IL141864A0 - Multi-modal optical tissue diagnostic system - Google Patents

Multi-modal optical tissue diagnostic system

Info

Publication number
IL141864A0
IL141864A0 IL14186499A IL14186499A IL141864A0 IL 141864 A0 IL141864 A0 IL 141864A0 IL 14186499 A IL14186499 A IL 14186499A IL 14186499 A IL14186499 A IL 14186499A IL 141864 A0 IL141864 A0 IL 141864A0
Authority
IL
Israel
Prior art keywords
diagnostic system
optical tissue
tissue diagnostic
modal optical
modal
Prior art date
Application number
IL14186499A
Other languages
English (en)
Original Assignee
Spectrx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spectrx Inc filed Critical Spectrx Inc
Publication of IL141864A0 publication Critical patent/IL141864A0/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/043Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235Details of waveform analysis
    • A61B5/7264Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
IL14186499A 1998-09-11 1999-09-10 Multi-modal optical tissue diagnostic system IL141864A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9987598P 1998-09-11 1998-09-11
US14357999P 1999-07-13 1999-07-13
PCT/US1999/020646 WO2000015101A1 (en) 1998-09-11 1999-09-10 Multi-modal optical tissue diagnostic system

Publications (1)

Publication Number Publication Date
IL141864A0 true IL141864A0 (en) 2002-03-10

Family

ID=26796580

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14186499A IL141864A0 (en) 1998-09-11 1999-09-10 Multi-modal optical tissue diagnostic system

Country Status (7)

Country Link
US (2) US6975899B2 (xx)
EP (1) EP1112022A4 (xx)
JP (1) JP4474050B2 (xx)
AU (1) AU6139199A (xx)
CA (1) CA2343401C (xx)
IL (1) IL141864A0 (xx)
WO (1) WO2000015101A1 (xx)

Families Citing this family (170)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040147843A1 (en) 1999-11-05 2004-07-29 Shabbir Bambot System and method for determining tissue characteristics
BR0015285A (pt) * 1999-11-05 2002-06-18 Spectrx Inc Método para diagnosticar uma condição de um tecido alvo, método para diagnosticar tecidos displásticos, e sistema para determinar uma condição de um tecido biológico alvo
EP1272102B1 (en) * 2000-03-31 2009-02-11 Koninklijke Philips Electronics N.V. Method and device for localizing a deviant region in a turbid medium
GB2361994B (en) * 2000-05-06 2004-12-08 Astron Clinica Ltd Apparatus and methods for analysing skin histology
EP1467197A1 (en) * 2000-06-26 2004-10-13 Fuji Photo Film Co., Ltd. Fluorescent image obtaining apparatus
JP2002095634A (ja) * 2000-09-26 2002-04-02 Fuji Photo Film Co Ltd 内視鏡装置
EP1434522B1 (en) 2000-10-30 2010-01-13 The General Hospital Corporation Optical systems for tissue analysis
EP1210907A1 (en) * 2000-12-04 2002-06-05 Fuji Photo Film Co., Ltd. Fluorescent image obtaining apparatus
AU2002305148A1 (en) * 2001-04-05 2002-10-21 Johns Hopkins University Imaging systems for in vivo protocols
US7139598B2 (en) * 2002-04-04 2006-11-21 Veralight, Inc. Determination of a measure of a glycation end-product or disease state using tissue fluorescence
US20070276199A1 (en) * 2002-04-04 2007-11-29 Ediger Marwood N Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence
US8131332B2 (en) * 2002-04-04 2012-03-06 Veralight, Inc. Determination of a measure of a glycation end-product or disease state using tissue fluorescence of various sites
US8140147B2 (en) * 2002-04-04 2012-03-20 Veralight, Inc. Determination of a measure of a glycation end-product or disease state using a flexible probe to determine tissue fluorescence of various sites
US20040073120A1 (en) * 2002-04-05 2004-04-15 Massachusetts Institute Of Technology Systems and methods for spectroscopy of biological tissue
US7257437B2 (en) * 2002-07-05 2007-08-14 The Regents Of The University Of California Autofluorescence detection and imaging of bladder cancer realized through a cystoscope
US8285015B2 (en) 2002-07-05 2012-10-09 Lawrence Livermore Natioonal Security, LLC Simultaneous acquisition of differing image types
US7459696B2 (en) * 2003-04-18 2008-12-02 Schomacker Kevin T Methods and apparatus for calibrating spectral data
US7309867B2 (en) * 2003-04-18 2007-12-18 Medispectra, Inc. Methods and apparatus for characterization of tissue samples
US7282723B2 (en) * 2002-07-09 2007-10-16 Medispectra, Inc. Methods and apparatus for processing spectral data for use in tissue characterization
US20040068193A1 (en) * 2002-08-02 2004-04-08 Barnes Russell H. Optical devices for medical diagnostics
JP4805142B2 (ja) 2003-03-31 2011-11-02 ザ ジェネラル ホスピタル コーポレイション 光路長が変更された異なる角度の光の合成により光学的に干渉する断層撮影におけるスペックルの減少
US20040202356A1 (en) * 2003-04-10 2004-10-14 Stookey George K. Optical detection of dental caries
EP2290337B1 (en) 2003-06-06 2018-12-12 The General Hospital Corporation Wavelength tuning laser
WO2005032361A2 (en) 2003-10-03 2005-04-14 Academisch Medisch Centrum System and method for imaging the reflectance of a substrate
WO2005059679A2 (en) * 2003-12-11 2005-06-30 Star Energetics Holding Company, L.L.C. Perceptible apparatus and method for reactive effect
WO2005087092A1 (en) * 2004-02-24 2005-09-22 Wisconsin Alumni Research Foundation Side-firing probe for performing optical spectroscopy during core needle biopsy
US20060155178A1 (en) * 2004-03-26 2006-07-13 Vadim Backman Multi-dimensional elastic light scattering
WO2007011571A2 (en) * 2004-05-05 2007-01-25 Chemimage Corporation Digitizing biology
US7697576B2 (en) * 2004-05-05 2010-04-13 Chem Image Corporation Cytological analysis by raman spectroscopic imaging
US20060281068A1 (en) * 2005-06-09 2006-12-14 Chemimage Corp. Cytological methods for detecting a disease condition such as malignancy by Raman spectroscopic imaging
US20080319286A1 (en) * 2004-05-24 2008-12-25 Trent Ridder Optical Probes for Non-Invasive Analyte Measurements
US7413572B2 (en) * 2004-06-14 2008-08-19 Reliant Technologies, Inc. Adaptive control of optical pulses for laser medicine
WO2006014392A1 (en) 2004-07-02 2006-02-09 The General Hospital Corporation Endoscopic imaging probe comprising dual clad fibre
WO2006006175A2 (en) * 2004-07-15 2006-01-19 Meddynamics Ltd. A directed energy for point oriented medical treatment
US8081316B2 (en) * 2004-08-06 2011-12-20 The General Hospital Corporation Process, system and software arrangement for determining at least one location in a sample using an optical coherence tomography
ES2379468T3 (es) 2004-08-24 2012-04-26 The General Hospital Corporation Procedimiento, sistema y configuración de software para determinar el módulo de elasticidad
EP2275024A3 (en) 2004-08-24 2011-05-04 The General Hospital Corporation Method and apparatus for imaging of vessel segments
WO2006058346A1 (en) 2004-11-29 2006-06-01 The General Hospital Corporation Arrangements, devices, endoscopes, catheters and methods for performing optical imaging by simultaneously illuminating and detecting multiple points on a sample
US9131861B2 (en) 2004-11-30 2015-09-15 Academisch Medisch Centrum Pulsed lighting imaging systems and methods
US7664300B2 (en) * 2005-02-03 2010-02-16 Sti Medical Systems, Llc Uterine cervical cancer computer-aided-diagnosis (CAD)
ATE451669T1 (de) 2005-04-28 2009-12-15 Gen Hospital Corp Bewertung von bildmerkmalen einer anatomischen struktur in optischen kohärenztomographiebildern
EP1889037A2 (en) 2005-06-01 2008-02-20 The General Hospital Corporation Apparatus, method and system for performing phase-resolved optical frequency domain imaging
US8253936B2 (en) * 2008-08-08 2012-08-28 Chemimage Corporation Raman characterization of transplant tissue
US20070038126A1 (en) * 2005-06-23 2007-02-15 Pyle Jason L System and method for monitoring of end organ oxygenation by measurement of in vivo cellular energy status
EP1907825A2 (en) * 2005-07-25 2008-04-09 Duke University Methods, systems, and computer program products for optimization of probes for spectroscopic measurement in turbid media
ATE484727T1 (de) 2005-08-09 2010-10-15 Gen Hospital Corp Gerät und verfahren zur durchführung von polarisationsbasierter quadraturdemodulation bei optischer kohärenztomographie
US20070121196A1 (en) 2005-09-29 2007-05-31 The General Hospital Corporation Method and apparatus for method for viewing and analyzing of one or more biological samples with progressively increasing resolutions
US7889348B2 (en) * 2005-10-14 2011-02-15 The General Hospital Corporation Arrangements and methods for facilitating photoluminescence imaging
US20090203977A1 (en) * 2005-10-27 2009-08-13 Vadim Backman Method of screening for cancer using parameters obtained by the detection of early increase in microvascular blood content
US9314164B2 (en) 2005-10-27 2016-04-19 Northwestern University Method of using the detection of early increase in microvascular blood content to distinguish between adenomatous and hyperplastic polyps
JP5384944B2 (ja) 2006-01-19 2014-01-08 ザ ジェネラル ホスピタル コーポレイション ビームスキャニングによる上皮性管腔器官の光学的撮像システム
US8145018B2 (en) 2006-01-19 2012-03-27 The General Hospital Corporation Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and methods for producing one or more optical arrangements
US8131112B1 (en) 2006-01-23 2012-03-06 Sandia Corporation Method for detecting cancer in a single cell using mitochondrial correlation microscopy
WO2007149603A2 (en) 2006-02-01 2007-12-27 The General Hospital Corporation Apparatus for applying a plurality of electro-magnetic radiations to a sample
WO2007149602A2 (en) 2006-02-01 2007-12-27 The General Hospital Corporation Methods and systems for providing electromagnetic radiation to at least one portion of a sample using conformal laser therapy procedures
EP2306141A1 (en) 2006-02-24 2011-04-06 The General Hospital Corporation Methods and systems for performing angle-resolved fourier-domain optical coherence tomography
US7818154B2 (en) * 2006-03-17 2010-10-19 Duke University Monte Carlo based model of fluorescence in turbid media and methods and systems for using same to determine intrinsic fluorescence of turbid media
WO2007126827A2 (en) * 2006-03-30 2007-11-08 Duke University Optical assay system for intraoperative assessment of tumor margins
EP1850117A1 (en) * 2006-04-24 2007-10-31 FOSS Analytical A/S Optical analyser
EP2015669A2 (en) 2006-05-10 2009-01-21 The General Hospital Corporation Processes, arrangements and systems for providing frequency domain imaging of a sample
AU2007254086B2 (en) * 2006-05-19 2013-03-21 Northshore University Health System Method and apparatus for recognizing abnormal tissue using the detection of early increase in microvascular blood content
EP2034890A4 (en) * 2006-06-01 2011-02-16 Gen Hospital Corp IN VIVO OPTICAL IMAGING METHOD COMPRISING THE ANALYSIS OF DYNAMIC IMAGES
GB2443203B (en) * 2006-06-26 2010-04-07 Osspray Ltd Apparatus for detecting infected tissue
JP2008005984A (ja) * 2006-06-28 2008-01-17 Univ Of Tokushima 青紫色レーザー光が誘導の自家蛍光を指標に用いる粘膜炎の定量的評価方法とその装置
JP2008043396A (ja) * 2006-08-11 2008-02-28 Olympus Corp 内視鏡システム
CA2662893A1 (en) * 2006-09-06 2008-03-13 University Health Network Fluorescence quantification and image acquisition in highly turbid media
US8838213B2 (en) 2006-10-19 2014-09-16 The General Hospital Corporation Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample, and effecting such portion(s)
JP2008148791A (ja) * 2006-12-14 2008-07-03 Olympus Corp 内視鏡システム
US20080270091A1 (en) * 2007-02-23 2008-10-30 Nirmala Ramanujam Scaling method for fast monte carlo simulation of diffuse reflectance spectra from multi-layered turbid media and methods and systems for using same to determine optical properties of multi-layered turbid medium from measured diffuse reflectance
EP2131741A4 (en) * 2007-03-02 2010-05-05 Wisconsin Alumni Res Found USE OF ENDOGENOUS FLUORESCENCE TO IDENTIFY INVASIVE METASTATIC BREAST TUMER CELLS
WO2008118781A2 (en) 2007-03-23 2008-10-02 The General Hospital Corporation Methods, arrangements and apparatus for utilizing a wavelength-swept laser using angular scanning and dispersion procedures
US10534129B2 (en) 2007-03-30 2020-01-14 The General Hospital Corporation System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque
WO2008144760A1 (en) * 2007-05-21 2008-11-27 Board Of Regents, The University Of Texas System Optical methods to intraoperatively detect positive prostate and kidney cancer margins
WO2008157406A1 (en) * 2007-06-15 2008-12-24 University Of Southern California Pattern analysis of retinal maps for diagnosis of optic nerve diseases by optical coherence tomography
EP2040050B1 (de) * 2007-09-24 2012-03-07 Universität Potsdam Messanordnung für ein optisches Spektrometer
EP2194878A2 (en) * 2007-09-27 2010-06-16 Duke University Optical assay system with a multi-probe imaging array
EP2194848A4 (en) * 2007-09-28 2013-08-14 Univ Duke SYSTEMS AND METHODS FOR SPECTRAL ANALYSIS OF A TISSUE MASS USING AN INSTRUMENT, AN OPTICAL PROBE AND A MONTE CARLO OR DIFFUSION ALGORITHM
US20090287093A1 (en) * 2008-05-15 2009-11-19 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
US20090287076A1 (en) * 2007-12-18 2009-11-19 Boyden Edward S System, devices, and methods for detecting occlusions in a biological subject
US20090281412A1 (en) * 2007-12-18 2009-11-12 Searete Llc, A Limited Liability Corporation Of The State Of Delaware System, devices, and methods for detecting occlusions in a biological subject
US20100036209A1 (en) * 2008-08-07 2010-02-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
US20100036268A1 (en) * 2008-08-07 2010-02-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
US8636670B2 (en) 2008-05-13 2014-01-28 The Invention Science Fund I, Llc Circulatory monitoring systems and methods
US20090287120A1 (en) 2007-12-18 2009-11-19 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
US20100036269A1 (en) * 2008-08-07 2010-02-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
US20090281413A1 (en) * 2007-12-18 2009-11-12 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems, devices, and methods for detecting occlusions in a biological subject
US9717896B2 (en) 2007-12-18 2017-08-01 Gearbox, Llc Treatment indications informed by a priori implant information
US20090292213A1 (en) * 2008-05-21 2009-11-26 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
US8280484B2 (en) * 2007-12-18 2012-10-02 The Invention Science Fund I, Llc System, devices, and methods for detecting occlusions in a biological subject
US20090287110A1 (en) * 2008-05-14 2009-11-19 Searete Llc Circulatory monitoring systems and methods
US9672471B2 (en) * 2007-12-18 2017-06-06 Gearbox Llc Systems, devices, and methods for detecting occlusions in a biological subject including spectral learning
US20090292222A1 (en) * 2008-05-14 2009-11-26 Searete Llc Circulatory monitoring systems and methods
US8118206B2 (en) * 2008-03-15 2012-02-21 Surgisense Corporation Sensing adjunct for surgical staplers
EP2277026A4 (en) * 2008-04-21 2013-12-25 Univ Drexel METHODS FOR MEASURING CHANGES IN THE OPTICAL PROPERTIES OF LESION TISSUE AND CORRELATION OF NEAR INFRARED ABSORPTION (FNIR) SPECTROSCOPY AND DIFFUSED REFLECTANCE SPECTROSCOPY (DRS) WITH TISSUE NEO-VASCULARIZATION AND CONCENTRATION OF COLLAGEN TO DETERMINE IF AN INJURY IS HUNTING
US20110105865A1 (en) * 2008-04-24 2011-05-05 Duke University Diffuse reflectance spectroscopy device for quantifying tissue absorption and scattering
CN104939806B (zh) 2008-05-20 2021-12-10 大学健康网络 用于基于荧光的成像和监测的装置和方法
US8201997B1 (en) * 2008-05-29 2012-06-19 Ipitek, Inc. Imaging temperature sensing system
US9254089B2 (en) 2008-07-14 2016-02-09 The General Hospital Corporation Apparatus and methods for facilitating at least partial overlap of dispersed ration on at least one sample
US8416405B2 (en) * 2008-08-08 2013-04-09 Chemimage Corporation Raman chemical imaging of implantable drug delivery devices
EP3330696B1 (en) 2008-12-10 2023-07-12 The General Hospital Corporation Systems, apparatus and methods for extending imaging depth range of optical coherence tomography through optical sub-sampling
US9615748B2 (en) 2009-01-20 2017-04-11 The General Hospital Corporation Endoscopic biopsy apparatus, system and method
EP2394336B1 (en) 2009-02-04 2023-05-24 The General Hospital Corporation Apparatus and method for utilization of a high-speed optical wavelength tuning source
US8254650B2 (en) * 2009-02-27 2012-08-28 General Electric Company System and method for contrast enhancement of time-resolved fluorescence images
US8461546B2 (en) 2009-04-03 2013-06-11 Lawrence Livermore National Security, Llc Compounds for neutron radiation detectors and systems thereof
US8872125B2 (en) 2009-04-03 2014-10-28 Lawrence Livermore National Security, Llc Solution-grown crystals for neutron radiation detectors, and methods of solution growth
JP5386752B2 (ja) * 2009-04-21 2014-01-15 国立大学法人 東京大学 微生物の数または量を測定する方法および装置
US8945511B2 (en) 2009-06-25 2015-02-03 Paul Weinberger Sensitive methods for detecting the presence of cancer associated with the over-expression of galectin-3 using biomarkers derived from galectin-3
BR112012001042A2 (pt) 2009-07-14 2016-11-22 Gen Hospital Corp equipamento e método de medição do fluxo de fluído dentro de estrutura anatômica.
US9091637B2 (en) 2009-12-04 2015-07-28 Duke University Smart fiber optic sensors systems and methods for quantitative optical spectroscopy
US8812084B1 (en) * 2009-12-31 2014-08-19 Albert Francis Messano, JR. Systems and methods for multispectral scanning and detection for medical diagnosis
US8971998B2 (en) 2009-12-31 2015-03-03 Integral Electromagnetronic Technologies Llc Systems and methods for multispectral scanning and detection for medical diagnosis
DK2542145T3 (da) 2010-03-05 2020-11-02 Massachusetts Gen Hospital Systemer der tilvejebringer mikroskopiske billeder af mindst en anatomisk struktur ved en bestemt opløsning
JP2011185843A (ja) 2010-03-10 2011-09-22 Fujifilm Corp 蛍光寿命を利用した細胞内のpHイメージング方法とその装置
JP5437864B2 (ja) 2010-03-10 2014-03-12 富士フイルム株式会社 pH測定装置の作動方法、検出装置の作動方法、及び生体物質分析装置の作動方法、並びに各装置
US9069130B2 (en) 2010-05-03 2015-06-30 The General Hospital Corporation Apparatus, method and system for generating optical radiation from biological gain media
WO2011149972A2 (en) 2010-05-25 2011-12-01 The General Hospital Corporation Systems, devices, methods, apparatus and computer-accessible media for providing optical imaging of structures and compositions
WO2011150069A2 (en) 2010-05-25 2011-12-01 The General Hospital Corporation Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images
EP2575591A4 (en) 2010-06-03 2017-09-13 The General Hospital Corporation Apparatus and method for devices for imaging structures in or at one or more luminal organs
US9510758B2 (en) 2010-10-27 2016-12-06 The General Hospital Corporation Apparatus, systems and methods for measuring blood pressure within at least one vessel
US9309456B2 (en) 2011-04-15 2016-04-12 Lawrence Livermore National Security, Llc Plastic scintillator with effective pulse shape discrimination for neutron and gamma detection
US9113934B2 (en) * 2011-05-16 2015-08-25 Covidien Lp Optical energy-based methods and apparatus for tissue sealing
JP5790190B2 (ja) * 2011-06-17 2015-10-07 コニカミノルタ株式会社 内視鏡
JP2014523536A (ja) 2011-07-19 2014-09-11 ザ ジェネラル ホスピタル コーポレイション 光コヒーレンストモグラフィーにおいて偏波モード分散補償を提供するためのシステム、方法、装置およびコンピュータアクセス可能な媒体
US9014789B2 (en) 2011-09-22 2015-04-21 The George Washington University Systems and methods for visualizing ablated tissue
US9084611B2 (en) 2011-09-22 2015-07-21 The George Washington University Systems and methods for visualizing ablated tissue
JP2015502562A (ja) 2011-10-18 2015-01-22 ザ ジェネラル ホスピタル コーポレイション 再循環光学遅延を生成および/または提供するための装置および方法
US9121947B2 (en) 2012-01-23 2015-09-01 Lawrence Livermore National Security, Llc Stress reduction for pillar filled structures
US9897543B2 (en) * 2012-03-29 2018-02-20 University Of Calcutta Half-frequency spectral signatures
EP2833776A4 (en) 2012-03-30 2015-12-09 Gen Hospital Corp IMAGING SYSTEM, METHOD AND DISTAL FIXATION FOR MULTIDIRECTIONAL FIELD ENDOSCOPY
US8580054B2 (en) 2012-04-04 2013-11-12 Lawrence Livermore National Security, Llc Melt-castable energetic compounds comprising oxadiazoles and methods of production thereof
US9650564B2 (en) 2012-05-14 2017-05-16 Lawrence Livermore National Security, Llc System and plastic scintillator for discrimination of thermal neutron, fast neutron, and gamma radiation
WO2013177154A1 (en) 2012-05-21 2013-11-28 The General Hospital Corporation Apparatus, device and method for capsule microscopy
US9833285B2 (en) 2012-07-17 2017-12-05 Covidien Lp Optical sealing device with cutting ability
EP2888616A4 (en) 2012-08-22 2016-04-27 Gen Hospital Corp SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIA FOR MANUFACTURING MINIATURE ENDOSCOPES USING SOFT LITHOGRAPHY
US20140171936A1 (en) * 2012-12-17 2014-06-19 Biosense Webster (Israel) Ltd. Irrigated catheter tip with temperature sensor and optic fiber arrays
US9615878B2 (en) * 2012-12-21 2017-04-11 Volcano Corporation Device, system, and method for imaging and tissue characterization of ablated tissue
WO2014117130A1 (en) 2013-01-28 2014-07-31 The General Hospital Corporation Apparatus and method for providing diffuse spectroscopy co-registered with optical frequency domain imaging
WO2014120791A1 (en) 2013-01-29 2014-08-07 The General Hospital Corporation Apparatus, systems and methods for providing information regarding the aortic valve
US11179028B2 (en) 2013-02-01 2021-11-23 The General Hospital Corporation Objective lens arrangement for confocal endomicroscopy
US9592027B2 (en) * 2013-03-14 2017-03-14 Volcano Corporation System and method of adventitial tissue characterization
US10478072B2 (en) 2013-03-15 2019-11-19 The General Hospital Corporation Methods and system for characterizing an object
WO2014168734A1 (en) 2013-03-15 2014-10-16 Cedars-Sinai Medical Center Time-resolved laser-induced fluorescence spectroscopy systems and uses thereof
GB201305171D0 (en) * 2013-03-21 2013-05-01 Univ Nottingham Measurement of tissue structures
US9784681B2 (en) 2013-05-13 2017-10-10 The General Hospital Corporation System and method for efficient detection of the phase and amplitude of a periodic modulation associated with self-interfering fluorescence
EP3021734B1 (en) 2013-07-19 2020-04-08 The General Hospital Corporation Imaging apparatus which utilizes multidirectional field of view endoscopy
EP3021735A4 (en) 2013-07-19 2017-04-19 The General Hospital Corporation Determining eye motion by imaging retina. with feedback
US9274237B2 (en) 2013-07-26 2016-03-01 Lawrence Livermore National Security, Llc Lithium-containing scintillators for thermal neutron, fast neutron, and gamma detection
WO2015013651A2 (en) 2013-07-26 2015-01-29 The General Hospital Corporation System, apparatus and method utilizing optical dispersion for fourier-domain optical coherence tomography
WO2015073871A2 (en) * 2013-11-14 2015-05-21 The George Washington University Systems and methods for determining lesion depth using fluorescence imaging
WO2015077474A1 (en) 2013-11-20 2015-05-28 The George Washington University Systems and methods for hyperspectral analysis of cardiac tissue
US9733460B2 (en) 2014-01-08 2017-08-15 The General Hospital Corporation Method and apparatus for microscopic imaging
US10736494B2 (en) 2014-01-31 2020-08-11 The General Hospital Corporation System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device
WO2015153982A1 (en) 2014-04-04 2015-10-08 The General Hospital Corporation Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s)
EP3957232A1 (en) 2014-07-24 2022-02-23 University Health Network Collection and analysis of data for diagnostic purposes
WO2016015052A1 (en) 2014-07-25 2016-01-28 The General Hospital Corporation Apparatus, devices and methods for in vivo imaging and diagnosis
JP6771731B2 (ja) 2014-11-03 2020-10-21 460メディカル・インコーポレイテッド460Medical, Inc. 接触性評価システム及び方法
US10722301B2 (en) 2014-11-03 2020-07-28 The George Washington University Systems and methods for lesion assessment
CA2974692A1 (en) * 2015-01-23 2016-07-28 Rigaku Raman Technologies, Inc. System and method to minimize nonrandom fixed pattern noise in spectrometers
US11202606B2 (en) 2015-04-17 2021-12-21 Koninklijke Philips N.V. Detection of anisotropic biological tissue
US9778231B2 (en) * 2015-05-13 2017-10-03 Spirit Aerosystems, Inc. Ultrasonic inspection end effector
US10779904B2 (en) 2015-07-19 2020-09-22 460Medical, Inc. Systems and methods for lesion formation and assessment
JP6833310B2 (ja) * 2015-07-27 2021-02-24 オリンパス株式会社 内視鏡システム
US20170150892A1 (en) * 2015-11-27 2017-06-01 Ricoh Company, Ltd. Pulse wave measuring device, system, and method
EP3436805A4 (en) 2016-04-01 2019-12-11 Black Light Surgical, Inc. SYSTEMS, DEVICES AND METHODS FOR TIME-RESOLUTION FLUORESCENCE SPECTROSCOPY
KR101904498B1 (ko) * 2016-11-22 2018-10-17 동서대학교산학협력단 다수 개의 근적외선 영상센서가 구비된 스캐너 및 이를 통해 촬영한 다수 개의 시간에 따른 2차원 생체영상을 시간에 따른 당뇨성 상처 확인용 3차원 생체영상으로 변환하는 방법
US11672425B2 (en) 2018-02-15 2023-06-13 Speclipse, Inc. Stand-alone apparatus and methods for in vivo detection of tissue malignancy using laser spectroscopy
WO2019183075A1 (en) * 2018-03-23 2019-09-26 Boston Scientific Neuromodulation Corporation An optical stimulation system with automated monitoring and methods of making and using
WO2020023377A1 (en) * 2018-07-23 2020-01-30 The Regents Of The University Of California Oral and oropharyngeal cancer screening system and methods of use
AU2019437773B2 (en) 2019-03-22 2021-10-28 Speclipse, Inc. Diagnostic method using laser induced breakdown spectroscopy, and diagnostic device for performing same
EP4008234A4 (en) * 2019-08-28 2022-09-07 Sony Olympus Medical Solutions Inc. MEDICAL IMAGE PROCESSING DEVICE AND MEDICAL OBSERVATION SYSTEM

Family Cites Families (172)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3494354A (en) 1964-09-30 1970-02-10 Tokyo Shibaura Electric Co Flexible endoscope for use in cancer diagnosis
US4125828A (en) 1972-08-04 1978-11-14 Med-El Inc. Method and apparatus for automated classification and analysis of cells
US4161515A (en) 1973-10-02 1979-07-17 Syva Company Double receptor fluorescent immunoassay
US4056724A (en) 1975-02-27 1977-11-01 International Diagnostic Technology Fluorometric system, method and test article
US4022529A (en) 1975-12-11 1977-05-10 White John U Feature extraction system for extracting a predetermined feature from a signal
US4084905A (en) 1976-03-11 1978-04-18 Canadian Patents & Development Limited Apparatus for detecting and measuring fluorescence emission
IL49622A0 (en) 1976-05-21 1976-07-30 Elscint Ltd A method and apparatus for classifying biological cells
US4071020A (en) 1976-06-03 1978-01-31 Xienta, Inc. Apparatus and methods for performing in-vivo measurements of enzyme activity
IL49776A (en) 1976-06-13 1979-05-31 Elscint Ltd Method and appararus for differentiating of normal and abnormal mammalian cells
US4144452A (en) 1976-07-08 1979-03-13 International Diagnostic Technology, Inc. Fluorometric system, method and test article
US4127773A (en) 1977-03-31 1978-11-28 Applied Photophysics Limited Characterizing and identifying materials
US4203670A (en) 1977-04-21 1980-05-20 Bromberg Nathan S System and method of fluorescence polarimetry
IT1079045B (it) 1977-05-16 1985-05-08 Syva Co Analisi imuunologica fluorescente a doppio ricettore
US4115699A (en) 1977-06-16 1978-09-19 Kabushiki Kaisha Nihon Kotai Kenkyujo Apparatus for sensitive detection and quantitative analysis of biological and biochemical substances
US4281645A (en) 1977-06-28 1981-08-04 Duke University, Inc. Method and apparatus for monitoring metabolism in body organs
US4213742A (en) 1977-10-17 1980-07-22 Union Pump Company Modified volute pump casing
US4236526A (en) 1978-01-31 1980-12-02 Richard Patricia A Method of screening for sickle cell disease by detection of porphyrins and porphyrin metabolites in human dentition
JPS54134309A (en) * 1978-04-10 1979-10-18 Nippon Soken Ac power generator for vehicles
US4162405A (en) 1978-05-23 1979-07-24 Britton Chance Flying spot fluoro-meter for oxidized flavoprotein and reduced pyridine nucleotide
JPS54158288A (en) 1978-06-05 1979-12-13 Hitachi Ltd Spectroscopic fluorescent photometer
JPS5552750A (en) 1978-10-12 1980-04-17 Mochida Pharm Co Ltd Laser knife* which can be detected* of tumor portion
ATE23752T1 (de) 1980-08-21 1986-12-15 Oriel Scient Ltd Optische analyseeinrichtung.
US4407964A (en) 1980-10-07 1983-10-04 The Regents Of The University Of California Homogeneous fluoroimmunoassay involving sensing radiation for forward and back directions
US4516856A (en) 1981-01-09 1985-05-14 Abbott Laboratories Optical apparatus for fluorescence polarization instrument
FR2521727A2 (fr) 1981-03-25 1983-08-19 Cilas Dispositif pour mesurer l'etat d'oxydo-reduction d'un organe vivant in situ
JPS58174833A (ja) 1982-04-07 1983-10-13 Hitachi Ltd 蛍光光度計
JPS5940830A (ja) 1982-08-31 1984-03-06 浜松ホトニクス株式会社 レ−ザ光パルスを用いた癌の診断装置
US4501970A (en) 1982-10-12 1985-02-26 Dynatech Laboratories Incorporated Fluorometer
JPS5972049A (ja) 1982-10-19 1984-04-23 Horiba Ltd 試料の発光寿命測定装置
US4697870A (en) 1983-01-25 1987-10-06 Pilling Co. Termination for light-conducting cable
US4577110A (en) 1983-04-11 1986-03-18 Biochem Sensors, Inc. Optical apparatus and method for measuring the characteristics of materials by their fluorescence
US4541438A (en) 1983-06-02 1985-09-17 The Johns Hopkins University Localization of cancerous tissue by monitoring infrared fluorescence emitted by intravenously injected porphyrin tumor-specific markers excited by long wavelength light
DE3329257A1 (de) 1983-08-12 1985-02-28 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Fluorometer
JPS6082821A (ja) 1983-10-13 1985-05-11 Horiba Ltd 時間分解発光スペクトル測定方法
GB8401672D0 (en) 1984-01-21 1984-02-22 Univ Strathclyde Measuring fluorescence decay characteristics of materials
JPS60209146A (ja) 1984-03-31 1985-10-21 Olympus Optical Co Ltd 螢光スペクトル分析装置
US4731326A (en) 1984-06-04 1988-03-15 Ortho Diagnostic Systems Inc. Disease diagnosis by detection of shed normal tissue antigens
FI843409A0 (fi) 1984-08-29 1984-08-29 Labsystems Oy Fluorometer.
US4681859A (en) 1984-09-21 1987-07-21 Ortho Diagnostic Systems Inc. Fluorescence polarization immunoassay for heavy antigens
SE455646B (sv) 1984-10-22 1988-07-25 Radians Innova Ab Fluorescensanordning
US4828984A (en) 1986-04-11 1989-05-09 Flow Cytometry Standards Corporation Composition, synthesis and use of simulated cells
US4682594A (en) 1985-03-11 1987-07-28 Mcm Laboratories, Inc. Probe-and-fire lasers
US4913142A (en) 1985-03-22 1990-04-03 Massachusetts Institute Of Technology Catheter for laser angiosurgery
US5104392A (en) 1985-03-22 1992-04-14 Massachusetts Institute Of Technology Laser spectro-optic imaging for diagnosis and treatment of diseased tissue
US5034010A (en) 1985-03-22 1991-07-23 Massachusetts Institute Of Technology Optical shield for a laser catheter
US5192278A (en) 1985-03-22 1993-03-09 Massachusetts Institute Of Technology Multi-fiber plug for a laser catheter
US5106387A (en) 1985-03-22 1992-04-21 Massachusetts Institute Of Technology Method for spectroscopic diagnosis of tissue
EP0195375B1 (en) * 1985-03-22 1994-09-21 Massachusetts Institute Of Technology Catheter for laser angiosurgery
US4718417A (en) 1985-03-22 1988-01-12 Massachusetts Institute Of Technology Visible fluorescence spectral diagnostic for laser angiosurgery
US5318024A (en) * 1985-03-22 1994-06-07 Massachusetts Institute Of Technology Laser endoscope for spectroscopic imaging
US5125404A (en) 1985-03-22 1992-06-30 Massachusetts Institute Of Technology Apparatus and method for obtaining spectrally resolved spatial images of tissue
CN85100424B (zh) 1985-04-01 1986-10-29 上海医疗器械研究所 恶性肿瘤固有荧光诊断仪
DE3513475A1 (de) 1985-04-15 1986-10-16 Erwin Sick Gmbh Optik-Elektronik, 7808 Waldkirch Lumineszenztaster
US4877965A (en) 1985-07-01 1989-10-31 Diatron Corporation Fluorometer
US4751190A (en) 1985-07-22 1988-06-14 Abbott Laboratories Fluorescence polarization immunoassay and reagents for use therein
DD254998A1 (de) 1985-07-26 1988-03-16 Zeiss Jena Veb Carl Anordnung zur bildlichen darstellung und analyse von fluoreszenzsignalen
AT387860B (de) 1985-09-16 1989-03-28 Optical Sensing Technology Verfahren und vorrichtung zur tumordiagnose mittels sera
US4988212A (en) 1985-10-25 1991-01-29 Luxtron Corporation Fiberoptic sensing of temperature and/or other physical parameters
US5042494A (en) 1985-11-13 1991-08-27 Alfano Robert R Method and apparatus for detecting cancerous tissue using luminescence excitation spectra
US4930516B1 (en) 1985-11-13 1998-08-04 Laser Diagnostic Instr Inc Method for detecting cancerous tissue using visible native luminescence
US4772093A (en) 1985-12-12 1988-09-20 Microvasive, Inc. Fiber-optic image-carrying device
US4758727A (en) 1986-02-12 1988-07-19 Ohio State University Research Foundation Method and apparatus for the measurement of low-level laser-induced fluorescence
CA1253247A (en) 1986-04-03 1989-04-25 Gerald W. Farnell Ultrasonic image camera using arrays of acoustic waveguides
JPS62247232A (ja) 1986-04-21 1987-10-28 Agency Of Ind Science & Technol 蛍光測定装置
US4925804A (en) 1986-06-17 1990-05-15 Baxter International Inc. Interligand metal transfer assay
US4895156A (en) 1986-07-02 1990-01-23 Schulze John E Sensor system using fluorometric decay measurements
US4840485A (en) 1986-12-17 1989-06-20 I.S.S. (U.S.A.) Inc. Frequency domain cross-correlation fluorometry with phase-locked loop frequency synthesizers
US4785806A (en) 1987-01-08 1988-11-22 Yale University Laser ablation process and apparatus
US4855930A (en) 1987-03-27 1989-08-08 Chimerix Corporation Method and appartatus for improved time-resolved fluorescence spectroscopy
JPS63246641A (ja) 1987-04-01 1988-10-13 Ajinomoto Co Inc 蛍光分析計
US4852579A (en) 1987-04-20 1989-08-01 Karl Storz Endoscopy Gmbh And Company Photocharacterization and treatment of normal abnormal and ectopic endometrium
US4833332A (en) 1987-06-12 1989-05-23 E. I. Du Pont De Nemours And Company Scanning fluorescent detection system
US4894547A (en) 1987-09-28 1990-01-16 Yale University Optical method and apparatus for detecting and measuring aging, photoaging, dermal disease and pigmentation in skin
DE3738964C1 (de) * 1987-11-17 1989-04-27 Daimler Benz Ag Unabhaengige Radaufhaengung fuer Kraftfahrzeuge
US4947850A (en) 1988-03-11 1990-08-14 Trustees Of The University Of Pennsylvania Method and apparatus for imaging an internal body portion of a host animal
JPH06105190B2 (ja) 1988-03-31 1994-12-21 工業技術院長 信号解析装置
DE3815743A1 (de) 1988-05-07 1989-11-16 Zeiss Carl Fa Vorrichtung zur messung und auswertung von eigenfluoreszenzspektren organischer gewebeflaechen
US4981138A (en) 1988-06-30 1991-01-01 Yale University Endoscopic fiberoptic fluorescence spectrometer
US4972331A (en) 1989-02-06 1990-11-20 Nim, Inc. Phase modulated spectrophotometry
US5402778A (en) * 1993-01-19 1995-04-04 Nim Incorporated Spectrophotometric examination of tissue of small dimension
US5596987A (en) * 1988-11-02 1997-01-28 Noninvasive Technology, Inc. Optical coupler for in vivo examination of biological tissue
US5122974A (en) 1989-02-06 1992-06-16 Nim, Inc. Phase modulated spectrophotometry
US5111821A (en) 1988-11-08 1992-05-12 Health Research, Inc. Fluorometric method for detecting abnormal tissue using dual long-wavelength excitation
US5205291A (en) * 1988-11-08 1993-04-27 Health Research, Inc. In vivo fluorescence photometer
US5353799A (en) * 1991-01-22 1994-10-11 Non Invasive Technology, Inc. Examination of subjects using photon migration with high directionality techniques
ATE133545T1 (de) * 1988-12-21 1996-02-15 Massachusetts Inst Technology Verfahren für laserinduzierte fluoreszenz von gewebe
US5386827A (en) * 1993-03-30 1995-02-07 Nim Incorporated Quantitative and qualitative in vivo tissue examination using time resolved spectroscopy
US5119815A (en) 1988-12-21 1992-06-09 Nim, Incorporated Apparatus for determining the concentration of a tissue pigment of known absorbance, in vivo, using the decay characteristics of scintered electromagnetic radiation
US5187672A (en) 1989-02-06 1993-02-16 Nim Incorporated Phase modulation spectroscopic system
US5022757A (en) 1989-01-23 1991-06-11 Modell Mark D Heterodyne system and method for sensing a target substance
US5092331A (en) 1989-01-30 1992-03-03 Olympus Optical Co., Ltd. Fluorescence endoscopy and endoscopic device therefor
US5061076A (en) 1989-01-31 1991-10-29 Enzo Diagnostics, Inc. Time-resolved fluorometer
US4937457A (en) 1989-02-10 1990-06-26 Slm Instruments, Inc. Picosecond multi-harmonic fourier fluorometer
US5090415A (en) 1989-02-14 1992-02-25 Hamamatsu Photonics Kabushiki Kaisha Examination apparatus
SE8900612D0 (sv) 1989-02-22 1989-02-22 Jonas Johansson Vaevnadskarakterisering utnyttjande ett blodfritt fluorescenskriterium
US5421337A (en) * 1989-04-14 1995-06-06 Massachusetts Institute Of Technology Spectral diagnosis of diseased tissue
US5201318A (en) * 1989-04-24 1993-04-13 Rava Richard P Contour mapping of spectral diagnostics
US5039219A (en) 1989-05-26 1991-08-13 Photon Technology Luminescence system and method for determining the nature of substances by measuring fluorescence and phosphorescence properties
US5030832A (en) 1989-06-08 1991-07-09 Minnesota Mining And Manufacturing Company Apparatus for detecting fluorescence of a luminescent material
US4973848A (en) 1989-07-28 1990-11-27 J. Mccaughan Laser apparatus for concurrent analysis and treatment
US5061075A (en) 1989-08-07 1991-10-29 Alfano Robert R Optical method and apparatus for diagnosing human spermatozoa
US5021661A (en) 1989-09-04 1991-06-04 Jeol Ltd. Time-resolved infrared spectrophotometer
US5053626A (en) 1989-09-29 1991-10-01 Boston University Dual wavelength spectrofluorometer
US5043585A (en) 1990-01-03 1991-08-27 Degussa Aktiengesellschaft Method and apparatus for measurement of the fluorescence relaxation period of a fluorescent substance
US5131398A (en) 1990-01-22 1992-07-21 Mediscience Technology Corp. Method and apparatus for distinguishing cancerous tissue from benign tumor tissue, benign tissue or normal tissue using native fluorescence
EP0448931B1 (en) * 1990-01-26 1996-04-03 Canon Kabushiki Kaisha Method for measuring a specimen by the use of fluorescence light
US5916210A (en) * 1990-01-26 1999-06-29 Intraluminal Therapeutics, Inc. Catheter for laser treatment of atherosclerotic plaque and other tissue abnormalities
JPH0713682Y2 (ja) 1990-02-01 1995-04-05 株式会社町田製作所 内視鏡カバーの係止構造
US5151869A (en) 1990-02-16 1992-09-29 The Boc Group, Inc. Frequency domain fluorometry using coherent sampling
US5127405A (en) 1990-02-16 1992-07-07 The Boc Group, Inc. Biomedical fiber optic probe with frequency domain signal processing
US5315993A (en) * 1990-02-16 1994-05-31 The Boc Group, Inc. Luminescence monitoring with modulation frequency multiplexing
US5143066A (en) 1990-05-08 1992-09-01 University Of Pittsburgh Optical fiber sensors for continuous monitoring of biochemicals and related method
US5213105A (en) * 1990-12-04 1993-05-25 Research Corporation Technologies, Inc. Frequency domain optical imaging using diffusion of intensity modulated radiation
US5212099A (en) * 1991-01-18 1993-05-18 Eastman Kodak Company Method and apparatus for optically measuring concentration of an analyte
EP0568596A1 (en) * 1991-01-24 1993-11-10 The University Of Maryland Method and apparatus for multi-dimensional phase fluorescence lifetime imaging
US5103387A (en) * 1991-01-31 1992-04-07 Northern Telecom Limited High voltage converter
US5168162A (en) 1991-02-04 1992-12-01 Cornell Research Foundation, Inc. Method of detecting the presence of anomalies in exfoliated cells using infrared spectroscopy
US5303026A (en) * 1991-02-26 1994-04-12 The Regents Of The University Of California Los Alamos National Laboratory Apparatus and method for spectroscopic analysis of scattering media
US5377676A (en) * 1991-04-03 1995-01-03 Cedars-Sinai Medical Center Method for determining the biodistribution of substances using fluorescence spectroscopy
US5293872A (en) * 1991-04-03 1994-03-15 Alfano Robert R Method for distinguishing between calcified atherosclerotic tissue and fibrous atherosclerotic tissue or normal cardiovascular tissue using Raman spectroscopy
US5318023A (en) * 1991-04-03 1994-06-07 Cedars-Sinai Medical Center Apparatus and method of use for a photosensitizer enhanced fluorescence based biopsy needle
US5196709A (en) * 1991-05-03 1993-03-23 University Of Maryland Systems Fluorometry method and apparatus using a semiconductor laser diode as a light source
WO1992019957A2 (en) * 1991-05-03 1992-11-12 University Of Maryland At Baltimore Method for optically measuring chemical analytes
CA2042075C (en) * 1991-05-08 2001-01-23 Branko Palcic Endoscopic imaging system
US5503616A (en) * 1991-06-10 1996-04-02 Endomedical Technologies, Inc. Collapsible access channel system
US5201908A (en) * 1991-06-10 1993-04-13 Endomedical Technologies, Inc. Sheath for protecting endoscope from contamination
US5203328A (en) * 1991-07-17 1993-04-20 Georgia Tech Research Corporation Apparatus and methods for quantitatively measuring molecular changes in the ocular lens
US5348018A (en) * 1991-11-25 1994-09-20 Alfano Robert R Method for determining if tissue is malignant as opposed to non-malignant using time-resolved fluorescence spectroscopy
US5635402A (en) * 1992-03-05 1997-06-03 Alfano; Robert R. Technique for determining whether a cell is malignant as opposed to non-malignant using extrinsic fluorescence spectroscopy
US5370114A (en) * 1992-03-12 1994-12-06 Wong; Jacob Y. Non-invasive blood chemistry measurement by stimulated infrared relaxation emission
US5323008A (en) * 1992-03-23 1994-06-21 Diatron Corporation Fluorometer detection system
US5386467A (en) * 1992-07-31 1995-01-31 At&T Corp. Intelligent network communication system
US5762609A (en) * 1992-09-14 1998-06-09 Sextant Medical Corporation Device and method for analysis of surgical tissue interventions
US5383467A (en) * 1992-11-18 1995-01-24 Spectrascience, Inc. Guidewire catheter and apparatus for diagnostic imaging
EP0669820B1 (en) * 1992-11-18 1997-04-16 Spectrascience, Inc. Apparatus for diagnostic imaging
US5515847A (en) * 1993-01-28 1996-05-14 Optiscan, Inc. Self-emission noninvasive infrared spectrophotometer
US5313941A (en) * 1993-01-28 1994-05-24 Braig James R Noninvasive pulsed infrared spectrophotometer
US5489536A (en) * 1993-02-23 1996-02-06 The United States Of America As Represented By The Department Of Energy Detection of chlorinated aromatic compounds
US5395752A (en) * 1993-03-19 1995-03-07 Ciba Corning Diagnostics Corp. Long emission wavelength chemiluminescent compounds and their use in test assays
JP2936947B2 (ja) * 1993-03-22 1999-08-23 株式会社日立製作所 分光蛍光光度計
US5408996A (en) * 1993-03-25 1995-04-25 Salb; Jesse System and method for localization of malignant tissue
US5413108A (en) * 1993-04-21 1995-05-09 The Research Foundation Of City College Of New York Method and apparatus for mapping a tissue sample for and distinguishing different regions thereof based on luminescence measurements of cancer-indicative native fluorophor
US5421339A (en) * 1993-05-12 1995-06-06 Board Of Regents, The University Of Texas System Diagnosis of dysplasia using laser induced fluoroescence
JP3292935B2 (ja) * 1993-05-18 2002-06-17 富士写真フイルム株式会社 蛍光分光画像計測装置
US5596992A (en) * 1993-06-30 1997-01-28 Sandia Corporation Multivariate classification of infrared spectra of cell and tissue samples
US5422719A (en) * 1993-11-12 1995-06-06 Auburn International, Inc. Multi-wave-length spectrofluorometer
US5497769A (en) * 1993-12-16 1996-03-12 I.S.S. (Usa) Inc. Photosensor with multiple light sources
US5492118A (en) * 1993-12-16 1996-02-20 Board Of Trustees Of The University Of Illinois Determining material concentrations in tissues
US5495323A (en) * 1994-02-28 1996-02-27 Xerox Corporation Clean spiral toner cartridge
US5491343A (en) * 1994-03-25 1996-02-13 Brooker; Gary High-speed multiple wavelength illumination source, apparatus containing the same, and applications thereof to methods of irradiating luminescent samples and of quantitative luminescence ratio microscopy
US5590660A (en) * 1994-03-28 1997-01-07 Xillix Technologies Corp. Apparatus and method for imaging diseased tissue using integrated autofluorescence
US5515864A (en) * 1994-04-21 1996-05-14 Zuckerman; Ralph Method and apparatus for the in vivo measurement of oxygen concentration levels by the indirect determination of fluoescence lifetime
US5712165A (en) * 1994-08-22 1998-01-27 Beth Israel Hospital Administration Method and apparatus for detecting hydrocarbon oxidation
US5701902A (en) * 1994-09-14 1997-12-30 Cedars-Sinai Medical Center Spectroscopic burn injury evaluation apparatus and method
DE4445683A1 (de) * 1994-12-21 1996-06-27 Boehringer Mannheim Gmbh Verfahren zur Untersuchung eines streuenden Mediums mit intensitätsmoduliertem Licht
US6070583A (en) * 1995-02-21 2000-06-06 Massachusetts Institute Of Technology Optical imaging of tissue using inelastically scattered light
US5517313A (en) * 1995-02-21 1996-05-14 Colvin, Jr.; Arthur E. Fluorescent optical sensor
US5697373A (en) * 1995-03-14 1997-12-16 Board Of Regents, The University Of Texas System Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies
JPH10501346A (ja) * 1995-03-23 1998-02-03 フィリップス エレクトロニクス エヌ ベー 混濁媒体内で光学的測定をなす装置
US5612540A (en) * 1995-03-31 1997-03-18 Board Of Regents, The University Of Texas Systems Optical method for the detection of cervical neoplasias using fluorescence spectroscopy
US5619992A (en) * 1995-04-06 1997-04-15 Guthrie; Robert B. Methods and apparatus for inhibiting contamination of reusable pulse oximetry sensors
US5628310A (en) * 1995-05-19 1997-05-13 Joseph R. Lakowicz Method and apparatus to perform trans-cutaneous analyte monitoring
US5713364A (en) * 1995-08-01 1998-02-03 Medispectra, Inc. Spectral volume microprobe analysis of materials
US5630423A (en) * 1996-01-31 1997-05-20 Wang; Lihong Method of measuring tissue optical properties using an optical beam of oblique incidence and uses thereof
US5902246A (en) * 1996-03-26 1999-05-11 Lifespex, Incorporated Method and apparatus for calibrating an optical probe
CA2192036A1 (en) * 1996-12-04 1998-06-04 Harvey Lui Fluorescence scope system for dermatologic diagnosis
US5893712A (en) * 1997-02-06 1999-04-13 Welch Allyn, Inc. Gripping handle for diagnostic instrument
US6008889A (en) * 1997-04-16 1999-12-28 Zeng; Haishan Spectrometer system for diagnosis of skin disease
US5901261A (en) * 1997-06-19 1999-05-04 Visionex, Inc. Fiber optic interface for optical probes with enhanced photonic efficiency, light manipulation, and stray light rejection
US6070093A (en) * 1997-12-02 2000-05-30 Abbott Laboratories Multiplex sensor and method of use
US6055451A (en) * 1997-12-12 2000-04-25 Spectrx, Inc. Apparatus and method for determining tissue characteristics
AU3970799A (en) * 1998-05-04 1999-11-23 Board Of Regents Combined fluorescence and reflectance spectroscopy

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