IL132208A - 2-aminopropane-1,3-diol derivatives and pharmaceutical compositions containing the same - Google Patents

2-aminopropane-1,3-diol derivatives and pharmaceutical compositions containing the same

Info

Publication number
IL132208A
IL132208A IL13220898A IL13220898A IL132208A IL 132208 A IL132208 A IL 132208A IL 13220898 A IL13220898 A IL 13220898A IL 13220898 A IL13220898 A IL 13220898A IL 132208 A IL132208 A IL 132208A
Authority
IL
Israel
Prior art keywords
compound
same
aminopropane
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL13220898A
Other languages
English (en)
Other versions
IL132208A0 (en
Original Assignee
Mitsubishi Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Pharma Corp filed Critical Mitsubishi Pharma Corp
Priority to IL15506598A priority Critical patent/IL155065A/en
Priority to IL15506698A priority patent/IL155066A/en
Publication of IL132208A0 publication Critical patent/IL132208A0/xx
Publication of IL132208A publication Critical patent/IL132208A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/16—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same carbon atom of an acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/34—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton and at least one hydroxy group bound to another carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C223/00—Compounds containing amino and —CHO groups bound to the same carbon skeleton
    • C07C223/02—Compounds containing amino and —CHO groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL13220898A 1997-04-04 1998-04-03 2-aminopropane-1,3-diol derivatives and pharmaceutical compositions containing the same IL132208A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL15506598A IL155065A (en) 1997-04-04 1998-04-03 History - 2 Aminopropene - 1, 3 - Diol and Pharmaceutical Preparations Containing Them
IL15506698A IL155066A (en) 1997-04-04 1998-04-03 History 2 - Amino - 2 - (2 - Ethyl (converted)) Propane - 1, 3 - Diol Efficacy in the preparation of 2 - Aminopropene - 1, 3 - Diol

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8625597 1997-04-04
PCT/JP1998/001571 WO1998045249A1 (fr) 1997-04-04 1998-04-03 Composes 2-aminopropane-1,3-diol, leur utilisation pharmaceutique, et intermediaires servant a leur synthese

Publications (2)

Publication Number Publication Date
IL132208A0 IL132208A0 (en) 2001-03-19
IL132208A true IL132208A (en) 2003-07-31

Family

ID=13881722

Family Applications (3)

Application Number Title Priority Date Filing Date
IL15506598A IL155065A (en) 1997-04-04 1998-04-03 History - 2 Aminopropene - 1, 3 - Diol and Pharmaceutical Preparations Containing Them
IL15506698A IL155066A (en) 1997-04-04 1998-04-03 History 2 - Amino - 2 - (2 - Ethyl (converted)) Propane - 1, 3 - Diol Efficacy in the preparation of 2 - Aminopropene - 1, 3 - Diol
IL13220898A IL132208A (en) 1997-04-04 1998-04-03 2-aminopropane-1,3-diol derivatives and pharmaceutical compositions containing the same

Family Applications Before (2)

Application Number Title Priority Date Filing Date
IL15506598A IL155065A (en) 1997-04-04 1998-04-03 History - 2 Aminopropene - 1, 3 - Diol and Pharmaceutical Preparations Containing Them
IL15506698A IL155066A (en) 1997-04-04 1998-04-03 History 2 - Amino - 2 - (2 - Ethyl (converted)) Propane - 1, 3 - Diol Efficacy in the preparation of 2 - Aminopropene - 1, 3 - Diol

Country Status (18)

Country Link
US (2) US6214873B1 (xx)
EP (2) EP1002792B1 (xx)
JP (1) JP4045364B2 (xx)
KR (1) KR100551931B1 (xx)
CN (2) CN1137086C (xx)
AT (2) ATE298740T1 (xx)
AU (1) AU735853B2 (xx)
BR (1) BR9808481A (xx)
CA (1) CA2286315C (xx)
DE (2) DE69830756T2 (xx)
DK (2) DK1319651T3 (xx)
ES (2) ES2240868T3 (xx)
IL (3) IL155065A (xx)
NZ (1) NZ500713A (xx)
PT (2) PT1319651E (xx)
RU (1) RU2198162C2 (xx)
SI (2) SI1319651T1 (xx)
WO (1) WO1998045249A1 (xx)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6861442B1 (en) * 1998-12-30 2005-03-01 Sugen, Inc. PYK2 and inflammation
US6515117B2 (en) * 1999-10-12 2003-02-04 Bristol-Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
NZ523554A (en) 2000-07-13 2004-12-24 Sankyo Co Amino alcohol derivatives
AU2001296536A1 (en) 2000-10-03 2002-04-15 University Of Virginian Patent Foundation Novel lysophosphatidic acid receptor agonists and antagonists
US20040241211A9 (en) * 2000-11-06 2004-12-02 Fischell Robert E. Devices and methods for reducing scar tissue formation
US6534693B2 (en) * 2000-11-06 2003-03-18 Afmedica, Inc. Surgically implanted devices having reduced scar tissue formation
WO2002064616A2 (en) 2001-01-30 2002-08-22 University Of Virgina Patent Foundation Agonists and antagonists of sphingosine-1-phosphate receptors
CN100479814C (zh) * 2001-02-22 2009-04-22 诺瓦提斯公司 促淋巴细胞归巢剂在制备用于治疗移植物功能恢复延迟的药物中的用途
US20030072717A1 (en) * 2001-02-23 2003-04-17 Vapotronics, Inc. Inhalation device having an optimized air flow path
DE60208355T2 (de) * 2001-03-26 2006-07-27 Novartis Ag 2-amino-propanol derivate
EP1389137B1 (en) * 2001-05-21 2006-07-19 InJet Digital Aerosols Limited Compositions for protein delivery via the pulmonary route
GB0117921D0 (en) * 2001-07-23 2001-09-12 Novartis Ag Organic compounds
JP4152884B2 (ja) 2001-09-27 2008-09-17 杏林製薬株式会社 ジアリールエーテル誘導体とその付加塩及び免疫抑制剤
CN1329372C (zh) * 2001-09-27 2007-08-01 杏林制药株式会社 二芳基硫醚衍生物及其加成盐和免疫抑制剂
GB0125443D0 (en) * 2001-10-23 2001-12-12 Novartis Ag Organic Compounds
AU2003202495B2 (en) * 2002-01-11 2006-07-20 Sankyo Company, Limited Amino alcohol derivative or phosphonic acid derivative and medicinal composition containing these
US6797722B2 (en) * 2002-05-03 2004-09-28 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole for the treatment of autoimmune diseases
DE60324416D1 (de) 2002-05-16 2008-12-11 Novartis Ag Verwendung von edg rezeptor bindenden wirkstoffen für die krebstherapie
GB0217152D0 (en) * 2002-07-24 2002-09-04 Novartis Ag Organic compounds
AU2003273865A1 (en) * 2002-09-13 2004-04-30 Novartis Ag Amino-propanol derivatives
RU2478378C2 (ru) 2002-09-24 2013-04-10 Новартис Аг Органические соединения
PE20150676A1 (es) * 2003-04-08 2015-05-17 Novartis Ag Composicion farmaceutica que contiene un agonista del receptor s1p y un alcohol de azucar
AU2008200368B2 (en) * 2003-04-08 2011-04-28 Mitsubishi Tanabe Pharma Corporation Solid pharmaceutical compositions comprising a S1P receptor agonist and a sugar alcohol
AU2011205050B2 (en) * 2003-04-08 2014-01-30 Mitsubishi Tanabe Pharma Corporation Solid pharmaceutical compositions comprising a S1P receptor agonist and a sugar alcohol
WO2004096752A1 (en) * 2003-04-30 2004-11-11 Novartis Ag Amino-propanol derivatives as sphingosine-1-phosphate receptor modulator
MY150088A (en) 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
EP1484057A1 (en) * 2003-06-06 2004-12-08 Aventis Pharma Deutschland GmbH Use of 2-amino-1-3-propanediol derivatives for the manufacture of a medicament for the treatment of various types of pain
US7524887B2 (en) 2003-06-06 2009-04-28 Sanofi-Aventis Deutschland Gmbh 2-amino-1,3-propanediol compounds for the treatment of acute pain
US20040265238A1 (en) * 2003-06-27 2004-12-30 Imtiaz Chaudry Inhalable formulations for treating pulmonary hypertension and methods of using same
GB0320638D0 (en) 2003-09-03 2003-10-01 Novartis Ag Organic compounds
GB0324210D0 (en) 2003-10-15 2003-11-19 Novartis Ag Organic compounds
GB0329498D0 (en) 2003-12-19 2004-01-28 Novartis Ag Organic compounds
GB0500020D0 (en) 2005-01-04 2005-02-09 Novartis Ag Organic compounds
NZ549162A (en) 2004-02-24 2009-12-24 Sankyo Co Amino-pyrrol alcohol compounds
AU2005237254B2 (en) * 2004-05-03 2010-02-04 Novartis Ag Combinations comprising a S1P receptor agonist and a JAK3 kinase inhibitor
EP1750722A4 (en) 2004-05-06 2010-03-10 Univ Virginia NEW LYSOPHOSPHIC ACID RECEPTORSELECTIVE ANTAGONISTS
GB0411929D0 (en) * 2004-05-27 2004-06-30 Novartis Ag Organic compounds
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
EP1772145B1 (en) * 2004-07-16 2011-03-23 Kyorin Pharmaceutical Co., Ltd. Method of effectively using medicine and method concerning prevention of side effect
TW200611687A (en) * 2004-07-29 2006-04-16 Sankyo Co Pharmaceutical compositions used for immunosuppressant
JP4919374B2 (ja) * 2004-07-29 2012-04-18 第一三共株式会社 免疫抑制剤としての医薬組成物
US20080096972A1 (en) 2004-07-30 2008-04-24 Thitiwan Buranachokpaisan Compound formulations of 2-amino-1, 3-propanediol compounds
US20060223866A1 (en) * 2004-08-13 2006-10-05 Praecis Pharmaceuticals, Inc. Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity
AU2005272619A1 (en) * 2004-08-13 2006-02-23 Praecis Pharmaceuticals, Inc. Methods and compositions for modulating sphingosine-1-phosphate (SIP) receptor activity
ES2563034T3 (es) * 2004-10-12 2016-03-10 Kyorin Pharmaceutical Co., Ltd. Procedimiento para producir hidrocloruro de 2-amino-2-[2-[4-(3-benciloxifeniltio)-2-clorofenil]etil]-1,3-propanodiol e hidratos del mismo, e intermedios para la producción de los mismos
KR20070085465A (ko) 2004-11-29 2007-08-27 노파르티스 아게 Ｓ１ｐ 수용체 효능제의 투여 용법
CA2595960A1 (en) * 2005-02-08 2006-08-17 Novartis Ag Antilymphocyte antibody induction by combination of an s1p receptor agonist/modulator and of immunosuppressive drugs
GB0504544D0 (en) 2005-03-04 2005-04-13 Novartis Ag Organic compounds
TW200702326A (en) * 2005-05-31 2007-01-16 Mitsubishi Pharma Corp 2-aminobutanol compound and its pharmaceutical use
TWI418350B (zh) * 2005-06-24 2013-12-11 Sankyo Co 含有ｐｐａｒ調節劑之醫藥組成物的用途
GT200600350A (es) * 2005-08-09 2007-03-28 Formulaciones líquidas
ES2385580T3 (es) * 2005-10-07 2012-07-26 Kyorin Pharmaceutical Co., Ltd. Agente terapéutico para enfermedades hepáticas que contiene un derivado de 2-amino-1,3-propanodiol como ingrediente activo
TWI389683B (zh) * 2006-02-06 2013-03-21 Kyorin Seiyaku Kk A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient
EP2007789B1 (en) 2006-04-11 2015-05-20 Novartis AG Spirocyclic HCV/HIV inhibitors and their uses
GB0612721D0 (en) 2006-06-27 2006-08-09 Novartis Ag Organic compounds
TW200815600A (en) 2006-08-04 2008-04-01 Daiichi Sankyo Co Ltd An enzyme for phosphorizing a medicine
RU2430925C2 (ru) * 2006-08-08 2011-10-10 Киорин Фармасьютикал Ко., Лтд. Производное аминофосфата и модулятор рецептора s1p, содержащий его в качестве активного ингредиента
US8273748B2 (en) * 2006-08-08 2012-09-25 Kyorin Pharmaceutical Co., Ltd. Amino alcohol derivative and immunosuppresive agent having same as an active ingredient
KR102044064B1 (ko) 2006-09-26 2019-11-12 노파르티스 아게 Ｓ１ｐ 조정제를 포함하는 제약 조성물
WO2008121709A1 (en) * 2007-03-30 2008-10-09 Transport Pharmaceuticals, Inc. Pharmaceutical formulations for iontophoretic delivery of an anti-fungal drug
JP5341754B2 (ja) 2007-06-14 2013-11-13 田辺三菱製薬株式会社 アミン化合物及びその医薬用途
DE102007039954A1 (de) * 2007-08-23 2009-02-26 Henkel Ag & Co. Kgaa Reduktive Entfärbung keratinhaltiger Fasern
KR101600098B1 (ko) 2007-10-12 2016-03-04 노파르티스 아게 스핑고신 1 포스페이트 (ｓ1ｐ) 수용체 조절제를 포함하는 조성물
US8476305B2 (en) 2008-02-07 2013-07-02 Kyorin Pharmaceutical Co., Ltd. Therapeutic agent or prophylactic agent for inflammatory bowel disease comprising amino alcohol derivative as active ingredient
US8512690B2 (en) 2009-04-10 2013-08-20 Novartis Ag Derivatised proline containing peptide compounds as protease inhibitors
US20110182850A1 (en) 2009-04-10 2011-07-28 Trixi Brandl Organic compounds and their uses
US9011833B2 (en) 2010-10-08 2015-04-21 Novartis Ag Vitamin E formulations of sulfamide NS3 inhibitors
JO3177B1 (ar) 2011-04-01 2018-03-08 Novartis Ag تركيبات تتالف من 2-أمينو-2- [ 2- ( 4- أكتيل فينيل ) إثيل ] بروبان - 3, 1- ديول
ES2665336T3 (es) 2012-04-23 2018-04-25 Mitsubishi Tanabe Pharma Corporation Compuesto amina y su uso para propósitos médicos
CN110862409B (zh) * 2019-12-04 2021-08-20 江南大学 一种制备含二元醇结构的硅烷类化合物及其改性水性聚氨酯的方法
US20220153684A1 (en) * 2020-11-13 2022-05-19 Shivalik Rasayan Limited Process for preparation of fingolimod hydrochloride

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3660488A (en) 1965-07-16 1972-05-02 Phillips Petroleum Co 2-halo-alkylene- and -cyclopentylene-2-amino-propane 1 3-diols
DE122011100012I1 (de) * 1992-10-21 2011-10-20 Mitsubishi Tanabe Pharma Corp 2-Amino-1, 3-propandiolverbindung und immunosuppressium.
DE69524962T4 (de) 1994-08-22 2003-08-28 Mitsubishi Pharma Corp., Osaka Benzolderivate und deren medizinische verwendung

Also Published As

Publication number Publication date
DE69825056D1 (de) 2004-08-19
CN1480450A (zh) 2004-03-10
DK1002792T3 (da) 2004-11-22
KR100551931B1 (ko) 2006-02-16
CA2286315A1 (en) 1998-10-15
KR20010006004A (ko) 2001-01-15
IL155065A (en) 2004-01-04
DK1319651T3 (da) 2005-08-01
PT1002792E (pt) 2004-12-31
EP1319651A2 (en) 2003-06-18
SI1319651T1 (en) 2005-10-31
EP1002792A1 (en) 2000-05-24
CN1290819C (zh) 2006-12-20
BR9808481A (pt) 2000-05-23
IL132208A0 (en) 2001-03-19
IL155066A0 (en) 2003-10-31
ES2240868T3 (es) 2005-10-16
USRE39072E1 (en) 2006-04-18
EP1002792A4 (en) 2002-03-20
EP1319651B1 (en) 2005-06-29
ES2226110T3 (es) 2005-03-16
DE69830756D1 (de) 2005-08-04
ATE298740T1 (de) 2005-07-15
JP4045364B2 (ja) 2008-02-13
ATE271028T1 (de) 2004-07-15
NZ500713A (en) 2000-07-28
PT1319651E (pt) 2005-09-30
EP1002792B1 (en) 2004-07-14
DE69830756T2 (de) 2006-05-04
AU6523098A (en) 1998-10-30
CN1259117A (zh) 2000-07-05
CA2286315C (en) 2007-03-06
US6214873B1 (en) 2001-04-10
IL155066A (en) 2004-06-20
IL155065A0 (en) 2003-10-31
WO1998045249A1 (fr) 1998-10-15
EP1319651A3 (en) 2004-01-02
CN1137086C (zh) 2004-02-04
RU2198162C2 (ru) 2003-02-10
AU735853B2 (en) 2001-07-19
DE69825056T2 (de) 2005-08-25
SI1002792T1 (en) 2004-12-31

Similar Documents

Publication Publication Date Title
IL132208A (en) 2-aminopropane-1,3-diol derivatives and pharmaceutical compositions containing the same
IL109615A0 (en) Polypeptide derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
CA2126337A1 (en) 2-amino-1,3-propanediol compound and immunosuppressant
IL147595A0 (en) Bicyclonucleoside analogues, oligonucleotide analogues and pharmaceutical compositions containing the same
TW369535B (en) A pyrazolopyridine compound and the process for preparing thereof
CA2275166A1 (en) Novel benzopyran derivatives
DE3572978D1 (en) Piperazine compound as paf-antagonist
HUT61780A (en) Process for producing new peptides and pharmaceutical compositions comprising same as active ingredient
DE68926981D1 (de) Cephemverbindungen und Verfahren zu ihrer Herstellung
EP0947513A4 (en) TRICYCLIC AMINE DERIVATIVES
HUT56089A (en) Process for producing quinazoline derivatives and pharmaceutical compositions containing them
IE891199L (en) 2-alkyl-3-benzoylbenzofurans and pharmaceutical compositions¹containing them
DK0420121T3 (da) Antitumormiddel
GR3007219T3 (xx)
IL108068A0 (en) Cephem derivatives and pharmaceutical compositions containing the same
TW360630B (en) A secoaporphine compounds on arrhythmia

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees