AU1277799A - Polycyclic alpha-amino-$m(e)-caprolactams and related compounds - Google Patents
Polycyclic alpha-amino-$m(e)-caprolactams and related compoundsInfo
- Publication number
- AU1277799A AU1277799A AU12777/99A AU1277799A AU1277799A AU 1277799 A AU1277799 A AU 1277799A AU 12777/99 A AU12777/99 A AU 12777/99A AU 1277799 A AU1277799 A AU 1277799A AU 1277799 A AU1277799 A AU 1277799A
- Authority
- AU
- Australia
- Prior art keywords
- caprolactams
- polycyclic
- alpha
- amino
- related compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/996,422 US6635632B1 (en) | 1996-12-23 | 1997-12-22 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
US08996422 | 1997-12-22 | ||
US10272698A | 1998-06-22 | 1998-06-22 | |
US09102726 | 1998-06-22 | ||
PCT/US1998/022637 WO1999032453A1 (en) | 1997-12-22 | 1998-10-29 | POLYCYCLIC α-AMINO-⊂-CAPROLACTAMS AND RELATED COMPOUNDS |
Publications (1)
Publication Number | Publication Date |
---|---|
AU1277799A true AU1277799A (en) | 1999-07-12 |
Family
ID=26799672
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU12777/99A Abandoned AU1277799A (en) | 1997-12-22 | 1998-10-29 | Polycyclic alpha-amino-$m(e)-caprolactams and related compounds |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1042298A1 (en) |
JP (1) | JP2003521438A (en) |
KR (1) | KR20010033408A (en) |
AU (1) | AU1277799A (en) |
BR (1) | BR9812773A (en) |
CA (1) | CA2307221A1 (en) |
HU (1) | HUP0100294A3 (en) |
IL (1) | IL135564A0 (en) |
WO (1) | WO1999032453A1 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ525513A (en) | 1998-08-07 | 2004-09-24 | Pont Pharmaceuticals Du | Succinoylamino lactams as inhibitors of Abeta protein production |
EP1313426A4 (en) | 1998-12-24 | 2003-05-28 | Bristol Myers Squibb Pharma Co | Succinoylamino benzodiazepines as inhibitors of a-beta protein production |
JP2003503476A (en) | 1999-07-06 | 2003-01-28 | バーテックス ファーマシューティカルズ インコーポレイテッド | Cyclic amide derivative |
US6960576B2 (en) | 1999-09-13 | 2005-11-01 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production |
CN1399634A (en) * | 1999-09-13 | 2003-02-26 | 布里斯托尔-迈尔斯斯奎布药品公司 | Hydroxyalkanoyl aminolactams and related structure as inhibitors of A beta protein production |
US6503902B2 (en) | 1999-09-13 | 2003-01-07 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production |
AU7997600A (en) | 1999-10-08 | 2001-04-23 | Du Pont Pharmaceuticals Company | Amino lactam sulfonamides as inhibitors of abeta protein production |
EP1261610A2 (en) | 2000-02-17 | 2002-12-04 | Bristol-Myers Squibb Pharma Company | Succinoylamino carbocycles and heterocycles as inhibitors of a-beta protein production |
BR0110051A (en) | 2000-04-03 | 2004-12-07 | Bristol Myers Squibb Pharma Co | Compound, Compound Use, Pharmaceutical Composition and Method of Treatment of Alzheimer's Disease |
US6759404B2 (en) | 2000-04-03 | 2004-07-06 | Richard E. Olson | Cyclic malonamides as inhibitors of aβ protein production |
CA2404273A1 (en) | 2000-04-11 | 2001-10-18 | Bristol-Myers Squibb Pharma Company | Substituted lactams as inhibitors of a.beta. protein production |
WO2001092235A1 (en) | 2000-06-01 | 2001-12-06 | Bristol-Myers Squibb Pharma Company | LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
US6432944B1 (en) | 2000-07-06 | 2002-08-13 | Bristol-Myers Squibb Company | Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4666829A (en) * | 1985-05-15 | 1987-05-19 | University Of California | Polypeptide marker for Alzheimer's disease and its use for diagnosis |
JP3553592B2 (en) * | 1992-10-26 | 2004-08-11 | ビー. シェンク,デイル | Methods and compositions for the detection of soluble β-amyloid peptide |
NZ264143A (en) * | 1993-08-09 | 1996-11-26 | Lilly Co Eli | Use of an aspartyl protease inhibitor to inhibit beta-amyloid peptide production |
US5580979A (en) * | 1994-03-15 | 1996-12-03 | Trustees Of Tufts University | Phosphotyrosine peptidomimetics for inhibiting SH2 domain interactions |
US6251928B1 (en) * | 1994-03-16 | 2001-06-26 | Eli Lilly And Company | Treatment of alzheimer's disease employing inhibitors of cathepsin D |
EA002100B1 (en) * | 1996-12-23 | 2001-12-24 | Элан Фармасьютикалз, Инк. | CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHOD FOR INHIBITING beta-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESISBY USE OF SUCH COMPOUNDS |
HRP980093A2 (en) * | 1997-02-28 | 1998-12-31 | Lilly Co Eli | Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting "beta"-amyloid peptide release and/or its synthesis by use of such compounds |
-
1998
- 1998-10-29 BR BR9812773-0A patent/BR9812773A/en not_active IP Right Cessation
- 1998-10-29 EP EP98956198A patent/EP1042298A1/en not_active Withdrawn
- 1998-10-29 HU HU0100294A patent/HUP0100294A3/en unknown
- 1998-10-29 IL IL13556498A patent/IL135564A0/en unknown
- 1998-10-29 KR KR1020007006883A patent/KR20010033408A/en not_active Application Discontinuation
- 1998-10-29 JP JP2000525390A patent/JP2003521438A/en not_active Withdrawn
- 1998-10-29 CA CA002307221A patent/CA2307221A1/en not_active Abandoned
- 1998-10-29 WO PCT/US1998/022637 patent/WO1999032453A1/en not_active Application Discontinuation
- 1998-10-29 AU AU12777/99A patent/AU1277799A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
IL135564A0 (en) | 2001-05-20 |
JP2003521438A (en) | 2003-07-15 |
EP1042298A1 (en) | 2000-10-11 |
WO1999032453A1 (en) | 1999-07-01 |
BR9812773A (en) | 2000-10-10 |
HUP0100294A2 (en) | 2001-09-28 |
HUP0100294A3 (en) | 2003-04-28 |
CA2307221A1 (en) | 1999-07-01 |
KR20010033408A (en) | 2001-04-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |