IL156774A0 - Inhibitors of cruzipain and other cysteine proteases - Google Patents

Inhibitors of cruzipain and other cysteine proteases

Info

Publication number: IL156774A0
Authority: IL; Israel
Prior art keywords: inhibitors; cruzipain; cysteine proteases; general formula; compounds
Prior art date: 2001-01-17

Application number

IL15677402A

Other languages

English (en)

Original Assignee

Amura Therapeutics Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-01-17

Filing date

2002-01-17

Publication date

2004-02-08

2001-01-17 Priority claimed from GB0101179A external-priority patent/GB0101179D0/en

2002-01-17 Application filed by Amura Therapeutics Ltd filed Critical Amura Therapeutics Ltd

2004-02-08 Publication of IL156774A0 publication Critical patent/IL156774A0/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Tropical Medicine & Parasitology (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)

IL15677402A 2001-01-17 2002-01-17 Inhibitors of cruzipain and other cysteine proteases IL156774A0 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0101179A GB0101179D0 (en)	2001-01-17	2001-01-17	Biologically active compounds
US27535901P	2001-03-13	2001-03-13
PCT/GB2002/000184 WO2002057270A1 (en)	2001-01-17	2002-01-17	Inhibitors of cruzipain and other cysteine proteases

Publications (1)

Publication Number	Publication Date
IL156774A0 true IL156774A0 (en)	2004-02-08

Family

ID=26245571

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL15677402A IL156774A0 (en)	2001-01-17	2002-01-17	Inhibitors of cruzipain and other cysteine proteases
IL156774A IL156774A (en)	2001-01-17	2003-07-03	Inhibitors of crucifine and other cysteine proteases

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL156774A IL156774A (en)	2001-01-17	2003-07-03	Inhibitors of crucifine and other cysteine proteases

Country Status (21)

Country	Link
US (2)	US7425562B2 (xx)
EP (1)	EP1362052B1 (xx)
JP (1)	JP4608183B2 (xx)
KR (1)	KR100860067B1 (xx)
CN (1)	CN1269822C (xx)
AT (1)	ATE356130T1 (xx)
AU (1)	AU2002219397B2 (xx)
BR (1)	BR0206501A (xx)
CA (1)	CA2436462C (xx)
CY (1)	CY1106640T1 (xx)
DE (1)	DE60218633T2 (xx)
DK (1)	DK1362052T3 (xx)
ES (1)	ES2281516T3 (xx)
HK (1)	HK1060729A1 (xx)
IL (2)	IL156774A0 (xx)
MX (1)	MXPA03006224A (xx)
NO (1)	NO328208B1 (xx)
NZ (1)	NZ526913A (xx)
PT (1)	PT1362052E (xx)
RU (1)	RU2329266C2 (xx)
WO (1)	WO2002057270A1 (xx)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2433520A1 (en)	2000-12-22	2002-07-04	Axys Pharmaceuticals, Inc.	Novel compounds and compositions as cathepsin inhibitors
US7030116B2 (en)	2000-12-22	2006-04-18	Aventis Pharmaceuticals Inc.	Compounds and compositions as cathepsin inhibitors
IL160819A0 (en)	2001-09-14	2004-08-31	Aventis Pharma Inc	Novel compounds and compositions as cathepsin inhibitors
BR0214104A (pt)	2001-11-14	2004-09-28	Aventis Pharma Inc	Oligopeptìdeos e composições contendo os mesmos como inibidores de catepsina
BR0312662A (pt) *	2002-07-16	2005-05-03	Amura Therapeutics Ltd	Compostos biologicamente ativos
US7399765B2 (en) *	2003-09-19	2008-07-15	Abbott Laboratories	Substituted diazabicycloalkane derivatives
ES2341869T3 (es)	2004-01-08	2010-06-29	Medivir Aktiebolag	Inhibidores de cisteina proteasa.
JP2005350417A (ja) *	2004-06-11	2005-12-22	Dai Ichi Seiyaku Co Ltd	還元的エーテル化法を用いたピロリジン誘導体の製造法
NZ561681A (en) *	2005-03-21	2011-01-28	Virobay Inc	Alpha ketoamide compounds as cysteine protease inhibitors
GB0513839D0 (en) *	2005-07-07	2005-08-10	Medivir Ab	Cysteine protease inhibitors
GB0513840D0 (en) *	2005-07-07	2005-08-10	Medivir Ab	Cysteine protease inhibitors
GB0614042D0 (en)	2006-07-14	2006-08-23	Amura Therapeutics Ltd	Compounds
GB0614052D0 (en)	2006-07-14	2006-08-23	Amura Therapeutics Ltd	Compounds
GB0614046D0 (en)	2006-07-14	2006-08-23	Amura Therapeutics Ltd	Compounds
GB0614044D0 (en) *	2006-07-14	2006-08-23	Amura Therapeutics Ltd	Compounds
GB0614073D0 (en) *	2006-07-14	2006-08-23	Amura Therapeutics Ltd	Compounds
GB0614053D0 (en) *	2006-07-14	2006-08-23	Amura Therapeutics Ltd	Compounds
GB0614037D0 (en)	2006-07-14	2006-08-23	Amura Therapeutics Ltd	Compounds
WO2008114054A1 (en) *	2007-03-19	2008-09-25	Medivir Ab	Protease inhibitors
US7893067B2 (en)	2007-06-27	2011-02-22	Medivir Ab	Cysteine protease inhibitors
EP2240491B1 (en)	2008-01-09	2015-07-15	Amura Therapeutics Limited	TETRAHYDROFURO(2,3-b)PYRROL-3-ONE DERIVATIVES AS INHIBITORS OF CYSTEINE PROTEINASES
GB0804702D0 (en)	2008-03-13	2008-04-16	Amura Therapeutics Ltd	Compounds
GB0804701D0 (en)	2008-03-13	2008-04-16	Amura Therapeutics Ltd	Compounds
US9409880B2 (en)	2011-01-20	2016-08-09	The Regents Of The University Of Colorado, A Body Corporate	Modulators of TLR3/dsRNA complex and uses thereof
DK2891492T3 (da) *	2012-08-30	2022-11-21	Univ Tokyo	Endoparasit kontrol middel
CN106279188A (zh) *	2016-07-21	2017-01-04	青岛科技大学	一种多取代呋喃并[2,3‑b]吡咯衍生物的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3652574A (en) *	1970-04-01	1972-03-28	Abbott Lab	Certain 1 2 3 4 - tetrahydro-5h-pyrido (4 3-b)indoles and the corresponding 1 2 3 4-tetrahydro-9h-pyrido(3 4-b)indoles and derivatives thereof
DZ2285A1 (fr)	1996-08-08	2002-12-25	Smithkline Beecham Corp	Inhibiteurs de protéase de la cystéine.
WO1998008802A1 (en)	1996-08-28	1998-03-05	Smithkline Beecham Corporation	Inhibitors of cysteine protease
CN1616432A (zh)	1996-12-23	2005-05-18	伊兰药品公司	化合物、其用途以及含有所述化合物的药物组合物
AR013079A1 (es) *	1997-05-06	2000-12-13	Smithkline Beecham Corp	Derivados sustituidos de tetrahidrofurano-3-onas, de tetrahidropirano-3- onas y tetrahidrotiofen-3-onas, un procedimiento para su preparacion unacomposicion farmaceutica de un medicamento util como inhibidores de proteasas e intermediarios
MA26618A1 (fr)	1998-04-09	2004-12-20	Smithkline Beecham Corp	Composes et compositions pharmaceutiques pour le traitement du paludisme
CO5150165A1 (es)	1998-11-13	2002-04-29	Smithkline Beecham Plc	Inhibidores de proteasa: tipo catepsina k
GB9911417D0 (en)	1999-05-18	1999-07-14	Peptide Therapeutics Ltd	Furanone derivatives as inhibitors of cathepsin s
WO2002040462A2 (en)	2000-11-17	2002-05-23	Medivir Uk Limited	Cysteine protease inhibitors
CA2433520A1 (en)	2000-12-22	2002-07-04	Axys Pharmaceuticals, Inc.	Novel compounds and compositions as cathepsin inhibitors

2002
- 2002-01-17 DK DK02732145T patent/DK1362052T3/da active
- 2002-01-17 US US10/466,384 patent/US7425562B2/en not_active Expired - Fee Related
- 2002-01-17 IL IL15677402A patent/IL156774A0/xx active IP Right Grant
- 2002-01-17 BR BR0206501-0A patent/BR0206501A/pt not_active IP Right Cessation
- 2002-01-17 KR KR1020037009524A patent/KR100860067B1/ko not_active IP Right Cessation
- 2002-01-17 MX MXPA03006224A patent/MXPA03006224A/es active IP Right Grant
- 2002-01-17 ES ES02732145T patent/ES2281516T3/es not_active Expired - Lifetime
- 2002-01-17 DE DE60218633T patent/DE60218633T2/de not_active Expired - Lifetime
- 2002-01-17 AT AT02732145T patent/ATE356130T1/de active
- 2002-01-17 EP EP02732145A patent/EP1362052B1/en not_active Expired - Lifetime
- 2002-01-17 WO PCT/GB2002/000184 patent/WO2002057270A1/en active IP Right Grant
- 2002-01-17 RU RU2003125270/04A patent/RU2329266C2/ru not_active IP Right Cessation
- 2002-01-17 PT PT02732145T patent/PT1362052E/pt unknown
- 2002-01-17 JP JP2002557947A patent/JP4608183B2/ja not_active Expired - Fee Related
- 2002-01-17 AU AU2002219397A patent/AU2002219397B2/en not_active Ceased
- 2002-01-17 CN CNB028038142A patent/CN1269822C/zh not_active Expired - Fee Related
- 2002-01-17 CA CA2436462A patent/CA2436462C/en not_active Expired - Fee Related
- 2002-01-17 NZ NZ526913A patent/NZ526913A/xx not_active IP Right Cessation
2003
- 2003-07-03 IL IL156774A patent/IL156774A/en not_active IP Right Cessation
- 2003-07-16 NO NO20033220A patent/NO328208B1/no not_active IP Right Cessation
2004
- 2004-05-14 HK HK04103421A patent/HK1060729A1/xx not_active IP Right Cessation
2007
- 2007-06-04 CY CY20071100742T patent/CY1106640T1/el unknown
2008
- 2008-09-15 US US12/211,069 patent/US20090247471A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CA2436462C (en)	2011-07-05
WO2002057270A1 (en)	2002-07-25
MXPA03006224A (es)	2004-10-15
DE60218633D1 (de)	2007-04-19
BR0206501A (pt)	2004-01-13
RU2003125270A (ru)	2005-02-20
KR100860067B1 (ko)	2008-09-24
RU2329266C2 (ru)	2008-07-20
US20040138250A1 (en)	2004-07-15
PT1362052E (pt)	2007-04-30
NZ526913A (en)	2004-12-24
NO20033220L (no)	2003-09-17
JP4608183B2 (ja)	2011-01-05
CN1486320A (zh)	2004-03-31
AU2002219397B2 (en)	2008-02-14
ATE356130T1 (de)	2007-03-15
US7425562B2 (en)	2008-09-16
NO20033220D0 (no)	2003-07-16
EP1362052A1 (en)	2003-11-19
CA2436462A1 (en)	2002-07-25
NO328208B1 (no)	2010-01-11
IL156774A (en)	2008-08-07
JP2004518674A (ja)	2004-06-24
ES2281516T3 (es)	2007-10-01
CY1106640T1 (el)	2012-01-25
KR20030075161A (ko)	2003-09-22
CN1269822C (zh)	2006-08-16
EP1362052B1 (en)	2007-03-07
DE60218633T2 (de)	2008-02-21
DK1362052T3 (da)	2007-07-09
HK1060729A1 (en)	2004-08-20
US20090247471A1 (en)	2009-10-01

Legal Events

Date	Code	Title	Description
2009-06-15	FF	Patent granted
2009-06-15	KB	Patent renewed

Publication	Publication Date	Title
IL156774A0 (en)	2004-02-08	Inhibitors of cruzipain and other cysteine proteases
TR199901191T2 (xx)	1999-12-21	Benzamidoaldehitlerin sistein proteaz� inhibit�r� olarak kullan�m�.
UA74372C2 (uk)	2005-12-15	Інгібітори серинових протеаз, фармацевтична композиція на їх основі
SE0201976D0 (sv)	2002-06-24	Novel compounds
BR0215405A (pt)	2005-01-25	Composições e processos de uso de collajolie
SE0102315D0 (sv)	2001-06-28	Compounds
DE60112974D1 (en)	2005-09-29	Carbolinderivate
DK1200418T3 (da)	2004-07-26	Nematodicide trifluorbutener
DE60216233D1 (en)	2007-01-04	Carbolinderivate
ATE303384T1 (de)	2005-09-15	1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren
SE0101932D0 (sv)	2001-05-31	Pharmaceutical combinations
AU2001264065A1 (en)	2001-12-24	Serine protease inhibitors
AU2001264081A1 (en)	2001-12-24	Serine protease inhibitors
MXPA04006041A (es)	2004-09-27	Antivirales de piridoquinoxalina.
SE0101038D0 (sv)	2001-03-23	Novel compounds
SE0003476D0 (sv)	2000-09-28	Compounds
UA83266C2 (xx)	2008-06-25	Оксазольні похідні тетрациклінів$оксазольные производные тетрациклинов
DE60202669D1 (de)	2005-02-24	6-phenylbenzonaphthyidine
DK1204659T3 (da)	2004-04-05	Serotonerge benzofuraner
WO2002057246A3 (en)	2002-11-21	Inhibitors of cruzipain and other cysteine proteases
EA200301101A1 (ru)	2004-04-29	Производные пиперазина и их применение в качестве ингибиторов pde4
DE60121048D1 (de)	2006-08-03	PYRAZINOi1'2':1,6öPYRIDOi3,4-BöINDOLDERIVATE
WO2002057248A3 (en)	2002-10-03	Inhibitors of cruzipain and other cysteine proteases
DK1244643T3 (da)	2004-10-18	Tryptaseinhibitorer
DE60216920D1 (en)	2007-02-01	Tryptase-inhibitoren