IL157415A0 - Supersecretable peptides, processes for their production, and parallel improvement of the secreted form of one or more other polypeptides - Google Patents

Supersecretable peptides, processes for their production, and parallel improvement of the secreted form of one or more other polypeptides

Info

Publication number
IL157415A0
IL157415A0 IL15741502A IL15741502A IL157415A0 IL 157415 A0 IL157415 A0 IL 157415A0 IL 15741502 A IL15741502 A IL 15741502A IL 15741502 A IL15741502 A IL 15741502A IL 157415 A0 IL157415 A0 IL 157415A0
Authority
IL
Israel
Prior art keywords
protein
dna sequence
codon
lys
arg
Prior art date
Application number
IL15741502A
Other languages
English (en)
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of IL157415A0 publication Critical patent/IL157415A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
IL15741502A 2001-02-20 2002-02-08 Supersecretable peptides, processes for their production, and parallel improvement of the secreted form of one or more other polypeptides IL157415A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10108100A DE10108100A1 (de) 2001-02-20 2001-02-20 Verwendung supersekretierbarer Peptide in Verfahren zu deren Herstellung und paralleler Verbesserung der Exportate eines oder mehrerer anderer Polypeptide von Interesse
PCT/EP2002/001306 WO2002066628A2 (en) 2001-02-20 2002-02-08 Supersecretable peptides, processes for their production, and parallel improvement of the secreted form of one or more other polypeptides

Publications (1)

Publication Number Publication Date
IL157415A0 true IL157415A0 (en) 2004-03-28

Family

ID=7674831

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15741502A IL157415A0 (en) 2001-02-20 2002-02-08 Supersecretable peptides, processes for their production, and parallel improvement of the secreted form of one or more other polypeptides

Country Status (21)

Country Link
EP (1) EP1364030B1 (zh)
JP (1) JP4243103B2 (zh)
KR (1) KR100858008B1 (zh)
CN (1) CN100575493C (zh)
AT (1) ATE320498T1 (zh)
AU (1) AU2002247696B2 (zh)
BR (1) BR0207385A (zh)
CA (1) CA2438935C (zh)
CY (1) CY1105696T1 (zh)
DE (2) DE10108100A1 (zh)
DK (1) DK1364030T3 (zh)
ES (1) ES2258619T3 (zh)
HK (1) HK1065818A1 (zh)
IL (1) IL157415A0 (zh)
MX (1) MXPA03007115A (zh)
NO (1) NO331375B1 (zh)
NZ (1) NZ527641A (zh)
PE (1) PE20020875A1 (zh)
PT (1) PT1364030E (zh)
WO (1) WO2002066628A2 (zh)
ZA (1) ZA200305867B (zh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060233808A1 (en) * 2003-04-04 2006-10-19 David Deperthes Peptabody for cancer treatment
DE102006031962A1 (de) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Amidiertes Insulin Glargin
DE102006031955A1 (de) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
KR101820024B1 (ko) 2008-10-17 2018-01-18 사노피-아벤티스 도이칠란트 게엠베하 인슐린과 ｇｌｐ－1 효능제의 병용물
EP3345593B1 (de) 2009-11-13 2023-09-06 Sanofi-Aventis Deutschland GmbH Pharmazeutische zusammensetzung umfassend despro36exendin-4(1-39)-lys6-nh2 und methionin
TR201809460T4 (tr) 2009-11-13 2018-07-23 Sanofi Aventis Deutschland Bir GLP- 1-agonisti, bir insülin ve metiyonin içeren farmasötik bileşim.
ES2606554T3 (es) 2010-08-30 2017-03-24 Sanofi-Aventis Deutschland Gmbh Uso de AVE0010 para la fabricación de un medicamento para el tratamiento de la diabetes mellitus de tipo 2
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
TWI608847B (zh) 2011-08-29 2017-12-21 賽諾菲阿凡提斯德意志有限公司 用於控制糖尿病二型病患血糖的醫藥組合物
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
PE20171622A1 (es) 2014-12-12 2017-11-02 Sanofi Aventis Deutschland Formulacion de relacion fija de insulina glargina/lixisenatida
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
CN108866205A (zh) * 2018-07-25 2018-11-23 中国食品药品检定研究院 基于分子生物学方法鉴别菲牛蛭的特异性引物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE58906966D1 (de) * 1988-06-23 1994-03-24 Hoechst Ag Mini-Proinsulin, seine Herstellung und Verwendung.
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids
FI92601C (fi) * 1992-03-11 1994-12-12 Marja Makarow Menetelmä hyötyproteiinien erittämiseksi hiivoista

Also Published As

Publication number Publication date
EP1364030A2 (en) 2003-11-26
AU2002247696B2 (en) 2006-10-12
CN100575493C (zh) 2009-12-30
DE10108100A1 (de) 2002-08-29
DE60209883D1 (de) 2006-05-11
NO20033671L (no) 2003-10-17
DE60209883T2 (de) 2006-09-07
ES2258619T3 (es) 2006-09-01
NO331375B1 (no) 2011-12-12
ZA200305867B (en) 2004-06-29
MXPA03007115A (es) 2003-11-18
BR0207385A (pt) 2004-02-10
ATE320498T1 (de) 2006-04-15
CY1105696T1 (el) 2010-12-22
CA2438935A1 (en) 2002-08-29
CA2438935C (en) 2012-01-24
PE20020875A1 (es) 2002-10-31
JP2004518442A (ja) 2004-06-24
NZ527641A (en) 2005-03-24
KR100858008B1 (ko) 2008-09-11
EP1364030B1 (en) 2006-03-15
WO2002066628A3 (en) 2002-11-14
DK1364030T3 (da) 2006-07-17
NO20033671D0 (no) 2003-08-19
KR20030074832A (ko) 2003-09-19
PT1364030E (pt) 2006-05-31
JP4243103B2 (ja) 2009-03-25
WO2002066628A2 (en) 2002-08-29
HK1065818A1 (en) 2005-03-04
CN1527882A (zh) 2004-09-08

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Legal Events

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