IL156460A0 - Ether derivatives useful as inhibitors of pde4 isozymes - Google Patents
Ether derivatives useful as inhibitors of pde4 isozymesInfo
- Publication number
- IL156460A0 IL156460A0 IL15646001A IL15646001A IL156460A0 IL 156460 A0 IL156460 A0 IL 156460A0 IL 15646001 A IL15646001 A IL 15646001A IL 15646001 A IL15646001 A IL 15646001A IL 156460 A0 IL156460 A0 IL 156460A0
- Authority
- IL
- Israel
- Prior art keywords
- inhibitors
- ether derivatives
- derivatives useful
- pde4 isozymes
- isozymes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Otolaryngology (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- AIDS & HIV (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26530401P | 2001-01-31 | 2001-01-31 | |
PCT/IB2001/002726 WO2002060896A1 (en) | 2001-01-31 | 2001-12-24 | Ether derivatives useful as inhibitors of pde4 isozymes |
Publications (1)
Publication Number | Publication Date |
---|---|
IL156460A0 true IL156460A0 (en) | 2004-01-04 |
Family
ID=23009905
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15646001A IL156460A0 (en) | 2001-01-31 | 2001-12-24 | Ether derivatives useful as inhibitors of pde4 isozymes |
Country Status (34)
Country | Link |
---|---|
US (3) | US6828333B2 (xx) |
EP (1) | EP1373258B1 (xx) |
JP (1) | JP2004518689A (xx) |
KR (1) | KR20030070150A (xx) |
CN (1) | CN1527830A (xx) |
AP (1) | AP2002002415A0 (xx) |
AR (1) | AR032522A1 (xx) |
AT (1) | ATE305467T1 (xx) |
BG (1) | BG107960A (xx) |
BR (1) | BR0116845A (xx) |
CA (1) | CA2436544A1 (xx) |
CR (1) | CR7043A (xx) |
CZ (1) | CZ20031902A3 (xx) |
DE (1) | DE60113731T2 (xx) |
EA (1) | EA200300652A1 (xx) |
EE (1) | EE200300361A (xx) |
ES (1) | ES2248231T3 (xx) |
GT (1) | GT200200012A (xx) |
HU (1) | HUP0302891A2 (xx) |
IL (1) | IL156460A0 (xx) |
IS (1) | IS6847A (xx) |
MA (1) | MA26984A1 (xx) |
MX (1) | MXPA03006885A (xx) |
NO (1) | NO20033399L (xx) |
NZ (1) | NZ526531A (xx) |
OA (1) | OA12541A (xx) |
PA (1) | PA8537901A1 (xx) |
PE (1) | PE20020846A1 (xx) |
PL (1) | PL364910A1 (xx) |
SK (1) | SK8942003A3 (xx) |
SV (1) | SV2003000861A (xx) |
TN (1) | TNSN03051A1 (xx) |
WO (1) | WO2002060896A1 (xx) |
ZA (1) | ZA200304893B (xx) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA200300652A1 (ru) * | 2001-01-31 | 2003-12-25 | Пфайзер Продактс Инк. | Эфирные производные, полезные в качестве ингибиторов изозимов pde4 |
US20030055026A1 (en) | 2001-04-17 | 2003-03-20 | Dey L.P. | Formoterol/steroid bronchodilating compositions and methods of use thereof |
US6777432B1 (en) | 2001-09-04 | 2004-08-17 | Darwin Molecular Corporation | Pharmaceutical uses and synthesis of nicotinamides |
CA2459757C (en) * | 2001-09-19 | 2011-08-30 | Altana Pharma Ag | Combination |
US20050158371A1 (en) * | 2002-02-12 | 2005-07-21 | Sumitomo Pharmaceuticals Co., Ltd. | Novel external agent |
CA2511521C (en) | 2002-12-30 | 2012-02-07 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
US20060083714A1 (en) * | 2003-01-27 | 2006-04-20 | Warner James M | Combination of a pde iv inhibitor and a tnf-alpha antagonist |
US20050186276A1 (en) * | 2003-07-17 | 2005-08-25 | Pfizer Inc | Pharmaceutical formulations |
US7132435B2 (en) | 2003-07-25 | 2006-11-07 | Pfizer Inc. | Compounds |
US7153870B2 (en) | 2003-07-25 | 2006-12-26 | Pfizer Inc. | Nicotinamide derivatives useful as PDE4 inhibitors |
GB0317484D0 (en) | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as pde4 inhibitors |
GB0317516D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as PDE4 inhibitors |
GB0317471D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Novel compounds |
US20050187278A1 (en) * | 2003-08-28 | 2005-08-25 | Pharmacia Corporation | Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors |
JP2007504201A (ja) * | 2003-09-05 | 2007-03-01 | アルタナ ファルマ アクチエンゲゼルシャフト | 真性糖尿病の治療のためのpde4阻害剤の使用 |
KR100783255B1 (ko) | 2004-02-13 | 2007-12-06 | 워너-램버트 캄파니 엘엘씨 | 안드로젠 수용체 조절제 |
JP2007532621A (ja) | 2004-04-13 | 2007-11-15 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | アンドロゲンモジュレータ |
BRPI0509980A (pt) | 2004-04-22 | 2007-10-16 | Warner Lambert Co | moduladores de androgênio |
JP4874965B2 (ja) | 2004-07-08 | 2012-02-15 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | アンドロゲン調節剤 |
WO2006094942A1 (en) * | 2005-03-08 | 2006-09-14 | Nycomed Gmbh | Roflumilast for the treatment of diabetes mellitus |
AU2006222060B2 (en) * | 2005-03-08 | 2011-09-01 | Takeda Gmbh | Roflumilast for the treatment of diabetes mellitus |
ES2433661T3 (es) * | 2005-04-19 | 2013-12-12 | Takeda Gmbh | Roflumilast para el tratamiento de hipertensión pulmonar |
TW200724139A (en) | 2005-05-05 | 2007-07-01 | Warner Lambert Co | Androgen modulators |
JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス,インコーポレイティド | ムスカリン性受容体調節による神経発生 |
EP2258357A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
AU2006304787A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
TWI385169B (zh) | 2005-10-31 | 2013-02-11 | Eisai R&D Man Co Ltd | 經雜環取代之吡啶衍生物及含有彼之抗真菌劑 |
AU2006311577B2 (en) | 2005-11-09 | 2013-02-07 | Zalicus Inc. | Methods, compositions, and kits for the treatment of medical conditions |
WO2007075801A2 (en) * | 2005-12-20 | 2007-07-05 | Tika Läkemedel Ab | Method and system for the delivery of corticosteroids having an enhanced pharmacokinetic profile |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
EP2021000A2 (en) | 2006-05-09 | 2009-02-11 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
EP2026813A2 (en) | 2006-05-09 | 2009-02-25 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
JP2010502722A (ja) | 2006-09-08 | 2010-01-28 | ブレインセルス,インコーポレイティド | 4−アシルアミノピリジン誘導体を含む組み合わせ |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
US8513287B2 (en) | 2007-12-27 | 2013-08-20 | Eisai R&D Management Co., Ltd. | Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same |
US8569229B2 (en) * | 2008-02-07 | 2013-10-29 | The Children's Hospital Of Philadelphia | Compositions and methods which modulate G-protein signaling for the treatment of inflammatory disorders such as asthma and allergic conjunctivitis |
CN102149702A (zh) | 2008-08-05 | 2011-08-10 | 俄亥俄州立大学研究基金会 | 新型亚甲二氧基酚化合物和其治疗疾病的用途 |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
US8728516B2 (en) * | 2009-04-30 | 2014-05-20 | Abbvie Inc. | Stabilized lipid formulation of apoptosis promoter |
US20100280031A1 (en) * | 2009-04-30 | 2010-11-04 | Paul David | Lipid formulation of apoptosis promoter |
US20100298255A1 (en) * | 2009-05-19 | 2010-11-25 | Vivia Biotech S.L. | Methods for providing personalized medicine test ex vivo for hematological neoplasms |
TWI532484B (zh) * | 2009-06-08 | 2016-05-11 | 艾伯維有限公司 | 包含凋亡促進劑之固態分散劑 |
TWI540132B (zh) * | 2009-06-08 | 2016-07-01 | 亞培公司 | Bcl-2族群抑制劑之口服醫藥劑型 |
US8697691B2 (en) * | 2009-12-21 | 2014-04-15 | Vanderbilt University | Alkyl 3-((2-amidoethyl)amino)-8-azabicyclo[3.2.1]octane-8-carboxylate analogs as selective M1 agonists and methods of making and using same |
BR112012014499A2 (pt) * | 2009-12-22 | 2016-08-16 | Abbott Lab | cápsula de abt-263 |
UA113500C2 (xx) | 2010-10-29 | 2017-02-10 | Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб | |
EP2804603A1 (en) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Beta-cell replication promoting compounds and methods of their use |
US9446131B2 (en) | 2013-01-31 | 2016-09-20 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
US9433680B2 (en) | 2013-01-31 | 2016-09-06 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
US8778365B1 (en) | 2013-01-31 | 2014-07-15 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
US9452173B2 (en) | 2013-01-31 | 2016-09-27 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
US10500232B2 (en) | 2013-08-26 | 2019-12-10 | The J. David Gladstone Ins., a testamentary trust established under the Will of J. David Gladstone | Small molecule cellular reprogramming to generate neuronal cells |
CN107501258B8 (zh) * | 2017-09-14 | 2018-10-16 | 青岛大学附属医院 | 一种噻唑基烟酰胺类化合物及其在制备抗过敏和哮喘药物中的应用 |
CN114728875A (zh) * | 2019-12-13 | 2022-07-08 | 因思博纳公司 | 金属盐及其用途 |
US11116737B1 (en) | 2020-04-10 | 2021-09-14 | University Of Georgia Research Foundation, Inc. | Methods of using probenecid for treatment of coronavirus infections |
KR102404883B1 (ko) | 2020-11-30 | 2022-06-07 | (주)이노보테라퓨틱스 | 벤즈브로마론을 포함하는 켈로이드 또는 비대흉터 예방 또는 치료용 약학 조성물 |
CN114907315B (zh) * | 2022-05-17 | 2023-09-12 | 重庆医科大学 | Selitrectinib中间体的合成方法 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2140772A5 (en) | 1971-06-07 | 1973-01-19 | Aries Robert | Phenoxynicotinoylaminophenols - analgesics tranquillisers antipyretics, anti-inflammatories and antirheumatics |
US4270946A (en) * | 1979-10-01 | 1981-06-02 | Stauffer Chemical Company | N-Aryl,2-phenoxy nicotinamide compounds and the herbicidal use thereof |
US4692185A (en) * | 1986-01-13 | 1987-09-08 | Stauffer Chemical Company | N-(ortho-substituted) benzyl, 3-trifluoromethylphenoxy nicotinamides as herbicides |
US4861891A (en) | 1988-08-31 | 1989-08-29 | Pfizer Inc. | Antidepressant N-substituted nicotinamide compounds |
ATE174343T1 (de) | 1991-02-27 | 1998-12-15 | Lacer Sa | Antihypertensive n-(alpha-substituiertes pyridyl)-carbonyldipeptide |
US5602438A (en) * | 1991-02-28 | 1997-02-11 | Robert Bosch Gmbh | Roll commutator for electric motors and dynamos, and method of manufacturing it |
DE4200323A1 (de) | 1992-01-09 | 1993-07-15 | Bayer Ag | Herbizide und pflanzennematizide mittel auf basis von mercaptonicotinsaeurederivaten |
US5552438A (en) | 1992-04-02 | 1996-09-03 | Smithkline Beecham Corporation | Compounds useful for treating allergic and inflammatory diseases |
AU7174794A (en) | 1993-06-18 | 1995-01-17 | Smithkline Beecham Corporation | Compounds |
JP3406689B2 (ja) | 1994-03-15 | 2003-05-12 | 株式会社大塚製薬工場 | ナフチリジン及びピリドピラジン誘導体 |
US5618027A (en) * | 1994-07-20 | 1997-04-08 | Nevrekar; Venkatesh R. | Gate valve |
EP0796096A4 (en) | 1994-12-23 | 1998-04-29 | Smithkline Beecham Corp | 4,4- (DISUBSTITUTED) CYCLOHEXAN-1-CARBOXYLATE MONOMERS AND RELATED COMPOUNDS |
TW429148B (en) * | 1995-10-27 | 2001-04-11 | Pfizer | Pharmaceutical agents for the treatment of acute and chronic inflammatory diseases |
EP0796619A1 (en) * | 1996-03-21 | 1997-09-24 | Merrell Pharmaceuticals Inc. | Use of (+)-alpha-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)-4-piperidinemethanol in treating depressive disorders and bipolar disorders |
FR2754178B1 (fr) * | 1996-10-04 | 2002-08-23 | Adir | Utilisation de la sulbutiamine pour l'obtention de compositions pharmaceutiques utiles dans le traitement de certains troubles psychomoteurs et psycho-intellectuels |
GB9622386D0 (en) | 1996-10-28 | 1997-01-08 | Sandoz Ltd | Organic compounds |
US5922557A (en) | 1997-01-09 | 1999-07-13 | Merck & Co., Inc. | System for stably expressing a high-affinity camp phosphodiesterase and use thereof |
EP0971894A1 (en) | 1997-04-04 | 2000-01-19 | Pfizer Products Inc. | Nicotinamide derivatives |
GB9715584D0 (en) * | 1997-07-23 | 1997-10-01 | Eisai Co Ltd | Compounds |
UA67753C2 (uk) | 1997-10-10 | 2004-07-15 | Смітклайн Бічам Корпорейшн | Спосіб отримання заміщених 4-феніл-4-ціанциклогексанових кислот |
AR015966A1 (es) | 1997-10-17 | 2001-05-30 | Smithkline Beecham Corp | Uso de un compuesto inhibidor de pde4 para la preparacion de un medicamento util para el tratamiento de prurito |
AR015190A1 (es) | 1997-10-23 | 2001-04-18 | Smithkline Beecham Corp | Un polimorfo cristalino de 1,3-diciclopropilmetil-8-aminoxantina, procedimiento para su preparacion, composiciones farmaceuticas que lo contienen y su usopara la manufactura de un medicamento |
MXPA02007465A (es) * | 2000-01-31 | 2002-12-13 | Pfizer Prod Inc | Carboxamidas de pirimidina utiles como inhibidores de isozimas pde4. |
PT1252158E (pt) * | 2000-01-31 | 2005-09-30 | Pfizer Prod Inc | Derivados heterociclilo benzo-condensado de nicotinamida uteis como inibidores selectivos de isozimas pde4 |
EA200300652A1 (ru) * | 2001-01-31 | 2003-12-25 | Пфайзер Продактс Инк. | Эфирные производные, полезные в качестве ингибиторов изозимов pde4 |
-
2001
- 2001-12-24 EA EA200300652A patent/EA200300652A1/ru unknown
- 2001-12-24 CA CA002436544A patent/CA2436544A1/en not_active Abandoned
- 2001-12-24 CN CNA018230989A patent/CN1527830A/zh active Pending
- 2001-12-24 NZ NZ526531A patent/NZ526531A/en unknown
- 2001-12-24 WO PCT/IB2001/002726 patent/WO2002060896A1/en active IP Right Grant
- 2001-12-24 KR KR10-2003-7010088A patent/KR20030070150A/ko not_active Application Discontinuation
- 2001-12-24 ES ES01273558T patent/ES2248231T3/es not_active Expired - Lifetime
- 2001-12-24 AT AT01273558T patent/ATE305467T1/de not_active IP Right Cessation
- 2001-12-24 HU HU0302891A patent/HUP0302891A2/hu unknown
- 2001-12-24 EP EP01273558A patent/EP1373258B1/en not_active Expired - Lifetime
- 2001-12-24 DE DE60113731T patent/DE60113731T2/de not_active Expired - Fee Related
- 2001-12-24 CZ CZ20031902A patent/CZ20031902A3/cs unknown
- 2001-12-24 JP JP2002561464A patent/JP2004518689A/ja active Pending
- 2001-12-24 BR BR0116845-2A patent/BR0116845A/pt not_active IP Right Cessation
- 2001-12-24 OA OA1200300176A patent/OA12541A/en unknown
- 2001-12-24 PL PL01364910A patent/PL364910A1/xx not_active Application Discontinuation
- 2001-12-24 MX MXPA03006885A patent/MXPA03006885A/es active IP Right Grant
- 2001-12-24 EE EEP200300361A patent/EE200300361A/xx unknown
- 2001-12-24 SK SK8942003A patent/SK8942003A3/sk unknown
- 2001-12-24 IL IL15646001A patent/IL156460A0/xx unknown
-
2002
- 2002-01-28 GT GT200200012A patent/GT200200012A/es unknown
- 2002-01-29 PA PA20028537901A patent/PA8537901A1/es unknown
- 2002-01-29 AR ARP020100307A patent/AR032522A1/es unknown
- 2002-01-30 PE PE2002000070A patent/PE20020846A1/es not_active Application Discontinuation
- 2002-01-30 SV SV2002000861A patent/SV2003000861A/es not_active Application Discontinuation
- 2002-01-31 US US10/066,503 patent/US6828333B2/en not_active Expired - Fee Related
- 2002-01-31 AP APAP/P/2002/002415A patent/AP2002002415A0/en unknown
-
2003
- 2003-06-16 IS IS6847A patent/IS6847A/is unknown
- 2003-06-24 ZA ZA200304893A patent/ZA200304893B/xx unknown
- 2003-07-01 BG BG107960A patent/BG107960A/xx unknown
- 2003-07-08 TN TNPCT/IB2001/002726A patent/TNSN03051A1/fr unknown
- 2003-07-21 MA MA27242A patent/MA26984A1/fr unknown
- 2003-07-30 CR CR7043A patent/CR7043A/es unknown
- 2003-07-30 NO NO20033399A patent/NO20033399L/no not_active Application Discontinuation
-
2004
- 2004-08-13 US US10/918,820 patent/US7183293B2/en not_active Expired - Fee Related
-
2007
- 2007-01-30 US US11/668,915 patent/US20070161681A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL156460A0 (en) | Ether derivatives useful as inhibitors of pde4 isozymes | |
IL150486A0 (en) | Pyrimidine carboxamides useful as inhibitors of pde4 isozymes | |
IL156413A0 (en) | Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes | |
IL150641A0 (en) | Nicotinamide benzofused-heterocyclyl derivatives useful as selective inhibitors of pde4 isozymes | |
PL363391A1 (en) | Phthalayinone-piperidino-derivatives as pde4 inhibitors | |
AU2002305205A1 (en) | 9-deazaguanine derivatives as inhibitors of gsk-3 | |
HK1208446A1 (en) | Derivatives of uk-2a uk-2a | |
PL373146A1 (en) | Pyridazinone-derivatives as pde4 inhibitors | |
HUP0202332A2 (en) | Pyrazole compositions useful as inhibitors of erk | |
HK1072545A1 (en) | Novel inhibitors of kinases | |
AU2001236720A1 (en) | Compositions useful as inhibitors of erk | |
AU2002360986A1 (en) | Methods for the transformation of vegetal plastids | |
GB0025782D0 (en) | Use of inhibitors | |
PL369742A1 (en) | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto | |
HUP0401641A3 (en) | Use of substituted diazonine derivatives as phosphorodiesterase iv inhibitors | |
AU2002214038A1 (en) | Inhibitors of transglutaminases | |
EP1430302A4 (en) | Glycosaminoglycan INHIBITORS | |
AU2002346812A1 (en) | Use of 1-phenyl-oxazolidine-2-one compounds as protease m inhibitors | |
AU2002221882A1 (en) | Use of 3-hydroxyl-3-methylglutaryl-coenzyme-a-reductase inhibitors | |
AU2002255613A1 (en) | Piperazine derivatives as metalloprotease inhibitors | |
AU2001240939A1 (en) | Isoquinoline derivatives as pde4 inhibitors | |
SI1252158T1 (en) | Nicotinamide benzofused-heterocyclyl derivatives useful as selective inhibitors of pde4 isozymes | |
AU2002328906A1 (en) | Inhibitors of polyq-aggregation | |
GB0109520D0 (en) | Use of (di-substituted-phenyl)-pyrimidinyl-imidazole derivatives as njk-inhibitors | |
AU2002320834A1 (en) | Novel use for pde 10a inhibitors |