Inc. | Psma and steap1 vaccines and their uses |
CA3183086A1 (en) | 2020-05-11 | 2021-11-18 | Janssen Pharmaceuticals, Inc. | Stabilized coronavirus spike protein fusion proteins |
CA3182703A1 (en) | 2020-05-12 | 2021-11-18 | Janssen Vaccines & Prevention B.V. | Administration of homologous adenoviral vectors |
US20230233661A1 (en) | 2020-06-29 | 2023-07-27 | Janssen Vaccines & Prevention B.V. | Vaccine combination against repiratory syncytial virus infection |
WO2022008438A1 (en) | 2020-07-06 | 2022-01-13 | Janssen Pharmaceuticals, Inc. | Stabilized corona virus spike protein fusion proteins |
KR20230050328A (ko) | 2020-07-08 | 2023-04-14 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | Hbv에 대한 rna 레플리콘 백신 |
WO2022013221A1 (en) | 2020-07-13 | 2022-01-20 | Transgene | Treatment of immune depression |
CN116438308A (zh) | 2020-08-06 | 2023-07-14 | 磨石生物公司 | 多表位疫苗盒 |
GB202013940D0 (en) | 2020-09-04 | 2020-10-21 | Synpromics Ltd | Regulatory nucleic acid sequences |
US20230374542A1 (en) | 2020-10-07 | 2023-11-23 | Asklepios Biopharmaceutical, Inc. | Therapeutic adeno-associated virus delivery of fukutin related protein (fkrp) for treating dystroglycanopathy. disorders including limb girdle 21 (lgmd21) |
WO2022084333A1 (en) | 2020-10-20 | 2022-04-28 | Janssen Vaccines & Prevention B.V. | Hiv vaccine regimens |
WO2022158879A1 (ko) * | 2021-01-21 | 2022-07-28 | 주식회사 셀리드 | 복제가능 아데노바이러스를 포함하지 않는 신규 아데노바이러스 벡터 및 이의 용도 |
JP2024509756A (ja) | 2021-02-19 | 2024-03-05 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | 安定化された融合前rsv fb抗原 |
WO2022175479A1 (en) | 2021-02-19 | 2022-08-25 | Janssen Vaccines & Prevention B.V. | Vaccine combinations against respiratory syncytial virus strain a and b infections |
WO2022207839A2 (en) | 2021-04-01 | 2022-10-06 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion piv3 f proteins |
WO2023020939A1 (en) | 2021-08-17 | 2023-02-23 | Janssen Pharmaceuticals, Inc. | Sars-cov-2 vaccines |
WO2023026182A1 (en) | 2021-08-24 | 2023-03-02 | Janssen Pharmaceuticals, Inc. | Sars-cov-2 vaccines |
WO2023047349A1 (en) | 2021-09-24 | 2023-03-30 | Janssen Pharmaceuticals, Inc. | Stabilized coronavirus spike protein fusion proteins |
WO2023047348A1 (en) | 2021-09-24 | 2023-03-30 | Janssen Pharmaceuticals, Inc. | Stabilized corona virus spike protein fusion proteins |
WO2023111725A1 (en) | 2021-12-14 | 2023-06-22 | Janssen Pharmaceuticals, Inc. | Sars-cov-2 vaccines |
WO2023110618A1 (en) | 2021-12-16 | 2023-06-22 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion hmpv fusion proteins |
WO2023198815A1 (en) | 2022-04-14 | 2023-10-19 | Janssen Vaccines & Prevention B.V. | Sequential administration of adenoviruses |
WO2023213764A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Fusion polypeptide comprising an anti-pd-l1 sdab and a member of the tnfsf |
WO2023217988A1 (en) | 2022-05-12 | 2023-11-16 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion hmpv fusion proteins |
CN117264902A (zh) * | 2022-06-15 | 2023-12-22 | 上海元宋生物技术有限公司 | 一种腺病毒包装与生产细胞系的构建方法及应用 |
EP4338727A1 (en) | 2022-09-14 | 2024-03-20 | Roquette Freres | Adenovirus formulations |
WO2024061759A1 (en) | 2022-09-23 | 2024-03-28 | Janssen Vaccines & Prevention B.V. | Stabilized coronavirus s proteins |
WO2024061757A1 (en) | 2022-09-23 | 2024-03-28 | Janssen Vaccines & Prevention B.V. | Pre-fusion human piv1 f proteins |
WO2024074584A1 (en) | 2022-10-06 | 2024-04-11 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion piv3 f proteins |
Family Cites Families (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4593002A (en) | 1982-01-11 | 1986-06-03 | Salk Institute Biotechnology/Industrial Associates, Inc. | Viruses with recombinant surface proteins |
US4487829A (en) | 1982-03-23 | 1984-12-11 | Massachusetts Institute Of Technology | Production and use of monoclonal antibodies against adenoviruses |
US4517686A (en) | 1982-08-04 | 1985-05-21 | La Jolla Cancer Research Foundation | Polypeptide |
US4578079A (en) | 1982-08-04 | 1986-03-25 | La Jolla Cancer Research Foundation | Tetrapeptide |
US4792525A (en) | 1982-08-04 | 1988-12-20 | La Jolla Cancer Research Foundation | Tetrapeptide |
US4589881A (en) | 1982-08-04 | 1986-05-20 | La Jolla Cancer Research Foundation | Polypeptide |
US4797368A (en) | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
US6007806A (en) | 1986-08-13 | 1999-12-28 | Transgene S.A. | Expression of a tumor-specific antigen by a recombinant vector virus and use thereof in preventive or curative treatment of the corresponding tumor |
FR2602790B1 (fr) | 1986-08-13 | 1990-06-01 | Transgene Sa | Expression d'un antigene specifique de tumeur par un virus vecteur recombinant et utilisation de celui-ci pour le traitement preventif ou curatif de la tumeur correspondante |
US5166320A (en) | 1987-04-22 | 1992-11-24 | University Of Connecticut | Carrier system and method for the introduction of genes into mammalian cells |
US4956281A (en) | 1987-06-03 | 1990-09-11 | Biogen, Inc. | DNA sequences, recombinant DNA molecules and processes for producing lymphocyte function associated antigen-3 |
US5024939A (en) | 1987-07-09 | 1991-06-18 | Genentech, Inc. | Transient expression system for producing recombinant protein |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
CA2000048A1 (en) | 1988-10-03 | 1990-04-03 | Edward F. Plow | Peptides and antibodies that inhibit integrin-ligand bindin g |
US5096815A (en) | 1989-01-06 | 1992-03-17 | Protein Engineering Corporation | Generation and selection of novel dna-binding proteins and polypeptides |
US5198346A (en) | 1989-01-06 | 1993-03-30 | Protein Engineering Corp. | Generation and selection of novel DNA-binding proteins and polypeptides |
US5223394A (en) | 1989-04-10 | 1993-06-29 | Biogen, Inc. | Recombinant dna molecule comprising lymphocyte function-associated antigen 3 phosphatidylinositol linkage signal sequence |
DK0479909T3 (da) | 1989-06-29 | 1997-04-07 | Medarex Inc | Bispecifikke reagenser til AIDS-behandling |
US5240846A (en) | 1989-08-22 | 1993-08-31 | The Regents Of The University Of Michigan | Gene therapy vector for cystic fibrosis |
US5332567A (en) | 1989-08-24 | 1994-07-26 | Immunomedics | Detection and treatment of infections with immunoconjugates |
US5436146A (en) | 1989-09-07 | 1995-07-25 | The Trustees Of Princeton University | Helper-free stocks of recombinant adeno-associated virus vectors |
EP0496818B1 (en) | 1989-10-20 | 1999-06-23 | Trustees Of Dartmouth College | MONOCLONAL ANTIBODY SPECIFIC FOR IgA RECEPTOR |
ES2133139T3 (es) | 1989-10-20 | 1999-09-01 | Medarex Inc | Hetero anticuerpos biespecificos con funciones efectoras dobles. |
AU7906691A (en) | 1990-05-23 | 1991-12-10 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Adeno-associated virus (aav)-based eucaryotic vectors |
US5349053A (en) | 1990-06-01 | 1994-09-20 | Protein Design Labs, Inc. | Chimeric ligand/immunoglobulin molecules and their uses |
US5246921A (en) | 1990-06-26 | 1993-09-21 | The Wistar Institute Of Anatomy And Biology | Method for treating leukemias |
GB2246779B (en) | 1990-08-03 | 1994-08-17 | Delta Biotechnology Ltd | Tumour-associated protease inhibitors targeted to tumour cells |
GB9101550D0 (en) | 1991-01-24 | 1991-03-06 | Mastico Robert A | Antigen-presenting chimaeric protein |
DE69233013T2 (de) | 1991-08-20 | 2004-03-04 | The Government Of The United States Of America As Represented By The Secretary Of National Institute Of Health, Office Of Technology Transfer | Adenovirus vermittelter gentransfer in den gastrointestinaltrakt |
FR2681786A1 (fr) | 1991-09-27 | 1993-04-02 | Centre Nat Rech Scient | Vecteurs recombinants d'origine virale, leur procede d'obtention et leur utilisation pour l'expression de polypeptides dans des cellules musculaires. |
US5521291A (en) | 1991-09-30 | 1996-05-28 | Boehringer Ingelheim International, Gmbh | Conjugates for introducing nucleic acid into higher eucaryotic cells |
IL103059A0 (en) | 1991-09-30 | 1993-02-21 | Boehringer Ingelheim Int | Conjugates for introducing nucleic acid into higher eucaryotic cells |
NZ244306A (en) | 1991-09-30 | 1995-07-26 | Boehringer Ingelheim Int | Composition for introducing nucleic acid complexes into eucaryotic cells, complex containing nucleic acid and endosomolytic agent, peptide with endosomolytic domain and nucleic acid binding domain and preparation |
DE69334238D1 (de) | 1992-09-25 | 2008-09-25 | Aventis Pharma Sa | Adenovirus vektoren für die übertragung fremder gene in zellen des zentralen nervensystems, insbesondere im gehirn |
GB9223084D0 (en) | 1992-11-04 | 1992-12-16 | Imp Cancer Res Tech | Compounds to target cells |
ATE307212T1 (de) | 1992-11-18 | 2005-11-15 | Arch Dev Corp | Adenovirus-gelenkter gen-transfer zum herz-und glatten vaskulären muskel |
GB9300686D0 (en) | 1993-01-15 | 1993-03-03 | Imp Cancer Res Tech | Compounds for targeting |
AU6133394A (en) | 1993-02-09 | 1994-08-29 | Scripps Research Institute, The | Targeting and delivery of genes and antiviral agents into cells by the adenovirus penton |
DE4311651A1 (de) | 1993-04-08 | 1994-10-13 | Boehringer Ingelheim Int | Virus für den Transport von Fremd-DNA in höhere eukaryotische Zellen |
EP1211319A2 (en) | 1993-05-10 | 2002-06-05 | The Regents of The University of Michigan | Gene transfer into pancreatic and biliary epithelial cells |
US5543328A (en) | 1993-08-13 | 1996-08-06 | Genetic Therapy, Inc. | Adenoviruses having modified fiber proteins |
EP0716711A1 (de) | 1993-09-03 | 1996-06-19 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Vektor für leber-gentherapie |
US5552311A (en) | 1993-09-14 | 1996-09-03 | University Of Alabama At Birmingham Research Foundation | Purine nucleoside phosphorylase gene therapy for human malignancy |
US5534423A (en) | 1993-10-08 | 1996-07-09 | Regents Of The University Of Michigan | Methods of increasing rates of infection by directing motion of vectors |
FR2712812B1 (fr) | 1993-11-23 | 1996-02-09 | Centre Nat Rech Scient | Composition pour la production de produits thérapeutiques in vivo. |
IT1271461B (it) | 1993-12-01 | 1997-05-28 | Menarini Ricerche Sud Spa | Anticorpo monoclonale bispecifico anti-cd3/anti-egfr,processo per la produzione e suo uso. |
US5443953A (en) | 1993-12-08 | 1995-08-22 | Immunomedics, Inc. | Preparation and use of immunoconjugates |
US5698443A (en) | 1995-06-27 | 1997-12-16 | Calydon, Inc. | Tissue specific viral vectors |
US6057299A (en) | 1994-01-13 | 2000-05-02 | Calydon, Inc. | Tissue-specific enhancer active in prostate |
US5928944A (en) | 1994-02-04 | 1999-07-27 | The United States Of America As Represented By The Department Of Health And Human Services | Method of adenoviral-medicated cell transfection |
US6312699B1 (en) | 1994-03-28 | 2001-11-06 | Uab Research Foundation | Ligands added to adenovirus fiber |
US7252989B1 (en) | 1994-04-04 | 2007-08-07 | Board Of Regents, The University Of Texas System | Adenovirus supervector system |
ATE200105T1 (de) | 1994-05-13 | 2001-04-15 | Chiron Corp | Verfahren und zusammensetzungen als vehikel zur zielgerichtete einbringen von genen |
US5571531A (en) | 1994-05-18 | 1996-11-05 | Mcmaster University | Microparticle delivery system with a functionalized silicone bonded to the matrix |
US5570975A (en) | 1994-06-27 | 1996-11-05 | Reinert, Sr.; Gary L. | Metal foundation push-it and installation apparatus and method |
FR2721943B1 (fr) | 1994-06-29 | 1996-08-02 | Rhone Poulenc Rorer Sa | Adenovirus comprenant un gene codant pour une superoxyde dismutase |
US5846782A (en) | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
US5559099A (en) | 1994-09-08 | 1996-09-24 | Genvec, Inc. | Penton base protein and methods of using same |
JPH10508743A (ja) | 1994-09-09 | 1998-09-02 | ニューロクライン バイオサイエンシーズ, インコーポレイテッド | インターロイキン−1 タイプ3レセプター |
FR2724846B1 (fr) | 1994-09-27 | 1996-12-20 | Rhone Poulenc Rorer Sa | Methode de traitement des cancers par regulation de l'activite des proteines ras |
FR2725726B1 (fr) | 1994-10-17 | 1997-01-03 | Centre Nat Rech Scient | Vecteurs viraux et utilisation en therapie genique |
US5856152A (en) | 1994-10-28 | 1999-01-05 | The Trustees Of The University Of Pennsylvania | Hybrid adenovirus-AAV vector and methods of use therefor |
FR2727867B1 (fr) | 1994-12-13 | 1997-01-31 | Rhone Poulenc Rorer Sa | Transfert de genes dans les motoneurones medullaires au moyen de vecteurs adenoviraux |
US5770442A (en) | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
US6127525A (en) | 1995-02-21 | 2000-10-03 | Cornell Research Foundation, Inc. | Chimeric adenoviral coat protein and methods of using same |
DE69638058D1 (de) | 1995-06-15 | 2009-11-26 | Crucell Holland Bv | Verpackungssysteme für humane rekombinante Adenoviren zur Gentherapie |
US7001764B2 (en) | 1995-06-27 | 2006-02-21 | Cell Genesys, Inc. | Compositions comprising tissue specific adenoviral vectors |
US6676935B2 (en) | 1995-06-27 | 2004-01-13 | Cell Genesys, Inc. | Tissue specific adenoviral vectors |
US5622699A (en) | 1995-09-11 | 1997-04-22 | La Jolla Cancer Research Foundation | Method of identifying molecules that home to a selected organ in vivo |
US5837511A (en) | 1995-10-02 | 1998-11-17 | Cornell Research Foundation, Inc. | Non-group C adenoviral vectors |
US5871727A (en) | 1995-12-08 | 1999-02-16 | Uab Research Foundation | Targeted adenovirus vectors |
WO1998001563A2 (en) * | 1996-07-05 | 1998-01-15 | Branton Philip E | Adenovirus e4 proteins for inducing cell death |
US5877011A (en) | 1996-11-20 | 1999-03-02 | Genzyme Corporation | Chimeric adenoviral vectors |
US5922315A (en) | 1997-01-24 | 1999-07-13 | Genetic Therapy, Inc. | Adenoviruses having altered hexon proteins |
EP1017421B1 (en) | 1997-03-07 | 2005-05-25 | The Wistar Institute Of Anatomy And Biology | Use of adenoviral vectors expressing VEGF or PDGF FOR HEALING TISSUE DEFECTS AND INDUCING HYPERVASCULARITY IN MAMMALIAN TISSUE |
US6100086A (en) | 1997-04-14 | 2000-08-08 | Genzyme Corporation | Transgene expression systems |
US5981275A (en) * | 1997-04-14 | 1999-11-09 | Genzyme Corporation | Transgene expression system for increased persistence |
NZ500791A (en) | 1997-05-08 | 2002-10-25 | Genetic Therapy Inc | Gene transfer with adenoviruses having modified fiber proteins |
US5849561A (en) * | 1997-05-22 | 1998-12-15 | Cornell Research Foundation, Inc. | Method for the production of non-group C adenoviral vectors |
US6287857B1 (en) | 1998-02-09 | 2001-09-11 | Genzyme Corporation | Nucleic acid delivery vehicles |
US6417168B1 (en) * | 1998-03-04 | 2002-07-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods of treating tumors |
AU3358999A (en) | 1998-03-20 | 1999-10-11 | Genzyme Corporation | Chimeric adenoviral vectors for targeted gene delivery |
US6436392B1 (en) | 1998-05-20 | 2002-08-20 | University Of Iowa Research Foundation | Adeno-associated virus vectors |
GB9811171D0 (en) * | 1998-05-22 | 1998-07-22 | Royal Free Hosp School Med | Viral vector |
US20030017138A1 (en) | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
US6383794B1 (en) | 1998-08-24 | 2002-05-07 | Uab Research Foundation | Methods of producing high titer recombinant adeno-associated virus |
WO2000029573A2 (en) * | 1998-11-18 | 2000-05-25 | Canji, Inc. | Adenoviral vectors |
EP1020529B1 (en) | 1998-11-20 | 2005-06-01 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
EP1016726A1 (en) | 1998-12-30 | 2000-07-05 | Introgene B.V. | Gene therapy to promote angiogenesis |
AU777041B2 (en) | 1999-05-17 | 2004-09-30 | Crucell Holland B.V. | Adenovirus derived gene delivery vehicles comprising at least one element of adenovirus type 35 |
US6913922B1 (en) | 1999-05-18 | 2005-07-05 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
US6492169B1 (en) * | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
EP1067188A1 (en) | 1999-07-08 | 2001-01-10 | Introgene B.V. | Infection with chimaeric adenoviruses of cells negative for the adenovirus serotype 5 Coxsacki adenovirus receptor (CAR) |
US7125705B2 (en) | 2000-04-28 | 2006-10-24 | Genzyme Corporation | Polynucleotides for use in recombinant adeno-associated virus virion production |
EP1157999A1 (en) | 2000-05-24 | 2001-11-28 | Introgene B.V. | Methods and means for enhancing skin transplantation using gene delivery vehicles having tropism for primary fibroblasts, as well as other uses thereof |
US20020152553A1 (en) * | 2001-03-22 | 2002-10-24 | Wynveen Pamela Sue | Travel pillow securing to bucket seats |
US6844192B2 (en) * | 2001-06-29 | 2005-01-18 | Wake Forest University | Adenovirus E4 protein variants for virus production |
US20030026783A1 (en) | 2001-08-03 | 2003-02-06 | Amine Abina | Method of modulating neutralizing antibodies formation in mammals, and uses thereof in gene therapy, animal transgenesis and in functional inactivation of an endogenous proteins |
CA2478651A1 (en) * | 2002-03-13 | 2003-09-25 | Merck & Co., Inc. | Method of inducing an enhanced immune response against hiv |
PL208588B1 (pl) * | 2002-04-25 | 2011-05-31 | Crucell Holland Bv | Rekombinowane adenowirusy, wyizolowane kwasy nukleinowe, komórki pakujące oraz sposoby zwiększania stabilności i/lub pojemności upakowania rekombinowanego adenowirusa |
JP4495587B2 (ja) * | 2002-04-25 | 2010-07-07 | クルセル ホランド ベー ヴェー | 組換えアデノウイルスベクターおよびその使用 |
AU2003288273A1 (en) | 2002-10-23 | 2004-05-13 | Crucell Holland B.V. | New settings for recombinant adenoviral-based vaccines |
SG156535A1 (en) | 2002-12-17 | 2009-11-26 | Crucell Holland Bv | Recombinant viral-based malaria vaccines |
US20070010016A1 (en) | 2005-03-11 | 2007-01-11 | Mccelland Alan | Gene transfer with adenoviruses having modified fiber proteins |
-
2003
- 2003-04-24 JP JP2004511527A patent/JP4495587B2/ja not_active Expired - Lifetime
- 2003-04-24 ES ES03753568T patent/ES2335657T3/es not_active Expired - Lifetime
- 2003-04-24 EP EP03753568A patent/EP1497438B1/en not_active Expired - Lifetime
- 2003-04-24 PT PT03753568T patent/PT1497438E/pt unknown
- 2003-04-24 CN CNB038093529A patent/CN100497639C/zh not_active Expired - Lifetime
- 2003-04-24 NZ NZ534866A patent/NZ534866A/en not_active IP Right Cessation
- 2003-04-24 DK DK03753568T patent/DK1497438T3/da active
- 2003-04-24 KR KR1020047016954A patent/KR101021387B1/ko active IP Right Grant
- 2003-04-24 BR BR0308783-2A patent/BR0308783A/pt not_active Application Discontinuation
- 2003-04-24 SI SI200331736T patent/SI1497438T1/sl unknown
- 2003-04-24 WO PCT/EP2003/050125 patent/WO2003104467A1/en active IP Right Grant
- 2003-04-24 MX MXPA04008891A patent/MXPA04008891A/es active IP Right Grant
- 2003-04-24 EA EA200401424A patent/EA010828B1/ru not_active IP Right Cessation
- 2003-04-24 DE DE60329835T patent/DE60329835D1/de not_active Expired - Lifetime
- 2003-04-24 PL PL373304A patent/PL215165B1/pl unknown
- 2003-04-24 IL IL16480303A patent/IL164803A0/xx unknown
- 2003-04-24 US US10/512,589 patent/US7468181B2/en active Active
- 2003-04-24 CA CA2477954A patent/CA2477954C/en not_active Expired - Lifetime
- 2003-04-24 AU AU2003271737A patent/AU2003271737B2/en not_active Expired
- 2003-04-24 AT AT03753568T patent/ATE447037T1/de active
-
2004
- 2004-08-31 ZA ZA2004/06942A patent/ZA200406942B/en unknown
- 2004-10-24 IL IL164803A patent/IL164803A/en active IP Right Grant
- 2004-11-24 NO NO20045130A patent/NO332108B1/no not_active IP Right Cessation
-
2005
- 2005-01-21 HK HK05100596.3A patent/HK1068371A1/xx not_active IP Right Cessation
-
2007
- 2007-05-07 US US11/800,871 patent/US7820440B2/en not_active Expired - Lifetime
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL164803A0 (en) | Means and methods for the production of adenovirusvectors | |
HK1069185A1 (en) | Stable adenoviral vectors and methods for propagation thereof | |
HK1080115A1 (en) | Cultures of e1-immortalized cells and processes for culturing the same to increase product yields therefrom e1- | |
WO2003049525A3 (en) | Methods and materials for the production of organic products in cells of $i(candida) species | |
WO2007005837A3 (en) | Inducible expression vectors and methods of use thereof | |
UA94385C2 (uk) | Спосіб обробки матеріалу, що складається з біомаси чи органічного відходу, що містить лігноцелюлозний матеріал | |
YU83101A (sh) | Postupci i materijali za sinteze organskih proizvoda | |
WO2007024756A3 (en) | Reduced genome e. coli | |
WO2001036615A3 (de) | Permanente amniozyten-zelllinie, ihre herstellung und verwendung zur herstellung von gentransfervektoren | |
EP1095158A4 (en) | METHOD AND MATERIALS FOR THE PRODUCTION OF GLUCOSAMINE | |
ATE319848T1 (de) | Herstellung von polyketiden | |
WO2006136831A3 (en) | Gene expression technique | |
WO2004092348A3 (en) | Method for production of oncolytic adenoviruses | |
WO2005087802A3 (en) | Process for producing polypeptides | |
WO2005033094A3 (de) | Verfahren zur herstellung von 3-methylamino-1-(thien-2-yl)-propan-1-ol | |
WO2005093069A3 (en) | Production of mersacidin and its variants in sigh and/or mrsa negative bacillus host cells | |
ATE174630T1 (de) | Expressionskassette, die einen aus dem schizosaccharomyces pombe-pho4-gene stammenden promotor enthält | |
DE69433385D1 (de) | Für die untereinheiten der 1,3-beta-d-glucansynthase kodierende dna | |
FR2823219B1 (fr) | Mutants de la desoxycytidine kinase possedant une activite enzymatique elargie | |
ATE382086T1 (de) | Candida tropicalis cytochrom b5 gen und protein und verwendungen davon | |
Kain et al. | 'Inspired by Color Aids'&'Say Hello to Me' | |
HUP0402045A2 (hu) | Az ee3-proteincsalád és az azokat kódoló DNS-szekvenciák | |
Panchak | Closing The Technology Gap. | |
Nagasawa | The Current State of Law concerning the Measures by Large-Scale Retail Stores for Preservation of Living Environment | |
Brosnan | General Shale's Kingsport Laboratory. |