IL159242A0 - Expression of functional human olfactory cyclic nucleotide gated (cng) channel in recombinant host cells and use thereof in cell based assays to identify smell modulators - Google Patents

Expression of functional human olfactory cyclic nucleotide gated (cng) channel in recombinant host cells and use thereof in cell based assays to identify smell modulators

Info

Publication number
IL159242A0
IL159242A0 IL15924202A IL15924202A IL159242A0 IL 159242 A0 IL159242 A0 IL 159242A0 IL 15924202 A IL15924202 A IL 15924202A IL 15924202 A IL15924202 A IL 15924202A IL 159242 A0 IL159242 A0 IL 159242A0
Authority
IL
Israel
Prior art keywords
cng
modulators
expression
channel
host cells
Prior art date
Application number
IL15924202A
Other languages
English (en)
Original Assignee
Senomyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senomyx Inc filed Critical Senomyx Inc
Publication of IL159242A0 publication Critical patent/IL159242A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
IL15924202A 2001-07-06 2002-07-08 Expression of functional human olfactory cyclic nucleotide gated (cng) channel in recombinant host cells and use thereof in cell based assays to identify smell modulators IL159242A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30314001P 2001-07-06 2001-07-06
US33715401P 2001-12-10 2001-12-10
PCT/US2002/021184 WO2003004611A2 (en) 2001-07-06 2002-07-08 Human olfactory nucleotide-gated ion channels

Publications (1)

Publication Number Publication Date
IL159242A0 true IL159242A0 (en) 2004-06-01

Family

ID=26973275

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15924202A IL159242A0 (en) 2001-07-06 2002-07-08 Expression of functional human olfactory cyclic nucleotide gated (cng) channel in recombinant host cells and use thereof in cell based assays to identify smell modulators

Country Status (10)

Country Link
US (2) US7052857B2 (ja)
EP (1) EP1414940A4 (ja)
JP (1) JP2005500836A (ja)
CN (1) CN1309736C (ja)
AU (1) AU2002329196B2 (ja)
CA (1) CA2452315A1 (ja)
IL (1) IL159242A0 (ja)
MX (1) MXPA03011805A (ja)
NO (1) NO20035808L (ja)
WO (1) WO2003004611A2 (ja)

Families Citing this family (38)

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US7166463B2 (en) * 2001-11-16 2007-01-23 The Regents Of The University Of Colorado Nucleic acids encoding modified olfactory cyclic nucleotide gated ion channels
DE10311769A1 (de) * 2003-03-18 2004-09-30 Bayer Healthcare Ag Testmethoden zur Bestimmung der intrazellulären Konzentration zyklischer Nukleotide
RU2006106920A (ru) * 2003-08-06 2007-09-20 Синомикс Инк. (Us) Гетеро-олигомерные вкусовые рецепторы t1r, клеточные линии, которые экспрессируют указанные рецепторы и вкусовые соединения
DE10350054B4 (de) * 2003-10-27 2007-01-11 Deutsches Institut für Ernährungsforschung Rekombinantes Zellsystem zur Deorphansisierung von G Protein-gekoppelten Rezeptoren
ATE445161T1 (de) * 2003-10-27 2009-10-15 Deutsches Inst Ernaehrungsfors Rekombinantes zellsystem zur deorphanisierung von g protein-gekoppelten rezeptoren
US20070065394A1 (en) * 2003-11-17 2007-03-22 Pinney Virginia R Compositions effective in altering the perception of malodor
US20060045953A1 (en) * 2004-08-06 2006-03-02 Catherine Tachdjian Aromatic amides and ureas and their uses as sweet and/or umami flavor modifiers, tastants and taste enhancers
WO2006068745A1 (en) 2004-12-22 2006-06-29 Cargill, Incorporated Methods for determining cellular response to stimuli
CA2597134C (en) * 2005-02-04 2015-05-26 Senomyx, Inc. Compounds comprising linked heteroaryl moieties and their use as novel umami flavor modifiers, tastants and taste enhancers for comestible compositions
TW200638882A (en) * 2005-02-04 2006-11-16 Senomyx Inc Molecules comprising linked organic moieties as flavor modifiers for comestible compositions
TW200715993A (en) * 2005-06-15 2007-05-01 Senomyx Inc Bis-aromatic amides and their uses as sweet flavor modifiers, tastants, and taste enhancers
US8926959B2 (en) 2005-07-22 2015-01-06 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US20090093403A1 (en) 2007-03-01 2009-04-09 Feng Zhang Systems, methods and compositions for optical stimulation of target cells
US9274099B2 (en) 2005-07-22 2016-03-01 The Board Of Trustees Of The Leland Stanford Junior University Screening test drugs to identify their effects on cell membrane voltage-gated ion channel
US8906360B2 (en) 2005-07-22 2014-12-09 The Board Of Trustees Of The Leland Stanford Junior University Light-activated cation channel and uses thereof
US20070224645A1 (en) * 2006-02-23 2007-09-27 Jianming Lu Novel cell-based phosphodiesterase assays
US7998708B2 (en) * 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
DK3235811T3 (en) 2006-04-21 2018-11-12 Senomyx Inc PROCEDURE FOR THE PREPARATION OF OXALAMIDS
WO2008086470A1 (en) 2007-01-10 2008-07-17 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
WO2009041113A1 (ja) * 2007-09-28 2009-04-02 Olympus Corporation Fc受容体遺伝子導入ＮＫ細胞、その作製方法、及びこれを用いた抗体依存性細胞障害のアッセイ方法
US10434327B2 (en) 2007-10-31 2019-10-08 The Board Of Trustees Of The Leland Stanford Junior University Implantable optical stimulators
EP2108954A1 (en) 2008-04-10 2009-10-14 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. A test system for detecting intracellular cyclic nucleotide level and methods and uses thereof
JP5690467B2 (ja) 2008-04-11 2015-03-25 花王株式会社 嗅覚感度抑制剤のスクリーニング法
ES2608498T3 (es) 2008-04-23 2017-04-11 The Board Of Trustees Of The Leland Stanford Junior University Sistemas, métodos y composiciones para la estimulación óptica de células diana
SG191604A1 (en) 2008-06-17 2013-07-31 Univ Leland Stanford Junior Apparatus and methods for controlling cellular development
WO2010006049A1 (en) 2008-07-08 2010-01-14 The Board Of Trustees Of The Leland Stanford Junior University Materials and approaches for optical stimulation of the peripheral nervous system
JP5759664B2 (ja) * 2008-08-29 2015-08-05 花王株式会社 Ｃｎｇチャネル阻害剤
JP5562716B2 (ja) * 2010-05-12 2014-07-30 花王株式会社 電位依存性カチオンチャネル抑制剤
EP2635111B1 (en) 2010-11-05 2018-05-23 The Board of Trustees of the Leland Stanford Junior University Stabilized step function opsin proteins and methods of using the same
US8696722B2 (en) 2010-11-22 2014-04-15 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic magnetic resonance imaging
CA2822594A1 (en) * 2010-12-24 2012-06-28 Otsuka Pharmaceutical Co., Ltd. Bioassay method for detecting physiologically active substance
EP2742350B1 (en) 2011-08-08 2019-10-30 The Coca-Cola Company Cell lines comprising endogenous taste receptors and their uses
CN104093833B (zh) 2011-12-16 2017-11-07 斯坦福大学托管董事会 视蛋白多肽及其使用方法
EP2817068B1 (en) 2012-02-21 2017-04-12 The Board of Trustees of the Leland Stanford Junior University Compositions for treating neurogenic disorders of the pelvic floor
EP2884280B1 (en) * 2013-12-15 2018-05-09 Symrise AG Method for evaluating the scent performance of perfumes and perfume mixtures
WO2016209654A1 (en) 2015-06-22 2016-12-29 The Board Of Trustees Of The Leland Stanford Junior University Methods and devices for imaging and/or optogenetic control of light-responsive neurons
CA3034419C (en) * 2016-09-30 2023-01-03 Mars, Incorporated Screening methods using olfactory receptors and novel compounds identified using the same
US11294165B2 (en) 2017-03-30 2022-04-05 The Board Of Trustees Of The Leland Stanford Junior University Modular, electro-optical device for increasing the imaging field of view using time-sequential capture

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US5993778A (en) * 1997-05-07 1999-11-30 Firestein; Stuart J. Functional expression of, and assay for, functional cellular receptors in vivo
AU764180B2 (en) 1998-07-28 2003-08-14 Regents Of The University Of California, The Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction
CA2395007A1 (en) * 1999-12-23 2001-06-28 Incyte Genomics, Inc. Transporters and ion channels
US6933147B2 (en) * 2000-08-17 2005-08-23 Icagen, Inc. Human cyclic nucleotide-gated channel polypeptide
TW201022287A (en) 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same

Also Published As

Publication number Publication date
WO2003004611A3 (en) 2004-02-26
AU2002329196B2 (en) 2008-08-07
CN1541223A (zh) 2004-10-27
US7052857B2 (en) 2006-05-30
EP1414940A2 (en) 2004-05-06
MXPA03011805A (es) 2004-07-01
US20110224095A1 (en) 2011-09-15
US20030228633A1 (en) 2003-12-11
EP1414940A4 (en) 2005-11-23
CA2452315A1 (en) 2003-01-16
NO20035808L (no) 2004-02-09
CN1309736C (zh) 2007-04-11
WO2003004611A2 (en) 2003-01-16
JP2005500836A (ja) 2005-01-13
US8357499B2 (en) 2013-01-22

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