IL136421A0 - Intermediates for preparing 1-benzyl -4-((5,6- dimethoxy -1-indanon)-2-yl) methylpiperidine - Google Patents
Intermediates for preparing 1-benzyl -4-((5,6- dimethoxy -1-indanon)-2-yl) methylpiperidineInfo
- Publication number
- IL136421A0 IL136421A0 IL13642196A IL13642196A IL136421A0 IL 136421 A0 IL136421 A0 IL 136421A0 IL 13642196 A IL13642196 A IL 13642196A IL 13642196 A IL13642196 A IL 13642196A IL 136421 A0 IL136421 A0 IL 136421A0
- Authority
- IL
- Israel
- Prior art keywords
- indanon
- methylpiperidine
- dimethoxy
- intermediates
- benzyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US875395P | 1995-12-15 | 1995-12-15 | |
| IL12445296A IL124452A0 (en) | 1995-12-15 | 1996-10-11 | Processes and intermediates for preparing 1-Benzyl-4-((5,6-dimethoxy-1-indanon)-2-YL)methylpiperidine |
| PCT/IB1996/001076 WO1997022584A1 (en) | 1995-12-15 | 1996-10-11 | Processes and intermediates for preparing 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL136421A0 true IL136421A0 (en) | 2001-06-14 |
Family
ID=21733469
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13642096A IL136420A0 (en) | 1995-12-15 | 1996-10-11 | Process for preparing 1- benzyl -4-((5,6 dimethoxy -1- indanon) -2-yl) methylpiperidine |
| IL13642196A IL136421A0 (en) | 1995-12-15 | 1996-10-11 | Intermediates for preparing 1-benzyl -4-((5,6- dimethoxy -1-indanon)-2-yl) methylpiperidine |
| IL12445296A IL124452A0 (en) | 1995-12-15 | 1996-10-11 | Processes and intermediates for preparing 1-Benzyl-4-((5,6-dimethoxy-1-indanon)-2-YL)methylpiperidine |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13642096A IL136420A0 (en) | 1995-12-15 | 1996-10-11 | Process for preparing 1- benzyl -4-((5,6 dimethoxy -1- indanon) -2-yl) methylpiperidine |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12445296A IL124452A0 (en) | 1995-12-15 | 1996-10-11 | Processes and intermediates for preparing 1-Benzyl-4-((5,6-dimethoxy-1-indanon)-2-YL)methylpiperidine |
Country Status (33)
| Country | Link |
|---|---|
| EP (1) | EP0883607A1 (en) |
| JP (1) | JP3066083B2 (en) |
| KR (1) | KR20000064387A (en) |
| AP (1) | AP708A (en) |
| AR (1) | AR004368A1 (en) |
| AU (1) | AU716462B2 (en) |
| BG (1) | BG102525A (en) |
| BR (1) | BR9612018A (en) |
| CA (1) | CA2237647A1 (en) |
| CO (1) | CO4750831A1 (en) |
| CZ (1) | CZ180898A3 (en) |
| DZ (1) | DZ2141A1 (en) |
| GT (1) | GT199600092A (en) |
| HN (1) | HN1996000065A (en) |
| HR (1) | HRP960592A2 (en) |
| HU (1) | HUP9904275A3 (en) |
| IL (3) | IL136420A0 (en) |
| IS (1) | IS4752A (en) |
| MA (1) | MA24032A1 (en) |
| NO (1) | NO982712L (en) |
| NZ (1) | NZ318843A (en) |
| OA (1) | OA10694A (en) |
| PE (1) | PE25698A1 (en) |
| PL (1) | PL197306B1 (en) |
| RO (1) | RO121382B1 (en) |
| RU (1) | RU2160731C2 (en) |
| SK (1) | SK75498A3 (en) |
| TN (1) | TNSN96153A1 (en) |
| TW (1) | TW414787B (en) |
| UY (1) | UY24401A1 (en) |
| WO (1) | WO1997022584A1 (en) |
| YU (1) | YU49486B (en) |
| ZA (1) | ZA9610533B (en) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1047674B1 (en) | 1998-01-16 | 2005-03-30 | Eisai Co., Ltd. | Process for production of donepezil derivatives |
| IL125809A (en) * | 1998-08-17 | 2005-08-31 | Finetech Lab Ltd | Process and intermediates for production of donepezil and related compounds |
| US7148354B2 (en) * | 2002-07-24 | 2006-12-12 | Dr. Reddy's Laboratories Limited | Process for preparation of donepezil |
| IL150982A (en) | 2002-07-30 | 2007-02-11 | Ori Lerman | Process for the preparation of donepezil |
| IL151253A0 (en) * | 2002-08-14 | 2003-04-10 | Finetech Lab Ltd | Process for production of highly pure donepezil hydrochloride |
| US6953856B2 (en) | 2003-02-12 | 2005-10-11 | Usv, Limited | Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI) |
| US6649765B1 (en) | 2003-02-12 | 2003-11-18 | Usv Limited, Bsd Marg. | Process for the preparation of 1-benzyl-4(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCL) |
| WO2004082685A1 (en) * | 2003-03-21 | 2004-09-30 | Ranbaxy Laboratories Limited | Process for the preparation of donepezil and derivatives thereof |
| WO2004099142A1 (en) * | 2003-05-05 | 2004-11-18 | Ranbaxy Laboratories Limited | Hydrobromide salt of benzyl-piperidylmethyl-indanone and its polymorphs |
| WO2005003092A1 (en) | 2003-07-01 | 2005-01-13 | Hetero Drugs Limited | Preparation of intermediates for acetyl cholinesterase inhibitors |
| CN1280273C (en) * | 2003-11-05 | 2006-10-18 | 天津和美生物技术有限公司 | Synthesis of donepizin and its derivative |
| WO2006035433A2 (en) | 2004-09-29 | 2006-04-06 | Chemagis Ltd. | Use of purified donepezil maleate for preparing pharmaceutically pure amorphous donepezil hydrochloride |
| CN100436416C (en) * | 2005-07-29 | 2008-11-26 | 西南合成制药股份有限公司 | Novel donepezil synthesis process |
| GB0515803D0 (en) * | 2005-07-30 | 2005-09-07 | Pliva Hrvatska D O O | Intermediate compounds |
| AR057910A1 (en) | 2005-11-18 | 2007-12-26 | Synthon Bv | PROCESS TO PREPARE DONEPEZILO |
| DE602007010725D1 (en) * | 2006-01-04 | 2011-01-05 | Cipla Ltd | METHOD AND INTERMEDIATE PRODUCT FOR THE PRODUCTION OF DONEZEPIL |
| MX2009005795A (en) * | 2006-12-11 | 2009-06-08 | Reviva Pharmaceuticals Inc | Compositions, synthesis, and methods of using indanone based cholinesterase inhibitors. |
| WO2013078608A1 (en) | 2011-11-29 | 2013-06-06 | Ziqiang Gu | Donepezil pamoate and methods of making and using the same |
| EP3033082B1 (en) | 2013-08-16 | 2021-06-16 | Universiteit Maastricht | Treatment of cognitive impairment with pde4 inhibitor |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI95572C (en) * | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Process for the preparation of a medicament useful as a piperidine derivative or its pharmaceutical salt |
| FR2642069B1 (en) * | 1989-01-20 | 1991-04-12 | Rhone Poulenc Sante | NOVEL BENZOPYRAN DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| DE4439822A1 (en) * | 1994-11-08 | 1996-08-29 | Bayer Ag | Process for the preparation of benzyl-piperidylmethyl-indanones |
-
1996
- 1996-10-11 CA CA002237647A patent/CA2237647A1/en not_active Abandoned
- 1996-10-11 SK SK754-98A patent/SK75498A3/en unknown
- 1996-10-11 CZ CZ981808A patent/CZ180898A3/en unknown
- 1996-10-11 IL IL13642096A patent/IL136420A0/en unknown
- 1996-10-11 AU AU70925/96A patent/AU716462B2/en not_active Ceased
- 1996-10-11 JP JP9522607A patent/JP3066083B2/en not_active Expired - Lifetime
- 1996-10-11 KR KR1019980704423A patent/KR20000064387A/en not_active Application Discontinuation
- 1996-10-11 HU HU9904275A patent/HUP9904275A3/en unknown
- 1996-10-11 BR BR9612018A patent/BR9612018A/en not_active Application Discontinuation
- 1996-10-11 RO RO98-01070A patent/RO121382B1/en unknown
- 1996-10-11 PL PL327512A patent/PL197306B1/en not_active IP Right Cessation
- 1996-10-11 IL IL13642196A patent/IL136421A0/en unknown
- 1996-10-11 WO PCT/IB1996/001076 patent/WO1997022584A1/en not_active Application Discontinuation
- 1996-10-11 RU RU98111204/04A patent/RU2160731C2/en not_active IP Right Cessation
- 1996-10-11 EP EP96931937A patent/EP0883607A1/en not_active Withdrawn
- 1996-10-11 IL IL12445296A patent/IL124452A0/en unknown
- 1996-10-11 NZ NZ318843A patent/NZ318843A/en unknown
- 1996-10-14 TW TW085112515A patent/TW414787B/en not_active IP Right Cessation
- 1996-10-15 HN HN1996000065A patent/HN1996000065A/en unknown
- 1996-11-18 GT GT199600092A patent/GT199600092A/en unknown
- 1996-12-09 PE PE1996000883A patent/PE25698A1/en not_active Application Discontinuation
- 1996-12-10 AR ARP960105577A patent/AR004368A1/en unknown
- 1996-12-11 DZ DZ960186A patent/DZ2141A1/en active
- 1996-12-11 TN TNTNSN96153A patent/TNSN96153A1/en unknown
- 1996-12-11 MA MA24424A patent/MA24032A1/en unknown
- 1996-12-11 YU YU66096A patent/YU49486B/en unknown
- 1996-12-12 CO CO96065334A patent/CO4750831A1/en unknown
- 1996-12-12 UY UY24401A patent/UY24401A1/en not_active IP Right Cessation
- 1996-12-12 AP APAP/P/1996/000892A patent/AP708A/en active
- 1996-12-13 HR HR60/008,753A patent/HRP960592A2/en not_active Application Discontinuation
- 1996-12-13 ZA ZA9610533A patent/ZA9610533B/en unknown
-
1998
- 1998-05-22 IS IS4752A patent/IS4752A/en unknown
- 1998-06-05 OA OA9800076A patent/OA10694A/en unknown
- 1998-06-09 BG BG102525A patent/BG102525A/en unknown
- 1998-06-12 NO NO982712A patent/NO982712L/en not_active Application Discontinuation
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