IL135564A0 - POLYCYCLIC α-AMINO-ɛ-CAPROLACTAMS AND RELATED COMPOUNDS - Google Patents
POLYCYCLIC α-AMINO-ɛ-CAPROLACTAMS AND RELATED COMPOUNDSInfo
- Publication number
- IL135564A0 IL135564A0 IL13556498A IL13556498A IL135564A0 IL 135564 A0 IL135564 A0 IL 135564A0 IL 13556498 A IL13556498 A IL 13556498A IL 13556498 A IL13556498 A IL 13556498A IL 135564 A0 IL135564 A0 IL 135564A0
- Authority
- IL
- Israel
- Prior art keywords
- caprolactams
- polycyclic
- amino
- related compounds
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/996,422 US6635632B1 (en) | 1996-12-23 | 1997-12-22 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US10272698A | 1998-06-22 | 1998-06-22 | |
| PCT/US1998/022637 WO1999032453A1 (en) | 1997-12-22 | 1998-10-29 | POLYCYCLIC α-AMINO-⊂-CAPROLACTAMS AND RELATED COMPOUNDS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL135564A0 true IL135564A0 (en) | 2001-05-20 |
Family
ID=26799672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13556498A IL135564A0 (en) | 1997-12-22 | 1998-10-29 | POLYCYCLIC α-AMINO-ɛ-CAPROLACTAMS AND RELATED COMPOUNDS |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1042298A1 (en) |
| JP (1) | JP2003521438A (en) |
| KR (1) | KR20010033408A (en) |
| AU (1) | AU1277799A (en) |
| BR (1) | BR9812773A (en) |
| CA (1) | CA2307221A1 (en) |
| HU (1) | HUP0100294A3 (en) |
| IL (1) | IL135564A0 (en) |
| WO (1) | WO1999032453A1 (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ525513A (en) | 1998-08-07 | 2004-09-24 | Pont Pharmaceuticals Du | Succinoylamino lactams as inhibitors of Abeta protein production |
| EP1313426A2 (en) | 1998-12-24 | 2003-05-28 | Bristol-Myers Squibb Pharma Company | Succinoylamino benzodiazepines as inhibitors of a-beta protein production |
| EP1226139A2 (en) * | 1999-07-06 | 2002-07-31 | Vertex Pharmaceuticals Incorporated | Cyclized amide derivatives for treating or preventing neuronal damage |
| US6960576B2 (en) | 1999-09-13 | 2005-11-01 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production |
| BR0014269A (en) * | 1999-09-13 | 2002-07-02 | Bristol Myers Squibb Pharma Co | Lactam compounds, their pharmaceutically acceptable salts and prodrugs, pharmaceutical composition, method of treating neurological disorders associated with the production of "beta" -amyloid, method of inhibiting "alpha" -secretase activity and uses of the compounds |
| US6503902B2 (en) | 1999-09-13 | 2003-01-07 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production |
| CA2387493A1 (en) * | 1999-10-08 | 2001-04-19 | Lorin Andrew Thompson | Amino lactam sulfonamides as inhibitors of a.beta. protein production |
| AU2001239791A1 (en) * | 2000-02-17 | 2001-08-27 | Du Pont Pharmaceuticals Company | Succinoylamino carbocycles and heterocycles as inhibitors of abeta protein production |
| AU2001253090A1 (en) | 2000-04-03 | 2001-10-15 | Bristol-Myers Squibb Pharma Company | Cyclic lactams as inhibitors of abeta protein production |
| BR0110051A (en) | 2000-04-03 | 2004-12-07 | Bristol Myers Squibb Pharma Co | Compound, Compound Use, Pharmaceutical Composition and Method of Treatment of Alzheimer's Disease |
| CA2404273A1 (en) | 2000-04-11 | 2001-10-18 | Bristol-Myers Squibb Pharma Company | Substituted lactams as inhibitors of a.beta. protein production |
| CA2379445C (en) | 2000-06-01 | 2007-08-21 | Bristol-Myers Squibb Pharma Company | Lactams substituted by cyclic succinates as inhibitors of a.beta. protein production |
| US6432944B1 (en) | 2000-07-06 | 2002-08-13 | Bristol-Myers Squibb Company | Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4666829A (en) * | 1985-05-15 | 1987-05-19 | University Of California | Polypeptide marker for Alzheimer's disease and its use for diagnosis |
| EP0667959B1 (en) * | 1992-10-26 | 2003-08-13 | Elan Pharmaceuticals, Inc. | Methods for identifying inhibitors of the production of beta-amyloid peptide |
| NZ264143A (en) * | 1993-08-09 | 1996-11-26 | Lilly Co Eli | Use of an aspartyl protease inhibitor to inhibit beta-amyloid peptide production |
| US5580979A (en) * | 1994-03-15 | 1996-12-03 | Trustees Of Tufts University | Phosphotyrosine peptidomimetics for inhibiting SH2 domain interactions |
| US6251928B1 (en) * | 1994-03-16 | 2001-06-26 | Eli Lilly And Company | Treatment of alzheimer's disease employing inhibitors of cathepsin D |
| KR20000069654A (en) * | 1996-12-23 | 2000-11-25 | 엘란 파마슈티칼스, 인크. | Cycloalkyl, Lactam, Lactone and Related Compounds, Pharmaceutical Compositions Comprising Same and Methods for Inhibiting β-Amyloid Peptide Release and/or Its Synthesis by Use of Such Compounds |
| HRP980093A2 (en) * | 1997-02-28 | 1998-12-31 | Lilly Co Eli | Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting "beta"-amyloid peptide release and/or its synthesis by use of such compounds |
-
1998
- 1998-10-29 WO PCT/US1998/022637 patent/WO1999032453A1/en not_active Application Discontinuation
- 1998-10-29 JP JP2000525390A patent/JP2003521438A/en not_active Withdrawn
- 1998-10-29 HU HU0100294A patent/HUP0100294A3/en unknown
- 1998-10-29 KR KR1020007006883A patent/KR20010033408A/en not_active Application Discontinuation
- 1998-10-29 AU AU12777/99A patent/AU1277799A/en not_active Abandoned
- 1998-10-29 EP EP98956198A patent/EP1042298A1/en not_active Withdrawn
- 1998-10-29 CA CA002307221A patent/CA2307221A1/en not_active Abandoned
- 1998-10-29 IL IL13556498A patent/IL135564A0/en unknown
- 1998-10-29 BR BR9812773-0A patent/BR9812773A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010033408A (en) | 2001-04-25 |
| BR9812773A (en) | 2000-10-10 |
| EP1042298A1 (en) | 2000-10-11 |
| JP2003521438A (en) | 2003-07-15 |
| HUP0100294A2 (en) | 2001-09-28 |
| HUP0100294A3 (en) | 2003-04-28 |
| AU1277799A (en) | 1999-07-12 |
| WO1999032453A1 (en) | 1999-07-01 |
| CA2307221A1 (en) | 1999-07-01 |
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