IL156518A0 - Heteocyclylalkylindole or-azaindole compounds as 5-hydroxytryptamine-6 ligands - Google Patents
Heteocyclylalkylindole or-azaindole compounds as 5-hydroxytryptamine-6 ligandsInfo
- Publication number
- IL156518A0 IL156518A0 IL15651801A IL15651801A IL156518A0 IL 156518 A0 IL156518 A0 IL 156518A0 IL 15651801 A IL15651801 A IL 15651801A IL 15651801 A IL15651801 A IL 15651801A IL 156518 A0 IL156518 A0 IL 156518A0
- Authority
- IL
- Israel
- Prior art keywords
- heteocyclylalkylindole
- hydroxytryptamine
- ligands
- azaindole compounds
- azaindole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25768400P | 2000-12-22 | 2000-12-22 | |
| PCT/US2001/047938 WO2002051832A2 (en) | 2000-12-22 | 2001-12-11 | Heterocyclylalkylindole or -azaindole compounds as 5-hydroxytryptamine-6 ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL156518A0 true IL156518A0 (en) | 2004-01-04 |
Family
ID=22977310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15651801A IL156518A0 (en) | 2000-12-22 | 2001-12-11 | Heteocyclylalkylindole or-azaindole compounds as 5-hydroxytryptamine-6 ligands |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6613781B2 (ja) |
| EP (1) | EP1355900B1 (ja) |
| JP (1) | JP2004520325A (ja) |
| KR (1) | KR20030062440A (ja) |
| CN (1) | CN1492863A (ja) |
| AR (1) | AR034284A1 (ja) |
| AT (1) | ATE327232T1 (ja) |
| BR (1) | BR0116481A (ja) |
| CA (1) | CA2432661A1 (ja) |
| DE (1) | DE60119982T2 (ja) |
| DK (1) | DK1355900T3 (ja) |
| EA (1) | EA200300716A1 (ja) |
| ES (1) | ES2264994T3 (ja) |
| HU (1) | HUP0400682A2 (ja) |
| IL (1) | IL156518A0 (ja) |
| MX (1) | MXPA03005433A (ja) |
| NO (1) | NO20032841L (ja) |
| PL (1) | PL363238A1 (ja) |
| WO (1) | WO2002051832A2 (ja) |
| ZA (1) | ZA200305625B (ja) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ20033529A3 (cs) * | 2001-06-07 | 2004-04-14 | F. Hoffman-La Roche Ag | Nové deriváty indolu s afinitou k receptoru 5-HT6 |
| US20030225121A1 (en) * | 2001-12-20 | 2003-12-04 | Wyeth | Heterocyclylalkylindole or-azaindole compounds as 5-hydroxytryptamine-6 ligands |
| US7838518B2 (en) * | 2002-02-12 | 2010-11-23 | N.V. Organon | 1-arylsulfonyl-3-substituted indole and indoline derivatives useful in the treatment of central nervous system disorders |
| TW200401641A (en) * | 2002-07-18 | 2004-02-01 | Wyeth Corp | 1-Heterocyclylalkyl-3-sulfonylindole or-indazole derivatives as 5-hydroxytryptamine-6 ligands |
| JP4559230B2 (ja) * | 2002-11-28 | 2010-10-06 | スベン ライフ サイエンシズ リミティド | セロトニン受容体に対する親和性を有する新規ｎ−アリールスルホニル−３−置換されたインドール、その調製方法、それを含有する医薬組成物 |
| CA2511806A1 (en) * | 2003-01-22 | 2004-08-12 | Eli Lilly And Company | Indole-derivative modulators of steroid hormone nuclear receptors |
| BRPI0407493A (pt) * | 2003-02-14 | 2006-02-14 | Wyeth Corp | derivados heterociclil-3-sulfinilazaindol ou -azaindazol como ligantes de 5-hidroxitriptamina-6 |
| EP1592683A2 (en) * | 2003-02-14 | 2005-11-09 | Wyeth | Heterocyclyl-3-sulfonylindazoles as 5-hydroxytryptamine-6 ligands |
| ES2222828B1 (es) * | 2003-07-30 | 2006-04-16 | Laboratorios Del Dr. Esteve, S.A. | Derivados de 1-sulfonilindoles, su preparacion y su aplicacion como medicamentos. |
| DE602004008474T2 (de) * | 2003-07-31 | 2008-05-15 | Wyeth | N-sulfonylheterocyclopyrrolylalkylamin-verbindungen als 5-hydroxytryptamin-6-liganden. |
| CN101258144B (zh) * | 2005-08-12 | 2012-05-30 | 苏文生命科学有限公司 | 作为功能性5-ht6配体的氨基芳基磺酰胺衍生物 |
| CN101282938A (zh) * | 2005-08-15 | 2008-10-08 | 惠氏公司 | 作为5-羟色胺-6配体的经取代3-磺酰基吲唑衍生物 |
| WO2007031838A1 (en) | 2005-09-16 | 2007-03-22 | Ranbaxy Laboratories Limited | Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors |
| EP1842541A1 (en) * | 2006-03-29 | 2007-10-10 | G.I.M.-Gesellschaft Für Innovative Medizin Gmbh Nfg Ohg | Plant components and extracts and uses thereof |
| BRPI0709718A2 (pt) * | 2006-04-05 | 2011-03-29 | Wyeth Corp | composto; método para tratamento de um transtorno do sistema nervoso central relacionado a ou afetado pelo receptor 5-ht6 em um paciente necessitado; composição farmacêutica; e proceso para a preparação do composto |
| WO2007120596A1 (en) * | 2006-04-12 | 2007-10-25 | Wyeth | DIHYDRO[1,4]DIOXINO[2,3-e]INDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS |
| EP2124944B1 (en) | 2007-03-14 | 2012-02-15 | Ranbaxy Laboratories Limited | Pyrazolo[3,4-b]pyridine derivatives as phosphodiesterase inhibitors |
| EP2162433A2 (en) * | 2007-05-24 | 2010-03-17 | Memory Pharmaceuticals Corporation | 4' substituted compounds having 5-ht6 receptor affinity |
| US20100016297A1 (en) * | 2008-06-24 | 2010-01-21 | Memory Pharmaceuticals Corporation | Alkyl-substituted 3' compounds having 5-ht6 receptor affinity |
| US20100022581A1 (en) * | 2008-07-02 | 2010-01-28 | Memory Pharmaceuticals Corporation | Pyrrolidine-substituted azaindole compounds having 5-ht6 receptor affinity |
| US20100029629A1 (en) * | 2008-07-25 | 2010-02-04 | Memory Pharmaceuticals Corporation | Acyclic compounds having 5-ht6 receptor affinity |
| US20100056531A1 (en) * | 2008-08-22 | 2010-03-04 | Memory Pharmaceuticals Corporation | Alkyl-substituted 3' compounds having 5-ht6 receptor affinity |
| JP6454346B2 (ja) | 2013-12-20 | 2019-01-16 | サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． | 芳香族複素環式化合物及び医薬におけるその応用 |
| AU2015286049B2 (en) | 2014-07-08 | 2018-03-01 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic derivatives and pharmaceutical applications thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4208417A (en) | 1978-06-29 | 1980-06-17 | Pharmindustrie | Indole derivatives and their use as anxiolytics |
| FR2701026B1 (fr) * | 1993-02-02 | 1995-03-31 | Adir | Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| IT1271352B (it) | 1993-04-08 | 1997-05-27 | Boehringer Ingelheim Italia | Derivati dell'indolo utili nel trattamento dei disturbi del sistema nervoso centrale |
| US6100291A (en) * | 1998-03-16 | 2000-08-08 | Allelix Biopharmaceuticals Inc. | Pyrrolidine-indole compounds having 5-HT6 affinity |
| US6133287A (en) * | 1998-03-24 | 2000-10-17 | Allelix Biopharmaceuticals Inc. | Piperidine-indole compounds having 5-HT6 affinity |
| WO1999055697A1 (en) * | 1998-04-29 | 1999-11-04 | American Home Products Corporation | Serotonergic agents |
| US6251893B1 (en) | 1998-06-15 | 2001-06-26 | Nps Allelix Corp. | Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity |
| US6066637A (en) | 1998-06-19 | 2000-05-23 | American Home Products Corporation | Indolyl derivatives as serotonergic agents |
| US6191141B1 (en) | 1999-08-12 | 2001-02-20 | Nps Allelix Corp. | Azaindoles having serotonin receptor affinity |
| KR100823908B1 (ko) * | 2000-10-20 | 2008-04-21 | 바이오비트럼 에이비(피유비엘) | 2-, 3-, 4-, 또는 5-치환-ｎ1-(벤젠술포닐)인돌 및 이의치료 용도 |
-
2001
- 2001-12-11 DK DK01993251T patent/DK1355900T3/da active
- 2001-12-11 IL IL15651801A patent/IL156518A0/xx unknown
- 2001-12-11 BR BR0116481-3A patent/BR0116481A/pt not_active IP Right Cessation
- 2001-12-11 DE DE60119982T patent/DE60119982T2/de not_active Expired - Fee Related
- 2001-12-11 HU HU0400682A patent/HUP0400682A2/hu unknown
- 2001-12-11 JP JP2002552927A patent/JP2004520325A/ja active Pending
- 2001-12-11 PL PL01363238A patent/PL363238A1/xx unknown
- 2001-12-11 AT AT01993251T patent/ATE327232T1/de not_active IP Right Cessation
- 2001-12-11 CA CA002432661A patent/CA2432661A1/en not_active Abandoned
- 2001-12-11 KR KR10-2003-7008333A patent/KR20030062440A/ko not_active Application Discontinuation
- 2001-12-11 WO PCT/US2001/047938 patent/WO2002051832A2/en active IP Right Grant
- 2001-12-11 EA EA200300716A patent/EA200300716A1/ru unknown
- 2001-12-11 CN CNA018228232A patent/CN1492863A/zh active Pending
- 2001-12-11 EP EP01993251A patent/EP1355900B1/en not_active Expired - Lifetime
- 2001-12-11 ES ES01993251T patent/ES2264994T3/es not_active Expired - Lifetime
- 2001-12-11 MX MXPA03005433A patent/MXPA03005433A/es active IP Right Grant
- 2001-12-20 US US10/028,487 patent/US6613781B2/en not_active Expired - Fee Related
- 2001-12-21 AR ARP010106003A patent/AR034284A1/es unknown
-
2003
- 2003-06-20 NO NO20032841A patent/NO20032841L/no not_active Application Discontinuation
- 2003-07-21 ZA ZA200305625A patent/ZA200305625B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR034284A1 (es) | 2004-02-18 |
| WO2002051832A2 (en) | 2002-07-04 |
| ZA200305625B (en) | 2004-10-21 |
| EP1355900B1 (en) | 2006-05-24 |
| CA2432661A1 (en) | 2002-07-04 |
| EP1355900A2 (en) | 2003-10-29 |
| ATE327232T1 (de) | 2006-06-15 |
| DE60119982D1 (de) | 2006-06-29 |
| US6613781B2 (en) | 2003-09-02 |
| ES2264994T3 (es) | 2007-02-01 |
| NO20032841L (no) | 2003-08-20 |
| PL363238A1 (en) | 2004-11-15 |
| JP2004520325A (ja) | 2004-07-08 |
| US20020128477A1 (en) | 2002-09-12 |
| EA200300716A1 (ru) | 2003-12-25 |
| CN1492863A (zh) | 2004-04-28 |
| WO2002051832A3 (en) | 2002-09-06 |
| BR0116481A (pt) | 2004-01-06 |
| NO20032841D0 (no) | 2003-06-20 |
| DE60119982T2 (de) | 2006-12-21 |
| KR20030062440A (ko) | 2003-07-25 |
| DK1355900T3 (da) | 2006-09-11 |
| HUP0400682A2 (hu) | 2004-06-28 |
| MXPA03005433A (es) | 2003-09-10 |
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