HUP0300952A2 - Use of a hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungs - Google Patents
Use of a hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungsInfo
- Publication number
- HUP0300952A2 HUP0300952A2 HU0300952A HUP0300952A HUP0300952A2 HU P0300952 A2 HUP0300952 A2 HU P0300952A2 HU 0300952 A HU0300952 A HU 0300952A HU P0300952 A HUP0300952 A HU P0300952A HU P0300952 A2 HUP0300952 A2 HU P0300952A2
- Authority
- HU
- Hungary
- Prior art keywords
- lungs
- oxygen uptake
- hyperpolarized gas
- magnetic resonance
- regional variations
- Prior art date
Links
- 210000004072 lung Anatomy 0.000 title abstract 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title abstract 3
- 239000001301 oxygen Substances 0.000 title abstract 3
- 229910052760 oxygen Inorganic materials 0.000 title abstract 3
- 238000001514 detection method Methods 0.000 title 1
- 239000007789 gas Substances 0.000 title 1
- 239000000463 material Substances 0.000 abstract 2
- 230000029058 respiratory gaseous exchange Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
Landscapes
- Physics & Mathematics (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Signal Processing (AREA)
- General Health & Medical Sciences (AREA)
- High Energy & Nuclear Physics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
A találmány tárgya olyan eljárás lélegző élőlény tüdejéből felvettoxigénmennyiség regionális változásainak detektálására, amelynek soránaz élőlény tüdejébe diagnosztikailag effektív mennyiségűhiperpolarizált, mágneses rezonancián alapuló felvételkészítésrealkalmas gáznemű anyagot juttatnak be, és detektálják a bejuttatottanyag által a tüdőből kisugárzott mágneses rezonancián alapuló jelet.A találmány értelmében meghatározzák a tüdő legalább egy vizsgáltrésze vonatkozásában kapott jel relaxációs tényezőjének időbeliváltozását, és ebből a változásból a fenti legalább egy vizsgált részoxigénkoncentrációját és - adott esetben - annak időfüggésétreprezentáló kvalitatív vagy kvantitatív értéket vagy képet állítanakelő. ÓThe subject of the invention is a method for detecting regional changes in the amount of oxygen taken up from the lungs of a breathing organism, during which a diagnostically effective amount of hyperpolarized gaseous material suitable for recording based on magnetic resonance is introduced into the lungs of the organism, and the signal based on the magnetic resonance emitted from the lungs by the introduced material is detected. According to the invention, the lungs are determined at least the change over time of the relaxation factor of the signal received in relation to a test part, and from this change a qualitative or quantitative value or image representing the oxygen concentration of at least one of the tested parts and - where applicable - its time dependence. HE
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9807879.3A GB9807879D0 (en) | 1998-04-09 | 1998-04-09 | Magnetic resonance imaging method |
| PCT/GB1999/001095 WO1999053332A1 (en) | 1998-04-09 | 1999-04-09 | Use of a hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0300952A2 true HUP0300952A2 (en) | 2003-08-28 |
Family
ID=10830295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0300952A HUP0300952A2 (en) | 1998-04-09 | 1999-04-09 | Use of a hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungs |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1070261A1 (en) |
| JP (1) | JP2002511329A (en) |
| CN (1) | CN1145042C (en) |
| AU (1) | AU760339B2 (en) |
| CA (1) | CA2327733C (en) |
| GB (1) | GB9807879D0 (en) |
| HU (1) | HUP0300952A2 (en) |
| IL (3) | IL138942A0 (en) |
| NO (1) | NO20005075L (en) |
| NZ (1) | NZ507434A (en) |
| PL (1) | PL192056B1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7179450B2 (en) * | 2001-09-20 | 2007-02-20 | Medi-Physics, Inc. | Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized Xe |
| US8808193B2 (en) * | 2007-09-11 | 2014-08-19 | Carefusion 207, Inc. | Regional oxygen uptake/perfusion measuring device and method |
| CN105301543B (en) * | 2015-11-16 | 2017-12-19 | 中国科学院武汉物理与数学研究所 | A kind of hyperpolarization angle calibration system method excited based on multi-angle in single breath-hold |
| CN111612860B (en) * | 2019-02-22 | 2023-09-15 | 曹生 | VRDS 4D medical image-based Ai identification method and product for embolism |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4775522A (en) * | 1983-03-04 | 1988-10-04 | Children's Hospital Research Foundation, A Division Of Children's Hospital Medical Center | NMR compositions for indirectly detecting a dissolved gas in an animal |
| US5545396A (en) * | 1994-04-08 | 1996-08-13 | The Research Foundation Of State University Of New York | Magnetic resonance imaging using hyperpolarized noble gases |
-
1998
- 1998-04-09 GB GBGB9807879.3A patent/GB9807879D0/en not_active Ceased
-
1999
- 1999-04-09 PL PL343379A patent/PL192056B1/en unknown
- 1999-04-09 JP JP2000543843A patent/JP2002511329A/en active Pending
- 1999-04-09 HU HU0300952A patent/HUP0300952A2/en unknown
- 1999-04-09 CN CNB998072273A patent/CN1145042C/en not_active Expired - Fee Related
- 1999-04-09 NZ NZ507434A patent/NZ507434A/en not_active Application Discontinuation
- 1999-04-09 CA CA002327733A patent/CA2327733C/en not_active Expired - Fee Related
- 1999-04-09 EP EP99915902A patent/EP1070261A1/en not_active Withdrawn
- 1999-04-09 IL IL13894299A patent/IL138942A0/en not_active IP Right Cessation
- 1999-04-09 AU AU34325/99A patent/AU760339B2/en not_active Ceased
-
2000
- 2000-10-09 NO NO20005075A patent/NO20005075L/en not_active Application Discontinuation
- 2000-10-10 IL IL138942A patent/IL138942A/en unknown
-
2003
- 2003-04-28 IL IL155607A patent/IL155607A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL343379A1 (en) | 2001-08-13 |
| CA2327733A1 (en) | 1999-10-21 |
| CA2327733C (en) | 2007-07-03 |
| IL155607A (en) | 2007-08-19 |
| CN1145042C (en) | 2004-04-07 |
| AU760339B2 (en) | 2003-05-15 |
| CN1305591A (en) | 2001-07-25 |
| AU3432599A (en) | 1999-11-01 |
| PL192056B1 (en) | 2006-08-31 |
| NZ507434A (en) | 2004-01-30 |
| GB9807879D0 (en) | 1998-06-10 |
| IL138942A0 (en) | 2001-11-25 |
| NO20005075D0 (en) | 2000-10-09 |
| EP1070261A1 (en) | 2001-01-24 |
| JP2002511329A (en) | 2002-04-16 |
| IL138942A (en) | 2007-03-08 |
| NO20005075L (en) | 2000-12-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |