GB2246779B - Tumour-associated protease inhibitors targeted to tumour cells - Google Patents
Tumour-associated protease inhibitors targeted to tumour cellsInfo
- Publication number
- GB2246779B GB2246779B GB9017083A GB9017083A GB2246779B GB 2246779 B GB2246779 B GB 2246779B GB 9017083 A GB9017083 A GB 9017083A GB 9017083 A GB9017083 A GB 9017083A GB 2246779 B GB2246779 B GB 2246779B
- Authority
- GB
- United Kingdom
- Prior art keywords
- tumour
- protease inhibitors
- associated protease
- inhibitors targeted
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
- 210000004881 tumor cell Anatomy 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8132—Plasminogen activator inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9017083A GB2246779B (en) | 1990-08-03 | 1990-08-03 | Tumour-associated protease inhibitors targeted to tumour cells |
PCT/GB1991/001322 WO1992002553A1 (en) | 1990-08-03 | 1991-08-02 | Tumor cell binding molecule with protease inhibiting region |
AU83185/91A AU8318591A (en) | 1990-08-03 | 1991-08-02 | Tumor cell binding molecule with protease inhibiting region |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9017083A GB2246779B (en) | 1990-08-03 | 1990-08-03 | Tumour-associated protease inhibitors targeted to tumour cells |
Publications (3)
Publication Number | Publication Date |
---|---|
GB9017083D0 GB9017083D0 (en) | 1990-09-19 |
GB2246779A GB2246779A (en) | 1992-02-12 |
GB2246779B true GB2246779B (en) | 1994-08-17 |
Family
ID=10680139
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB9017083A Expired - Lifetime GB2246779B (en) | 1990-08-03 | 1990-08-03 | Tumour-associated protease inhibitors targeted to tumour cells |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU8318591A (en) |
GB (1) | GB2246779B (en) |
WO (1) | WO1992002553A1 (en) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2051676A1 (en) * | 1989-04-07 | 1990-10-08 | Keld Dano | Urokinase-type plasminogen activator receptor |
US6120765A (en) * | 1993-04-02 | 2000-09-19 | Shiseido Co. Ltd. | Urokinase plasminogen activator fragments |
KR960702846A (en) * | 1993-05-28 | 1996-05-23 | 로버트 피. 블랙버언 | PEPTIDE INHBITORS OF UROKINASE RECEPTOR ACTIVITY |
US5559099A (en) * | 1994-09-08 | 1996-09-24 | Genvec, Inc. | Penton base protein and methods of using same |
US6465253B1 (en) | 1994-09-08 | 2002-10-15 | Genvec, Inc. | Vectors and methods for gene transfer to cells |
US5846782A (en) | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
US5965541A (en) * | 1995-11-28 | 1999-10-12 | Genvec, Inc. | Vectors and methods for gene transfer to cells |
US6127525A (en) * | 1995-02-21 | 2000-10-03 | Cornell Research Foundation, Inc. | Chimeric adenoviral coat protein and methods of using same |
US5770442A (en) * | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
US6783980B2 (en) | 1995-06-15 | 2004-08-31 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
US6509445B1 (en) | 1996-01-08 | 2003-01-21 | Nissin Food Products Co., Ltd. | Cancerous metastasis inhibitor |
EP0981606A2 (en) * | 1997-05-12 | 2000-03-01 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Method and construct for inhibition of cell migration |
US5994309A (en) | 1997-07-25 | 1999-11-30 | Angstrom Pharmaceuticals, Inc. | Anti-invasive and anti-angiogenic compositions and methods |
US6077508A (en) * | 1998-03-23 | 2000-06-20 | American Diagnostica Inc. | Urokinase plasminogen activator receptor as a target for diagnosis of metastases |
US20030017138A1 (en) | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
US6929946B1 (en) | 1998-11-20 | 2005-08-16 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
US6913922B1 (en) | 1999-05-18 | 2005-07-05 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
US6492169B1 (en) | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
DE60138403D1 (en) | 2000-09-26 | 2009-05-28 | Crucell Holland Bv | ADENOVIRAL VECTORS FOR THE TRANSFER OF GENES IN CELLS OF THE SKELETAL MUSCULATORY OR MYOBLAST |
DK1497438T3 (en) | 2002-04-25 | 2010-01-04 | Crucell Holland Bv | Means and methods for producing adenovirus vectors |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0044167A2 (en) * | 1980-07-14 | 1982-01-20 | The Regents Of The University Of California | Antibody targeted cytotoxic agent |
EP0122132A2 (en) * | 1983-04-08 | 1984-10-17 | Kureha Kagaku Kogyo Kabushiki Kaisha | Anti-tumour substance |
EP0383599A2 (en) * | 1989-02-17 | 1990-08-22 | Merck & Co. Inc. | Protein anti-cancer agent |
WO1990012091A1 (en) * | 1989-04-07 | 1990-10-18 | Cancerforskningsfondet Af 1989 | Urokinase-type plasminogen activator receptor |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0623113B2 (en) * | 1986-01-31 | 1994-03-30 | 浩 前田 | Cancerous breast / ascites retention inhibitor |
WO1991000912A1 (en) * | 1989-07-07 | 1991-01-24 | Massachusetts Institute Of Technology | Production and use of hybrid protease inhibitors |
-
1990
- 1990-08-03 GB GB9017083A patent/GB2246779B/en not_active Expired - Lifetime
-
1991
- 1991-08-02 WO PCT/GB1991/001322 patent/WO1992002553A1/en active Application Filing
- 1991-08-02 AU AU83185/91A patent/AU8318591A/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0044167A2 (en) * | 1980-07-14 | 1982-01-20 | The Regents Of The University Of California | Antibody targeted cytotoxic agent |
EP0122132A2 (en) * | 1983-04-08 | 1984-10-17 | Kureha Kagaku Kogyo Kabushiki Kaisha | Anti-tumour substance |
EP0383599A2 (en) * | 1989-02-17 | 1990-08-22 | Merck & Co. Inc. | Protein anti-cancer agent |
WO1990012091A1 (en) * | 1989-04-07 | 1990-10-18 | Cancerforskningsfondet Af 1989 | Urokinase-type plasminogen activator receptor |
Non-Patent Citations (8)
Title |
---|
Biochemistry International,Vol 19, No.2,1989, pages 313-323 * |
BLOOD, Vol.74, 1989, pages 1396-1402. * |
CELL, Vol.52, No.3, 1988, pages 321-328. * |
Europ.J.Cancer,Vol 14,1978,pages 23-31 * |
J.BIOL.CHEM., Vol.62, No.10, 1987, pages 4437-4440. * |
J.IMMUNOL., Vol.143, 1989, pages 2634-2639. * |
J.Natl.Cancer Inst.,Vol. 74, No.5, 1985,pages 1031-1035 * |
PROC. NATL. ACAD. SCI.USA, Vol.87, pages 2230-2234, 1990. * |
Also Published As
Publication number | Publication date |
---|---|
AU8318591A (en) | 1992-03-02 |
GB2246779A (en) | 1992-02-12 |
WO1992002553A1 (en) | 1992-02-20 |
GB9017083D0 (en) | 1990-09-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PE20 | Patent expired after termination of 20 years |
Expiry date: 20100802 |