IL157386A0 - A stereoselective process for the preparation of (s)-1-arylethanol derivatives - Google Patents

A stereoselective process for the preparation of (s)-1-arylethanol derivatives

Info

Publication number
IL157386A0
IL157386A0 IL15738602A IL15738602A IL157386A0 IL 157386 A0 IL157386 A0 IL 157386A0 IL 15738602 A IL15738602 A IL 15738602A IL 15738602 A IL15738602 A IL 15738602A IL 157386 A0 IL157386 A0 IL 157386A0
Authority
IL
Israel
Prior art keywords
arylethanol
derivatives
preparation
stereoselective process
stereoselective
Prior art date
Application number
IL15738602A
Other languages
English (en)
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of IL157386A0 publication Critical patent/IL157386A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/938—Pichia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
IL15738602A 2001-03-22 2002-03-06 A stereoselective process for the preparation of (s)-1-arylethanol derivatives IL157386A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27802501P 2001-03-22 2001-03-22
PCT/US2002/006783 WO2002077258A1 (en) 2001-03-22 2002-03-06 Stereoselective reduction of substituted acetophenone

Publications (1)

Publication Number Publication Date
IL157386A0 true IL157386A0 (en) 2004-02-19

Family

ID=23063377

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15738602A IL157386A0 (en) 2001-03-22 2002-03-06 A stereoselective process for the preparation of (s)-1-arylethanol derivatives

Country Status (13)

Country Link
US (1) US6800477B2 (xx)
EP (1) EP1370677A1 (xx)
JP (1) JP2004532017A (xx)
KR (1) KR20030085012A (xx)
CN (1) CN1498273A (xx)
BR (1) BR0208265A (xx)
CA (1) CA2441267A1 (xx)
CZ (1) CZ20032496A3 (xx)
HU (1) HUP0400261A3 (xx)
IL (1) IL157386A0 (xx)
MX (1) MXPA03008437A (xx)
PL (1) PL364577A1 (xx)
WO (1) WO2002077258A1 (xx)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1453516A2 (de) * 2001-10-17 2004-09-08 Boehringer Ingelheim Pharma GmbH & Co.KG 5-substituierte 4-amino-2-phenylamino-pyrimdinderivate und ihre verwendung als beta-amyloid modulatoren
EP1791965A1 (en) * 2004-08-26 2007-06-06 Pfizer, Inc. Enantioselective biotransformation for preparation of protein tyrosine kinase inhibitor intermediates
WO2007084625A2 (en) * 2006-01-19 2007-07-26 Mount Sinai School Of Medicine Novel compounds and methods for inhibiting p53 activity
CN101528917B (zh) * 2006-10-02 2015-07-29 科德克希思公司 用于制备立体异构纯的他汀类及其合成中间体的组合物和方法
JP2010517574A (ja) * 2007-02-08 2010-05-27 コデクシス， インコーポレイテッド ケトレダクターゼおよびその使用
JP2010536385A (ja) 2007-08-24 2010-12-02 コデクシス， インコーポレイテッド （ｒ）−３−ヒドロキシチオランの立体選択的生成のための改善されたケトレダクターゼポリペプチド
JP5973131B2 (ja) 2007-09-13 2016-08-23 コデクシス， インコーポレイテッド アセトフェノンの還元のためのケトレダクターゼポリペプチド
KR20100061571A (ko) 2007-09-28 2010-06-07 코덱시스, 인코포레이티드 케토리덕타제 폴리펩티드 및 이의 용도
WO2009046153A1 (en) 2007-10-01 2009-04-09 Codexis, Inc. Ketoreductase polypeptides for the production of azetidinone
US8288141B2 (en) 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
WO2010027710A2 (en) 2008-08-27 2010-03-11 Codexis, Inc. Ketoreductase polypeptides and uses thereof
SI2329013T1 (sl) 2008-08-27 2016-03-31 Codexis, Inc. Polipeptidi ketoreduktaze za proizvodnjo 3-aril-3-hidroksipropanamina iz 3-aril-3-ketopropanamina
US8273554B2 (en) 2008-08-29 2012-09-25 Codexis, Inc. Ketoreductase polypeptides for the stereoselective production of (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
CN102482648B (zh) 2009-06-22 2014-12-10 科德克希思公司 酮还原酶介导的产生α氯代醇的立体选择性途径
CN102803233B (zh) * 2009-06-22 2017-03-01 爱思开生物制药株式会社 制备氨基甲酸(r)‑1‑芳基‑2‑四唑基‑乙酯的方法
EP2467473B1 (en) 2009-08-19 2016-03-23 Codexis, Inc. Ketoreductase polypeptides for the preparation of phenylephrine
US8404461B2 (en) 2009-10-15 2013-03-26 SK Biopharmaceutical Co. Ltd. Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester
WO2011100265A2 (en) 2010-02-10 2011-08-18 Codexis, Inc. Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system
EP2566497B1 (en) 2010-05-04 2015-07-29 Codexis, Inc. Biocatalysts for ezetimibe synthesis
WO2012046254A2 (en) * 2010-10-08 2012-04-12 Cadila Healthcare Limited Process for preparing an intermediate of sitagliptin via enzymatic conversion
US9139819B2 (en) 2011-11-18 2015-09-22 Codexis, Inc. Biocatalysts for the preparation of hydroxy substituted carbamates
DE102012017026A1 (de) 2012-08-28 2014-03-06 Forschungszentrum Jülich GmbH Sensor für NADP(H) und Entwicklung von Alkoholdehydrogenasen
ES2830725T3 (es) 2015-02-10 2021-06-04 Codexis Inc Polipéptidos cetoreductasa para la síntesis de compuestos quirales
CN110831618B (zh) 2017-04-27 2023-08-25 科德克希思公司 酮还原酶多肽及多核苷酸
CN107686447A (zh) * 2017-08-25 2018-02-13 许昌恒生制药有限公司 一种替格瑞洛中间体的制备方法
EP3587393B1 (en) 2018-06-21 2024-01-17 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Enzymatic process for the preparation of droxidopa
TW202304921A (zh) 2021-04-02 2023-02-01 美商建南德克公司 製造雙環酮化合物之方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0538693A3 (en) 1991-10-23 1994-08-17 Squibb & Sons Inc Stereoselective preparation of halophenyl alcohols
US5523223A (en) 1992-03-13 1996-06-04 Forschungszentrum Julich Gmbh Ketoester reductase for conversion of keto acid esters to optically active hydroxy acid esters
CA2103932A1 (en) 1992-11-05 1994-05-06 Ramesh N. Patel Stereoselective reduction of ketones
AU1302999A (en) 1997-11-04 1999-05-24 Eli Lilly And Company Ketoreductase gene and protein from yeast

Also Published As

Publication number Publication date
WO2002077258A1 (en) 2002-10-03
CA2441267A1 (en) 2002-10-03
CN1498273A (zh) 2004-05-19
KR20030085012A (ko) 2003-11-01
HUP0400261A2 (hu) 2004-09-28
HUP0400261A3 (en) 2005-11-28
US20030068811A1 (en) 2003-04-10
PL364577A1 (en) 2004-12-13
US6800477B2 (en) 2004-10-05
CZ20032496A3 (cs) 2003-12-17
EP1370677A1 (en) 2003-12-17
JP2004532017A (ja) 2004-10-21
MXPA03008437A (es) 2004-01-29
BR0208265A (pt) 2004-03-02

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