IL138942A - Use of hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungs - Google Patents
Use of hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungsInfo
- Publication number
- IL138942A IL138942A IL138942A IL13894200A IL138942A IL 138942 A IL138942 A IL 138942A IL 138942 A IL138942 A IL 138942A IL 13894200 A IL13894200 A IL 13894200A IL 138942 A IL138942 A IL 138942A
- Authority
- IL
- Israel
- Prior art keywords
- magnetic resonance
- lungs
- imaging
- agent
- hyperpolarized
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
Landscapes
- Physics & Mathematics (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Signal Processing (AREA)
- General Health & Medical Sciences (AREA)
- High Energy & Nuclear Physics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Claims (22)
1. A method of detecting regional variations in oxygen uptake from the lungs of an air-breathing animal subject, said method comprising administering into the lungs of said subject a diagnostically effective amount of a gaseous hyperpolarized magnetic resonance imaging agent, detecting the magnetic resonance signal from said agent in said lungs, and characterized in that by determining the temporal variation in relaxation rate for said signal for at least one region of interest within said lungs, a qualitative or quantitative value or image indicative of the oxygen concentration in said at least one region of interest is generated from said variation, and if desired the time dependency of such concentration.
2. A method as claimed in claim 1 wherein said hyperpolarized agent comprises 3He.
3. A method as claimed in claim 1 wherein detection of said magnetic resonance signal is effected during a period of at least 1 second during which there is substantially no gas flow into or out of the lungs.
4. A method as claimed in claim 1 wherein said regions of interest comprise regions of alveolar space.
5. A method as claimed in claim 1 wherein a temporal and/or spatial mr image of at least part of the lungs comprising said regions of interest is also generated.
6. A method as claimed in claim 5 wherein said temporal and/or spatial image is constructed from magnetic resonance signals from said hyperpolarized agent.
7. A method as claimed in claim 5 wherein said temporal and/or spatial image is constructed from magnetic resonance signals from magnetic resonance active nuclei in a further magnetic resonance imaging agent administered into the vasculature or lungs of said subject.
8. A method as claimed in claim 7 wherein said further agent comprises a 19F fluorocarbon. 33 138942/3
9. A method as claimed in claim 1 wherein said magnetic resonance signals are detected in at least two different types of magnetic resonance imaging sequence.
10. A method as claimed in claim 9 wherein said types of sequence differ in the intensity of the magnetic resonance signal stimulating radiation.
11. A method as claimed in claim 9 wherein said types of sequence differ in the sequence timing.
12. A method as claimed in claim 9 wherein said types of sequence are interleaved.
13. A method as claimed in claim 1 wherein magnetic resonance signal detection is effected in an imaging sequence with an image acquisition time of less than 2 seconds.
14. A method as claimed in claim 1 wherein magnetic resonance signal detection is effected in an imaging sequence involving imposition of a flip angle of less than 7°.
15. A method as claimed in claim 1 wherein said hyperpolarized agent is administered as a bolus.
16. A method as claimed in claim 1 wherein said hyperpolarized agent is administered as a bolus of volume 1 to 1000 ml.
17. A method as claimed in claim 1 wherein a mr imager with a primary field strength in the range of 0.05 to 8T, preferably 0.05 to 3.5T, is used to detect said magnetic resonance signal.
18. A method as claimed in claim 1 wherein said hyperpolarized agent comprises 129Xe.
19. A method as claimed in any one of the preceding claims wherein the acquisition time of said image is in the subsecond range.
20. A method as claimed in any one of the preceding claims wherein said image is produced by any method selected from the group of gradient-recalled-echo imaging, echo-planar imaging, turbo-spin-echo imaging and imaging based on projection techniques.
21. A method of diagnosis of lung malfunction comprising the method as described in any one of claims 1 to 20. 34 138942/3
22. Use of 3He or other mr active nuclei containing materials for the preparation of a hyperpolarized imaging agent for use in methods of treatment or diagnosis involving performance of the method as described in any one of claims 1 to 20. For the Applicants, REINHOLD COHN AND PARTNERS By:
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9807879.3A GB9807879D0 (en) | 1998-04-09 | 1998-04-09 | Magnetic resonance imaging method |
| PCT/GB1999/001095 WO1999053332A1 (en) | 1998-04-09 | 1999-04-09 | Use of a hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL138942A true IL138942A (en) | 2007-03-08 |
Family
ID=10830295
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13894299A IL138942A0 (en) | 1998-04-09 | 1999-04-09 | Use of hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungs |
| IL138942A IL138942A (en) | 1998-04-09 | 2000-10-10 | Use of hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungs |
| IL155607A IL155607A (en) | 1998-04-09 | 2003-04-28 | Use of hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungs |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13894299A IL138942A0 (en) | 1998-04-09 | 1999-04-09 | Use of hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungs |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL155607A IL155607A (en) | 1998-04-09 | 2003-04-28 | Use of hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungs |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1070261A1 (en) |
| JP (1) | JP2002511329A (en) |
| CN (1) | CN1145042C (en) |
| AU (1) | AU760339B2 (en) |
| CA (1) | CA2327733C (en) |
| GB (1) | GB9807879D0 (en) |
| HU (1) | HUP0300952A2 (en) |
| IL (3) | IL138942A0 (en) |
| NO (1) | NO20005075L (en) |
| NZ (1) | NZ507434A (en) |
| PL (1) | PL192056B1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7179450B2 (en) * | 2001-09-20 | 2007-02-20 | Medi-Physics, Inc. | Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized Xe |
| US8808193B2 (en) * | 2007-09-11 | 2014-08-19 | Carefusion 207, Inc. | Regional oxygen uptake/perfusion measuring device and method |
| CN105301543B (en) * | 2015-11-16 | 2017-12-19 | 中国科学院武汉物理与数学研究所 | A kind of hyperpolarization angle calibration system method excited based on multi-angle in single breath-hold |
| CN111612860B (en) * | 2019-02-22 | 2023-09-15 | 曹生 | VRDS 4D medical image-based Ai identification method and product for embolism |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4775522A (en) * | 1983-03-04 | 1988-10-04 | Children's Hospital Research Foundation, A Division Of Children's Hospital Medical Center | NMR compositions for indirectly detecting a dissolved gas in an animal |
| US5545396A (en) * | 1994-04-08 | 1996-08-13 | The Research Foundation Of State University Of New York | Magnetic resonance imaging using hyperpolarized noble gases |
-
1998
- 1998-04-09 GB GBGB9807879.3A patent/GB9807879D0/en not_active Ceased
-
1999
- 1999-04-09 PL PL343379A patent/PL192056B1/en unknown
- 1999-04-09 JP JP2000543843A patent/JP2002511329A/en active Pending
- 1999-04-09 HU HU0300952A patent/HUP0300952A2/en unknown
- 1999-04-09 CN CNB998072273A patent/CN1145042C/en not_active Expired - Fee Related
- 1999-04-09 NZ NZ507434A patent/NZ507434A/en not_active Application Discontinuation
- 1999-04-09 CA CA002327733A patent/CA2327733C/en not_active Expired - Fee Related
- 1999-04-09 EP EP99915902A patent/EP1070261A1/en not_active Withdrawn
- 1999-04-09 IL IL13894299A patent/IL138942A0/en not_active IP Right Cessation
- 1999-04-09 AU AU34325/99A patent/AU760339B2/en not_active Ceased
-
2000
- 2000-10-09 NO NO20005075A patent/NO20005075L/en not_active Application Discontinuation
- 2000-10-10 IL IL138942A patent/IL138942A/en unknown
-
2003
- 2003-04-28 IL IL155607A patent/IL155607A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL343379A1 (en) | 2001-08-13 |
| CA2327733A1 (en) | 1999-10-21 |
| CA2327733C (en) | 2007-07-03 |
| IL155607A (en) | 2007-08-19 |
| CN1145042C (en) | 2004-04-07 |
| AU760339B2 (en) | 2003-05-15 |
| CN1305591A (en) | 2001-07-25 |
| AU3432599A (en) | 1999-11-01 |
| PL192056B1 (en) | 2006-08-31 |
| NZ507434A (en) | 2004-01-30 |
| GB9807879D0 (en) | 1998-06-10 |
| HUP0300952A2 (en) | 2003-08-28 |
| IL138942A0 (en) | 2001-11-25 |
| NO20005075D0 (en) | 2000-10-09 |
| EP1070261A1 (en) | 2001-01-24 |
| JP2002511329A (en) | 2002-04-16 |
| NO20005075L (en) | 2000-12-07 |
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