IL158806A0 - Tri-and tetraaza-acenaphthylen derivatives as crf receptor antagonists - Google Patents

Tri-and tetraaza-acenaphthylen derivatives as crf receptor antagonists

Info

Publication number
IL158806A0
IL158806A0 IL15880602A IL15880602A IL158806A0 IL 158806 A0 IL158806 A0 IL 158806A0 IL 15880602 A IL15880602 A IL 15880602A IL 15880602 A IL15880602 A IL 15880602A IL 158806 A0 IL158806 A0 IL 158806A0
Authority
IL
Israel
Prior art keywords
sub
crf receptor
receptor antagonists
acenaphthylen
tetraaza
Prior art date
Application number
IL15880602A
Other languages
English (en)
Original Assignee
Neurocrine Inc
Sb Pharmco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Inc, Sb Pharmco Inc filed Critical Neurocrine Inc
Publication of IL158806A0 publication Critical patent/IL158806A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IL15880602A 2001-05-21 2002-05-21 Tri-and tetraaza-acenaphthylen derivatives as crf receptor antagonists IL158806A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29266001P 2001-05-21 2001-05-21
PCT/GB2002/002377 WO2002094826A1 (fr) 2001-05-21 2002-05-21 Derives tri- et tetraaza-acenaphthylene utilises comme antagonistes du recepteur crf

Publications (1)

Publication Number Publication Date
IL158806A0 true IL158806A0 (en) 2004-05-12

Family

ID=23125629

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15880602A IL158806A0 (en) 2001-05-21 2002-05-21 Tri-and tetraaza-acenaphthylen derivatives as crf receptor antagonists

Country Status (21)

Country Link
US (1) US7446108B2 (fr)
EP (1) EP1392689B1 (fr)
JP (1) JP2004530702A (fr)
KR (1) KR20040018260A (fr)
CN (1) CN1529705A (fr)
AT (1) ATE343578T1 (fr)
AU (1) AU2002257939B2 (fr)
BR (1) BR0209947A (fr)
CA (1) CA2450535A1 (fr)
CO (1) CO5540310A2 (fr)
CZ (1) CZ20033165A3 (fr)
DE (1) DE60215637T2 (fr)
ES (1) ES2274972T3 (fr)
HU (1) HUP0400854A2 (fr)
IL (1) IL158806A0 (fr)
MX (1) MXPA03010635A (fr)
NO (1) NO20035148D0 (fr)
NZ (1) NZ529471A (fr)
PL (1) PL367771A1 (fr)
WO (1) WO2002094826A1 (fr)
ZA (1) ZA200308810B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
GB0308208D0 (en) 2003-04-09 2003-05-14 Glaxo Group Ltd Chemical compounds
CN1910187A (zh) 2004-01-06 2007-02-07 大正制药株式会社 三氮杂－环戊烷并[cd]茚衍生物
EP2527360B1 (fr) 2007-06-04 2015-10-28 Synergy Pharmaceuticals Inc. Agonistes de guanylase cyclase utiles pour le traitement de troubles gastro-intestinaux, d'inflammation, de cancer et d'autres troubles
US20100120694A1 (en) 2008-06-04 2010-05-13 Synergy Pharmaceuticals, Inc. Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
WO2010114905A1 (fr) 2009-03-31 2010-10-07 Arqule, Inc. Composés pyrazolo-pyrimidine péri-fusionnés
JP5719840B2 (ja) * 2009-06-08 2015-05-20 武田薬品工業株式会社 Ｊａｋの阻害剤としてのジヒドロピロロナフチリジノン化合物
WO2014151200A2 (fr) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions utiles pour le traitement de troubles gastro-intestinaux
WO2014151206A1 (fr) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonistes de la guanylate cyclase et leurs utilisations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04211063A (ja) * 1990-03-05 1992-08-03 Takeda Chem Ind Ltd 縮合三環性複素環化合物、その製造法、用途及び中間体
ZA973884B (en) * 1996-05-23 1998-11-06 Du Pont Merck Pharma Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders
BR9711970A (pt) 1996-08-28 1999-08-24 Pfizer Derivados 6,5-substitu¡do-heterobic¡clicos
ATE225349T1 (de) * 1998-11-12 2002-10-15 Neurocrine Biosciences Inc Crf rezeptor-antagonisten und darauf bezogene methoden
GB0117395D0 (en) 2001-07-17 2001-09-05 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
ATE343578T1 (de) 2006-11-15
EP1392689B1 (fr) 2006-10-25
EP1392689A1 (fr) 2004-03-03
ES2274972T3 (es) 2007-06-01
WO2002094826A1 (fr) 2002-11-28
DE60215637D1 (de) 2006-12-07
KR20040018260A (ko) 2004-03-02
AU2002257939B2 (en) 2006-08-24
HUP0400854A2 (hu) 2004-08-30
NO20035148D0 (no) 2003-11-19
CO5540310A2 (es) 2005-07-29
NZ529471A (en) 2005-12-23
US7446108B2 (en) 2008-11-04
PL367771A1 (en) 2005-03-07
ZA200308810B (en) 2004-11-30
BR0209947A (pt) 2004-04-27
CZ20033165A3 (cs) 2004-10-13
JP2004530702A (ja) 2004-10-07
CA2450535A1 (fr) 2002-11-28
MXPA03010635A (es) 2004-12-06
CN1529705A (zh) 2004-09-15
US20040198726A1 (en) 2004-10-07
DE60215637T2 (de) 2007-08-23

Similar Documents

Publication Publication Date Title
HK1038926A1 (en) Crf receptor antagonists and methods relating thereto
ZA200600475B (en) Pyrimidine-2,4-dione derivatives as gonadotripin-releasing hormone receptor antagonists
IL172834A0 (en) Pyrimidine-,2,4-dione derivatives and pharmaceutical compositions containing the same
IL155702A0 (en) Piperazinylpyrazine compounds as agonist or antagonist of serotonin 5-ht2 receptor
HK1068136A1 (en) Muscarinic antagonists
HK1038925A1 (en) Crf receptor antagonists and methods relating thereto crf
IL158806A0 (en) Tri-and tetraaza-acenaphthylen derivatives as crf receptor antagonists
AU2001261850A1 (en) Crf receptor antagonists and methods relating thereto
AU2001263329A1 (en) Crf receptor antagonists and methods relating thereto
HK1077303A1 (en) Hexacyclic compounds
DE602004012318D1 (de) Crf-rezeptorantagonisten und diese betreffende verfahren