IL131515A0 - Substituted 4-arylmethylene-2-imino-2,3- dihydrothiazoles and derivatives and their pharmaceutical use - Google Patents
Substituted 4-arylmethylene-2-imino-2,3- dihydrothiazoles and derivatives and their pharmaceutical useInfo
- Publication number
- IL131515A0 IL131515A0 IL13151598A IL13151598A IL131515A0 IL 131515 A0 IL131515 A0 IL 131515A0 IL 13151598 A IL13151598 A IL 13151598A IL 13151598 A IL13151598 A IL 13151598A IL 131515 A0 IL131515 A0 IL 131515A0
- Authority
- IL
- Israel
- Prior art keywords
- carbon atoms
- optionally substituted
- group
- group containing
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9705428.2A GB9705428D0 (en) | 1997-03-15 | 1997-03-15 | Therapeutic agents |
PCT/EP1998/001358 WO1998041528A1 (fr) | 1997-03-15 | 1998-03-09 | 4-arylmethylene-2-imino-2,3-dihydrothiazoles substitues, leurs derives, et leur utilisation pharmaceutique |
Publications (1)
Publication Number | Publication Date |
---|---|
IL131515A0 true IL131515A0 (en) | 2001-01-28 |
Family
ID=10809320
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13151598A IL131515A0 (en) | 1997-03-15 | 1998-03-09 | Substituted 4-arylmethylene-2-imino-2,3- dihydrothiazoles and derivatives and their pharmaceutical use |
Country Status (22)
Country | Link |
---|---|
US (1) | US6187802B1 (fr) |
EP (1) | EP0970090B1 (fr) |
JP (1) | JP2001515501A (fr) |
KR (1) | KR20000076190A (fr) |
CN (1) | CN1255136A (fr) |
AT (1) | ATE218573T1 (fr) |
AU (1) | AU6728898A (fr) |
BG (1) | BG103754A (fr) |
BR (1) | BR9808254A (fr) |
CA (1) | CA2283438A1 (fr) |
DE (1) | DE69805781D1 (fr) |
GB (1) | GB9705428D0 (fr) |
HU (1) | HUP0001508A3 (fr) |
ID (1) | ID22636A (fr) |
IL (1) | IL131515A0 (fr) |
NO (1) | NO994452L (fr) |
NZ (1) | NZ337378A (fr) |
PL (1) | PL335696A1 (fr) |
SK (1) | SK122099A3 (fr) |
TR (1) | TR199902291T2 (fr) |
WO (1) | WO1998041528A1 (fr) |
ZA (1) | ZA982134B (fr) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19856965A1 (de) * | 1998-12-10 | 2000-06-15 | Bayer Ag | Substituierte 2-Imino-thiazoline |
US6803387B1 (en) | 1999-03-19 | 2004-10-12 | Abbott Gmbh & Co. Kg | Treatment of neuropathic pain or fibromyalgia |
US6372798B1 (en) | 1999-03-19 | 2002-04-16 | Knoll Pharmaceutical Company | Treatment of hyperactivity disorders |
AU3895300A (en) | 1999-03-19 | 2000-10-09 | Knoll Pharmaceutical Company | Treatment of chronic fatigue syndrome |
AU3760600A (en) | 1999-03-19 | 2000-10-09 | Knoll Pharmaceutical Company | Treatment of orthostatic hypotension |
MXPA01009468A (es) | 1999-03-19 | 2004-03-19 | Knoll Gmbh | Tratamiento de hipertension pulmonar. |
WO2000056308A1 (fr) | 1999-03-19 | 2000-09-28 | Knoll Pharmaceutical Company | Prevention de maladies cardio-vasculaires |
WO2000056311A1 (fr) | 1999-03-19 | 2000-09-28 | Knoll Pharmaceutical Company | Regulation du metabolisme |
US6376554B1 (en) | 1999-03-19 | 2002-04-23 | Knoll Pharmaceutical Company | Method of treating sexual dysfunction |
GB9911881D0 (en) * | 1999-05-21 | 1999-07-21 | Knoll Ag | Therapeutic agents |
GB9911863D0 (en) * | 1999-05-21 | 1999-07-21 | Knoll Ag | Therapeutic agents |
FR2796643B1 (fr) * | 1999-07-22 | 2005-04-29 | Sod Conseils Rech Applic | Derives de 2-arylimino-2, 3-dihydrothiazoles, leurs procedes de preparation et leur utilisation therapeutique |
GB0005789D0 (en) * | 2000-03-11 | 2000-05-03 | Knoll Ag | Therapeutic agents |
AU2002314744A1 (en) | 2001-04-17 | 2002-10-28 | Sepracor, Inc. | Thiazole and other heterocyclic ligands and use thereof |
US20060281797A1 (en) * | 2001-12-11 | 2006-12-14 | University Of Virginia Patent Foundation | Neurorestoration with R(+) Pramipexole |
ATE480235T1 (de) * | 2001-12-11 | 2010-09-15 | Univ Virginia | Verwendung von pramipexol zur behandlung von amyotrophischer lateralsklerose |
US6743797B2 (en) | 2002-02-22 | 2004-06-01 | Chantest, Inc. | Methods for treating cardiac arrhythmia |
US20050054010A1 (en) * | 2003-07-15 | 2005-03-10 | Brown Arthur M. | High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins |
US7211407B2 (en) * | 2003-07-15 | 2007-05-01 | Chan Test, Inc. | High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins |
US20050208595A1 (en) * | 2004-03-19 | 2005-09-22 | Brown Arthur M | High throughput assay systems and methods for identifying agents that alter expression of cellular proteins |
JP2009504748A (ja) * | 2005-08-15 | 2009-02-05 | ユニバーシティ オブ バージニア パテント ファウンデーション | R(+)プラミペキソールを用いた神経回復 |
US20070203111A1 (en) * | 2006-01-06 | 2007-08-30 | Sepracor Inc. | Cycloalkylamines as monoamine reuptake inhibitors |
KR100752757B1 (ko) * | 2006-04-05 | 2007-08-29 | 한국과학기술연구원 | 2-페닐이미노-1,3-티아졸린을 포함하는 미백 조성물 |
US20070259930A1 (en) * | 2006-04-10 | 2007-11-08 | Knopp Neurosciences, Inc. | Compositions and methods of using r(+) pramipexole |
US8518926B2 (en) * | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
KR20090021169A (ko) | 2006-05-16 | 2009-02-27 | 크놉 뉴로사이언시스 인코포레이티드 | R(+) 및 s(-) 프라미펙솔을 포함하는 조성물 및 이의 사용 방법 |
US8524695B2 (en) * | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
WO2008113056A2 (fr) | 2007-03-14 | 2008-09-18 | Knopp Neurosciences, Inc. | Synthèse de benzothiazole diamines substituées et purifiées du point de vue chiral |
EP2334185A4 (fr) * | 2008-08-19 | 2011-09-21 | Knopp Neurosciences Inc | Compositions et procédés employant du (r)-pramipexole |
KR101049935B1 (ko) * | 2008-12-03 | 2011-07-15 | 한국과학기술연구원 | 신규한 티아졸린계 화합물 및 이를 포함하는 t-형 칼슘 채널 저해제 |
MX2011013577A (es) * | 2009-06-19 | 2012-04-10 | Knopp Neurosciences Inc | Composiciones y metodos para tratar esclerosis lateral amiotrofica. |
WO2013096816A1 (fr) | 2011-12-22 | 2013-06-27 | Biogen Idec Ma Inc. | Synthèse améliorée de composés substitués par amine de 4,5,6,7-tétrahydrobenzothiazole |
US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
PL3019167T3 (pl) | 2013-07-12 | 2021-06-14 | Knopp Biosciences Llc | Leczenie podwyższonych poziomów eozynofili i/lub bazofili |
US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
ES2813674T3 (es) | 2013-08-13 | 2021-03-24 | Knopp Biosciences Llc | Composiciones y métodos para el tratamiento de trastornos de células plasmáticas y trastornos prolinfocíticos de células b |
HUE055850T2 (hu) | 2013-08-13 | 2022-01-28 | Knopp Biosciences Llc | Készítmények és módszerek a krónikus urticaria (csalánkiütés) kezelésére |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4347248A (en) * | 1981-03-23 | 1982-08-31 | American Cyanamid Company | 2,3-Disubstituted-thiazolo[3,2-a]pyrimidines |
US5232921A (en) | 1987-03-12 | 1993-08-03 | Sanofi | Thiazole derivatives active on the cholinergic system, process for obtention and pharmaceutical compositions |
FR2612187B1 (fr) * | 1987-03-12 | 1989-07-21 | Sanofi Sa | Derives du thiazole actifs sur le systeme cholinergique, leur procede de preparation et compositions pharmaceutiques en contenant |
US5463069A (en) * | 1992-12-04 | 1995-10-31 | Sumitomo Chemical Company, Limited | Process of producing 2-iminothiazoline derivatives and process of producing their intermediates |
CN1113242A (zh) * | 1994-04-04 | 1995-12-13 | 住友化学工业株式会社 | 亚氨基噻唑啉衍生物及含有它们作为活性成分的除草剂 |
GB9513467D0 (en) | 1995-07-01 | 1995-09-06 | Knoll Ag | Therapeutic agents |
-
1997
- 1997-03-15 GB GBGB9705428.2A patent/GB9705428D0/en active Pending
-
1998
- 1998-03-09 HU HU0001508A patent/HUP0001508A3/hu unknown
- 1998-03-09 ID IDW991023A patent/ID22636A/id unknown
- 1998-03-09 AT AT98912459T patent/ATE218573T1/de not_active IP Right Cessation
- 1998-03-09 BR BR9808254-0A patent/BR9808254A/pt not_active IP Right Cessation
- 1998-03-09 EP EP98912459A patent/EP0970090B1/fr not_active Expired - Lifetime
- 1998-03-09 AU AU67288/98A patent/AU6728898A/en not_active Abandoned
- 1998-03-09 CA CA002283438A patent/CA2283438A1/fr not_active Abandoned
- 1998-03-09 IL IL13151598A patent/IL131515A0/xx unknown
- 1998-03-09 WO PCT/EP1998/001358 patent/WO1998041528A1/fr not_active Application Discontinuation
- 1998-03-09 NZ NZ337378A patent/NZ337378A/xx unknown
- 1998-03-09 PL PL98335696A patent/PL335696A1/xx unknown
- 1998-03-09 US US09/380,967 patent/US6187802B1/en not_active Expired - Fee Related
- 1998-03-09 JP JP54009198A patent/JP2001515501A/ja active Pending
- 1998-03-09 KR KR1019997008284A patent/KR20000076190A/ko not_active Application Discontinuation
- 1998-03-09 TR TR1999/02291T patent/TR199902291T2/xx unknown
- 1998-03-09 CN CN98804891A patent/CN1255136A/zh active Pending
- 1998-03-09 SK SK1220-99A patent/SK122099A3/sk unknown
- 1998-03-09 DE DE69805781T patent/DE69805781D1/de not_active Expired - Lifetime
- 1998-03-13 ZA ZA9802134A patent/ZA982134B/xx unknown
-
1999
- 1999-09-14 NO NO994452A patent/NO994452L/no unknown
- 1999-09-24 BG BG103754A patent/BG103754A/bg unknown
Also Published As
Publication number | Publication date |
---|---|
ZA982134B (en) | 1999-09-13 |
ID22636A (id) | 1999-12-02 |
HUP0001508A2 (hu) | 2001-01-29 |
GB9705428D0 (en) | 1997-04-30 |
US6187802B1 (en) | 2001-02-13 |
TR199902291T2 (xx) | 1999-12-21 |
HUP0001508A3 (en) | 2003-01-28 |
ATE218573T1 (de) | 2002-06-15 |
AU6728898A (en) | 1998-10-12 |
DE69805781D1 (de) | 2002-07-11 |
BR9808254A (pt) | 2000-05-16 |
CN1255136A (zh) | 2000-05-31 |
BG103754A (bg) | 2000-06-30 |
EP0970090A1 (fr) | 2000-01-12 |
SK122099A3 (en) | 2000-05-16 |
EP0970090B1 (fr) | 2002-06-05 |
NO994452D0 (no) | 1999-09-14 |
WO1998041528A1 (fr) | 1998-09-24 |
NO994452L (no) | 1999-09-14 |
CA2283438A1 (fr) | 1998-09-24 |
JP2001515501A (ja) | 2001-09-18 |
NZ337378A (en) | 2001-01-26 |
KR20000076190A (ko) | 2000-12-26 |
PL335696A1 (en) | 2000-05-08 |
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