IL134224A0 - Methods of preparing and purifying 9-nitro-20-camptothecin - Google Patents

Methods of preparing and purifying 9-nitro-20-camptothecin

Info

Publication number: IL134224A0
Authority: IL; Israel
Prior art keywords: camptothecin; methods; nitrocamptothecin; purifying; nitro
Prior art date: 1997-08-05

Application number

IL13422498A

Other languages

English (en)

Original Assignee

Stehlin Foundation For Cancer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-05

Filing date

1998-07-10

Publication date

2001-04-30

1998-07-10 Application filed by Stehlin Foundation For Cancer filed Critical Stehlin Foundation For Cancer

2001-04-30 Publication of IL134224A0 publication Critical patent/IL134224A0/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IL13422498A 1997-08-05 1998-07-10 Methods of preparing and purifying 9-nitro-20-camptothecin IL134224A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/906,434 US5922877A (en)	1997-08-05	1997-08-05	Methods of preparing and purifying 9-nitro-20-camptothecin
PCT/US1998/014532 WO1999007709A1 (en)	1997-08-05	1998-07-10	Methods of preparing and purifying 9-nitro-20-camptothecin

Publications (1)

Publication Number	Publication Date
IL134224A0 true IL134224A0 (en)	2001-04-30

Family

ID=25422444

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL13422498A IL134224A0 (en)	1997-08-05	1998-07-10	Methods of preparing and purifying 9-nitro-20-camptothecin
IL134224A IL134224A (en)	1997-08-05	2000-01-26	Methods of preparing and purifying 9-nitro-20-camptothecin and the product obtained thereby

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL134224A IL134224A (en)	1997-08-05	2000-01-26	Methods of preparing and purifying 9-nitro-20-camptothecin and the product obtained thereby

Country Status (14)

Country	Link
US (1)	US5922877A (xx)
EP (1)	EP1003750B1 (xx)
JP (2)	JP3651778B2 (xx)
CN (2)	CN101186609A (xx)
AT (1)	ATE390429T1 (xx)
AU (1)	AU736323B2 (xx)
CA (1)	CA2296731C (xx)
DE (1)	DE69839306T2 (xx)
DK (1)	DK1003750T3 (xx)
ES (1)	ES2303355T3 (xx)
HU (1)	HUP0003206A3 (xx)
IL (2)	IL134224A0 (xx)
PT (1)	PT1003750E (xx)
WO (1)	WO1999007709A1 (xx)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5527913A (en) *	1993-02-25	1996-06-18	The Stehlin Foundation For Cancer Research	Methods for purifying camptothecin compounds
US5731316A (en)	1996-01-30	1998-03-24	The Stehlin Foundation For Cancer Research	Derivatives of camptothecin and methods of treating cancer using these derivatives
US6407118B1 (en)	1996-01-30	2002-06-18	The Stehlin Foundation For Cancer Research	Derivatives of camptothecin and methods of treating cancer using these derivatives
US6352996B1 (en)	1999-08-03	2002-03-05	The Stehlin Foundation For Cancer Research	Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
AU775373B2 (en)	1999-10-01	2004-07-29	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
DE10063766B4 (de) *	2000-12-21	2005-01-27	Daimlerchrysler Ag	Airbagvorrichtung für einen Personenkraftwagen
US7071202B2 (en) *	2002-02-21	2006-07-04	Supergen, Inc.	Compositions and formulations of 9-nitrocamptothecin polymorphs and methods of use therefor
EP2266590A3 (en)	2002-02-22	2011-04-20	Shire LLC	Active agent delivery sytems and methods for protecting and administering active agents
US6699875B2 (en)	2002-05-06	2004-03-02	The Stehlin Foundation For Cancer Research	Cascade esters of camptothecins and methods of treating cancer using these compounds
US6703399B2 (en)	2002-05-06	2004-03-09	The Stehlin Foundation For Cancer Research	Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds
US20040204435A1 (en) *	2003-04-09	2004-10-14	Joachim Liehr	Alternating treatment with topoisomerase I and topoisomerase II inhibitors
CN1324032C (zh) *	2004-01-07	2007-07-04	重庆医药工业研究院有限责任公司	一种新的9－硝基喜树碱晶型和药物组合物
CN100334089C (zh) *	2004-07-21	2007-08-29	王洋	一种9－硝基喜树碱的生产方法
CN1312155C (zh) *	2005-01-21	2007-04-25	华东理工大学	一种分离纯化9－硝基喜树碱的方法
MX2009001505A (es) *	2006-08-11	2009-03-25	Christus Stehlin Foundation Fo	Metodos para hacer esteres de camptotecinas.
US7572803B2 (en) *	2007-10-25	2009-08-11	The Christus Stehlin Foundation For Cancer Research	Hydrated crystalline esters of camptothecin
JP2012155651A (ja) *	2011-01-28	2012-08-16	Sony Corp	信号処理装置および方法、並びに、プログラム
CN104628737B (zh) *	2015-01-28	2017-06-06	华南理工大学	两种新晶型的9‑硝基喜树碱及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4981968A (en) *	1987-03-31	1991-01-01	Research Triangle Institute	Synthesis of camptothecin and analogs thereof
US5527913A (en) *	1993-02-25	1996-06-18	The Stehlin Foundation For Cancer Research	Methods for purifying camptothecin compounds
GB9319944D0 (en) *	1993-09-28	1993-11-17	Erba Carlo Spa	Process for the preparation of 9-amino camptothecin
US5731316A (en) *	1996-01-30	1998-03-24	The Stehlin Foundation For Cancer Research	Derivatives of camptothecin and methods of treating cancer using these derivatives

1997
- 1997-08-05 US US08/906,434 patent/US5922877A/en not_active Ceased
1998
- 1998-07-10 CN CNA2007101625950A patent/CN101186609A/zh active Pending
- 1998-07-10 ES ES98933340T patent/ES2303355T3/es not_active Expired - Lifetime
- 1998-07-10 AT AT98933340T patent/ATE390429T1/de not_active IP Right Cessation
- 1998-07-10 CN CN98807978A patent/CN1266435A/zh active Pending
- 1998-07-10 DK DK98933340T patent/DK1003750T3/da active
- 1998-07-10 JP JP2000506212A patent/JP3651778B2/ja not_active Expired - Fee Related
- 1998-07-10 AU AU83003/98A patent/AU736323B2/en not_active Ceased
- 1998-07-10 EP EP98933340A patent/EP1003750B1/en not_active Expired - Lifetime
- 1998-07-10 PT PT98933340T patent/PT1003750E/pt unknown
- 1998-07-10 CA CA002296731A patent/CA2296731C/en not_active Expired - Fee Related
- 1998-07-10 HU HU0003206A patent/HUP0003206A3/hu unknown
- 1998-07-10 DE DE69839306T patent/DE69839306T2/de not_active Expired - Fee Related
- 1998-07-10 IL IL13422498A patent/IL134224A0/xx active IP Right Grant
- 1998-07-10 WO PCT/US1998/014532 patent/WO1999007709A1/en active IP Right Grant
2000
- 2000-01-26 IL IL134224A patent/IL134224A/en not_active IP Right Cessation
2004
- 2004-12-22 JP JP2004372250A patent/JP3842278B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CN101186609A (zh)	2008-05-28
US5922877A (en)	1999-07-13
AU736323B2 (en)	2001-07-26
DK1003750T3 (da)	2008-07-21
PT1003750E (pt)	2008-04-29
JP2001512732A (ja)	2001-08-28
IL134224A (en)	2006-10-31
DE69839306D1 (de)	2008-05-08
WO1999007709A1 (en)	1999-02-18
HUP0003206A3 (en)	2001-12-28
CA2296731C (en)	2007-01-09
EP1003750A1 (en)	2000-05-31
DE69839306T2 (de)	2009-04-09
JP2005145981A (ja)	2005-06-09
CA2296731A1 (en)	1999-02-18
HUP0003206A2 (hu)	2001-10-28
ES2303355T3 (es)	2008-08-01
JP3842278B2 (ja)	2006-11-08
CN1266435A (zh)	2000-09-13
ATE390429T1 (de)	2008-04-15
AU8300398A (en)	1999-03-01
EP1003750B1 (en)	2008-03-26
JP3651778B2 (ja)	2005-05-25

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Legal Events

Date	Code	Title	Description
2007-02-12	ERR	Corrigendum	Free format text: IN JOURNAL 8/2006 P. 3029 PATENT APPLICATION NO. 134224 LINE 2 OF THE ABRIDGEMENT, CORRECT THE NAMEOF THE COMPOUND - "2 CAMPTOTHECIN" TO "20 CAMPTOTHECIN"
2007-06-17	FF	Patent granted
2007-07-06	KB	Patent renewed
2008-11-03	KB	Patent renewed