IL126404A0 - Pyrazinone thrombin inhibitors - Google Patents

Pyrazinone thrombin inhibitors

Info

Publication number
IL126404A0
IL126404A0 IL12640497A IL12640497A IL126404A0 IL 126404 A0 IL126404 A0 IL 126404A0 IL 12640497 A IL12640497 A IL 12640497A IL 12640497 A IL12640497 A IL 12640497A IL 126404 A0 IL126404 A0 IL 126404A0
Authority
IL
Israel
Prior art keywords
thrombin inhibitors
pyrazinone
pyrazinone thrombin
inhibitors
compounds
Prior art date
Application number
IL12640497A
Other languages
English (en)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9609714.2A external-priority patent/GB9609714D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IL126404A0 publication Critical patent/IL126404A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL12640497A 1996-04-23 1997-04-18 Pyrazinone thrombin inhibitors IL126404A0 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1604196P 1996-04-23 1996-04-23
GBGB9609714.2A GB9609714D0 (en) 1996-05-09 1996-05-09 Pyridinone thrombin inhibitors
US4300997P 1997-04-14 1997-04-14
PCT/US1997/006744 WO1997040024A1 (en) 1996-04-23 1997-04-18 Pyrazinone thrombin inhibitors

Publications (1)

Publication Number Publication Date
IL126404A0 true IL126404A0 (en) 1999-05-09

Family

ID=27268274

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12640497A IL126404A0 (en) 1996-04-23 1997-04-18 Pyrazinone thrombin inhibitors

Country Status (21)

Country Link
EP (1) EP0900207B1 (xx)
JP (1) JP3140790B2 (xx)
KR (1) KR20000010650A (xx)
AT (1) ATE209191T1 (xx)
AU (1) AU714985B2 (xx)
BG (1) BG102948A (xx)
BR (1) BR9708859A (xx)
CA (1) CA2252964A1 (xx)
CZ (1) CZ340898A3 (xx)
DE (1) DE69709727T2 (xx)
EE (1) EE9800353A (xx)
HR (1) HRP970211A2 (xx)
IL (1) IL126404A0 (xx)
IS (1) IS4853A (xx)
NO (1) NO984928L (xx)
NZ (1) NZ331993A (xx)
PE (1) PE13399A1 (xx)
PL (1) PL329441A1 (xx)
SK (1) SK145398A3 (xx)
TR (1) TR199802133T2 (xx)
WO (1) WO1997040024A1 (xx)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU746024B2 (en) * 1996-04-23 2002-04-11 Merck & Co., Inc. Pyrazinone thrombin inhibitors
DE69710594T2 (de) * 1996-09-16 2002-08-29 Du Pont Pharmaceuticals Co., Wilmington Eine resorbierbare röntgenopake markierung enthaltendes chirurgisches implantat und verfahren zum verriegeln desselben in einem körper
AU728006B2 (en) * 1997-03-24 2001-01-04 Merck & Co., Inc. Thrombin inhibitors
US6011038A (en) * 1997-09-05 2000-01-04 Merck & Co., Inc. Pyrazinone thrombin inhibitors
EP1079835A4 (en) * 1998-05-19 2002-10-29 Merck & Co Inc PYRAZINONE AS THROMBINE INHIBITORS
US6147078A (en) * 1998-05-19 2000-11-14 Merck & Co., Inc. Pyrazinone thrombin inhibitors
CA2333040A1 (en) * 1998-05-26 1999-12-02 Merck & Co., Inc. Imidazopyridine thrombin inhibitors
PL344749A1 (en) 1998-06-11 2001-11-19 Dimensional Pharmaceuticals 3 Pyrazinone protease inhibitors
ATE253076T1 (de) 1998-08-14 2003-11-15 Pfizer Antithrombosemittel
JP2002525370A (ja) * 1998-09-28 2002-08-13 メルク エンド カムパニー インコーポレーテッド トロンビン阻害剤
CA2348530A1 (en) 1998-10-30 2000-05-11 Merck & Co., Inc. Thrombin inhibitors
EP1124822A4 (en) 1998-10-30 2002-04-03 Merck & Co Inc THROMBIN INHIBITORS
WO2000039102A1 (en) * 1998-12-23 2000-07-06 Du Pont Pharmaceuticals Company THROMBIN OR FACTOR Xa INHIBITORS
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
US6716838B1 (en) 1999-05-19 2004-04-06 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents
US7015230B1 (en) 1999-05-19 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
BR0011295A (pt) * 1999-05-19 2002-05-28 Pharmacia Corp Aril e heteroaril pirazinonas policìclicas substituìdas úteis para inibição seletiva de cascata de coagulação
US6664255B1 (en) 1999-05-19 2003-12-16 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
US6750342B1 (en) 1999-05-19 2004-06-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6458952B1 (en) 1999-05-19 2002-10-01 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6653316B1 (en) 1999-05-19 2003-11-25 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6867217B1 (en) 1999-05-19 2005-03-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
EP1586565A1 (en) * 1999-05-19 2005-10-19 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
UA58636C2 (uk) * 1999-06-04 2003-08-15 Мерк Енд Ко., Інк. Піразинонові інгібітори тромбіну, фармацевтична композиція, спосіб інгібування утворення тромбів у крові, спосіб лікування станів, пов'язаних із тромбоутворенням
DE60031686T2 (de) 1999-07-19 2007-08-30 Merck Frosst Canada Ltd., Kirkland Pyrazinone, diese verbindungen enthaltende zusammenstellungen
CA2391012A1 (en) 1999-11-23 2001-05-31 Merck & Co., Inc. Pyrazinone thrombin inhibitors
AU2001243598A1 (en) 2000-03-13 2001-09-24 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade
EP1267876A1 (en) 2000-03-23 2003-01-02 Merck & Co., Inc. Thrombin inhibitors
CA2405306A1 (en) 2000-04-05 2001-10-18 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade
ATE289299T1 (de) 2000-04-05 2005-03-15 Pharmacia Corp Polyzyclisch aryl und heteroaryl substituierte 4- pyronen verwendbar als selektive hemmung von dem koagulationsprozess
WO2001079193A2 (en) * 2000-04-14 2001-10-25 Corvas International, Inc. Substituted hydrazinyl heteroaromatic inhibitors of thrombin
US6506760B1 (en) 2000-04-14 2003-01-14 Corvas International, Inc. Substituted hydrazinyl heteroaromatic inhibitors of thrombin
US6506761B1 (en) 2000-04-14 2003-01-14 Corvas International, Inc. Substituted hydrazinyl heteroaromatic inhibitors of thrombin
US20040171616A9 (en) 2000-04-17 2004-09-02 South Michael S. Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade
US6476016B2 (en) 2000-07-17 2002-11-05 3-Dimensional Pharmaceuticals, Inc. Cyclic oxyguanidine pyrazinones as protease inhibitors
US6710058B2 (en) 2000-11-06 2004-03-23 Bristol-Myers Squibb Pharma Company Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
US7015223B1 (en) 2000-11-20 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade
MXPA03004458A (es) 2000-11-20 2005-01-25 Pharmacia Corp Arilpiridinas y heteroarilpiridinas sustituidas utiles para inhibicion selectiva de la cascada de coagulacion.
US7119094B1 (en) 2000-11-20 2006-10-10 Warner-Lambert Company Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade
US7105559B2 (en) 2001-10-03 2006-09-12 Pharmacia Corporation Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade
JP2005519866A (ja) 2001-10-03 2005-07-07 ファルマシア・コーポレーション 凝固カスケードの選択阻害に有用な６員複素環式化合物
PL218749B1 (pl) 2002-02-14 2015-01-30 Pharmacia Corp Pochodna pirydynonu oraz jej zastosowanie do wytwarzania leku
GB0306615D0 (en) * 2003-03-22 2003-04-30 Astrazeneca Ab New use
EP1526131A1 (en) * 2003-10-22 2005-04-27 Graffinity Pharmaceuticals Aktiengesellschaft Aminoalkyl-pyrazinones and -pyridones as thrombin inhibitors
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
MX2007016090A (es) * 2005-06-17 2008-03-10 Astrazeneca Ab Derivados de 2-oxo-1,2,5,6-tetrahidropiridina que inhiben trombina.
WO2017067670A1 (en) 2015-10-23 2017-04-27 Pharmathen S.A. A novel process for the preparation of tryptamines and derivatives thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2037738T3 (es) * 1986-09-26 1993-07-01 Ciba-Geigy Ag Procedimiento para la obtencion de aminopirazinonas y aminotriazinonas.

Also Published As

Publication number Publication date
PL329441A1 (en) 1999-03-29
EP0900207A1 (en) 1999-03-10
IS4853A (is) 1998-09-25
DE69709727D1 (de) 2002-02-21
JP3140790B2 (ja) 2001-03-05
CA2252964A1 (en) 1997-10-30
DE69709727T2 (de) 2002-08-08
KR20000010650A (ko) 2000-02-25
NZ331993A (en) 2000-04-28
WO1997040024A1 (en) 1997-10-30
NO984928D0 (no) 1998-10-22
BG102948A (bg) 1999-11-30
BR9708859A (pt) 1999-08-03
AU2679997A (en) 1997-11-12
ATE209191T1 (de) 2001-12-15
NO984928L (no) 1998-12-22
EP0900207B1 (en) 2001-11-21
TR199802133T2 (xx) 2000-09-21
CZ340898A3 (cs) 1999-02-17
EE9800353A (et) 1999-04-15
PE13399A1 (es) 1999-02-11
JP2000508334A (ja) 2000-07-04
SK145398A3 (en) 1999-05-07
AU714985B2 (en) 2000-01-13
HRP970211A2 (en) 1998-06-30

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