BG102525A - Method and intermediate compounds for the preparation of 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)-methylpiperidine - Google Patents
Method and intermediate compounds for the preparation of 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)-methylpiperidineInfo
- Publication number
- BG102525A BG102525A BG102525A BG10252598A BG102525A BG 102525 A BG102525 A BG 102525A BG 102525 A BG102525 A BG 102525A BG 10252598 A BG10252598 A BG 10252598A BG 102525 A BG102525 A BG 102525A
- Authority
- BG
- Bulgaria
- Prior art keywords
- alkyl
- compound
- formulawhere
- trifluoromethyl
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The invetnion relates to a method for the preparation of acompound with the formulawhere R1 is R20(C=0)- or R3(C=0-, R2 is (C1-C4)alkyl and R3 is(C10C4)alkyl or phenyl, optionally substituted by from one tothree substituents selected separately from each other from(C1-C4)alkyl, (C1-C4)alkoxy, halogen or trifluoromethyl. Themethod includes: interaction of a compound with the formulawhere R1 is R20(C=0)- or R3(C=0)-, R2 is (C1-C4)alkyl and R3 is(C1-C4) alkyl or phenyl, optionally substituted by from one tothree substituents selected separately from each other from(C1-C4)alkyl, (C1-C4)alkoxy, halogen or trifluoromethyl withmethylating agent in order to produce a compound with the formulawhere R1 is R20(C=0)- or R3(C=0)-, R2 is (C1-C4)alkyl and R3 is(C1-C4) alkyl or phenyl, optionally substituted by from one tothree substituents selected separately from each other from(C1-C4)alkyl, (C1-C4)alkoxy, halogen or trifluoromethyl. Thecompounds so produced with the formula II interacts with a strongacid. The production includes an additional stage of the reactionof the compound with formula I with hydroxide until the productionof a compound with the formulaand the raction of a compound with formula VI andbenzylhalogenide. The invention also relates to new intermediatecompounds with formulae I, II & III.16 claims
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US875395P | 1995-12-15 | 1995-12-15 | |
| PCT/IB1996/001076 WO1997022584A1 (en) | 1995-12-15 | 1996-10-11 | Processes and intermediates for preparing 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG102525A true BG102525A (en) | 1999-05-31 |
Family
ID=21733469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG102525A BG102525A (en) | 1995-12-15 | 1998-06-09 | Method and intermediate compounds for the preparation of 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)-methylpiperidine |
Country Status (33)
| Country | Link |
|---|---|
| EP (1) | EP0883607A1 (en) |
| JP (1) | JP3066083B2 (en) |
| KR (1) | KR20000064387A (en) |
| AP (1) | AP708A (en) |
| AR (1) | AR004368A1 (en) |
| AU (1) | AU716462B2 (en) |
| BG (1) | BG102525A (en) |
| BR (1) | BR9612018A (en) |
| CA (1) | CA2237647A1 (en) |
| CO (1) | CO4750831A1 (en) |
| CZ (1) | CZ180898A3 (en) |
| DZ (1) | DZ2141A1 (en) |
| GT (1) | GT199600092A (en) |
| HN (1) | HN1996000065A (en) |
| HR (1) | HRP960592A2 (en) |
| HU (1) | HUP9904275A3 (en) |
| IL (3) | IL136421A0 (en) |
| IS (1) | IS4752A (en) |
| MA (1) | MA24032A1 (en) |
| NO (1) | NO982712L (en) |
| NZ (1) | NZ318843A (en) |
| OA (1) | OA10694A (en) |
| PE (1) | PE25698A1 (en) |
| PL (1) | PL197306B1 (en) |
| RO (1) | RO121382B1 (en) |
| RU (1) | RU2160731C2 (en) |
| SK (1) | SK75498A3 (en) |
| TN (1) | TNSN96153A1 (en) |
| TW (1) | TW414787B (en) |
| UY (1) | UY24401A1 (en) |
| WO (1) | WO1997022584A1 (en) |
| YU (1) | YU49486B (en) |
| ZA (1) | ZA9610533B (en) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999036405A1 (en) | 1998-01-16 | 1999-07-22 | Eisai Co., Ltd. | Process for production of donepezil derivative |
| IL125809A (en) * | 1998-08-17 | 2005-08-31 | Finetech Lab Ltd | Process and intermediates for production of donepezil and related compounds |
| US7148354B2 (en) * | 2002-07-24 | 2006-12-12 | Dr. Reddy's Laboratories Limited | Process for preparation of donepezil |
| IL150982A (en) | 2002-07-30 | 2007-02-11 | Ori Lerman | Process for the preparation of donepezil |
| IL151253A0 (en) * | 2002-08-14 | 2003-04-10 | Finetech Lab Ltd | Process for production of highly pure donepezil hydrochloride |
| US6953856B2 (en) | 2003-02-12 | 2005-10-11 | Usv, Limited | Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI) |
| US6649765B1 (en) | 2003-02-12 | 2003-11-18 | Usv Limited, Bsd Marg. | Process for the preparation of 1-benzyl-4(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCL) |
| EP1608371A1 (en) * | 2003-03-21 | 2005-12-28 | Ranbaxy Laboratories, Ltd. | Process for the preparation of donepezil and derivatives thereof |
| WO2004099142A1 (en) * | 2003-05-05 | 2004-11-18 | Ranbaxy Laboratories Limited | Hydrobromide salt of benzyl-piperidylmethyl-indanone and its polymorphs |
| AU2003247158A1 (en) | 2003-07-01 | 2005-01-21 | Hetero Drugs Limited | Preparation of intermediates for acetyl cholinesterase inhibitors |
| CN1280273C (en) | 2003-11-05 | 2006-10-18 | 天津和美生物技术有限公司 | Synthesis of donepizin and its derivative |
| JP2008514691A (en) | 2004-09-29 | 2008-05-08 | ケマジス リミティド | Use of purified donepezil maleate to produce pharmaceutically pure amorphous donepezil hydrochloride |
| CN100436416C (en) * | 2005-07-29 | 2008-11-26 | 西南合成制药股份有限公司 | Novel donepezil synthesis process |
| GB0515803D0 (en) | 2005-07-30 | 2005-09-07 | Pliva Hrvatska D O O | Intermediate compounds |
| AR057910A1 (en) | 2005-11-18 | 2007-12-26 | Synthon Bv | PROCESS TO PREPARE DONEPEZILO |
| ES2354737T3 (en) | 2006-01-04 | 2011-03-17 | Cipla Limited | PROCEDURE AND INTERMEDIATE PRODUCT FOR THE PREPARATION OF DONEPEZYLO. |
| BRPI0720211A2 (en) * | 2006-12-11 | 2013-12-24 | Reviva Pharmaceuticals Inc | INDANONE DERIVATIVE, COMPOSITION, AND, USE OF A COMPOSITION |
| WO2013078608A1 (en) * | 2011-11-29 | 2013-06-06 | Ziqiang Gu | Donepezil pamoate and methods of making and using the same |
| AU2014307803A1 (en) | 2013-08-16 | 2016-03-10 | Universiteit Maastricht | Treatment of cognitive impairment with PDE4 inhibitor |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI95572C (en) * | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Process for the preparation of a medicament useful as a piperidine derivative or its pharmaceutical salt |
| FR2642069B1 (en) * | 1989-01-20 | 1991-04-12 | Rhone Poulenc Sante | NOVEL BENZOPYRAN DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| DE4439822A1 (en) * | 1994-11-08 | 1996-08-29 | Bayer Ag | Process for the preparation of benzyl-piperidylmethyl-indanones |
-
1996
- 1996-10-11 SK SK754-98A patent/SK75498A3/en unknown
- 1996-10-11 IL IL13642196A patent/IL136421A0/en unknown
- 1996-10-11 CA CA002237647A patent/CA2237647A1/en not_active Abandoned
- 1996-10-11 KR KR1019980704423A patent/KR20000064387A/en not_active Application Discontinuation
- 1996-10-11 BR BR9612018A patent/BR9612018A/en not_active Application Discontinuation
- 1996-10-11 IL IL12445296A patent/IL124452A0/en unknown
- 1996-10-11 WO PCT/IB1996/001076 patent/WO1997022584A1/en not_active Application Discontinuation
- 1996-10-11 IL IL13642096A patent/IL136420A0/en unknown
- 1996-10-11 RO RO98-01070A patent/RO121382B1/en unknown
- 1996-10-11 PL PL327512A patent/PL197306B1/en not_active IP Right Cessation
- 1996-10-11 RU RU98111204/04A patent/RU2160731C2/en not_active IP Right Cessation
- 1996-10-11 CZ CZ981808A patent/CZ180898A3/en unknown
- 1996-10-11 JP JP9522607A patent/JP3066083B2/en not_active Expired - Lifetime
- 1996-10-11 NZ NZ318843A patent/NZ318843A/en unknown
- 1996-10-11 EP EP96931937A patent/EP0883607A1/en not_active Withdrawn
- 1996-10-11 AU AU70925/96A patent/AU716462B2/en not_active Ceased
- 1996-10-11 HU HU9904275A patent/HUP9904275A3/en unknown
- 1996-10-14 TW TW085112515A patent/TW414787B/en not_active IP Right Cessation
- 1996-10-15 HN HN1996000065A patent/HN1996000065A/en unknown
- 1996-11-18 GT GT199600092A patent/GT199600092A/en unknown
- 1996-12-09 PE PE1996000883A patent/PE25698A1/en not_active Application Discontinuation
- 1996-12-10 AR ARP960105577A patent/AR004368A1/en unknown
- 1996-12-11 YU YU66096A patent/YU49486B/en unknown
- 1996-12-11 DZ DZ960186A patent/DZ2141A1/en active
- 1996-12-11 MA MA24424A patent/MA24032A1/en unknown
- 1996-12-11 TN TNTNSN96153A patent/TNSN96153A1/en unknown
- 1996-12-12 AP APAP/P/1996/000892A patent/AP708A/en active
- 1996-12-12 UY UY24401A patent/UY24401A1/en not_active IP Right Cessation
- 1996-12-12 CO CO96065334A patent/CO4750831A1/en unknown
- 1996-12-13 ZA ZA9610533A patent/ZA9610533B/en unknown
- 1996-12-13 HR HR60/008,753A patent/HRP960592A2/en not_active Application Discontinuation
-
1998
- 1998-05-22 IS IS4752A patent/IS4752A/en unknown
- 1998-06-05 OA OA9800076A patent/OA10694A/en unknown
- 1998-06-09 BG BG102525A patent/BG102525A/en unknown
- 1998-06-12 NO NO982712A patent/NO982712L/en not_active Application Discontinuation
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